9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine

C248H168N8O2S2 — CID 157403389

IUPAC9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine
SMILESCC1(C)c2ccccc2-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4cccc5c4oc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)cc21.CC1(C)c2ccccc2-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4cccc5c4sc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)cc21.c1ccc(-c2ccc(N(c3ccc(-c4cccc5c4oc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)c3ccc4c(c3)C(c3ccccc3)(c3ccccc3)c3ccccc3-4)cc2)cc1.c1ccc(-c2ccc(N(c3ccc(-c4cccc5c4sc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)c3ccc4c(c3)C(c3ccccc3)(c3ccccc3)c3ccccc3-4)cc2)cc1
InChIInChI=1S/C67H44N2O.C67H44N2S.C57H40N2O.C57H40N2S/c2*1-5-18-45(19-6-1)46-32-36-51(37-33-46)68(53-40-41-56-55-26-13-15-30-60(55)67(61(56)44-53,48-20-7-2-8-21-48)49-22-9-3-10-23-49)52-38-34-47(35-39-52)54-28-17-29-57-58-42-43-63-64(66(58)70-65(54)57)59-27-14-16-31-62(59)69(63)50-24-11-4-12-25-50;2*1-57(2)50-22-11-9-18-45(50)46-33-32-43(36-51(46)57)58(41-28-24-38(25-29-41)37-14-5-3-6-15-37)42-30-26-39(27-31-42)44-20-13-21-47-48-34-35-53-54(56(48)60-55(44)47)49-19-10-12-23-52(49)59(53)40-16-7-4-8-17-40/h2*1-44H;2*3-36H,1-2H3
InChIKeyBNKYZHPVVPKIIF-UHFFFAOYSA-N
MW3356.26 g/mol
LogP68.22
Rot. Bonds28

About 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine

9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine (PubChem CID 157403389) has the molecular formula C248H168N8O2S2 and a molecular weight of 3356.26 g/mol. Its IUPAC name is 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine.

Molecular Properties

Compound Name9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine
PubChem CID157403389
Molecular FormulaC248H168N8O2S2
Molecular Weight3356.26 g/mol
Exact Mass3353.27
IUPAC Name9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine
SMILESCC1(C)c2ccccc2-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4cccc5c4oc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)cc21.CC1(C)c2ccccc2-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4cccc5c4sc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)cc21.c1ccc(-c2ccc(N(c3ccc(-c4cccc5c4oc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)c3ccc4c(c3)C(c3ccccc3)(c3ccccc3)c3ccccc3-4)cc2)cc1.c1ccc(-c2ccc(N(c3ccc(-c4cccc5c4sc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)c3ccc4c(c3)C(c3ccccc3)(c3ccccc3)c3ccccc3-4)cc2)cc1
InChIInChI=1S/C67H44N2O.C67H44N2S.C57H40N2O.C57H40N2S/c2*1-5-18-45(19-6-1)46-32-36-51(37-33-46)68(53-40-41-56-55-26-13-15-30-60(55)67(61(56)44-53,48-20-7-2-8-21-48)49-22-9-3-10-23-49)52-38-34-47(35-39-52)54-28-17-29-57-58-42-43-63-64(66(58)70-65(54)57)59-27-14-16-31-62(59)69(63)50-24-11-4-12-25-50;2*1-57(2)50-22-11-9-18-45(50)46-33-32-43(36-51(46)57)58(41-28-24-38(25-29-41)37-14-5-3-6-15-37)42-30-26-39(27-31-42)44-20-13-21-47-48-34-35-53-54(56(48)60-55(44)47)49-19-10-12-23-52(49)59(53)40-16-7-4-8-17-40/h2*1-44H;2*3-36H,1-2H3
InChIKeyBNKYZHPVVPKIIF-UHFFFAOYSA-N
XLogP68.22
TPSA58.96 Ų
H-Bond Donors
H-Bond Acceptors12
Rotatable Bonds28
Heavy Atoms260
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5003356.26
LogP ≤ 568.22
H-Bond Donors ≤ 50
H-Bond Acceptors ≤ 1012

