1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile

C216H235F3N64O10 — CID 158598881

IUPAC1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
SMILESCC(C)N(C)C(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)C1(C)CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)CC1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(O)CN(C)C(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.COCC(C)NC(=O)C1(C)CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.Cn1cc(-c2cc(-c3ccc(N4CCC(C(=O)N5CCCC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCC(C)(C(=O)NCCC(F)(F)F)CC4)nc3)c3c(C#N)cnn3c2)cn1
InChIInChI=1S/C28H32N8O2.C27H27F3N8O.C27H30N8O2.C27H28N8O.3C27H30N8O.C26H28N8O/c1-19(18-38-4)33-27(37)28(2)7-9-35(10-8-28)25-6-5-20(13-30-25)24-11-21(23-15-31-34(3)16-23)17-36-26(24)22(12-29)14-32-36;1-26(25(39)32-8-5-27(28,29)30)6-9-37(10-7-26)23-4-3-18(13-33-23)22-11-19(21-15-34-36(2)16-21)17-38-24(22)20(12-31)14-35-38;1-18(36)15-32(2)27(37)19-6-8-34(9-7-19)25-5-4-20(12-29-25)24-10-21(23-14-30-33(3)16-23)17-35-26(24)22(11-28)13-31-35;1-32-17-23(16-30-32)21-12-24(26-22(13-28)15-31-35(26)18-21)20-4-5-25(29-14-20)33-10-6-19(7-11-33)27(36)34-8-2-3-9-34;1-18(2)33(4)27(36)19-7-9-34(10-8-19)25-6-5-20(13-29-25)24-11-21(23-15-30-32(3)16-23)17-35-26(24)22(12-28)14-31-35;1-18(2)32-26(36)27(3)7-9-34(10-8-27)24-6-5-19(13-29-24)23-11-20(22-15-30-33(4)16-22)17-35-25(23)21(12-28)14-31-35;1-18(2)32-26(36)10-19-6-8-34(9-7-19)25-5-4-20(13-29-25)24-11-21(23-15-30-33(3)16-23)17-35-27(24)22(12-28)14-31-35;1-17(2)31-26(35)18-6-8-33(9-7-18)24-5-4-19(12-28-24)23-10-20(22-14-29-32(3)15-22)16-34-25(23)21(11-27)13-30-34/h5-6,11,13-17,19H,7-10,18H2,1-4H3,(H,33,37);3-4,11,13-17H,5-10H2,1-2H3,(H,32,39);4-5,10,12-14,16-19,36H,6-9,15H2,1-3H3;4-5,12,14-19H,2-3,6-11H2,1H3;5-6,11,13-19H,7-10H2,1-4H3;5-6,11,13-18H,7-10H2,1-4H3,(H,32,36);4-5,11,13-19H,6-10H2,1-3H3,(H,32,36);4-5,10,12-18H,6-9H2,1-3H3,(H,31,35)
InChIKeyHVJMOGOICBJOSO-UHFFFAOYSA-N
MW3944.69 g/mol
LogP28.76
Rot. Bonds44

About 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile

1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile (PubChem CID 158598881) has the molecular formula C216H235F3N64O10 and a molecular weight of 3944.69 g/mol. Its IUPAC name is 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile.

