4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile

C92H78Cl5F2N33O5 — CID 158288376

IUPAC4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile
SMILESCOc1cncc(-n2c([C@H](C)Nc3nc(C)nc(N)c3C#N)nc3cccc(Cl)c3c2=O)c1.Cc1nc(N)c(C#N)c(N[C@@H](C)c2nc3ccc(F)c(Cl)c3c(=O)n2-c2cnccc2C)n1.Cc1nc(N)c(C#N)c(N[C@H](c2nc3c(Cl)ccc(Cl)c3c(=O)n2-c2cnc(N)cc2C)C2CC2)n1.Cc1nc(N)c(C#N)c(N[C@H](c2nc3cccc(Cl)c3c(=O)n2-c2cncc(F)c2C)C2CC2)n1
InChIInChI=1S/C24H21Cl2N9O.C24H20ClFN8O.C22H18ClFN8O.C22H19ClN8O2/c1-10-7-17(28)30-9-16(10)35-23(34-20-15(26)6-5-14(25)18(20)24(35)36)19(12-3-4-12)33-22-13(8-27)21(29)31-11(2)32-22;1-11-16(26)9-29-10-18(11)34-23(32-17-5-3-4-15(25)19(17)24(34)35)20(13-6-7-13)33-22-14(8-27)21(28)30-12(2)31-22;1-10-6-7-27-9-16(10)32-21(31-15-5-4-14(24)18(23)17(15)22(32)33)11(2)28-20-13(8-25)19(26)29-12(3)30-20;1-11(27-20-15(8-24)19(25)28-12(2)29-20)21-30-17-6-4-5-16(23)18(17)22(32)31(21)13-7-14(33-3)10-26-9-13/h5-7,9,12,19H,3-4H2,1-2H3,(H2,28,30)(H3,29,31,32,33);3-5,9-10,13,20H,6-7H2,1-2H3,(H3,28,30,31,33);4-7,9,11H,1-3H3,(H3,26,28,29,30);4-7,9-11H,1-3H3,(H3,25,27,28,29)/t19-;20-;2*11-/m0000/s1
InChIKeyGLBFQADPDAWKPE-LTCWPJRESA-N
MW1941.12 g/mol
LogP14.87
Rot. Bonds19

About 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile

4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile (PubChem CID 158288376) has the molecular formula C92H78Cl5F2N33O5 and a molecular weight of 1941.12 g/mol. Its IUPAC name is 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile.

Molecular Properties

Compound Name4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile
PubChem CID158288376
Molecular FormulaC92H78Cl5F2N33O5
Molecular Weight1941.12 g/mol
Exact Mass1937.53
IUPAC Name4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile
SMILESCOc1cncc(-n2c([C@H](C)Nc3nc(C)nc(N)c3C#N)nc3cccc(Cl)c3c2=O)c1.Cc1nc(N)c(C#N)c(N[C@@H](C)c2nc3ccc(F)c(Cl)c3c(=O)n2-c2cnccc2C)n1.Cc1nc(N)c(C#N)c(N[C@H](c2nc3c(Cl)ccc(Cl)c3c(=O)n2-c2cnc(N)cc2C)C2CC2)n1.Cc1nc(N)c(C#N)c(N[C@H](c2nc3cccc(Cl)c3c(=O)n2-c2cncc(F)c2C)C2CC2)n1
InChIInChI=1S/C24H21Cl2N9O.C24H20ClFN8O.C22H18ClFN8O.C22H19ClN8O2/c1-10-7-17(28)30-9-16(10)35-23(34-20-15(26)6-5-14(25)18(20)24(35)36)19(12-3-4-12)33-22-13(8-27)21(29)31-11(2)32-22;1-11-16(26)9-29-10-18(11)34-23(32-17-5-3-4-15(25)19(17)24(34)35)20(13-6-7-13)33-22-14(8-27)21(28)30-12(2)31-22;1-10-6-7-27-9-16(10)32-21(31-15-5-4-14(24)18(23)17(15)22(32)33)11(2)28-20-13(8-25)19(26)29-12(3)30-20;1-11(27-20-15(8-24)19(25)28-12(2)29-20)21-30-17-6-4-5-16(23)18(17)22(32)31(21)13-7-14(33-3)10-26-9-13/h5-7,9,12,19H,3-4H2,1-2H3,(H2,28,30)(H3,29,31,32,33);3-5,9-10,13,20H,6-7H2,1-2H3,(H3,28,30,31,33);4-7,9,11H,1-3H3,(H3,26,28,29,30);4-7,9-11H,1-3H3,(H3,25,27,28,29)/t19-;20-;2*11-/m0000/s1
InChIKeyGLBFQADPDAWKPE-LTCWPJRESA-N
XLogP14.87
TPSA576.85 Ų
H-Bond Donors9
H-Bond Acceptors38
Rotatable Bonds19
Heavy Atoms137
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5001941.12
LogP ≤ 514.87
H-Bond Donors ≤ 59
H-Bond Acceptors ≤ 1038

