7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

C353H399Cl5F10N82O26 — CID 158644503

IUPAC7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2C(F)(F)F)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C4CC4)ccc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(Cl)c(F)cc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(O)cccc2F)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cc(O)cc4ccccc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc(Cl)c2Cl)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C1.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C)cccc1Cl)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C)cccc1F)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C4CC4)ccc4[nH]ncc14)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(Cl)c(F)cc4[nH]ncc14)C3)C2
InChIInChI=1S/C33H38N8O2.C31H36N8O2.C31H34N6O3.C30H32ClFN8O2.C30H35ClN6O2.C30H35FN6O2.C29H33F3N6O2.C29H34N8O2.C28H30ClFN8O2.C28H31F3N6O2.C27H30Cl2N6O2.C27H31FN6O3/c1-3-29(42)40-17-33(18-40)19-41(20-33)31-24-10-12-39(30-23(21-6-7-21)8-9-27-26(30)14-35-37-27)15-28(24)36-32(25(31)13-34)43-16-22-5-4-11-38(22)2;1-3-28(40)39-15-20(16-39)34-29-23-10-12-38(30-22(19-6-7-19)8-9-26-25(30)14-33-36-26)17-27(23)35-31(24(29)13-32)41-18-21-5-4-11-37(21)2;1-3-29(39)37-16-21(17-37)33-30-25-10-12-36(28-14-23(38)13-20-7-4-5-9-24(20)28)18-27(25)34-31(26(30)15-32)40-19-22-8-6-11-35(22)2;1-3-25(41)39-14-30(15-39)16-40(17-30)27-19-6-8-38(28-21-11-34-36-23(21)9-22(32)26(28)31)12-24(19)35-29(20(27)10-33)42-13-18-5-4-7-37(18)2;2*1-4-26(38)36-16-30(17-36)18-37(19-30)28-22-10-12-35(27-20(2)7-5-9-24(27)31)14-25(22)33-29(23(28)13-32)39-15-21-8-6-11-34(21)3;1-4-25(39)38-14-19(15-38)34-26-21-10-12-37(27-18(2)7-5-9-23(27)29(30,31)32)16-24(21)35-28(22(26)13-33)40-17-20-8-6-11-36(20)3;1-4-26(38)37-14-19(15-37)32-27-21-9-11-36(28-18(2)7-8-24-23(28)13-31-34-24)16-25(21)33-29(22(27)12-30)39-17-20-6-5-10-35(20)3;1-3-24(39)38-12-16(13-38)33-26-18-6-8-37(27-20-11-32-35-22(20)9-21(30)25(27)29)14-23(18)34-28(19(26)10-31)40-15-17-5-4-7-36(17)2;1-3-25(38)37-14-18(15-37)33-26-20-10-12-36(24-9-5-4-8-22(24)28(29,30)31)16-23(20)34-27(21(26)13-32)39-17-19-7-6-11-35(19)2;1-3-24(36)35-13-17(14-35)31-26-19-9-11-34(23-8-4-7-21(28)25(23)29)15-22(19)32-27(20(26)12-30)37-16-18-6-5-10-33(18)2;1-3-24(36)34-13-17(14-34)30-25-19-9-11-33(26-21(28)7-4-8-23(26)35)15-22(19)31-27(20(25)12-29)37-16-18-6-5-10-32(18)2/h3,8-9,14,21-22H,1,4-7,10-12,15-20H2,2H3,(H,35,37);3,8-9,14,19-21H,1,4-7,10-12,15-18H2,2H3,(H,33,36)(H,34,35);3-5,7,9,13-14,21-22,38H,1,6,8,10-12,16-19H2,2H3,(H,33,34);3,9,11,18H,1,4-8,12-17H2,2H3,(H,34,36);2*4-5,7,9,21H,1,6,8,10-12,14-19H2,2-3H3;4-5,7,9,19-20H,1,6,8,10-12,14-17H2,2-3H3,(H,34,35);4,7-8,13,19-20H,1,5-6,9-11,14-17H2,2-3H3,(H,31,34)(H,32,33);3,9,11,16-17H,1,4-8,12-15H2,2H3,(H,32,35)(H,33,34);3-5,8-9,18-19H,1,6-7,10-12,14-17H2,2H3,(H,33,34);3-4,7-8,17-18H,1,5-6,9-11,13-16H2,2H3,(H,31,32);3-4,7-8,17-18,35H,1,5-6,9-11,13-16H2,2H3,(H,30,31)/t22-;21-;22-;18-;2*21-;2*20-;17-;19-;2*18-/m000000000000/s1
InChIKeyIAUJPWSOWFDGBO-VZOHOXIQSA-N
MW6573.87 g/mol
LogP42.47
Rot. Bonds82

About 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (PubChem CID 158644503) has the molecular formula C353H399Cl5F10N82O26 and a molecular weight of 6573.87 g/mol. Its IUPAC name is 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.