Molecular Properties

Compound Name1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
PubChem CID158598881
Molecular FormulaC216H235F3N64O10
Molecular Weight3944.69 g/mol
Exact Mass3941.98
IUPAC Name1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
SMILESCC(C)N(C)C(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)C1(C)CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)CC1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(O)CN(C)C(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.COCC(C)NC(=O)C1(C)CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.Cn1cc(-c2cc(-c3ccc(N4CCC(C(=O)N5CCCC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCC(C)(C(=O)NCCC(F)(F)F)CC4)nc3)c3c(C#N)cnn3c2)cn1
InChIInChI=1S/C28H32N8O2.C27H27F3N8O.C27H30N8O2.C27H28N8O.3C27H30N8O.C26H28N8O/c1-19(18-38-4)33-27(37)28(2)7-9-35(10-8-28)25-6-5-20(13-30-25)24-11-21(23-15-31-34(3)16-23)17-36-26(24)22(12-29)14-32-36;1-26(25(39)32-8-5-27(28,29)30)6-9-37(10-7-26)23-4-3-18(13-33-23)22-11-19(21-15-34-36(2)16-21)17-38-24(22)20(12-31)14-35-38;1-18(36)15-32(2)27(37)19-6-8-34(9-7-19)25-5-4-20(12-29-25)24-10-21(23-14-30-33(3)16-23)17-35-26(24)22(11-28)13-31-35;1-32-17-23(16-30-32)21-12-24(26-22(13-28)15-31-35(26)18-21)20-4-5-25(29-14-20)33-10-6-19(7-11-33)27(36)34-8-2-3-9-34;1-18(2)33(4)27(36)19-7-9-34(10-8-19)25-6-5-20(13-29-25)24-11-21(23-15-30-32(3)16-23)17-35-26(24)22(12-28)14-31-35;1-18(2)32-26(36)27(3)7-9-34(10-8-27)24-6-5-19(13-29-24)23-11-20(22-15-30-33(4)16-22)17-35-25(23)21(12-28)14-31-35;1-18(2)32-26(36)10-19-6-8-34(9-7-19)25-5-4-20(13-29-25)24-11-21(23-15-30-33(3)16-23)17-35-27(24)22(12-28)14-31-35;1-17(2)31-26(35)18-6-8-33(9-7-18)24-5-4-19(12-28-24)23-10-20(22-14-29-32(3)15-22)16-34-25(23)21(11-27)13-30-34/h5-6,11,13-17,19H,7-10,18H2,1-4H3,(H,33,37);3-4,11,13-17H,5-10H2,1-2H3,(H,32,39);4-5,10,12-14,16-19,36H,6-9,15H2,1-3H3;4-5,12,14-19H,2-3,6-11H2,1H3;5-6,11,13-19H,7-10H2,1-4H3;5-6,11,13-18H,7-10H2,1-4H3,(H,32,36);4-5,11,13-19H,6-10H2,1-3H3,(H,32,36);4-5,10,12-18H,6-9H2,1-3H3,(H,31,35)
InChIKeyHVJMOGOICBJOSO-UHFFFAOYSA-N
XLogP28.76
TPSA836.21 Ų
H-Bond Donors6
H-Bond Acceptors66
Rotatable Bonds44
Heavy Atoms293
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003944.69
LogP ≤ 528.76
H-Bond Donors ≤ 56
H-Bond Acceptors ≤ 1066

Analyze 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile with MolForge

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Related Compounds

1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-ethyl-N-propan-2-ylpiperidine-4-carboxamide
CID 126740062
7-[4-[3-cyano-4-[6-[4-methyl-4-(propan-2-ylcarbamoyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]pyrazol-1-yl]-2-azaspiro[3.5]nonane-2-carboxylic acid
CID 175476843
4-[6-[4-[2-[(2-methylpropan-2-yl)oxy]acetyl]piperidin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
CID 148655588
4-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-cyclopropyl-N-methylpiperazine-1-carboxamide;2,2,2-trifluoroacetaldehyde
CID 157078083
4-[6-[4-(2-hydroxy-3-methoxypropyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
CID 126740288
4-[6-[4-(4-methoxybut-2-ynylamino)piperidin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
CID 146660352
4-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-ethyl-N-methylpiperazine-1-carboxamide
CID 126740296
4-methyl-1-[5-[3-[(methylideneamino)methyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide
CID 138603888
4-[6-[4-(2-methoxyacetyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
CID 126740252
1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(3-ethynylphenyl)piperidine-4-carboxamide
CID 164754989
4-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-methylpropyl)piperazine-1-carboxamide
CID 126740093
tert-butyl N-[2-[4-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperazin-1-yl]ethyl]carbamate
CID 126752988

