2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

C109H106F6N40O8 — CID 158526203

IUPAC2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
SMILESCN1CCN(C(=O)c2ccc(-c3c(F)cncc3NC(=O)c3c(N)nn4cc(F)cnc34)cc2)CC1.Cc1nc(C(=O)N2CCN(C)CC2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Cc1nc(N2CCN(C)CC2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Cc1nc(O[C@@H]2CCN(C)C2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Nc1nn2cc(F)cnc2c1C(=O)Nc1cnccc1C1CC1
InChIInChI=1S/C24H22F2N8O2.C24H24FN9O2.C23H24FN9O.C23H23FN8O2.C15H13FN6O/c1-32-6-8-33(9-7-32)24(36)15-4-2-14(3-5-15)19-17(26)11-28-12-18(19)30-23(35)20-21(27)31-34-13-16(25)10-29-22(20)34;1-14-16(3-4-18(29-14)24(36)33-9-7-32(2)8-10-33)17-5-6-27-12-19(17)30-23(35)20-21(26)31-34-13-15(25)11-28-22(20)34;1-14-16(3-4-19(28-14)32-9-7-31(2)8-10-32)17-5-6-26-12-18(17)29-23(34)20-21(25)30-33-13-15(24)11-27-22(20)33;1-13-16(3-4-19(28-13)34-15-6-8-31(2)12-15)17-5-7-26-10-18(17)29-23(33)20-21(25)30-32-11-14(24)9-27-22(20)32;16-9-5-19-14-12(13(17)21-22(14)7-9)15(23)20-11-6-18-4-3-10(11)8-1-2-8/h2-5,10-13H,6-9H2,1H3,(H2,27,31)(H,30,35);3-6,11-13H,7-10H2,1-2H3,(H2,26,31)(H,30,35);3-6,11-13H,7-10H2,1-2H3,(H2,25,30)(H,29,34);3-5,7,9-11,15H,6,8,12H2,1-2H3,(H2,25,30)(H,29,33);3-8H,1-2H2,(H2,17,21)(H,20,23)/t;;;15-;/m...1./s1
InChIKeyHMUVDZQBDYFYNH-IJPZNPOWSA-N
MW2218.31 g/mol
LogP10.89
Rot. Bonds20

About 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (PubChem CID 158526203) has the molecular formula C109H106F6N40O8 and a molecular weight of 2218.31 g/mol. Its IUPAC name is 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide.

Molecular Properties

Compound Name2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
PubChem CID158526203
Molecular FormulaC109H106F6N40O8
Molecular Weight2218.31 g/mol
Exact Mass2216.90
IUPAC Name2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
SMILESCN1CCN(C(=O)c2ccc(-c3c(F)cncc3NC(=O)c3c(N)nn4cc(F)cnc34)cc2)CC1.Cc1nc(C(=O)N2CCN(C)CC2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Cc1nc(N2CCN(C)CC2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Cc1nc(O[C@@H]2CCN(C)C2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Nc1nn2cc(F)cnc2c1C(=O)Nc1cnccc1C1CC1
InChIInChI=1S/C24H22F2N8O2.C24H24FN9O2.C23H24FN9O.C23H23FN8O2.C15H13FN6O/c1-32-6-8-33(9-7-32)24(36)15-4-2-14(3-5-15)19-17(26)11-28-12-18(19)30-23(35)20-21(27)31-34-13-16(25)10-29-22(20)34;1-14-16(3-4-18(29-14)24(36)33-9-7-32(2)8-10-33)17-5-6-27-12-19(17)30-23(35)20-21(26)31-34-13-15(25)11-28-22(20)34;1-14-16(3-4-19(28-14)32-9-7-31(2)8-10-32)17-5-6-26-12-18(17)29-23(34)20-21(25)30-33-13-15(24)11-27-22(20)33;1-13-16(3-4-19(28-13)34-15-6-8-31(2)12-15)17-5-7-26-10-18(17)29-23(33)20-21(25)30-32-11-14(24)9-27-22(20)32;16-9-5-19-14-12(13(17)21-22(14)7-9)15(23)20-11-6-18-4-3-10(11)8-1-2-8/h2-5,10-13H,6-9H2,1H3,(H2,27,31)(H,30,35);3-6,11-13H,7-10H2,1-2H3,(H2,26,31)(H,30,35);3-6,11-13H,7-10H2,1-2H3,(H2,25,30)(H,29,34);3-5,7,9-11,15H,6,8,12H2,1-2H3,(H2,25,30)(H,29,33);3-8H,1-2H2,(H2,17,21)(H,20,23)/t;;;15-;/m...1./s1
InChIKeyHMUVDZQBDYFYNH-IJPZNPOWSA-N
XLogP10.89
TPSA595.72 Ų
H-Bond Donors10
H-Bond Acceptors41
Rotatable Bonds20
Heavy Atoms163
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5002218.31
LogP ≤ 510.89
H-Bond Donors ≤ 510
H-Bond Acceptors ≤ 1041

