6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide

C135H119F27N26O13S6 — CID 158210558

About 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide

6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide (PubChem CID 158210558) has the molecular formula C135H119F27N26O13S6 and a molecular weight of 3018.95 g/mol. Its IUPAC name is 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide.

Molecular Properties

• Compound Name: 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide
• PubChem CID: 158210558
• Molecular Formula: C135H119F27N26O13S6
• Molecular Weight: 3018.95 g/mol
• Exact Mass: 3016.73
• IUPAC Name: 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide
• SMILES: C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2-c2ccccn2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(C(F)F)ccc3n2C2CCCC2)nc1)C(F)(F)F.Cc1c(F)cc2c(C#N)c(-c3ccc(S(=O)(=O)NC(CF)CF)cn3)n(C3CCC3)c2c1F.Cc1c(F)cc2c(C#N)c(-c3ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn3)n(C3CCC3)c2c1F.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCCC2)c2ccc(C(F)F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCCC2)c2ccc(C(F)F)cc12
• InChI: InChI=1S/C23H16F5N5O3S.C23H21F5N4O2S.C23H22F4N4O2S.C22H19F5N4O2S.C22H21F4N5O2S.C22H20F4N4O2S/c1-13(23(26,27)28)32-37(34,35)15-6-8-18(31-12-15)21-17(11-29)16-7-5-14(36-22(24)25)10-19(16)33(21)20-4-2-3-9-30-20;1-13(23(26,27)28)31-35(33,34)16-7-8-19(30-12-16)21-18(11-29)17-10-14(22(24)25)6-9-20(17)32(21)15-4-2-3-5-15;24-10-15(11-25)30-34(32,33)17-6-7-20(29-13-17)22-19(12-28)18-9-14(23(26)27)5-8-21(18)31(22)16-3-1-2-4-16;1-11-17(23)8-15-16(9-28)20(31(13-4-3-5-13)21(15)19(11)24)18-7-6-14(10-29-18)34(32,33)30-12(2)22(25,26)27;23-8-14(9-24)30-34(32,33)16-11-28-22(29-12-16)20-18(10-27)17-7-13(21(25)26)5-6-19(17)31(20)15-3-1-2-4-15;1-12-18(25)7-16-17(10-27)21(30(14-3-2-4-14)22(16)20(12)26)19-6-5-15(11-28-19)33(31,32)29-13(8-23)9-24/h2-10,12-13,22,32H,1H3;6-10,12-13,15,22,31H,2-5H2,1H3;5-9,13,15-16,23,30H,1-4,10-11H2;6-8,10,12-13,30H,3-5H2,1-2H3;5-7,11-12,14-15,21,30H,1-4,8-9H2;5-7,11,13-14,29H,2-4,8-9H2,1H3/t2*13-;;12-;;/m10.0../s1
• InChIKey: GCAIHVIDKXLKLK-WWBHCOSNSA-N
• XLogP: 30.06
• TPSA: 561.69 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 33
• Rotatable Bonds: 41
• Heavy Atoms: 207
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3018.95
LogP ≤ 5	30.06
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	33

Frequently Asked Questions

What is the IUPAC name of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

The IUPAC name of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide (CID 158210558) is 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide.

What is the SMILES notation for 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

The canonical SMILES for 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide is C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2-c2ccccn2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(C(F)F)ccc3n2C2CCCC2)nc1)C(F)(F)F.Cc1c(F)cc2c(C#N)c(-c3ccc(S(=O)(=O)NC(CF)CF)cn3)n(C3CCC3)c2c1F.Cc1c(F)cc2c(C#N)c(-c3ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn3)n(C3CCC3)c2c1F.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCCC2)c2ccc(C(F)F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCCC2)c2ccc(C(F)F)cc12.

What is the InChIKey of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

The InChIKey is GCAIHVIDKXLKLK-WWBHCOSNSA-N. The full InChI is InChI=1S/C23H16F5N5O3S.C23H21F5N4O2S.C23H22F4N4O2S.C22H19F5N4O2S.C22H21F4N5O2S.C22H20F4N4O2S/c1-13(23(26,27)28)32-37(34,35)15-6-8-18(31-12-15)21-17(11-29)16-7-5-14(36-22(24)25)10-19(16)33(21)20-4-2-3-9-30-20;1-13(23(26,27)28)31-35(33,34)16-7-8-19(30-12-16)21-18(11-29)17-10-14(22(24)25)6-9-20(17)32(21)15-4-2-3-5-15;24-10-15(11-25)30-34(32,33)17-6-7-20(29-13-17)22-19(12-28)18-9-14(23(26)27)5-8-21(18)31(22)16-3-1-2-4-16;1-11-17(23)8-15-16(9-28)20(31(13-4-3-5-13)21(15)19(11)24)18-7-6-14(10-29-18)34(32,33)30-12(2)22(25,26)27;23-8-14(9-24)30-34(32,33)16-11-28-22(29-12-16)20-18(10-27)17-7-13(21(25)26)5-6-19(17)31(20)15-3-1-2-4-15;1-12-18(25)7-16-17(10-27)21(30(14-3-2-4-14)22(16)20(12)26)19-6-5-15(11-28-19)33(31,32)29-13(8-23)9-24/h2-10,12-13,22,32H,1H3;6-10,12-13,15,22,31H,2-5H2,1H3;5-9,13,15-16,23,30H,1-4,10-11H2;6-8,10,12-13,30H,3-5H2,1-2H3;5-7,11-12,14-15,21,30H,1-4,8-9H2;5-7,11,13-14,29H,2-4,8-9H2,1H3/t2*13-;;12-;;/m10.0../s1.

What are the key properties of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide has a molecular weight of 3018.95 g/mol, XLogP of 30.06, 41 rotatable bonds, 6 hydrogen bond donors, and 33 hydrogen bond acceptors.

Where does this data come from?

All data for 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[3-cyano-1-cyclopentyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyridin-2-ylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide is sourced from PubChem (CID 158210558), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).