2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide

C173H171F11N24O25 — CID 157328206

IUPAC2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide
SMILESCOc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc1C1(CF)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc1C1(O)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)cnc2C)cc1C1(F)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)O)c3)cnc2C)cc1C1(F)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(F)F)c3)ccc2C)cc1C1(CF)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(F)F)c3)ccc2C)cc1C1(O)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C4(C#N)CC4)c3)ccc2C)cc1C1(O)COC1
InChIInChI=1S/C26H27F2N3O3.C26H24N4O4.C25H24F3N3O3.C25H26FN3O4.C24H24F2N4O3.C24H25FN4O4.C23H21F2N3O4/c1-16-5-6-19(31-23(32)17-7-8-29-22(10-17)25(2,3)28)11-20(16)18-9-21(24(33-4)30-12-18)26(13-27)14-34-15-26;1-16-3-4-19(30-23(31)17-5-8-28-22(10-17)25(13-27)6-7-25)11-20(16)18-9-21(24(33-2)29-12-18)26(32)14-34-15-26;1-15-4-5-18(31-22(32)16-6-7-29-21(9-16)24(2,27)28)10-19(15)17-8-20(23(33-3)30-11-17)25(12-26)13-34-14-25;1-15-5-6-18(29-22(30)16-7-8-27-21(10-16)24(2,3)26)11-19(15)17-9-20(23(32-4)28-12-17)25(31)13-33-14-25;1-14-18(16-7-19(22(32-4)29-10-16)24(26)12-33-13-24)9-17(11-28-14)30-21(31)15-5-6-27-20(8-15)23(2,3)25;1-14-18(16-7-19(22(32-4)28-10-16)24(25)12-33-13-24)9-17(11-27-14)29-21(30)15-5-6-26-20(8-15)23(2,3)31;1-13-3-4-16(28-21(29)14-5-6-26-19(8-14)20(24)25)9-17(13)15-7-18(22(31-2)27-10-15)23(30)11-32-12-23/h5-12H,13-15H2,1-4H3,(H,31,32);3-5,8-12,32H,6-7,14-15H2,1-2H3,(H,30,31);4-11H,12-14H2,1-3H3,(H,31,32);5-12,31H,13-14H2,1-4H3,(H,29,30);5-11H,12-13H2,1-4H3,(H,30,31);5-11,31H,12-13H2,1-4H3,(H,29,30);3-10,20,30H,11-12H2,1-2H3,(H,28,29)
InChIKeyBEYYSPMENFYRTE-UHFFFAOYSA-N
MW3195.39 g/mol
LogP29.74
Rot. Bonds44

About 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide

2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide (PubChem CID 157328206) has the molecular formula C173H171F11N24O25 and a molecular weight of 3195.39 g/mol. Its IUPAC name is 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide.

Molecular Properties

Compound Name2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide
PubChem CID157328206
Molecular FormulaC173H171F11N24O25
Molecular Weight3195.39 g/mol
Exact Mass3193.27
IUPAC Name2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide
SMILESCOc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc1C1(CF)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc1C1(O)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)cnc2C)cc1C1(F)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)O)c3)cnc2C)cc1C1(F)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(F)F)c3)ccc2C)cc1C1(CF)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(F)F)c3)ccc2C)cc1C1(O)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C4(C#N)CC4)c3)ccc2C)cc1C1(O)COC1
InChIInChI=1S/C26H27F2N3O3.C26H24N4O4.C25H24F3N3O3.C25H26FN3O4.C24H24F2N4O3.C24H25FN4O4.C23H21F2N3O4/c1-16-5-6-19(31-23(32)17-7-8-29-22(10-17)25(2,3)28)11-20(16)18-9-21(24(33-4)30-12-18)26(13-27)14-34-15-26;1-16-3-4-19(30-23(31)17-5-8-28-22(10-17)25(13-27)6-7-25)11-20(16)18-9-21(24(33-2)29-12-18)26(32)14-34-15-26;1-15-4-5-18(31-22(32)16-6-7-29-21(9-16)24(2,27)28)10-19(15)17-8-20(23(33-3)30-11-17)25(12-26)13-34-14-25;1-15-5-6-18(29-22(30)16-7-8-27-21(10-16)24(2,3)26)11-19(15)17-9-20(23(32-4)28-12-17)25(31)13-33-14-25;1-14-18(16-7-19(22(32-4)29-10-16)24(26)12-33-13-24)9-17(11-28-14)30-21(31)15-5-6-27-20(8-15)23(2,3)25;1-14-18(16-7-19(22(32-4)28-10-16)24(25)12-33-13-24)9-17(11-27-14)29-21(30)15-5-6-26-20(8-15)23(2,3)31;1-13-3-4-16(28-21(29)14-5-6-26-19(8-14)20(24)25)9-17(13)15-7-18(22(31-2)27-10-15)23(30)11-32-12-23/h5-12H,13-15H2,1-4H3,(H,31,32);3-5,8-12,32H,6-7,14-15H2,1-2H3,(H,30,31);4-11H,12-14H2,1-3H3,(H,31,32);5-12,31H,13-14H2,1-4H3,(H,29,30);5-11H,12-13H2,1-4H3,(H,30,31);5-11,31H,12-13H2,1-4H3,(H,29,30);3-10,20,30H,11-12H2,1-2H3,(H,28,29)
InChIKeyBEYYSPMENFYRTE-UHFFFAOYSA-N
XLogP29.74
TPSA643.87 Ų
H-Bond Donors11
H-Bond Acceptors42
Rotatable Bonds44
Heavy Atoms233
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003195.39
LogP ≤ 529.74
H-Bond Donors ≤ 511
H-Bond Acceptors ≤ 1042

