(4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one

C41H34F9N5O3S — CID 157138833

About (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one

(4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one (PubChem CID 157138833) has the molecular formula C41H34F9N5O3S and a molecular weight of 847.80 g/mol. Its IUPAC name is (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one.

Molecular Properties

• Compound Name: (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one
• PubChem CID: 157138833
• Molecular Formula: C41H34F9N5O3S
• Molecular Weight: 847.80 g/mol
• Exact Mass: 847.22
• IUPAC Name: (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one
• SMILES: C=S(C)(=O)Cc1nn(C)c2c(-c3ccc(C#CC4(O)CC(F)(F)C4)nc3[C@@H](CC(=O)Cn3nc(C(F)(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)Cc3cc(F)cc(F)c3)cccc12
• InChI: InChI=1S/C41H34F9N5O3S/c1-54-35-28(5-4-6-29(35)32(52-54)18-59(2,3)58)27-8-7-25(9-10-38(57)19-39(44,45)20-38)51-34(27)22(11-21-12-23(42)15-24(43)13-21)14-26(56)17-55-37-33(36(53-55)41(48,49)50)30-16-31(30)40(37,46)47/h4-8,12-13,15,22,30-31,57H,2,11,14,16-20H2,1,3H3/t22-,30+,31-,59?/m1/s1
• InChIKey: HIGXKNCWKQFYRQ-UYQVVYIGSA-N
• XLogP: 7.68
• TPSA: 102.90 Ų
• H-Bond Donors: 1
• H-Bond Acceptors: 8
• Rotatable Bonds: 10
• Heavy Atoms: 59
• Complexity: —

Lipinski Rule of Five

2 violations

Rule	Value
MW ≤ 500	847.80
LogP ≤ 5	7.68
H-Bond Donors ≤ 5	1
H-Bond Acceptors ≤ 10	8

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'Thiocarbonyl_group', 'substructure': 'N/A'}, {'alert_name': 'triple_bond', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one?

The IUPAC name of (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one (CID 157138833) is (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one.

What is the SMILES notation for (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one?

The canonical SMILES for (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one is C=S(C)(=O)Cc1nn(C)c2c(-c3ccc(C#CC4(O)CC(F)(F)C4)nc3[C@@H](CC(=O)Cn3nc(C(F)(F)F)c4c3C(F)(F)[C@@H]3C[C@H]43)Cc3cc(F)cc(F)c3)cccc12.

What is the InChIKey of (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one?

The InChIKey is HIGXKNCWKQFYRQ-UYQVVYIGSA-N. The full InChI is InChI=1S/C41H34F9N5O3S/c1-54-35-28(5-4-6-29(35)32(52-54)18-59(2,3)58)27-8-7-25(9-10-38(57)19-39(44,45)20-38)51-34(27)22(11-21-12-23(42)15-24(43)13-21)14-26(56)17-55-37-33(36(53-55)41(48,49)50)30-16-31(30)40(37,46)47/h4-8,12-13,15,22,30-31,57H,2,11,14,16-20H2,1,3H3/t22-,30+,31-,59?/m1/s1.

What are the key properties of (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one?

(4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one has a molecular weight of 847.80 g/mol, XLogP of 7.68, 10 rotatable bonds, 1 hydrogen bond donors, and 8 hydrogen bond acceptors.

Where does this data come from?

All data for (4R)-4-[6-[2-(3,3-difluoro-1-hydroxycyclobutyl)ethynyl]-3-[1-methyl-3-[(methyl-methylidene-oxo-λ6-sulfanyl)methyl]indazol-7-yl]-2-pyridinyl]-5-(3,5-difluorophenyl)-1-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]pentan-2-one is sourced from PubChem (CID 157138833), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).