2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane

C125H189BClN25O12S3Si6 — CID 158381259

About 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane

2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane (PubChem CID 158381259) has the molecular formula C125H189BClN25O12S3Si6 and a molecular weight of 2545.03 g/mol. Its IUPAC name is 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane.

Molecular Properties

• Compound Name: 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
• PubChem CID: 158381259
• Molecular Formula: C125H189BClN25O12S3Si6
• Molecular Weight: 2545.03 g/mol
• Exact Mass: 2542.25
• IUPAC Name: 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
• SMILES: CC1=CC([Si](C(C)C)(C(C)C)C(C)C)C=C1B1OC(C)(C)C(C)(C)O1.CCS(=O)(=O)N1CC(=CC#N)C1.CCS(=O)(=O)N1CC(CC#N)(n2cc(C)c(-c3ncnc4[nH]ccc34)c2)C1.CCS(=O)(=O)N1CC(CC#N)(n2cc(C)c(-c3ncnc4c3ccn4COCC[Si](C)(C)C)c2)C1.C[Si](C)(C)CCOCn1ccc2c(Cl)ncnc21.Cc1c[nH]cc1-c1ncnc2c1ccn2COCC[Si](C)(C)C.Cc1cn([Si](C(C)C)(C(C)C)C(C)C)cc1-c1ncnc2c1ccn2COCC[Si](C)(C)C
• InChI: InChI=1S/C26H44N4OSi2.C24H34N6O3SSi.C21H39BO2Si.C18H20N6O2S.C17H24N4OSi.C12H18ClN3OSi.C7H10N2O2S/c1-19(2)33(20(3)4,21(5)6)30-15-22(7)24(16-30)25-23-11-12-29(26(23)28-17-27-25)18-31-13-14-32(8,9)10;1-6-34(31,32)30-15-24(16-30,8-9-25)29-13-19(2)21(14-29)22-20-7-10-28(23(20)27-17-26-22)18-33-11-12-35(3,4)5;1-14(2)25(15(3)4,16(5)6)18-12-17(7)19(13-18)22-23-20(8,9)21(10,11)24-22;1-3-27(25,26)24-10-18(11-24,5-6-19)23-8-13(2)15(9-23)16-14-4-7-20-17(14)22-12-21-16;1-13-9-18-10-15(13)16-14-5-6-21(17(14)20-11-19-16)12-22-7-8-23(2,3)4;1-18(2,3)7-6-17-9-16-5-4-10-11(13)14-8-15-12(10)16;1-2-12(10,11)9-5-7(6-9)3-4-8/h11-12,15-17,19-21H,13-14,18H2,1-10H3;7,10,13-14,17H,6,8,11-12,15-16,18H2,1-5H3;12-16,18H,1-11H3;4,7-9,12H,3,5,10-11H2,1-2H3,(H,20,21,22);5-6,9-11,18H,7-8,12H2,1-4H3;4-5,8H,6-7,9H2,1-3H3;3H,2,5-6H2,1H3
• InChIKey: GVUXSZNMORSDIT-UHFFFAOYSA-N
• XLogP: 27.45
• TPSA: 433.88 Ų
• H-Bond Donors: 2
• H-Bond Acceptors: 32
• Rotatable Bonds: 43
• Heavy Atoms: 173
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2545.03
LogP ≤ 5	27.45
H-Bond Donors ≤ 5	2
H-Bond Acceptors ≤ 10	32

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'dyes5A(27)', 'substructure': 'N/A'}, {'alert_name': 'Aliphatic_long_chain', 'substructure': 'N/A'}, {'alert_name': 'conjugated_nitrile_group', 'substructure': 'N/A'}, {'alert_name': 'heavy_metal', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane?

The IUPAC name of 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane (CID 158381259) is 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane.

What is the SMILES notation for 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane?

The canonical SMILES for 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane is CC1=CC([Si](C(C)C)(C(C)C)C(C)C)C=C1B1OC(C)(C)C(C)(C)O1.CCS(=O)(=O)N1CC(=CC#N)C1.CCS(=O)(=O)N1CC(CC#N)(n2cc(C)c(-c3ncnc4[nH]ccc34)c2)C1.CCS(=O)(=O)N1CC(CC#N)(n2cc(C)c(-c3ncnc4c3ccn4COCC[Si](C)(C)C)c2)C1.C[Si](C)(C)CCOCn1ccc2c(Cl)ncnc21.Cc1c[nH]cc1-c1ncnc2c1ccn2COCC[Si](C)(C)C.Cc1cn([Si](C(C)C)(C(C)C)C(C)C)cc1-c1ncnc2c1ccn2COCC[Si](C)(C)C.

What is the InChIKey of 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane?

The InChIKey is GVUXSZNMORSDIT-UHFFFAOYSA-N. The full InChI is InChI=1S/C26H44N4OSi2.C24H34N6O3SSi.C21H39BO2Si.C18H20N6O2S.C17H24N4OSi.C12H18ClN3OSi.C7H10N2O2S/c1-19(2)33(20(3)4,21(5)6)30-15-22(7)24(16-30)25-23-11-12-29(26(23)28-17-27-25)18-31-13-14-32(8,9)10;1-6-34(31,32)30-15-24(16-30,8-9-25)29-13-19(2)21(14-29)22-20-7-10-28(23(20)27-17-26-22)18-33-11-12-35(3,4)5;1-14(2)25(15(3)4,16(5)6)18-12-17(7)19(13-18)22-23-20(8,9)21(10,11)24-22;1-3-27(25,26)24-10-18(11-24,5-6-19)23-8-13(2)15(9-23)16-14-4-7-20-17(14)22-12-21-16;1-13-9-18-10-15(13)16-14-5-6-21(17(14)20-11-19-16)12-22-7-8-23(2,3)4;1-18(2,3)7-6-17-9-16-5-4-10-11(13)14-8-15-12(10)16;1-2-12(10,11)9-5-7(6-9)3-4-8/h11-12,15-17,19-21H,13-14,18H2,1-10H3;7,10,13-14,17H,6,8,11-12,15-16,18H2,1-5H3;12-16,18H,1-11H3;4,7-9,12H,3,5,10-11H2,1-2H3,(H,20,21,22);5-6,9-11,18H,7-8,12H2,1-4H3;4-5,8H,6-7,9H2,1-3H3;3H,2,5-6H2,1H3.

What are the key properties of 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane?

2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane has a molecular weight of 2545.03 g/mol, XLogP of 27.45, 43 rotatable bonds, 2 hydrogen bond donors, and 32 hydrogen bond acceptors.

Where does this data come from?

All data for 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane;2-(1-ethylsulfonylazetidin-3-ylidene)acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrol-1-yl]azetidin-3-yl]acetonitrile;2-[1-ethylsulfonyl-3-[3-methyl-4-[7-(2-trimethylsilylethoxymethyl)pyrrolo[2,3-d]pyrimidin-4-yl]pyrrol-1-yl]azetidin-3-yl]acetonitrile;[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopenta-2,4-dien-1-yl]-tri(propan-2-yl)silane;trimethyl-[2-[[4-(4-methyl-1H-pyrrol-3-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane;trimethyl-[2-[[4-[4-methyl-1-tri(propan-2-yl)silylpyrrol-3-yl]pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane is sourced from PubChem (CID 158381259), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).