Analyze 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide with MolForge

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Launch Full Analysis

Related Compounds

US10167279, Example 100
CID 135133233
2-(2-cyanopropan-2-yl)-N-[3-[6-[(2R)-2-hydroxypropoxy]-5-[2-[[4-[[5-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]-3-pyridinyl]-3-morpholin-4-yl-2-pyridinyl]oxy]piperidin-1-yl]methyl]morpholin-4-yl]-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide
CID 130425624
N-[5-[2-[3-(fluoromethyl)oxetan-3-yl]-6-[2-[[2-[3-(3-fluorooxetan-3-yl)-5-(3-hydroxyoxetan-3-yl)phenyl]-4-[[2-(trifluoromethyl)pyridine-4-carbonyl]amino]phenyl]methoxy]ethoxy]pyridin-4-yl]-6-methylpyridin-3-yl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide
CID 135139020
N-[3-[(4aR)-spiro[2,4,4a,6-tetrahydro-1H-[1,4]oxazino[4,3-a][1,5]naphthyridine-5,3'-oxetane]-9-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide;2-(2-cyanopropan-2-yl)-N-(4-methyl-3-spiro[2,4,4a,6-tetrahydro-1H-[1,4]oxazino[4,3-a][1,5]naphthyridine-5,3'-oxetane]-9-ylphenyl)pyridine-4-carboxamide;bis(2-(1,1-difluoroethyl)-N-[3-(6-hydroxy-5,5-dimethyl-2,4,4a,6-tetrahydro-1H-[1,4]oxazino[4,3-a][1,5]naphthyridin-9-yl)-4-methylphenyl]pyridine-4-carboxamide);2-(1,1-difluoroethyl)-N-(4-methyl-3-spiro[2,4,4a,6-tetrahydro-1H-[1,4]oxazino[4,3-a][1,5]naphthyridine-5,3'-oxetane]-9-ylphenyl)pyridine-4-carboxamide;N-(4-methyl-3-spiro[2,4,4a,6-tetrahydro-1H-[1,4]oxazino[4,3-a][1,5]naphthyridine-5,3'-oxetane]-9-ylphenyl)-2-(trifluoromethyl)pyridine-4-carboxamide
CID 157182730
4-(2-cyanopropan-2-yl)-N-[5-[6-(2-hydroxyethoxy)-5-morpholin-4-yl-3-pyridinyl]-6-methyl-3-pyridinyl]pyridine-2-carboxamide;4-(2-cyanopropan-2-yl)-N-[6-methyl-5-[5-morpholin-4-yl-6-(2-oxaspiro[3.3]heptan-6-yloxy)-3-pyridinyl]-3-pyridinyl]pyridine-2-carboxamide;4-(1,1-difluoroethyl)-N-[5-[6-(2-hydroxyethoxy)-5-morpholin-4-yl-3-pyridinyl]-6-methyl-3-pyridinyl]pyridine-2-carboxamide;4-(2-fluoropropan-2-yl)-N-[5-[6-(2-hydroxyethoxy)-5-morpholin-4-yl-3-pyridinyl]-6-methyl-3-pyridinyl]pyridine-2-carboxamide;N-[5-[6-(2-hydroxyethoxy)-5-morpholin-4-yl-3-pyridinyl]-6-methyl-3-pyridinyl]-4-(2-hydroxypropan-2-yl)pyridine-2-carboxamide;4-(2-hydroxypropan-2-yl)-N-[6-methyl-5-[5-morpholin-4-yl-6-(2-oxaspiro[3.3]heptan-6-yloxy)-3-pyridinyl]-3-pyridinyl]pyridine-2-carboxamide
CID 157290414
2-(2-cyanopropan-2-yl)-N-[6-methyl-5-(5-morpholin-4-yl-6-propan-2-yloxy-3-pyridinyl)-3-pyridinyl]pyridine-4-carboxamide;4-(1,1-difluoroethyl)-N-[6-methyl-5-(5-morpholin-4-yl-6-propan-2-yloxy-3-pyridinyl)-3-pyridinyl]pyridine-2-carboxamide;2-(2-fluoropropan-2-yl)-N-[6-methyl-5-(5-morpholin-4-yl-6-propan-2-yloxy-3-pyridinyl)-3-pyridinyl]pyridine-4-carboxamide;4-(2-fluoropropan-2-yl)-N-[6-methyl-5-(5-morpholin-4-yl-6-propan-2-yloxy-3-pyridinyl)-3-pyridinyl]pyridine-2-carboxamide;2-(2-hydroxypropan-2-yl)-N-[6-methyl-5-(5-morpholin-4-yl-6-propan-2-yloxy-3-pyridinyl)-3-pyridinyl]pyridine-4-carboxamide
