2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine

C114H93Cl2F8N23O — CID 157139148

IUPAC2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine
SMILESCN1CCC(n2cc(-c3cncc(-c4cc(-c5cc(F)ccc5F)nc5ncccc45)c3)cn2)CC1.Fc1ccc(C(F)(F)F)cc1-c1cc(-c2cncc(-c3cnn(CCN4CCOCC4)c3)c2)c2cccnc2n1.Fc1ccc(Cl)cc1-c1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2)c2cccnc2n1.Fc1ccc(Cl)cc1-c1cc(-c2cncc(-c3ccc(N4CCNCC4)nc3)c2)c2cccnc2n1
InChIInChI=1S/C29H23ClFN5.C29H24F4N6O.C28H22ClFN6.C28H24F2N6/c30-22-5-8-27(31)26(15-22)28-16-25(24-2-1-9-34-29(24)35-28)21-14-20(17-33-18-21)19-3-6-23(7-4-19)36-12-10-32-11-13-36;30-26-4-3-22(29(31,32)33)13-25(26)27-14-24(23-2-1-5-35-28(23)37-27)20-12-19(15-34-16-20)21-17-36-39(18-21)7-6-38-8-10-40-11-9-38;29-21-4-5-25(30)24(13-21)26-14-23(22-2-1-7-33-28(22)35-26)20-12-19(15-32-16-20)18-3-6-27(34-17-18)36-10-8-31-9-11-36;1-35-9-6-22(7-10-35)36-17-20(16-33-36)18-11-19(15-31-14-18)24-13-27(25-12-21(29)4-5-26(25)30)34-28-23(24)3-2-8-32-28/h1-9,14-18,32H,10-13H2;1-5,12-18H,6-11H2;1-7,12-17,31H,8-11H2;2-5,8,11-17,22H,6-7,9-10H2,1H3
InChIKeyAJZFWGWURHVQFF-UHFFFAOYSA-N
MW2024.05 g/mol
LogP23.33
Rot. Bonds18

About 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine

2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine (PubChem CID 157139148) has the molecular formula C114H93Cl2F8N23O and a molecular weight of 2024.05 g/mol. Its IUPAC name is 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine.

Molecular Properties

Compound Name2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine
PubChem CID157139148
Molecular FormulaC114H93Cl2F8N23O
Molecular Weight2024.05 g/mol
Exact Mass2021.72
IUPAC Name2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine
SMILESCN1CCC(n2cc(-c3cncc(-c4cc(-c5cc(F)ccc5F)nc5ncccc45)c3)cn2)CC1.Fc1ccc(C(F)(F)F)cc1-c1cc(-c2cncc(-c3cnn(CCN4CCOCC4)c3)c2)c2cccnc2n1.Fc1ccc(Cl)cc1-c1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2)c2cccnc2n1.Fc1ccc(Cl)cc1-c1cc(-c2cncc(-c3ccc(N4CCNCC4)nc3)c2)c2cccnc2n1
InChIInChI=1S/C29H23ClFN5.C29H24F4N6O.C28H22ClFN6.C28H24F2N6/c30-22-5-8-27(31)26(15-22)28-16-25(24-2-1-9-34-29(24)35-28)21-14-20(17-33-18-21)19-3-6-23(7-4-19)36-12-10-32-11-13-36;30-26-4-3-22(29(31,32)33)13-25(26)27-14-24(23-2-1-5-35-28(23)37-27)20-12-19(15-34-16-20)21-17-36-39(18-21)7-6-38-8-10-40-11-9-38;29-21-4-5-25(30)24(13-21)26-14-23(22-2-1-7-33-28(22)35-26)20-12-19(15-32-16-20)18-3-6-27(34-17-18)36-10-8-31-9-11-36;1-35-9-6-22(7-10-35)36-17-20(16-33-36)18-11-19(15-31-14-18)24-13-27(25-12-21(29)4-5-26(25)30)34-28-23(24)3-2-8-32-28/h1-9,14-18,32H,10-13H2;1-5,12-18H,6-11H2;1-7,12-17,31H,8-11H2;2-5,8,11-17,22H,6-7,9-10H2,1H3
InChIKeyAJZFWGWURHVQFF-UHFFFAOYSA-N
XLogP23.33
TPSA249.46 Ų
H-Bond Donors2
H-Bond Acceptors24
Rotatable Bonds18
Heavy Atoms148
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5002024.05
LogP ≤ 523.33
H-Bond Donors ≤ 52
H-Bond Acceptors ≤ 1024