Analyze 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile with MolForge

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Launch Full Analysis

Related Compounds

4-amino-6-[[(5-chloro-8-fluoro-4-oxo-3-pyridin-3-ylquinazolin-2-yl)-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile
CID 118103190
4-amino-6-[[(1S)-1-[3-(6-amino-3-pyridinyl)-5-chloro-6-fluoro-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile
CID 118600611
4-amino-6-[[(1S)-1-[5-chloro-3-(3,5-difluorophenyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile
CID 118677920
2,4-diamino-6-[1-[5-chloro-3-(5-methoxy-2-methylphenyl)-4-oxoquinazolin-2-yl]ethylamino]pyrimidine-5-carbonitrile
CID 90234952
5-[5-chloro-2-[(S)-cyclopropyl-[(2,6-diamino-5-cyanopyrimidin-4-yl)amino]methyl]-4-oxoquinazolin-3-yl]pyridine-3-carboxamide
CID 118571316
4-amino-6-[[(1S)-1-[5-chloro-3-(3-cyanophenyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile
CID 118103182
2,4-diamino-6-[1-[5-chloro-3-[3-(difluoromethyl)-5-methoxyphenyl]-4-oxoquinazolin-2-yl]ethylamino]pyrimidine-5-carbonitrile
CID 90235272
3-[5-chloro-2-[(S)-cyclopropyl-[(2,6-diamino-5-cyanopyrimidin-4-yl)amino]methyl]-8-fluoro-4-oxoquinazolin-3-yl]benzamide
CID 118571204
2-[(1S)-1-[(6-amino-5-cyano-2-methylpyrimidin-4-yl)amino]ethyl]-8-fluoro-4-oxo-3-pyridin-3-ylquinazoline-5-carbonitrile
CID 118600577
3-[2-[[(2-amino-5-cyano-6-methylpyrimidin-4-yl)amino]-cyclopropylmethyl]-5-chloro-8-fluoro-4-oxoquinazolin-3-yl]benzamide
CID 118571342
2,4-diamino-6-[1-[5,8-dichloro-3-(3,5-difluorophenyl)-4-oxoquinazolin-2-yl]ethylamino]pyrimidine-5-carbonitrile
CID 90234660
2,4-diamino-6-[[(1S)-1-[5-chloro-3-(3-cyanophenyl)-8-fluoro-4-oxoquinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
CID 90235811

Frequently Asked Questions

What is the IUPAC name of 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile?
The IUPAC name of 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile (CID 158288376) is 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile.
What is the SMILES notation for 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile?
The canonical SMILES for 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile is COc1cncc(-n2c([C@H](C)Nc3nc(C)nc(N)c3C#N)nc3cccc(Cl)c3c2=O)c1.Cc1nc(N)c(C#N)c(N[C@@H](C)c2nc3ccc(F)c(Cl)c3c(=O)n2-c2cnccc2C)n1.Cc1nc(N)c(C#N)c(N[C@H](c2nc3c(Cl)ccc(Cl)c3c(=O)n2-c2cnc(N)cc2C)C2CC2)n1.Cc1nc(N)c(C#N)c(N[C@H](c2nc3cccc(Cl)c3c(=O)n2-c2cncc(F)c2C)C2CC2)n1.
What is the InChIKey of 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile?
The InChIKey is GLBFQADPDAWKPE-LTCWPJRESA-N. The full InChI is InChI=1S/C24H21Cl2N9O.C24H20ClFN8O.C22H18ClFN8O.C22H19ClN8O2/c1-10-7-17(28)30-9-16(10)35-23(34-20-15(26)6-5-14(25)18(20)24(35)36)19(12-3-4-12)33-22-13(8-27)21(29)31-11(2)32-22;1-11-16(26)9-29-10-18(11)34-23(32-17-5-3-4-15(25)19(17)24(34)35)20(13-6-7-13)33-22-14(8-27)21(28)30-12(2)31-22;1-10-6-7-27-9-16(10)32-21(31-15-5-4-14(24)18(23)17(15)22(32)33)11(2)28-20-13(8-25)19(26)29-12(3)30-20;1-11(27-20-15(8-24)19(25)28-12(2)29-20)21-30-17-6-4-5-16(23)18(17)22(32)31(21)13-7-14(33-3)10-26-9-13/h5-7,9,12,19H,3-4H2,1-2H3,(H2,28,30)(H3,29,31,32,33);3-5,9-10,13,20H,6-7H2,1-2H3,(H3,28,30,31,33);4-7,9,11H,1-3H3,(H3,26,28,29,30);4-7,9-11H,1-3H3,(H3,25,27,28,29)/t19-;20-;2*11-/m0000/s1.
What are the key properties of 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile?
4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile has a molecular weight of 1941.12 g/mol, XLogP of 14.87, 19 rotatable bonds, 9 hydrogen bond donors, and 38 hydrogen bond acceptors.
Where does this data come from?
All data for 4-amino-6-[[(S)-[3-(6-amino-4-methyl-3-pyridinyl)-5,8-dichloro-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(S)-[5-chloro-3-(5-fluoro-4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]-cyclopropylmethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-6-fluoro-3-(4-methyl-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile;4-amino-6-[[(1S)-1-[5-chloro-3-(5-methoxy-3-pyridinyl)-4-oxoquinazolin-2-yl]ethyl]amino]-2-methylpyrimidine-5-carbonitrile is sourced from PubChem (CID 158288376), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).