N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide

C130H120Cl3N35O6 — CID 157261141

About N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide

N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide (PubChem CID 157261141) has the molecular formula C130H120Cl3N35O6 and a molecular weight of 2374.99 g/mol. Its IUPAC name is N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide.

Molecular Properties

• Compound Name: N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide
• PubChem CID: 157261141
• Molecular Formula: C130H120Cl3N35O6
• Molecular Weight: 2374.99 g/mol
• Exact Mass: 2371.92
• IUPAC Name: N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide
• SMILES: CCc1c(-c2cnccc2C)nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3CC#N)cc12.CCc1c(-c2cnccc2C)nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc12.Cc1ccccc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3CC#N)cc2c1Cl.Cc1ccccc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)cc2c1Cl.Cc1ccccc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1Cl.Cc1ccncc1-c1nc(N)c2cnc(NC(=O)C3CC3)cc2c1-c1cn[nH]c1
• InChI: InChI=1S/C23H21ClN6O.2C22H22N6O.2C21H18ClN5O.C21H19N7O/c1-12-5-3-4-6-14(12)21-20(24)16-8-19(26-10-18(16)22(25)29-21)28-23(31)17-7-15(17)13-9-27-30(2)11-13;2*1-3-14-16-9-19(27-22(29)15-8-13(15)4-6-23)26-11-18(16)21(24)28-20(14)17-10-25-7-5-12(17)2;2*1-11-4-2-3-5-13(11)19-18(22)15-9-17(25-10-16(15)20(24)27-19)26-21(28)14-8-12(14)6-7-23;1-11-4-5-23-9-15(11)19-18(13-7-25-26-8-13)14-6-17(27-21(29)12-2-3-12)24-10-16(14)20(22)28-19/h3-6,8-11,15,17H,7H2,1-2H3,(H2,25,29)(H,26,28,31);2*5,7,9-11,13,15H,3-4,8H2,1-2H3,(H2,24,28)(H,26,27,29);2*2-5,9-10,12,14H,6,8H2,1H3,(H2,24,27)(H,25,26,28);4-10,12H,2-3H2,1H3,(H2,22,28)(H,25,26)(H,24,27,29)/t15-,17+;2*13-,15-;2*12-,14-;/m01010./s1
• InChIKey: AXLUSVFZCKMXKU-QKGKWQHTSA-N
• XLogP: 23.56
• TPSA: 665.73 Ų
• H-Bond Donors: 13
• H-Bond Acceptors: 34
• Rotatable Bonds: 26
• Heavy Atoms: 174
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2374.99
LogP ≤ 5	23.56
H-Bond Donors ≤ 5	13
H-Bond Acceptors ≤ 10	34

Frequently Asked Questions

What is the IUPAC name of N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

The IUPAC name of N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide (CID 157261141) is N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide.

What is the SMILES notation for N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

The canonical SMILES for N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide is CCc1c(-c2cnccc2C)nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3CC#N)cc12.CCc1c(-c2cnccc2C)nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc12.Cc1ccccc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3CC#N)cc2c1Cl.Cc1ccccc1-c1nc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)cc2c1Cl.Cc1ccccc1-c1nc(N)c2cnc(NC(=O)[C@H]3C[C@@H]3CC#N)cc2c1Cl.Cc1ccncc1-c1nc(N)c2cnc(NC(=O)C3CC3)cc2c1-c1cn[nH]c1.

What is the InChIKey of N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

The InChIKey is AXLUSVFZCKMXKU-QKGKWQHTSA-N. The full InChI is InChI=1S/C23H21ClN6O.2C22H22N6O.2C21H18ClN5O.C21H19N7O/c1-12-5-3-4-6-14(12)21-20(24)16-8-19(26-10-18(16)22(25)29-21)28-23(31)17-7-15(17)13-9-27-30(2)11-13;2*1-3-14-16-9-19(27-22(29)15-8-13(15)4-6-23)26-11-18(16)21(24)28-20(14)17-10-25-7-5-12(17)2;2*1-11-4-2-3-5-13(11)19-18(22)15-9-17(25-10-16(15)20(24)27-19)26-21(28)14-8-12(14)6-7-23;1-11-4-5-23-9-15(11)19-18(13-7-25-26-8-13)14-6-17(27-21(29)12-2-3-12)24-10-16(14)20(22)28-19/h3-6,8-11,15,17H,7H2,1-2H3,(H2,25,29)(H,26,28,31);2*5,7,9-11,13,15H,3-4,8H2,1-2H3,(H2,24,28)(H,26,27,29);2*2-5,9-10,12,14H,6,8H2,1H3,(H2,24,27)(H,25,26,28);4-10,12H,2-3H2,1H3,(H2,22,28)(H,25,26)(H,24,27,29)/t15-,17+;2*13-,15-;2*12-,14-;/m01010./s1.

What are the key properties of N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide has a molecular weight of 2374.99 g/mol, XLogP of 23.56, 26 rotatable bonds, 13 hydrogen bond donors, and 34 hydrogen bond acceptors.

Where does this data come from?

All data for N-[8-amino-6-(4-methyl-3-pyridinyl)-5-(1H-pyrazol-4-yl)-2,7-naphthyridin-3-yl]cyclopropanecarboxamide;cis-(1S,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1S,2R)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;cis-(1R,2S)-N-[8-amino-5-ethyl-6-(4-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(cyanomethyl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-5-chloro-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide is sourced from PubChem (CID 157261141), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).