Frequently Asked Questions

What is the IUPAC name of 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
The IUPAC name of 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile (CID 158598881) is 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile.
What is the SMILES notation for 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
The canonical SMILES for 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile is CC(C)N(C)C(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)C1(C)CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(C)NC(=O)CC1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.CC(O)CN(C)C(=O)C1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.COCC(C)NC(=O)C1(C)CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.Cn1cc(-c2cc(-c3ccc(N4CCC(C(=O)N5CCCC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCC(C)(C(=O)NCCC(F)(F)F)CC4)nc3)c3c(C#N)cnn3c2)cn1.
What is the InChIKey of 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
The InChIKey is HVJMOGOICBJOSO-UHFFFAOYSA-N. The full InChI is InChI=1S/C28H32N8O2.C27H27F3N8O.C27H30N8O2.C27H28N8O.3C27H30N8O.C26H28N8O/c1-19(18-38-4)33-27(37)28(2)7-9-35(10-8-28)25-6-5-20(13-30-25)24-11-21(23-15-31-34(3)16-23)17-36-26(24)22(12-29)14-32-36;1-26(25(39)32-8-5-27(28,29)30)6-9-37(10-7-26)23-4-3-18(13-33-23)22-11-19(21-15-34-36(2)16-21)17-38-24(22)20(12-31)14-35-38;1-18(36)15-32(2)27(37)19-6-8-34(9-7-19)25-5-4-20(12-29-25)24-10-21(23-14-30-33(3)16-23)17-35-26(24)22(11-28)13-31-35;1-32-17-23(16-30-32)21-12-24(26-22(13-28)15-31-35(26)18-21)20-4-5-25(29-14-20)33-10-6-19(7-11-33)27(36)34-8-2-3-9-34;1-18(2)33(4)27(36)19-7-9-34(10-8-19)25-6-5-20(13-29-25)24-11-21(23-15-30-32(3)16-23)17-35-26(24)22(12-28)14-31-35;1-18(2)32-26(36)27(3)7-9-34(10-8-27)24-6-5-19(13-29-24)23-11-20(22-15-30-33(4)16-22)17-35-25(23)21(12-28)14-31-35;1-18(2)32-26(36)10-19-6-8-34(9-7-19)25-5-4-20(13-29-25)24-11-21(23-15-30-33(3)16-23)17-35-27(24)22(12-28)14-31-35;1-17(2)31-26(35)18-6-8-33(9-7-18)24-5-4-19(12-28-24)23-10-20(22-14-29-32(3)15-22)16-34-25(23)21(11-27)13-30-34/h5-6,11,13-17,19H,7-10,18H2,1-4H3,(H,33,37);3-4,11,13-17H,5-10H2,1-2H3,(H,32,39);4-5,10,12-14,16-19,36H,6-9,15H2,1-3H3;4-5,12,14-19H,2-3,6-11H2,1H3;5-6,11,13-19H,7-10H2,1-4H3;5-6,11,13-18H,7-10H2,1-4H3,(H,32,36);4-5,11,13-19H,6-10H2,1-3H3,(H,32,36);4-5,10,12-18H,6-9H2,1-3H3,(H,31,35).
What are the key properties of 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile has a molecular weight of 3944.69 g/mol, XLogP of 28.76, 44 rotatable bonds, 6 hydrogen bond donors, and 66 hydrogen bond acceptors.
Where does this data come from?
All data for 1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(2-hydroxypropyl)-N-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-(1-methoxypropan-2-yl)-4-methylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-propan-2-ylpiperidine-4-carboxamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-4-methyl-N-(3,3,3-trifluoropropyl)piperidine-4-carboxamide;2-[1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]piperidin-4-yl]-N-propan-2-ylacetamide;1-[5-[3-cyano-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]-2-pyridinyl]-N-propan-2-ylpiperidine-4-carboxamide;6-(1-methylpyrazol-4-yl)-4-[6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile is sourced from PubChem (CID 158598881), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).