Analyze 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine with MolForge

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Related Compounds

N-[4-(3-carbazol-9-ylphenyl)phenyl]-N-(4-dibenzofuran-4-ylphenyl)-4-phenylaniline;N-(4-dibenzofuran-4-ylphenyl)-N-(9,9-dimethylfluoren-2-yl)-9,9-dimethylfluoren-2-amine;N-(4-dibenzofuran-4-ylphenyl)-9,9-dimethyl-N-[4-(4-phenylphenyl)phenyl]fluoren-2-amine;N-(4-dibenzofuran-4-ylphenyl)-N-[4-(3,5-diphenylphenyl)phenyl]-9,9-dimethylfluoren-2-amine;N-(9,9-diphenylfluoren-2-yl)-9,9-diphenyl-N-(4-phenylphenyl)fluoren-2-amine;N-(9,9-diphenylfluoren-2-yl)-N,9,9-triphenylfluoren-2-amine
CID 162020018
9,9-dimethyl-N-[4-[6-[4-(9-phenylfluoren-9-yl)phenyl]dibenzofuran-4-yl]phenyl]-N-(4-phenylphenyl)fluoren-2-amine
CID 164724626
9,9-dimethyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-phenyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]fluoren-2-amine;9,9-diphenyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine
CID 160652754
N-[9-(4-dibenzofuran-4-ylphenyl)-9-phenylfluoren-2-yl]-9-phenyl-N-(4-phenylphenyl)carbazol-3-amine
CID 164769090
9,9-dimethyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]-N-(3-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-phenyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]fluoren-2-amine;9,9-dimethyl-N-phenyl-N-[4-[9-(4-phenylphenyl)carbazol-3-yl]phenyl]fluoren-2-amine;9,9-diphenyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine
CID 162087677
9,9-dimethyl-N-phenyl-N-[4-[9-(4-phenylphenyl)carbazol-3-yl]phenyl]fluoren-2-amine;9,9-diphenyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;N,9,9-triphenyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]fluoren-2-amine
CID 158043752
9,9-dimethyl-7-[6-[4-(9-phenylcarbazol-3-yl)phenyl]dibenzofuran-4-yl]-N,N-bis(4-phenylphenyl)fluoren-2-amine
CID 118402458
4-[4-[24-(9,9-dimethylfluoren-2-yl)-15-thia-6,24-diazaheptacyclo[14.11.0.02,14.05,13.07,12.017,25.018,23]heptacosa-1(16),2(14),3,5(13),7,9,11,17(25),18,20,22,26-dodecaen-6-yl]phenyl]-N,N-diphenylaniline
CID 118651731
N-(9,9-dimethylfluoren-2-yl)-N-[4-(9,9-diphenylfluoren-2-yl)phenyl]-9-phenylcarbazol-3-amine
CID 126605201
3-(9,9-dimethylfluoren-2-yl)-9-phenyl-6-[3-(6-phenyldibenzothiophen-4-yl)-5-(3-phenylphenyl)phenyl]carbazole;3,9-diphenyl-6-[3-(6-phenyldibenzofuran-4-yl)-5-(4-phenylphenyl)phenyl]carbazole;3-[3-(6-phenyldibenzothiophen-4-yl)-5-(3-phenylphenyl)phenyl]-9-(3-phenylphenyl)carbazole
CID 159386036
N-[9-(4-dibenzofuran-4-ylphenyl)-9-(4-phenylphenyl)fluoren-2-yl]-9-phenyl-N-(4-phenylphenyl)carbazol-3-amine
CID 154955024
9,9-dimethyl-N-phenyl-N-[4-[9-(4-phenylphenyl)carbazol-3-yl]phenyl]fluoren-2-amine;9,9-diphenyl-N-[4-(9-phenylcarbazol-3-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;methane
CID 159335093

Frequently Asked Questions

What is the IUPAC name of 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine?
The IUPAC name of 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine (CID 157403389) is 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine.
What is the SMILES notation for 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine?
The canonical SMILES for 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine is CC1(C)c2ccccc2-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4cccc5c4oc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)cc21.CC1(C)c2ccccc2-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3ccc(-c4cccc5c4sc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)cc21.c1ccc(-c2ccc(N(c3ccc(-c4cccc5c4oc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)c3ccc4c(c3)C(c3ccccc3)(c3ccccc3)c3ccccc3-4)cc2)cc1.c1ccc(-c2ccc(N(c3ccc(-c4cccc5c4sc4c5ccc5c4c4ccccc4n5-c4ccccc4)cc3)c3ccc4c(c3)C(c3ccccc3)(c3ccccc3)c3ccccc3-4)cc2)cc1.
What is the InChIKey of 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine?
The InChIKey is BNKYZHPVVPKIIF-UHFFFAOYSA-N. The full InChI is InChI=1S/C67H44N2O.C67H44N2S.C57H40N2O.C57H40N2S/c2*1-5-18-45(19-6-1)46-32-36-51(37-33-46)68(53-40-41-56-55-26-13-15-30-60(55)67(61(56)44-53,48-20-7-2-8-21-48)49-22-9-3-10-23-49)52-38-34-47(35-39-52)54-28-17-29-57-58-42-43-63-64(66(58)70-65(54)57)59-27-14-16-31-62(59)69(63)50-24-11-4-12-25-50;2*1-57(2)50-22-11-9-18-45(50)46-33-32-43(36-51(46)57)58(41-28-24-38(25-29-41)37-14-5-3-6-15-37)42-30-26-39(27-31-42)44-20-13-21-47-48-34-35-53-54(56(48)60-55(44)47)49-19-10-12-23-52(49)59(53)40-16-7-4-8-17-40/h2*1-44H;2*3-36H,1-2H3.
What are the key properties of 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine?
9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine has a molecular weight of 3356.26 g/mol, XLogP of 68.22, 28 rotatable bonds, 0 hydrogen bond donors, and 12 hydrogen bond acceptors.
Where does this data come from?
All data for 9,9-dimethyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-dimethyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzofuro[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine;9,9-diphenyl-N-[4-(5-phenyl-[1]benzothiolo[3,2-c]carbazol-11-yl)phenyl]-N-(4-phenylphenyl)fluoren-2-amine is sourced from PubChem (CID 157403389), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).