2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one

C198H206F7N45O8S3 — CID 158471280

About 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one

2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one (PubChem CID 158471280) has the molecular formula C198H206F7N45O8S3 and a molecular weight of 3573.32 g/mol. Its IUPAC name is 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one.

Molecular Properties

• Compound Name: 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one
• PubChem CID: 158471280
• Molecular Formula: C198H206F7N45O8S3
• Molecular Weight: 3573.32 g/mol
• Exact Mass: 3570.61
• IUPAC Name: 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one
• SMILES: Cc1cc(C2CCCC2)ncc1-c1cc2cnc(Nc3ccc(N4C[C@@H](C)N[C@@H](C)C4)c(F)c3)nc2n(-c2ccccc2)c1=O.Cc1cnc(C2CCCC2)nc1-c1cc2cnc(Nc3ccc(C4CCCC4)cc3)nc2n(-c2nccs2)c1=O.Cc1nc(C2CCCC2)ncc1-c1cc2cnc(Nc3ccc(C4=CCNCC4)cc3)nc2n(Cc2nccs2)c1=O.Cc1nc(C2CCCN2)ccc1-c1cc2cnc(Nc3ccc(N4CCNCC4)c(C(F)(F)F)c3)nc2n(CC(F)(F)F)c1=O.Cc1nn(-c2ccccc2)c(C)c1-c1cc2cnc(Nc3ccc(C4CCCCC4)cc3)nc2n(CC(=O)N2CCCC2)c1=O.Cc1sc(-c2ccccn2)nc1-c1cc2cnc(Nc3ccc(C4CCN(C)C4)cc3)nc2n(CCN2CCOCC2)c1=O
• InChI: InChI=1S/C36H38FN7O.C36H39N7O2.C33H36N8O2S.C32H32N8OS.C31H31N7OS.C30H30F6N8O/c1-22-15-32(25-9-7-8-10-25)38-19-30(22)29-16-26-18-39-36(42-34(26)44(35(29)45)28-11-5-4-6-12-28)41-27-13-14-33(31(37)17-27)43-20-23(2)40-24(3)21-43;1-24-33(25(2)43(40-24)30-13-7-4-8-14-30)31-21-28-22-37-36(38-29-17-15-27(16-18-29)26-11-5-3-6-12-26)39-34(28)42(35(31)45)23-32(44)41-19-9-10-20-41;1-22-29(37-31(44-22)28-5-3-4-11-34-28)27-19-25-20-35-33(36-26-8-6-23(7-9-26)24-10-12-39(2)21-24)38-30(25)41(32(27)42)14-13-40-15-17-43-18-16-40;1-20-27(18-35-29(37-20)23-4-2-3-5-23)26-16-24-17-36-32(39-30(24)40(31(26)41)19-28-34-14-15-42-28)38-25-8-6-21(7-9-25)22-10-12-33-13-11-22;1-19-17-33-27(22-8-4-5-9-22)36-26(19)25-16-23-18-34-30(37-28(23)38(29(25)39)31-32-14-15-40-31)35-24-12-10-21(11-13-24)20-6-2-3-7-20;1-17-20(5-6-24(40-17)23-3-2-8-38-23)21-13-18-15-39-28(42-26(18)44(27(21)45)16-29(31,32)33)41-19-4-7-25(22(14-19)30(34,35)36)43-11-9-37-10-12-43/h4-6,11-19,23-25,40H,7-10,20-21H2,1-3H3,(H,39,41,42);4,7-8,13-18,21-22,26H,3,5-6,9-12,19-20,23H2,1-2H3,(H,37,38,39);3-9,11,19-20,24H,10,12-18,21H2,1-2H3,(H,35,36,38);6-10,14-18,23,33H,2-5,11-13,19H2,1H3,(H,36,38,39);10-18,20,22H,2-9H2,1H3,(H,34,35,37);4-7,13-15,23,37-38H,2-3,8-12,16H2,1H3,(H,39,41,42)/t23-,24+
• InChIKey: HGJMULVZNWGLLH-PRYORATJSA-N
• XLogP: 36.55
• TPSA: 596.20 Ų
• H-Bond Donors: 10
• H-Bond Acceptors: 55
• Rotatable Bonds: 40
• Heavy Atoms: 261
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3573.32
LogP ≤ 5	36.55
H-Bond Donors ≤ 5	10
H-Bond Acceptors ≤ 10	55

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'anil_di_alk_A(478)', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

The IUPAC name of 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one (CID 158471280) is 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one.

