Latest Pharmaceutical Research

Pharmacology

Immunogenicity, Safety and Immune Persistence of Sabin Strain Inactivated Poliovirus Vaccine: A Phase III Clinical Trial.

Published in Scand J Immunol. doi: 10.1111/sji.70097

Huang T 2026 Mar

Pharmacology

Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols.

Published in CPT Pharmacometrics Syst Pharmacol. doi: 10.1002/psp4.70201

Waikar S 2026 Mar

ADMET

Comprehensive Pathophysiology Repository for PBPK Modeling in Liver Cirrhosis: Quantifying Continuous Disease Progression and Population Variability.

Published in CPT Pharmacometrics Syst Pharmacol. doi: 10.1002/psp4.70215

Schneider ARP 2026 Mar

Pharmacology

Continuous review for ethical conduct of clinical trial-are the ethics committees complying?

Published in Perspect Clin Res. doi: 10.4103/picr.picr_184_25

Kalikar MV 2026 Jan-Mar

Pharmacology

Trends and innovations in amphotericin clinical trials: Insights from the clinical trial registry of India.

Published in Perspect Clin Res. doi: 10.4103/picr.picr_55_25

Nivasini NT 2026 Jan-Mar

Drug Interactions

Polypharmacy and potential drug-drug interactions among older patients: A cross-sectional baseline study pre-2023 Palestine crisis.

Published in Sci Prog. doi: 10.1177/00368504261423340

Mosleh R 2026 Jan-Mar

Pharmacology

Incidence and impact of remimazolam-induced paradoxical reactions in pediatric same-day bidirectional endoscopy: a randomized, controlled clinical trial.

Published in Minerva Anestesiol. doi: 10.23736/S0375-9393.25.19235-3

Zhou S 2026 Jan-Feb

Pharmacology

Effect of Ultrasound Combined with Microbubbles on Blood Perfusion in Invasive Breast Cancer-A Prospective Clinical Trial.

Published in Technol Cancer Res Treat. doi: 10.1177/15330338261423051

Dong Y 2026 Jan-Dec

Drug Discovery

Leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands: application to the histamine H(1) receptor.

Published in RSC Med Chem. doi: 10.1039/d5md01081k

Dekker T 2026 Jan 29

Drug Discovery

Mining the Hidden Pharmacopeia: Fungal Endophytes, Natural Products, and the Rise of AI-Driven Drug Discovery.

Published in Int J Mol Sci. doi: 10.3390/ijms27031365

Al Shami R 2026 Jan 29

ADMET

Direct Oral Anti-Xa Anticoagulants and the Future of Factor XI/FXIa Inhibition: A New Paradigm in Thrombosis Prevention.

Published in Pharmacy (Basel). pii: 19. doi: 10.3390/pharmacy14010019

Bernardi FF 2026 Jan 27

ADMET

Oral Baclofen Toxicity in a Pediatric Patient Managed Without Invasive Intervention: A Case Report and Literature Review.

Published in Cureus. doi: 10.7759/cureus.101812

Alqahtani B 2026 Jan

Drug Discovery

High throughput quantitative tracking of Plasmodium falciparum clonal blood stage parasite growth and applications for antimalarial drug discovery.

Published in bioRxiv. pii: 2025.11.30.691439. doi: 10.1101/2025.11.30.691439

Cheng Z 2026 Feb 6

ADMET

Efficacy and Safety of Minocycline-Containing Bismuth Quadruple Therapies Versus Standard First-Line Bismuth Quadruple Therapies for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis.

Published in Infect Dis Rep. pii: 16. doi: 10.3390/idr18010016

Wazir HU 2026 Feb 6

Drug Discovery

In situ mapping of HSA reabsorption by a NIR fluorogenic sensor as a practical phenotypic assay for nephroprotective drug discovery.

Published in Biosens Bioelectron. doi: 10.1016/j.bios.2026.118490

Fan Y 2026 Feb 5

Drug Discovery

Direct-to-Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery.

Published in ChemMedChem. doi: 10.1002/cmdc.202501080

Hübner AF 2026 Feb 25

ADMET

Modulation of inflammatory and oxidative stress pathways by ethanolic extract of Suaeda fruticosa Forssk. Ex J.F.Gmel in animal models of ulcerative colitis.