CID 157358027
2-(2-cyanopropan-2-yl)-N-[3-[6-[(2R)-2-hydroxypropoxy]-5-morpholin-4-yl-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(2-cyanopropan-2-yl)-N-[5-[6-[(2R)-2-hydroxypropoxy]-5-morpholin-4-yl-3-pyridinyl]-6-methyl-3-pyridinyl]pyridine-4-carboxamide;1-[3-(6-ethoxy-5-morpholin-4-yl-3-pyridinyl)-4-methylphenyl]-2-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]ethanone;1-[5-(6-ethoxy-5-morpholin-4-yl-3-pyridinyl)-6-methyl-3-pyridinyl]-2-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]ethanone;2-(2-fluoropropan-2-yl)-N-[5-[6-[(2R)-2-hydroxypropoxy]-5-morpholin-4-yl-3-pyridinyl]-6-methyl-3-pyridinyl]pyridine-4-carboxamide;N-[6-methyl-5-[6-(1-methylpiperidin-4-yl)oxy-5-morpholin-4-yl-3-pyridinyl]-3-pyridinyl]-3-(trifluoromethyl)benzamide
CID 157397421
N-[5-[6-ethoxy-5-(3-fluorooxolan-3-yl)-3-pyridinyl]-6-methyl-3-pyridinyl]-3-(trifluoromethyl)benzamide;N-[3-[6-ethoxy-5-(3-hydroxyoxolan-3-yl)-3-pyridinyl]-4-methylphenyl]-2-(2-methylbut-3-yn-2-yl)pyridine-4-carboxamide
CID 157400767
CID 157550020
CID 157550020
2-(1,1-difluoroethyl)-N-[3-[2-[3-(fluoromethyl)oxetan-3-yl]-6-(2-hydroxyethoxy)-4-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[2-[3-(fluoromethyl)oxetan-3-yl]-6-(2-hydroxyethoxy)-4-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[2-[3-(difluoromethyl)oxetan-3-yl]-6-(2-hydroxyethoxy)-4-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide;N-[3-[2-[3-(fluoromethyl)oxetan-3-yl]-6-(2-hydroxyethoxy)-4-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide;N-[3-[6-(2-hydroxyethoxy)-5-(3-methoxyoxetan-3-yl)-3-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide
CID 157697728
2-(2-cyanopropan-2-yl)-N-[3-[5-(3-formyloxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[5-[5-(3-fluorooxetan-3-yl)-6-(2-hydroxyethoxy)-3-pyridinyl]-6-methyl-3-pyridinyl]pyridine-4-carboxamide;N-[5-[5-[3-(difluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[3-[5-(3-fluorooxetan-3-yl)-6-(2-hydroxyethoxy)-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-(2-hydroxyethoxy)-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[4-(3-fluorooxetan-3-yl)-5-(3-hydroxypropoxy)-2-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide
CID 157700858
2-(2-cyanopropan-2-yl)-N-[3-[6-ethoxy-5-[3-(fluoromethyl)oxetan-3-yl]-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(2-cyanopropan-2-yl)-N-[3-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(2-cyanopropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-(oxan-4-yloxy)-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(2-cyanopropan-2-yl)-N-[5-[5-(3-hydroxyoxetan-3-yl)-6-(oxan-4-yloxy)-3-pyridinyl]-6-methyl-3-pyridinyl]pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-(2-hydroxyethoxy)-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(trifluoromethyl)pyridine-4-carboxamide;N-[3-[5-(3-hydroxyoxetan-3-yl)-6-(oxan-4-yloxy)-3-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide
CID 157705195

