4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide

C105H82F11N25O14S — CID 158105845

About 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide

4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide (PubChem CID 158105845) has the molecular formula C105H82F11N25O14S and a molecular weight of 2159.02 g/mol. Its IUPAC name is 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide.

Molecular Properties

• Compound Name: 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide
• PubChem CID: 158105845
• Molecular Formula: C105H82F11N25O14S
• Molecular Weight: 2159.02 g/mol
• Exact Mass: 2157.60
• IUPAC Name: 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide
• SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(-c4cnc(F)s4)cc(-n4cnc(C)c4)c3)cc2)ccn1.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(C(=O)c4c(F)ccnc4F)c(C(F)(F)F)c3)cc2)ccn1.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(CNC(=O)n4nccc4C)c(C(F)(F)F)c3)cc2)ccn1.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(-c4cnc(F)nc4F)c3)cc2)ccn1
• InChI: InChI=1S/C27H18F5N5O4.C27H24F3N7O4.C27H22FN7O3S.C24H18F2N6O3/c1-33-25(39)21-13-17(8-10-34-21)41-16-5-2-14(3-6-16)36-26(40)37-15-4-7-18(19(12-15)27(30,31)32)23(38)22-20(28)9-11-35-24(22)29;1-16-9-12-34-37(16)26(40)33-15-17-3-4-19(13-22(17)27(28,29)30)36-25(39)35-18-5-7-20(8-6-18)41-21-10-11-32-23(14-21)24(38)31-2;1-16-14-35(15-32-16)20-10-17(24-13-31-26(28)39-24)9-19(11-20)34-27(37)33-18-3-5-21(6-4-18)38-22-7-8-30-23(12-22)25(36)29-2;1-27-22(33)20-12-18(9-10-28-20)35-17-7-5-15(6-8-17)30-24(34)31-16-4-2-3-14(11-16)19-13-29-23(26)32-21(19)25/h2-13H,1H3,(H,33,39)(H2,36,37,40);3-14H,15H2,1-2H3,(H,31,38)(H,33,40)(H2,35,36,39);3-15H,1-2H3,(H,29,36)(H2,33,34,37);2-13H,1H3,(H,27,33)(H2,30,31,34)
• InChIKey: FPUXAEMDWIVXCR-UHFFFAOYSA-N
• XLogP: 21.21
• TPSA: 502.77 Ų
• H-Bond Donors: 13
• H-Bond Acceptors: 27
• Rotatable Bonds: 27
• Heavy Atoms: 156
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2159.02
LogP ≤ 5	21.21
H-Bond Donors ≤ 5	13
H-Bond Acceptors ≤ 10	27

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': '2-halo_pyridine', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide?

The IUPAC name of 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide (CID 158105845) is 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide.

What is the SMILES notation for 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide?

The canonical SMILES for 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide is CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(-c4cnc(F)s4)cc(-n4cnc(C)c4)c3)cc2)ccn1.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(C(=O)c4c(F)ccnc4F)c(C(F)(F)F)c3)cc2)ccn1.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(CNC(=O)n4nccc4C)c(C(F)(F)F)c3)cc2)ccn1.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(-c4cnc(F)nc4F)c3)cc2)ccn1.

What is the InChIKey of 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide?

The InChIKey is FPUXAEMDWIVXCR-UHFFFAOYSA-N. The full InChI is InChI=1S/C27H18F5N5O4.C27H24F3N7O4.C27H22FN7O3S.C24H18F2N6O3/c1-33-25(39)21-13-17(8-10-34-21)41-16-5-2-14(3-6-16)36-26(40)37-15-4-7-18(19(12-15)27(30,31)32)23(38)22-20(28)9-11-35-24(22)29;1-16-9-12-34-37(16)26(40)33-15-17-3-4-19(13-22(17)27(28,29)30)36-25(39)35-18-5-7-20(8-6-18)41-21-10-11-32-23(14-21)24(38)31-2;1-16-14-35(15-32-16)20-10-17(24-13-31-26(28)39-24)9-19(11-20)34-27(37)33-18-3-5-21(6-4-18)38-22-7-8-30-23(12-22)25(36)29-2;1-27-22(33)20-12-18(9-10-28-20)35-17-7-5-15(6-8-17)30-24(34)31-16-4-2-3-14(11-16)19-13-29-23(26)32-21(19)25/h2-13H,1H3,(H,33,39)(H2,36,37,40);3-14H,15H2,1-2H3,(H,31,38)(H,33,40)(H2,35,36,39);3-15H,1-2H3,(H,29,36)(H2,33,34,37);2-13H,1H3,(H,27,33)(H2,30,31,34).

What are the key properties of 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide?

4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide has a molecular weight of 2159.02 g/mol, XLogP of 21.21, 27 rotatable bonds, 13 hydrogen bond donors, and 27 hydrogen bond acceptors.

Where does this data come from?

All data for 4-[4-[[4-(2,4-difluoropyridine-3-carbonyl)-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2,4-difluoropyrimidin-5-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-[4-[[3-(2-fluoro-1,3-thiazol-5-yl)-5-(4-methylimidazol-1-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;N-methyl-4-[4-[[4-[[(5-methylpyrazole-1-carbonyl)amino]methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide is sourced from PubChem (CID 158105845), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).