(4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide

C202H212F21N45O31S20 — CID 157407849

IUPAC(4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide
SMILESCCN1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.CN1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.CS(=O)(=O)N1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CC(F)(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CC(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CCF)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(S(=O)(=O)C(F)(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCNC[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@H]2N1CCN(CC(F)(F)F)C[C@H]1c1ccc(F)cc1
InChIInChI=1S/2C23H23F4N5O3S2.C23H24F3N5O3S2.C23H25F2N5O3S2.C23H26FN5O3S2.C22H21F4N5O5S3.C22H24FN5O5S3.C22H24FN5O3S2.C21H22FN5O3S2/c2*24-16-3-1-15(2-4-16)20-12-31(13-23(25,26)27)8-9-32(20)19-7-10-35-21-11-17(5-6-18(19)21)37(33,34)30-22-28-14-29-36-22;24-16-3-1-15(2-4-16)20-12-30(13-22(25)26)8-9-31(20)19-7-10-34-21-11-17(5-6-18(19)21)36(32,33)29-23-27-14-28-35-23;24-8-9-29-10-11-30(21(14-29)16-1-3-17(25)4-2-16)20-7-12-33-22-13-18(5-6-19(20)22)35(31,32)28-23-26-15-27-34-23;1-2-28-10-11-29(21(14-28)16-3-5-17(24)6-4-16)20-9-12-32-22-13-18(7-8-19(20)22)34(30,31)27-23-25-15-26-33-23;23-15-3-1-14(2-4-15)19-12-30(39(34,35)22(24,25)26)8-9-31(19)18-7-10-36-20-11-16(5-6-17(18)20)38(32,33)29-21-27-13-28-37-21;1-35(29,30)27-9-10-28(20(13-27)15-2-4-16(23)5-3-15)19-8-11-33-21-12-17(6-7-18(19)21)36(31,32)26-22-24-14-25-34-22;1-27-9-10-28(20(13-27)15-2-4-16(23)5-3-15)19-8-11-31-21-12-17(6-7-18(19)21)33(29,30)26-22-24-14-25-32-22;22-15-3-1-14(2-4-15)19-12-23-8-9-27(19)18-7-10-30-20-11-16(5-6-17(18)20)32(28,29)26-21-24-13-25-31-21/h2*1-6,11,14,19-20H,7-10,12-13H2,(H,28,29,30);1-6,11,14,19-20,22H,7-10,12-13H2,(H,27,28,29);1-6,13,15,20-21H,7-12,14H2,(H,26,27,28);3-8,13,15,20-21H,2,9-12,14H2,1H3,(H,25,26,27);1-6,11,13,18-19H,7-10,12H2,(H,27,28,29);2-7,12,14,19-20H,8-11,13H2,1H3,(H,24,25,26);2-7,12,14,19-20H,8-11,13H2,1H3,(H,24,25,26);1-6,11,13,18-19,23H,7-10,12H2,(H,24,25,26)/t19-,20+;2*19-,20-;2*20-,21-;18-,19-;2*19-,20-;18-,19-/m100000000/s1
InChIKeyBNXXPNGRFPNLPL-CBMPXVLLSA-N
MW4806.50 g/mol
LogP32.05
Rot. Bonds54

About (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide

(4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide (PubChem CID 157407849) has the molecular formula C202H212F21N45O31S20 and a molecular weight of 4806.50 g/mol. Its IUPAC name is (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide.

Molecular Properties

Compound Name(4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide
PubChem CID157407849
Molecular FormulaC202H212F21N45O31S20
Molecular Weight4806.50 g/mol
Exact Mass4802.05
IUPAC Name(4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide
SMILESCCN1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.CN1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.CS(=O)(=O)N1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CC(F)(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CC(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CCF)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(S(=O)(=O)C(F)(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCNC[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@H]2N1CCN(CC(F)(F)F)C[C@H]1c1ccc(F)cc1
InChIInChI=1S/2C23H23F4N5O3S2.C23H24F3N5O3S2.C23H25F2N5O3S2.C23H26FN5O3S2.C22H21F4N5O5S3.C22H24FN5O5S3.C22H24FN5O3S2.C21H22FN5O3S2/c2*24-16-3-1-15(2-4-16)20-12-31(13-23(25,26)27)8-9-32(20)19-7-10-35-21-11-17(5-6-18(19)21)37(33,34)30-22-28-14-29-36-22;24-16-3-1-15(2-4-16)20-12-30(13-22(25)26)8-9-31(20)19-7-10-34-21-11-17(5-6-18(19)21)36(32,33)29-23-27-14-28-35-23;24-8-9-29-10-11-30(21(14-29)16-1-3-17(25)4-2-16)20-7-12-33-22-13-18(5-6-19(20)22)35(31,32)28-23-26-15-27-34-23;1-2-28-10-11-29(21(14-28)16-3-5-17(24)6-4-16)20-9-12-32-22-13-18(7-8-19(20)22)34(30,31)27-23-25-15-26-33-23;23-15-3-1-14(2-4-15)19-12-30(39(34,35)22(24,25)26)8-9-31(19)18-7-10-36-20-11-16(5-6-17(18)20)38(32,33)29-21-27-13-28-37-21;1-35(29,30)27-9-10-28(20(13-27)15-2-4-16(23)5-3-15)19-8-11-33-21-12-17(6-7-18(19)21)36(31,32)26-22-24-14-25-34-22;1-27-9-10-28(20(13-27)15-2-4-16(23)5-3-15)19-8-11-31-21-12-17(6-7-18(19)21)33(29,30)26-22-24-14-25-32-22;22-15-3-1-14(2-4-15)19-12-23-8-9-27(19)18-7-10-30-20-11-16(5-6-17(18)20)32(28,29)26-21-24-13-25-31-21/h2*1-6,11,14,19-20H,7-10,12-13H2,(H,28,29,30);1-6,11,14,19-20,22H,7-10,12-13H2,(H,27,28,29);1-6,13,15,20-21H,7-12,14H2,(H,26,27,28);3-8,13,15,20-21H,2,9-12,14H2,1H3,(H,25,26,27);1-6,11,13,18-19H,7-10,12H2,(H,27,28,29);2-7,12,14,19-20H,8-11,13H2,1H3,(H,24,25,26);2-7,12,14,19-20H,8-11,13H2,1H3,(H,24,25,26);1-6,11,13,18-19,23H,7-10,12H2,(H,24,25,26)/t19-,20+;2*19-,20-;2*20-,21-;18-,19-;2*19-,20-;18-,19-/m100000000/s1
InChIKeyBNXXPNGRFPNLPL-CBMPXVLLSA-N
XLogP32.05
TPSA866.01 Ų
H-Bond Donors10
H-Bond Acceptors74
Rotatable Bonds54
Heavy Atoms319
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5004806.50
LogP ≤ 532.05
H-Bond Donors ≤ 510
H-Bond Acceptors ≤ 1074

