(2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide

C148H154Cl2F2N34O16S6 — CID 157124054

About (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide

(2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide (PubChem CID 157124054) has the molecular formula C148H154Cl2F2N34O16S6 and a molecular weight of 2966.39 g/mol. Its IUPAC name is (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide.

Molecular Properties

• Compound Name: (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide
• PubChem CID: 157124054
• Molecular Formula: C148H154Cl2F2N34O16S6
• Molecular Weight: 2966.39 g/mol
• Exact Mass: 2963.00
• IUPAC Name: (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide
• SMILES: CNC(=O)[C@@H](C)Cn1cnc2ccc(-c3cnc(C)c(NCc4sc(C)nc4C)c3)cc2c1=O.CNC(=O)[C@@H](C)Cn1cnc2ccc(-c3cnc(C)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O.CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(C)c(NCc4sc(C)nc4C)c3)cc2c1=O.CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(C)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O.Cc1nc(C)c(CNc2cc(-c3ccc4ncn(C[C@@H](C)C(N)=O)c(=O)c4c3)cnc2C)s1.Cc1nc(C)c(CNc2cc(-c3ccc4ncn(C[C@H](C)C(N)=O)c(=O)c4c3)cnc2C)s1
• InChI: InChI=1S/2C25H23ClFN5O4S.2C25H28N6O2S.2C24H26N6O2S/c2*1-14(24(33)28-3)12-32-13-30-21-6-4-16(8-19(21)25(32)34)17-9-22(15(2)29-11-17)31-37(35,36)23-7-5-18(27)10-20(23)26;2*1-14(24(32)26-5)12-31-13-29-21-7-6-18(8-20(21)25(31)33)19-9-22(15(2)27-10-19)28-11-23-16(3)30-17(4)34-23;2*1-13(23(25)31)11-30-12-28-20-6-5-17(7-19(20)24(30)32)18-8-21(14(2)26-9-18)27-10-22-15(3)29-16(4)33-22/h2*4-11,13-14,31H,12H2,1-3H3,(H,28,33);2*6-10,13-14,28H,11-12H2,1-5H3,(H,26,32);2*5-9,12-13,27H,10-11H2,1-4H3,(H2,25,31)/t4*14-;2*13-/m101010/s1
• InChIKey: AIHSIMUCZTYGRF-AYMXKJDFSA-N
• XLogP: 22.30
• TPSA: 681.28 Ų
• H-Bond Donors: 12
• H-Bond Acceptors: 46
• Rotatable Bonds: 42
• Heavy Atoms: 208
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2966.39
LogP ≤ 5	22.30
H-Bond Donors ≤ 5	12
H-Bond Acceptors ≤ 10	46

Frequently Asked Questions

What is the IUPAC name of (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide?

The IUPAC name of (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide (CID 157124054) is (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide.

What is the SMILES notation for (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide?

The canonical SMILES for (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide is CNC(=O)[C@@H](C)Cn1cnc2ccc(-c3cnc(C)c(NCc4sc(C)nc4C)c3)cc2c1=O.CNC(=O)[C@@H](C)Cn1cnc2ccc(-c3cnc(C)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O.CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(C)c(NCc4sc(C)nc4C)c3)cc2c1=O.CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(C)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O.Cc1nc(C)c(CNc2cc(-c3ccc4ncn(C[C@@H](C)C(N)=O)c(=O)c4c3)cnc2C)s1.Cc1nc(C)c(CNc2cc(-c3ccc4ncn(C[C@H](C)C(N)=O)c(=O)c4c3)cnc2C)s1.

What is the InChIKey of (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide?

The InChIKey is AIHSIMUCZTYGRF-AYMXKJDFSA-N. The full InChI is InChI=1S/2C25H23ClFN5O4S.2C25H28N6O2S.2C24H26N6O2S/c2*1-14(24(33)28-3)12-32-13-30-21-6-4-16(8-19(21)25(32)34)17-9-22(15(2)29-11-17)31-37(35,36)23-7-5-18(27)10-20(23)26;2*1-14(24(32)26-5)12-31-13-29-21-7-6-18(8-20(21)25(31)33)19-9-22(15(2)27-10-19)28-11-23-16(3)30-17(4)34-23;2*1-13(23(25)31)11-30-12-28-20-6-5-17(7-19(20)24(30)32)18-8-21(14(2)26-9-18)27-10-22-15(3)29-16(4)33-22/h2*4-11,13-14,31H,12H2,1-3H3,(H,28,33);2*6-10,13-14,28H,11-12H2,1-5H3,(H,26,32);2*5-9,12-13,27H,10-11H2,1-4H3,(H2,25,31)/t4*14-;2*13-/m101010/s1.

What are the key properties of (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide?

(2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide has a molecular weight of 2966.39 g/mol, XLogP of 22.30, 42 rotatable bonds, 12 hydrogen bond donors, and 46 hydrogen bond acceptors.

Where does this data come from?

All data for (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide;(2R)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide;(2S)-3-[6-[5-[(2,4-dimethyl-1,3-thiazol-5-yl)methylamino]-6-methyl-3-pyridinyl]-4-oxoquinazolin-3-yl]-2-methylpropanamide is sourced from PubChem (CID 157124054), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).