3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine

C70H73N31OS2 — CID 158176344

About 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine

3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine (PubChem CID 158176344) has the molecular formula C70H73N31OS2 and a molecular weight of 1428.70 g/mol. Its IUPAC name is 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine.

Molecular Properties

• Compound Name: 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine
• PubChem CID: 158176344
• Molecular Formula: C70H73N31OS2
• Molecular Weight: 1428.70 g/mol
• Exact Mass: 1427.61
• IUPAC Name: 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine
• SMILES: CC(C)c1cc(Nc2nccn3c(-c4cnn(C)c4)cnc23)sn1.Cn1cc(-c2cnc3c(Nc4cc(C5CC5)ns4)nccn23)cn1.Cn1cc(-c2cnc3c(Nc4ccnc(N5CCNCC5)c4)nccn23)cn1.Cn1cc(-c2cnc3c(Nc4ccnc(O[C@@H]5CCNC5)c4)nccn23)cn1
• InChI: InChI=1S/C19H21N9.C19H20N8O.C16H15N7S.C16H17N7S/c1-26-13-14(11-24-26)16-12-23-19-18(22-6-9-28(16)19)25-15-2-3-21-17(10-15)27-7-4-20-5-8-27;1-26-12-13(9-24-26)16-11-23-19-18(22-6-7-27(16)19)25-14-2-5-21-17(8-14)28-15-3-4-20-10-15;1-22-9-11(7-19-22)13-8-18-16-15(17-4-5-23(13)16)20-14-6-12(21-24-14)10-2-3-10;1-10(2)12-6-14(24-21-12)20-15-16-18-8-13(23(16)5-4-17-15)11-7-19-22(3)9-11/h2-3,6,9-13,20H,4-5,7-8H2,1H3,(H,21,22,25);2,5-9,11-12,15,20H,3-4,10H2,1H3,(H,21,22,25);4-10H,2-3H2,1H3,(H,17,20);4-10H,1-3H3,(H,17,20)/t;15-;;/m.1../s1
• InChIKey: FYAUJVOCJTYRGK-FTBZCSGFSA-N
• XLogP: 10.35
• TPSA: 328.25 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 34
• Rotatable Bonds: 17
• Heavy Atoms: 104
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	1428.70
LogP ≤ 5	10.35
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	34

Frequently Asked Questions

What is the IUPAC name of 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine?

The IUPAC name of 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine (CID 158176344) is 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine.

What is the SMILES notation for 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine?

The canonical SMILES for 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine is CC(C)c1cc(Nc2nccn3c(-c4cnn(C)c4)cnc23)sn1.Cn1cc(-c2cnc3c(Nc4cc(C5CC5)ns4)nccn23)cn1.Cn1cc(-c2cnc3c(Nc4ccnc(N5CCNCC5)c4)nccn23)cn1.Cn1cc(-c2cnc3c(Nc4ccnc(O[C@@H]5CCNC5)c4)nccn23)cn1.

What is the InChIKey of 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine?

The InChIKey is FYAUJVOCJTYRGK-FTBZCSGFSA-N. The full InChI is InChI=1S/C19H21N9.C19H20N8O.C16H15N7S.C16H17N7S/c1-26-13-14(11-24-26)16-12-23-19-18(22-6-9-28(16)19)25-15-2-3-21-17(10-15)27-7-4-20-5-8-27;1-26-12-13(9-24-26)16-11-23-19-18(22-6-7-27(16)19)25-14-2-5-21-17(8-14)28-15-3-4-20-10-15;1-22-9-11(7-19-22)13-8-18-16-15(17-4-5-23(13)16)20-14-6-12(21-24-14)10-2-3-10;1-10(2)12-6-14(24-21-12)20-15-16-18-8-13(23(16)5-4-17-15)11-7-19-22(3)9-11/h2-3,6,9-13,20H,4-5,7-8H2,1H3,(H,21,22,25);2,5-9,11-12,15,20H,3-4,10H2,1H3,(H,21,22,25);4-10H,2-3H2,1H3,(H,17,20);4-10H,1-3H3,(H,17,20)/t;15-;;/m.1../s1.

What are the key properties of 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine?

3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine has a molecular weight of 1428.70 g/mol, XLogP of 10.35, 17 rotatable bonds, 6 hydrogen bond donors, and 34 hydrogen bond acceptors.

Where does this data come from?

All data for 3-cyclopropyl-N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine;N-[3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-propan-2-yl-1,2-thiazol-5-amine;3-(1-methylpyrazol-4-yl)-N-(2-piperazin-1-yl-4-pyridinyl)imidazo[1,2-a]pyrazin-8-amine;3-(1-methylpyrazol-4-yl)-N-[2-[(3R)-pyrrolidin-3-yl]oxy-4-pyridinyl]imidazo[1,2-a]pyrazin-8-amine is sourced from PubChem (CID 158176344), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).