Analyze 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide with MolForge

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Launch Full Analysis

Related Compounds

3-[6-[3-[2-[2-[2-[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]propyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
CID 162676852
2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 90199752
N-[6-[1-[[1-[4-(2,6-dioxopiperidin-3-yl)-3-fluorophenyl]piperidin-4-yl]methyl]piperidin-4-yl]-7-oxo-2-propan-2-yloxy-5H-pyrrolo[3,4-b]pyridin-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 170740953
US20240368194, Example 13
CID 167439846
US20240368194, Example 33
CID 172494536
(E)-N-[2-[4-amino-6-[3-[2-(4-cyclopropyl-2-fluorophenyl)-2-oxoethyl]-5-fluoro-2-methylphenyl]pyrimidin-5-yl]oxyethyl]-4-[4-[2-[2-[2-[[5-[[[3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]methyl]-2-pyridinyl]oxy]ethoxy]ethoxy]ethoxy]piperidin-1-yl]-N-methylbut-2-enamide
CID 176733052
(E)-N-[2-[4-amino-6-[3-[2-(4-cyclopropyl-2-fluorophenyl)-2-oxoethyl]-5-fluoro-2-methylphenyl]pyrimidin-5-yl]oxyethyl]-4-[3-[4-[3-[[5-[[[3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]methyl]-2-pyridinyl]oxy]propyl]piperazin-1-yl]propyl-methylamino]-N-methylbut-2-enamide
CID 176733057
2-methyl-N-[6-[3-[(6-morpholin-4-ylpyridin-2-yl)carbamoyl]-6-[3-(trifluoromethyl)piperidin-1-yl]imidazo[1,2-b]pyridazin-8-yl]oxypyridin-2-yl]-5-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 123457530
6-(3-fluoropyrrolidin-1-yl)-N-(6-morpholin-4-yl-2-pyridinyl)-8-[[6-[[5-[2-(trifluoromethyl)phenyl]-1-[[6-[[5-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino]-2-pyridinyl]oxy]pyrazolo[1,5-a]pyrimidin-1-ium-3-carbonyl]amino]-2-pyridinyl]oxymethyl]imidazo[1,2-b]pyridazine-3-carboxamide
CID 124017564
1-[7-[5-[[2-[2-[3-ethoxy-4-[4-[2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-2-oxoacetyl]piperazin-1-yl]phenyl]-4-pyridinyl]ethylamino]methyl]-1H-pyrazol-3-yl]-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl]-2-[4-(1-phenyltetrazol-5-yl)piperazin-1-yl]ethane-1,2-dione
CID 143573582
N-[3-(difluoromethyl)-1-[4-[[[6-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]propoxy]-3-pyridinyl]-methylamino]methyl]cyclohexyl]pyrazol-4-yl]-5-morpholin-4-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 146599496
N-[3-(difluoromethyl)-1-[4-[[[6-[3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]propoxy]-3-pyridinyl]methylamino]methyl]cyclohexyl]pyrazol-4-yl]-5-morpholin-4-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 146599498

Frequently Asked Questions

What is the IUPAC name of 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
The IUPAC name of 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (CID 158526203) is 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide.
What is the SMILES notation for 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
The canonical SMILES for 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide is CN1CCN(C(=O)c2ccc(-c3c(F)cncc3NC(=O)c3c(N)nn4cc(F)cnc34)cc2)CC1.Cc1nc(C(=O)N2CCN(C)CC2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Cc1nc(N2CCN(C)CC2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Cc1nc(O[C@@H]2CCN(C)C2)ccc1-c1ccncc1NC(=O)c1c(N)nn2cc(F)cnc12.Nc1nn2cc(F)cnc2c1C(=O)Nc1cnccc1C1CC1.
What is the InChIKey of 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
The InChIKey is HMUVDZQBDYFYNH-IJPZNPOWSA-N. The full InChI is InChI=1S/C24H22F2N8O2.C24H24FN9O2.C23H24FN9O.C23H23FN8O2.C15H13FN6O/c1-32-6-8-33(9-7-32)24(36)15-4-2-14(3-5-15)19-17(26)11-28-12-18(19)30-23(35)20-21(27)31-34-13-16(25)10-29-22(20)34;1-14-16(3-4-18(29-14)24(36)33-9-7-32(2)8-10-33)17-5-6-27-12-19(17)30-23(35)20-21(26)31-34-13-15(25)11-28-22(20)34;1-14-16(3-4-19(28-14)32-9-7-31(2)8-10-32)17-5-6-26-12-18(17)29-23(34)20-21(25)30-33-13-15(24)11-27-22(20)33;1-13-16(3-4-19(28-13)34-15-6-8-31(2)12-15)17-5-7-26-10-18(17)29-23(33)20-21(25)30-32-11-14(24)9-27-22(20)32;16-9-5-19-14-12(13(17)21-22(14)7-9)15(23)20-11-6-18-4-3-10(11)8-1-2-8/h2-5,10-13H,6-9H2,1H3,(H2,27,31)(H,30,35);3-6,11-13H,7-10H2,1-2H3,(H2,26,31)(H,30,35);3-6,11-13H,7-10H2,1-2H3,(H2,25,30)(H,29,34);3-5,7,9-11,15H,6,8,12H2,1-2H3,(H2,25,30)(H,29,33);3-8H,1-2H2,(H2,17,21)(H,20,23)/t;;;15-;/m...1./s1.
What are the key properties of 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide has a molecular weight of 2218.31 g/mol, XLogP of 10.89, 20 rotatable bonds, 10 hydrogen bond donors, and 41 hydrogen bond acceptors.
Where does this data come from?
All data for 2-amino-N-(4-cyclopropyl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazine-1-carbonyl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-(4-methylpiperazin-1-yl)-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-6-[(3R)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide is sourced from PubChem (CID 158526203), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).