Published in Inflammopharmacology. doi: 10.1007/s10787-026-02131-7

Liu J 2026 Feb 20

ADMET

Pharmacokinetic-pharmacodynamic modeling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo.

Published in Antimicrob Agents Chemother. doi: 10.1128/aac.01788-25

Saporta R 2026 Feb 20

Drug Interactions

Drug Interactions Between Direct Oral Anticoagulants and Nonsteroidal Anti-inflammatory Drugs: A Clinical Risk-Benefit Analysis With Focus on Special Populations.

Published in Am J Ther. doi: 10.1097/MJT.0000000000002105

Mameli A 2026 Feb 20

Drug Discovery

Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary Fibrosis.

Published in bioRxiv. pii: 2026.01.29.702646. doi: 10.64898/2026.01.29.702646

Sen C 2026 Feb 2

Pharmacology

CYP2D6-Guided Opioid Management and Postoperative Pain Control: A Randomized Clinical Trial.

Published in JAMA Netw Open. doi: 10.1001/jamanetworkopen.2025.58299

Cavallari LH 2026 Feb 2

Pharmacology

Pharmacist Intervention for Safer Prescribing in Patients With Type 2 Diabetes at High Risk: A Randomized Clinical Trial.

Published in JAMA Netw Open. doi: 10.1001/jamanetworkopen.2025.59946

Gilliam LK 2026 Feb 2

Pharmacology

Adjuvant Pembrolizumab for Stage IIB or IIC Melanoma: A Secondary Analysis of a Randomized Clinical Trial.

Published in JAMA Netw Open. doi: 10.1001/jamanetworkopen.2025.59603

Leachman SA 2026 Feb 2

ADMET

Effects of extracorporeal membrane oxygenation on the pharmacokinetics and tissue penetration rates of vancomycin and linezolid: data from Landrace pigs.

Published in J Antimicrob Chemother. pii: dkag063. doi: 10.1093/jac/dkag063

Zhang H 2026 Feb 2

Drug Interactions

Point-Prevalence of Antimicrobial-Related Potential Drug-Drug Interactions in Hospitalized Older Adults: A Multicenter Study Using Lexicomp.

Published in J Clin Med. doi: 10.3390/jcm15031163

Arslan Y 2026 Feb 2

Drug Discovery

Short-term electrical stimulation promotes partial functional and morphological maturation of human-induced pluripotent stem cell-derived cardiomyocytes enabling cardiotoxicity risk mitigation at early-stage drug discovery for cardiac contractility modulation.

Published in Toxicol Sci. pii: kfag018. doi: 10.1093/toxsci/kfag018

Miyoshi H 2026 Feb 19

ADMET

Pharmacokinetics-Driven Optimization of Immunotherapeutic Agents Targeting the Adenosine A(2A) Receptor (A(2A)R) and Histone Deacetylases (HDACs).

Published in J Med Chem. doi: 10.1021/acs.jmedchem.5c03481

Yan W 2026 Feb 19

Drug Discovery

Closing the translational gap in cardiovascular artificial intelligence: from drug discovery to evidence synthesis.

Published in J Cardiovasc Pharmacol. doi: 10.1097/FJC.0000000000001808

Biondi-Zoccai G 2026 Feb 18

Drug Interactions

Navigating drug-drug interactions with apalutamide.

Published in Prostate Cancer Prostatic Dis. doi: 10.1038/s41391-026-01086-8

Siddiqui BA 2026 Feb 18

Drug Discovery

Advances in computational methods for PROTAC drug discovery.

Published in Drug Discov Today. doi: 10.1016/j.drudis.2026.104627

Martinez-Cortés MS 2026 Feb 17

Pharmacology

Public involvement in the design of a complex neurosurgical clinical trial (the GDNF trial) and an associated support package: reflections and recommendations.

Published in Trials. doi: 10.1186/s13063-026-09529-2

Bakshi N 2026 Feb 17

Pharmacology

Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.

Published in BMJ. doi: 10.1136/bmj-2025-087438

Hu KL 2026 Feb 17

Pharmacology

Evaluating Pain Relief After Dental Implant Surgery Using 0.3% Benzydamine Hydrochloride Spray: A Double-Blind, Randomized Clinical Trial.

Published in J Oral Implantol. doi: 10.1563/aaid-joi-D-25-00034

Kaboosaya B 2026 Feb 17

Drug Discovery

Enabling multi-target drug discovery through latent evolutionary optimization and synthesis-aware prioritization (EVOSYNTH).