Analyze (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide with MolForge

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What is the IUPAC name of (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide?
The IUPAC name of (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide (CID 157407849) is (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide.
What is the SMILES notation for (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide?
The canonical SMILES for (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide is CCN1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.CN1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.CS(=O)(=O)N1CCN([C@H]2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)[C@H](c2ccc(F)cc2)C1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CC(F)(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CC(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(CCF)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCN(S(=O)(=O)C(F)(F)F)C[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CCNC[C@H]1c1ccc(F)cc1.O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@H]2N1CCN(CC(F)(F)F)C[C@H]1c1ccc(F)cc1.
What is the InChIKey of (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide?
The InChIKey is BNXXPNGRFPNLPL-CBMPXVLLSA-N. The full InChI is InChI=1S/2C23H23F4N5O3S2.C23H24F3N5O3S2.C23H25F2N5O3S2.C23H26FN5O3S2.C22H21F4N5O5S3.C22H24FN5O5S3.C22H24FN5O3S2.C21H22FN5O3S2/c2*24-16-3-1-15(2-4-16)20-12-31(13-23(25,26)27)8-9-32(20)19-7-10-35-21-11-17(5-6-18(19)21)37(33,34)30-22-28-14-29-36-22;24-16-3-1-15(2-4-16)20-12-30(13-22(25)26)8-9-31(20)19-7-10-34-21-11-17(5-6-18(19)21)36(32,33)29-23-27-14-28-35-23;24-8-9-29-10-11-30(21(14-29)16-1-3-17(25)4-2-16)20-7-12-33-22-13-18(5-6-19(20)22)35(31,32)28-23-26-15-27-34-23;1-2-28-10-11-29(21(14-28)16-3-5-17(24)6-4-16)20-9-12-32-22-13-18(7-8-19(20)22)34(30,31)27-23-25-15-26-33-23;23-15-3-1-14(2-4-15)19-12-30(39(34,35)22(24,25)26)8-9-31(19)18-7-10-36-20-11-16(5-6-17(18)20)38(32,33)29-21-27-13-28-37-21;1-35(29,30)27-9-10-28(20(13-27)15-2-4-16(23)5-3-15)19-8-11-33-21-12-17(6-7-18(19)21)36(31,32)26-22-24-14-25-34-22;1-27-9-10-28(20(13-27)15-2-4-16(23)5-3-15)19-8-11-31-21-12-17(6-7-18(19)21)33(29,30)26-22-24-14-25-32-22;22-15-3-1-14(2-4-15)19-12-23-8-9-27(19)18-7-10-30-20-11-16(5-6-17(18)20)32(28,29)26-21-24-13-25-31-21/h2*1-6,11,14,19-20H,7-10,12-13H2,(H,28,29,30);1-6,11,14,19-20,22H,7-10,12-13H2,(H,27,28,29);1-6,13,15,20-21H,7-12,14H2,(H,26,27,28);3-8,13,15,20-21H,2,9-12,14H2,1H3,(H,25,26,27);1-6,11,13,18-19H,7-10,12H2,(H,27,28,29);2-7,12,14,19-20H,8-11,13H2,1H3,(H,24,25,26);2-7,12,14,19-20H,8-11,13H2,1H3,(H,24,25,26);1-6,11,13,18-19,23H,7-10,12H2,(H,24,25,26)/t19-,20+;2*19-,20-;2*20-,21-;18-,19-;2*19-,20-;18-,19-/m100000000/s1.
What are the key properties of (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide?
(4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide has a molecular weight of 4806.50 g/mol, XLogP of 32.05, 54 rotatable bonds, 10 hydrogen bond donors, and 74 hydrogen bond acceptors.
Where does this data come from?
All data for (4S)-4-[(2R)-4-(2,2-difluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-ethyl-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-4-(2-fluoroethyl)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-methylsulfonylpiperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4R)-4-[(2R)-2-(4-fluorophenyl)-4-(2,2,2-trifluoroethyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide;(4S)-4-[(2R)-2-(4-fluorophenyl)-4-(trifluoromethylsulfonyl)piperazin-1-yl]-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-chromene-7-sulfonamide is sourced from PubChem (CID 157407849), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).