What is the SMILES notation for 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

The canonical SMILES for 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one is Cc1cc(C2CCCC2)ncc1-c1cc2cnc(Nc3ccc(N4C[C@@H](C)N[C@@H](C)C4)c(F)c3)nc2n(-c2ccccc2)c1=O.Cc1cnc(C2CCCC2)nc1-c1cc2cnc(Nc3ccc(C4CCCC4)cc3)nc2n(-c2nccs2)c1=O.Cc1nc(C2CCCC2)ncc1-c1cc2cnc(Nc3ccc(C4=CCNCC4)cc3)nc2n(Cc2nccs2)c1=O.Cc1nc(C2CCCN2)ccc1-c1cc2cnc(Nc3ccc(N4CCNCC4)c(C(F)(F)F)c3)nc2n(CC(F)(F)F)c1=O.Cc1nn(-c2ccccc2)c(C)c1-c1cc2cnc(Nc3ccc(C4CCCCC4)cc3)nc2n(CC(=O)N2CCCC2)c1=O.Cc1sc(-c2ccccn2)nc1-c1cc2cnc(Nc3ccc(C4CCN(C)C4)cc3)nc2n(CCN2CCOCC2)c1=O.

What is the InChIKey of 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

The InChIKey is HGJMULVZNWGLLH-PRYORATJSA-N. The full InChI is InChI=1S/C36H38FN7O.C36H39N7O2.C33H36N8O2S.C32H32N8OS.C31H31N7OS.C30H30F6N8O/c1-22-15-32(25-9-7-8-10-25)38-19-30(22)29-16-26-18-39-36(42-34(26)44(35(29)45)28-11-5-4-6-12-28)41-27-13-14-33(31(37)17-27)43-20-23(2)40-24(3)21-43;1-24-33(25(2)43(40-24)30-13-7-4-8-14-30)31-21-28-22-37-36(38-29-17-15-27(16-18-29)26-11-5-3-6-12-26)39-34(28)42(35(31)45)23-32(44)41-19-9-10-20-41;1-22-29(37-31(44-22)28-5-3-4-11-34-28)27-19-25-20-35-33(36-26-8-6-23(7-9-26)24-10-12-39(2)21-24)38-30(25)41(32(27)42)14-13-40-15-17-43-18-16-40;1-20-27(18-35-29(37-20)23-4-2-3-5-23)26-16-24-17-36-32(39-30(24)40(31(26)41)19-28-34-14-15-42-28)38-25-8-6-21(7-9-25)22-10-12-33-13-11-22;1-19-17-33-27(22-8-4-5-9-22)36-26(19)25-16-23-18-34-30(37-28(23)38(29(25)39)31-32-14-15-40-31)35-24-12-10-21(11-13-24)20-6-2-3-7-20;1-17-20(5-6-24(40-17)23-3-2-8-38-23)21-13-18-15-39-28(42-26(18)44(27(21)45)16-29(31,32)33)41-19-4-7-25(22(14-19)30(34,35)36)43-11-9-37-10-12-43/h4-6,11-19,23-25,40H,7-10,20-21H2,1-3H3,(H,39,41,42);4,7-8,13-18,21-22,26H,3,5-6,9-12,19-20,23H2,1-2H3,(H,37,38,39);3-9,11,19-20,24H,10,12-18,21H2,1-2H3,(H,35,36,38);6-10,14-18,23,33H,2-5,11-13,19H2,1H3,(H,36,38,39);10-18,20,22H,2-9H2,1H3,(H,34,35,37);4-7,13-15,23,37-38H,2-3,8-12,16H2,1H3,(H,39,41,42)/t23-,24+;;;;;.

What are the key properties of 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one has a molecular weight of 3573.32 g/mol, XLogP of 36.55, 40 rotatable bonds, 10 hydrogen bond donors, and 55 hydrogen bond acceptors.

Where does this data come from?

All data for 2-(4-cyclohexylanilino)-6-(3,5-dimethyl-1-phenylpyrazol-4-yl)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-6-(2-cyclopentyl-5-methylpyrimidin-4-yl)-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(6-cyclopentyl-4-methyl-3-pyridinyl)-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentyl-4-methylpyrimidin-5-yl)-2-[4-(1,2,3,6-tetrahydropyridin-4-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-yl-1,3-thiazol-4-yl)-2-[4-(1-methylpyrrolidin-3-yl)anilino]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-methyl-6-pyrrolidin-2-yl-3-pyridinyl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one is sourced from PubChem (CID 158471280), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).