Frequently Asked Questions

What is the IUPAC name of 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide?
The IUPAC name of 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide (CID 157328206) is 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide.
What is the SMILES notation for 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide?
The canonical SMILES for 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide is COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc1C1(CF)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc1C1(O)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)cnc2C)cc1C1(F)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)O)c3)cnc2C)cc1C1(F)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(F)F)c3)ccc2C)cc1C1(CF)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C(F)F)c3)ccc2C)cc1C1(O)COC1.COc1ncc(-c2cc(NC(=O)c3ccnc(C4(C#N)CC4)c3)ccc2C)cc1C1(O)COC1.
What is the InChIKey of 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide?
The InChIKey is BEYYSPMENFYRTE-UHFFFAOYSA-N. The full InChI is InChI=1S/C26H27F2N3O3.C26H24N4O4.C25H24F3N3O3.C25H26FN3O4.C24H24F2N4O3.C24H25FN4O4.C23H21F2N3O4/c1-16-5-6-19(31-23(32)17-7-8-29-22(10-17)25(2,3)28)11-20(16)18-9-21(24(33-4)30-12-18)26(13-27)14-34-15-26;1-16-3-4-19(30-23(31)17-5-8-28-22(10-17)25(13-27)6-7-25)11-20(16)18-9-21(24(33-2)29-12-18)26(32)14-34-15-26;1-15-4-5-18(31-22(32)16-6-7-29-21(9-16)24(2,27)28)10-19(15)17-8-20(23(33-3)30-11-17)25(12-26)13-34-14-25;1-15-5-6-18(29-22(30)16-7-8-27-21(10-16)24(2,3)26)11-19(15)17-9-20(23(32-4)28-12-17)25(31)13-33-14-25;1-14-18(16-7-19(22(32-4)29-10-16)24(26)12-33-13-24)9-17(11-28-14)30-21(31)15-5-6-27-20(8-15)23(2,3)25;1-14-18(16-7-19(22(32-4)28-10-16)24(25)12-33-13-24)9-17(11-27-14)29-21(30)15-5-6-26-20(8-15)23(2,3)31;1-13-3-4-16(28-21(29)14-5-6-26-19(8-14)20(24)25)9-17(13)15-7-18(22(31-2)27-10-15)23(30)11-32-12-23/h5-12H,13-15H2,1-4H3,(H,31,32);3-5,8-12,32H,6-7,14-15H2,1-2H3,(H,30,31);4-11H,12-14H2,1-3H3,(H,31,32);5-12,31H,13-14H2,1-4H3,(H,29,30);5-11H,12-13H2,1-4H3,(H,30,31);5-11,31H,12-13H2,1-4H3,(H,29,30);3-10,20,30H,11-12H2,1-2H3,(H,28,29).
What are the key properties of 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide?
2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide has a molecular weight of 3195.39 g/mol, XLogP of 29.74, 44 rotatable bonds, 11 hydrogen bond donors, and 42 hydrogen bond acceptors.
Where does this data come from?
All data for 2-(1-cyanocyclopropyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(1,1-difluoroethyl)-N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;2-(difluoromethyl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide;N-[3-[5-[3-(fluoromethyl)oxetan-3-yl]-6-methoxy-3-pyridinyl]-4-methylphenyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-fluoropropan-2-yl)pyridine-4-carboxamide;N-[5-[5-(3-fluorooxetan-3-yl)-6-methoxy-3-pyridinyl]-6-methyl-3-pyridinyl]-2-(2-hydroxypropan-2-yl)pyridine-4-carboxamide;2-(2-fluoropropan-2-yl)-N-[3-[5-(3-hydroxyoxetan-3-yl)-6-methoxy-3-pyridinyl]-4-methylphenyl]pyridine-4-carboxamide is sourced from PubChem (CID 157328206), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).