Published in Commun Chem. doi: 10.1038/s42004-026-01945-4

Nguyen VTD 2026 Feb 16

Pharmacology

Improvements in quality-of-life dimensions through medium-chain triglyceride (MCT) supplementation in rheumatoid arthritis: updated findings from a randomised clinical trial.

Published in RMD Open. doi: 10.1136/rmdopen-2025-006036

Gaudioso G 2026 Feb 16

ADMET

Pyrazolo[3,4-d]pyrimidine derivatives as VEGFR-2 and EGFR(T790M) dual inhibitors: design, docking, ADMET, synthesis and anticancer evaluations.

Published in RSC Adv. doi: 10.1039/d6ra00037a

Aziz NAAM 2026 Feb 16

Drug Discovery

Kinic index: an artificial intelligence-driven predictive model and multitarget drug discovery framework for hepatocellular carcinoma patients.

Published in NPJ Precis Oncol. doi: 10.1038/s41698-026-01324-1

Zhou J 2026 Feb 14

Drug Interactions

Drug Interactions Are Crucial in the Care of Patients on Opioid Substitutional Therapy-A Case Report.

Published in Reports (MDPI). pii: 64. doi: 10.3390/reports9010064

Devarapalli SK 2026 Feb 14

Drug Discovery

Unlocking Multiscale Allosteric Mechanisms: Advanced Computational Strategies for Drug Discovery.

Published in Med Res Rev. doi: 10.1002/med.70036

Zhu R 2026 Feb 13

Pharmacology

Preventive effect of transcutaneous acupoint electrical stimulation on emergence agitation after general anesthesia in pediatric patients undergoing tonsillectomy: A randomized clinical trial.

Published in Medicine (Baltimore). doi: 10.1097/MD.0000000000047737

Li X 2026 Feb 13

Drug Discovery

The Value of Academic and Industrial Collaborations in Drug Discovery.

Published in ACS Med Chem Lett. doi: 10.1021/acsmedchemlett.5c00786

Djuric SW 2026 Feb 12

Drug Discovery

Optimizing Drug Discovery in Resource-Limited Settings: Multi-Parameter Optimization and Data-Driven Workflows.

Published in ACS Med Chem Lett. doi: 10.1021/acsmedchemlett.5c00501

Nchinda AT 2026 Feb 12

Drug Discovery

Targeting enzyme trafficking: From molecular mechanisms to drug discovery.

Published in Drug Discov Today. doi: 10.1016/j.drudis.2026.104625

Dong H 2026 Feb 12

Drug Discovery

Small-Molecule Drug Discovery Targeting RNAs: Hope or Hype?

Published in J Med Chem. doi: 10.1021/acs.jmedchem.6c00070

Kang C 2026 Feb 12

Drug Discovery

Plant-derived coumarins: emerging natural scaffolds for antidiabetic drug discovery.

Published in Mol Divers. doi: 10.1007/s11030-026-11474-w

Attri S 2026 Feb 12

Drug Interactions

Potentially Clinically Significant Drug-Drug Interactions in Older Adults with Atrial Fibrillation and Multimorbidity: Prevalence, Correlates, and Association with Adverse Clinical Outcomes in a Swedish National Register-Based Study.

Published in Cardiovasc Drugs Ther. doi: 10.1007/s10557-025-07825-8

Amrouch C 2026 Feb 12

Drug Interactions

Evaluation of drug-drug interactions associated with metamizole in clinical practice.

Published in Expert Rev Clin Pharmacol. doi: 10.1080/17512433.2026.2630755

Jacobs TG 2026 Feb 12

Drug Discovery

Big Data for Drug Discovery: Some Historical Landscape, Considerations, and Applications for a Medicinal Chemist.

Published in ACS Omega. doi: 10.1021/acsomega.5c08828

de Lima JAL 2026 Feb 10

Drug Interactions

Evaluation of dental practitioners' knowledge and attitudes regarding drug interactions: a cross-sectional survey.

Published in BMC Oral Health. doi: 10.1186/s12903-026-07832-7

Karaaslan S 2026 Feb 10

Drug Discovery

Next-Generation Artificial Intelligence for ADME Prediction in Drug Discovery: From Small Molecules to Biologics.

Published in Yonago Acta Med. doi: 10.33160/yam.2026.02.001

Tanihata S 2026 Feb