Molecular Properties

Compound Name7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
PubChem CID158644503
Molecular FormulaC353H399Cl5F10N82O26
Molecular Weight6573.87 g/mol
Exact Mass6567.07
IUPAC Name7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2C(F)(F)F)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C4CC4)ccc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(Cl)c(F)cc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(O)cccc2F)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cc(O)cc4ccccc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc(Cl)c2Cl)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C1.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C)cccc1Cl)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C)cccc1F)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C4CC4)ccc4[nH]ncc14)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(Cl)c(F)cc4[nH]ncc14)C3)C2
InChIInChI=1S/C33H38N8O2.C31H36N8O2.C31H34N6O3.C30H32ClFN8O2.C30H35ClN6O2.C30H35FN6O2.C29H33F3N6O2.C29H34N8O2.C28H30ClFN8O2.C28H31F3N6O2.C27H30Cl2N6O2.C27H31FN6O3/c1-3-29(42)40-17-33(18-40)19-41(20-33)31-24-10-12-39(30-23(21-6-7-21)8-9-27-26(30)14-35-37-27)15-28(24)36-32(25(31)13-34)43-16-22-5-4-11-38(22)2;1-3-28(40)39-15-20(16-39)34-29-23-10-12-38(30-22(19-6-7-19)8-9-26-25(30)14-33-36-26)17-27(23)35-31(24(29)13-32)41-18-21-5-4-11-37(21)2;1-3-29(39)37-16-21(17-37)33-30-25-10-12-36(28-14-23(38)13-20-7-4-5-9-24(20)28)18-27(25)34-31(26(30)15-32)40-19-22-8-6-11-35(22)2;1-3-25(41)39-14-30(15-39)16-40(17-30)27-19-6-8-38(28-21-11-34-36-23(21)9-22(32)26(28)31)12-24(19)35-29(20(27)10-33)42-13-18-5-4-7-37(18)2;2*1-4-26(38)36-16-30(17-36)18-37(19-30)28-22-10-12-35(27-20(2)7-5-9-24(27)31)14-25(22)33-29(23(28)13-32)39-15-21-8-6-11-34(21)3;1-4-25(39)38-14-19(15-38)34-26-21-10-12-37(27-18(2)7-5-9-23(27)29(30,31)32)16-24(21)35-28(22(26)13-33)40-17-20-8-6-11-36(20)3;1-4-26(38)37-14-19(15-37)32-27-21-9-11-36(28-18(2)7-8-24-23(28)13-31-34-24)16-25(21)33-29(22(27)12-30)39-17-20-6-5-10-35(20)3;1-3-24(39)38-12-16(13-38)33-26-18-6-8-37(27-20-11-32-35-22(20)9-21(30)25(27)29)14-23(18)34-28(19(26)10-31)40-15-17-5-4-7-36(17)2;1-3-25(38)37-14-18(15-37)33-26-20-10-12-36(24-9-5-4-8-22(24)28(29,30)31)16-23(20)34-27(21(26)13-32)39-17-19-7-6-11-35(19)2;1-3-24(36)35-13-17(14-35)31-26-19-9-11-34(23-8-4-7-21(28)25(23)29)15-22(19)32-27(20(26)12-30)37-16-18-6-5-10-33(18)2;1-3-24(36)34-13-17(14-34)30-25-19-9-11-33(26-21(28)7-4-8-23(26)35)15-22(19)31-27(20(25)12-29)37-16-18-6-5-10-32(18)2/h3,8-9,14,21-22H,1,4-7,10-12,15-20H2,2H3,(H,35,37);3,8-9,14,19-21H,1,4-7,10-12,15-18H2,2H3,(H,33,36)(H,34,35);3-5,7,9,13-14,21-22,38H,1,6,8,10-12,16-19H2,2H3,(H,33,34);3,9,11,18H,1,4-8,12-17H2,2H3,(H,34,36);2*4-5,7,9,21H,1,6,8,10-12,14-19H2,2-3H3;4-5,7,9,19-20H,1,6,8,10-12,14-17H2,2-3H3,(H,34,35);4,7-8,13,19-20H,1,5-6,9-11,14-17H2,2-3H3,(H,31,34)(H,32,33);3,9,11,16-17H,1,4-8,12-15H2,2H3,(H,32,35)(H,33,34);3-5,8-9,18-19H,1,6-7,10-12,14-17H2,2H3,(H,33,34);3-4,7-8,17-18H,1,5-6,9-11,13-16H2,2H3,(H,31,32);3-4,7-8,17-18,35H,1,5-6,9-11,13-16H2,2H3,(H,30,31)/t22-;21-;22-;18-;2*21-;2*20-;17-;19-;2*18-/m000000000000/s1
InChIKeyIAUJPWSOWFDGBO-VZOHOXIQSA-N
XLogP42.47
TPSA1165.46 Ų
H-Bond Donors15
H-Bond Acceptors91
Rotatable Bonds82
Heavy Atoms476
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5006573.87
LogP ≤ 542.47
H-Bond Donors ≤ 515
H-Bond Acceptors ≤ 1091