Analyze 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine with MolForge

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Related Compounds

US11453683, Example 147
CID 156124833
4-[2-[4-[5-[2-(5-Chloro-2-fluorophenyl)-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine
CID 53345071
2-(5-Chloro-2-fluorophenyl)-4-[5-[1-[1-(2-methoxyethyl)piperidin-4-yl]pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine
CID 53345298
2-(5-Chloro-2-fluorophenyl)-4-[5-[1-(2-piperazin-1-ylethyl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine
CID 68264549
4-[3-[4-[5-[2-(5-Chloro-2-fluorophenyl)-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]propyl]morpholine
CID 134188458
4-[4-(3-chlorophenyl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl]morpholine;4-[8-(1H-pyrazol-5-yl)-4-[3-(trifluoromethyl)phenyl]-1,7-naphthyridin-2-yl]morpholine
CID 135313157
2-[5-chloro-2-fluoro-3-[4-(3-pyridin-2-yl-1H-pyrazol-4-yl)quinolin-6-yl]phenyl]-N-pyridin-4-ylpteridin-4-amine
CID 136654835
N-(4-chlorophenyl)-6-[4-[5-[4-[4-(4-fluorophenyl)-6-(4-pyrimidin-2-ylpiperazin-1-yl)pyridazin-3-yl]phenyl]pyrimidin-2-yl]piperazin-1-yl]-3-[3-[2-[4-(5-morpholin-4-yl-6-phenylpyridazin-3-yl)piperazin-1-yl]pyrimidin-5-yl]phenyl]pyridazin-4-amine
CID 143573055
4-[6-[(6-aminopyrimidin-4-yl)amino]pyrazolo[4,3-c]pyridin-1-yl]-3-chlorobenzonitrile;3-chloro-5-fluoro-4-[6-[(6-morpholin-4-ylpyrimidin-4-yl)amino]pyrazolo[4,3-c]pyridin-1-yl]benzonitrile;4-N-[1-[2-fluoro-6-(trifluoromethyl)phenyl]pyrazolo[4,3-c]pyridin-6-yl]pyrimidine-4,6-diamine
CID 156094467
7-(8-Chloronaphthalen-1-yl)-4-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-8-fluoro-2-(2-pyrazol-1-ylethoxy)pyrido[4,3-d]pyrimidine
CID 156645429
N,N-diethyl-4-propan-2-yl-2-(trifluoromethyl)aniline;N-ethyl-N-[(4-propan-2-ylphenyl)methyl]ethanamine;1-methyl-4-[(4-propan-2-ylphenyl)methyl]piperazine;1-methyl-4-[4-propan-2-yl-2-(trifluoromethyl)phenyl]piperazine;4-[(4-propan-2-ylphenyl)methyl]morpholine;1-[(4-propan-2-ylphenyl)methyl]piperazine;2-propan-2-ylpyridine;3-propan-2-ylpyridine;4-propan-2-ylpyridine;1-[4-propan-2-yl-2-(trifluoromethyl)phenyl]imidazole;4-[4-propan-2-yl-2-(trifluoromethyl)phenyl]morpholine;1-[4-propan-2-yl-2-(trifluoromethyl)phenyl]piperazine;1-[4-propan-2-yl-2-(trifluoromethyl)phenyl]pyrazole;1-[4-propan-2-yl-2-(trifluoromethyl)phenyl]pyrrolidine
CID 157445607
2-(5-Chloro-2-fluorophenyl)-4-[5-[1-[1-(2-methoxyethyl)piperidin-4-yl]pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-[4-(4-methylpiperazin-1-yl)phenyl]-3-pyridinyl]-1,8-naphthyridine;2-[4-[4-[5-[2-(5-chloro-2-fluorophenyl)-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]piperidin-1-yl]ethanol;2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethanol
CID 157807234

Frequently Asked Questions

What is the IUPAC name of 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine?
The IUPAC name of 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine (CID 157139148) is 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine.
What is the SMILES notation for 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine?
The canonical SMILES for 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine is CN1CCC(n2cc(-c3cncc(-c4cc(-c5cc(F)ccc5F)nc5ncccc45)c3)cn2)CC1.Fc1ccc(C(F)(F)F)cc1-c1cc(-c2cncc(-c3cnn(CCN4CCOCC4)c3)c2)c2cccnc2n1.Fc1ccc(Cl)cc1-c1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2)c2cccnc2n1.Fc1ccc(Cl)cc1-c1cc(-c2cncc(-c3ccc(N4CCNCC4)nc3)c2)c2cccnc2n1.
What is the InChIKey of 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine?
The InChIKey is AJZFWGWURHVQFF-UHFFFAOYSA-N. The full InChI is InChI=1S/C29H23ClFN5.C29H24F4N6O.C28H22ClFN6.C28H24F2N6/c30-22-5-8-27(31)26(15-22)28-16-25(24-2-1-9-34-29(24)35-28)21-14-20(17-33-18-21)19-3-6-23(7-4-19)36-12-10-32-11-13-36;30-26-4-3-22(29(31,32)33)13-25(26)27-14-24(23-2-1-5-35-28(23)37-27)20-12-19(15-34-16-20)21-17-36-39(18-21)7-6-38-8-10-40-11-9-38;29-21-4-5-25(30)24(13-21)26-14-23(22-2-1-7-33-28(22)35-26)20-12-19(15-32-16-20)18-3-6-27(34-17-18)36-10-8-31-9-11-36;1-35-9-6-22(7-10-35)36-17-20(16-33-36)18-11-19(15-31-14-18)24-13-27(25-12-21(29)4-5-26(25)30)34-28-23(24)3-2-8-32-28/h1-9,14-18,32H,10-13H2;1-5,12-18H,6-11H2;1-7,12-17,31H,8-11H2;2-5,8,11-17,22H,6-7,9-10H2,1H3.
What are the key properties of 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine?
2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine has a molecular weight of 2024.05 g/mol, XLogP of 23.33, 18 rotatable bonds, 2 hydrogen bond donors, and 24 hydrogen bond acceptors.
Where does this data come from?
All data for 2-(5-chloro-2-fluorophenyl)-4-[5-(4-piperazin-1-ylphenyl)-3-pyridinyl]-1,8-naphthyridine;2-(5-chloro-2-fluorophenyl)-4-[5-(6-piperazin-1-yl-3-pyridinyl)-3-pyridinyl]-1,8-naphthyridine;2-(2,5-difluorophenyl)-4-[5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-1,8-naphthyridine;4-[2-[4-[5-[2-[2-fluoro-5-(trifluoromethyl)phenyl]-1,8-naphthyridin-4-yl]-3-pyridinyl]pyrazol-1-yl]ethyl]morpholine is sourced from PubChem (CID 157139148), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).