Analyze 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile with MolForge

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What is the IUPAC name of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The IUPAC name of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (CID 158644503) is 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.
What is the SMILES notation for 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The canonical SMILES for 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2C(F)(F)F)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C4CC4)ccc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(Cl)c(F)cc4[nH]ncc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(O)cccc2F)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cc(O)cc4ccccc24)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc(Cl)c2Cl)C3)C1.C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C1.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C)cccc1Cl)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C)cccc1F)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(C4CC4)ccc4[nH]ncc14)C3)C2.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OC[C@@H]3CCCN3C)nc3c1CCN(c1c(Cl)c(F)cc4[nH]ncc14)C3)C2.
What is the InChIKey of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The InChIKey is IAUJPWSOWFDGBO-VZOHOXIQSA-N. The full InChI is InChI=1S/C33H38N8O2.C31H36N8O2.C31H34N6O3.C30H32ClFN8O2.C30H35ClN6O2.C30H35FN6O2.C29H33F3N6O2.C29H34N8O2.C28H30ClFN8O2.C28H31F3N6O2.C27H30Cl2N6O2.C27H31FN6O3/c1-3-29(42)40-17-33(18-40)19-41(20-33)31-24-10-12-39(30-23(21-6-7-21)8-9-27-26(30)14-35-37-27)15-28(24)36-32(25(31)13-34)43-16-22-5-4-11-38(22)2;1-3-28(40)39-15-20(16-39)34-29-23-10-12-38(30-22(19-6-7-19)8-9-26-25(30)14-33-36-26)17-27(23)35-31(24(29)13-32)41-18-21-5-4-11-37(21)2;1-3-29(39)37-16-21(17-37)33-30-25-10-12-36(28-14-23(38)13-20-7-4-5-9-24(20)28)18-27(25)34-31(26(30)15-32)40-19-22-8-6-11-35(22)2;1-3-25(41)39-14-30(15-39)16-40(17-30)27-19-6-8-38(28-21-11-34-36-23(21)9-22(32)26(28)31)12-24(19)35-29(20(27)10-33)42-13-18-5-4-7-37(18)2;2*1-4-26(38)36-16-30(17-36)18-37(19-30)28-22-10-12-35(27-20(2)7-5-9-24(27)31)14-25(22)33-29(23(28)13-32)39-15-21-8-6-11-34(21)3;1-4-25(39)38-14-19(15-38)34-26-21-10-12-37(27-18(2)7-5-9-23(27)29(30,31)32)16-24(21)35-28(22(26)13-33)40-17-20-8-6-11-36(20)3;1-4-26(38)37-14-19(15-37)32-27-21-9-11-36(28-18(2)7-8-24-23(28)13-31-34-24)16-25(21)33-29(22(27)12-30)39-17-20-6-5-10-35(20)3;1-3-24(39)38-12-16(13-38)33-26-18-6-8-37(27-20-11-32-35-22(20)9-21(30)25(27)29)14-23(18)34-28(19(26)10-31)40-15-17-5-4-7-36(17)2;1-3-25(38)37-14-18(15-37)33-26-20-10-12-36(24-9-5-4-8-22(24)28(29,30)31)16-23(20)34-27(21(26)13-32)39-17-19-7-6-11-35(19)2;1-3-24(36)35-13-17(14-35)31-26-19-9-11-34(23-8-4-7-21(28)25(23)29)15-22(19)32-27(20(26)12-30)37-16-18-6-5-10-33(18)2;1-3-24(36)34-13-17(14-34)30-25-19-9-11-33(26-21(28)7-4-8-23(26)35)15-22(19)31-27(20(25)12-29)37-16-18-6-5-10-32(18)2/h3,8-9,14,21-22H,1,4-7,10-12,15-20H2,2H3,(H,35,37);3,8-9,14,19-21H,1,4-7,10-12,15-18H2,2H3,(H,33,36)(H,34,35);3-5,7,9,13-14,21-22,38H,1,6,8,10-12,16-19H2,2H3,(H,33,34);3,9,11,18H,1,4-8,12-17H2,2H3,(H,34,36);2*4-5,7,9,21H,1,6,8,10-12,14-19H2,2-3H3;4-5,7,9,19-20H,1,6,8,10-12,14-17H2,2-3H3,(H,34,35);4,7-8,13,19-20H,1,5-6,9-11,14-17H2,2-3H3,(H,31,34)(H,32,33);3,9,11,16-17H,1,4-8,12-15H2,2H3,(H,32,35)(H,33,34);3-5,8-9,18-19H,1,6-7,10-12,14-17H2,2H3,(H,33,34);3-4,7-8,17-18H,1,5-6,9-11,13-16H2,2H3,(H,31,32);3-4,7-8,17-18,35H,1,5-6,9-11,13-16H2,2H3,(H,30,31)/t22-;21-;22-;18-;2*21-;2*20-;17-;19-;2*18-/m000000000000/s1.
What are the key properties of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile has a molecular weight of 6573.87 g/mol, XLogP of 42.47, 82 rotatable bonds, 15 hydrogen bond donors, and 91 hydrogen bond acceptors.
Where does this data come from?
All data for 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-chloro-6-fluoro-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is sourced from PubChem (CID 158644503), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).