7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

C364H433Cl5F12N78O26 — CID 158712024

IUPAC7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2Cl)C3)C1.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2C(F)(F)F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2Cl)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C4CC4)ccc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(Cl)c(F)cc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(O)cccc2F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cc(O)cc4ccccc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc(Cl)c2Cl)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@H]1C
InChIInChI=1S/C33H40N8O2.C33H38N6O3.C31H37F3N6O2.C31H38N8O2.C30H34ClFN8O2.C30H37ClN6O2.2C30H35F3N6O2.C30H37FN6O2.C29H34Cl2N6O2.C29H35FN6O3.C28H33ClN6O2/c1-4-30(42)41-15-14-40(18-21(41)2)32-25-11-13-39(31-24(22-7-8-22)9-10-28-27(31)17-35-37-28)19-29(25)36-33(26(32)16-34)43-20-23-6-5-12-38(23)3;1-4-31(41)39-15-14-38(19-22(39)2)32-27-11-13-37(30-17-25(40)16-23-8-5-6-10-26(23)30)20-29(27)35-33(28(32)18-34)42-21-24-9-7-12-36(24)3;1-5-27(41)40-15-14-39(17-21(40)3)29-23-11-13-38(28-20(2)8-6-10-25(28)31(32,33)34)18-26(23)36-30(24(29)16-35)42-19-22-9-7-12-37(22)4;1-5-28(40)39-14-13-38(17-21(39)3)30-23-10-12-37(29-20(2)8-9-26-25(29)16-33-35-26)18-27(23)34-31(24(30)15-32)41-19-22-7-6-11-36(22)4;1-4-26(41)40-11-10-39(15-18(40)2)28-20-7-9-38(29-22-14-34-36-24(22)12-23(32)27(29)31)16-25(20)35-30(21(28)13-33)42-17-19-6-5-8-37(19)3;1-5-27(38)37-15-14-36(17-21(37)3)29-23-11-13-35(28-20(2)8-6-10-25(28)31)18-26(23)33-30(24(29)16-32)39-19-22-9-7-12-34(22)4;2*1-4-27(40)39-15-14-38(17-20(39)2)28-22-11-13-37(26-10-6-5-9-24(26)30(31,32)33)18-25(22)35-29(23(28)16-34)41-19-21-8-7-12-36(21)3;1-5-27(38)37-15-14-36(17-21(37)3)29-23-11-13-35(28-20(2)8-6-10-25(28)31)18-26(23)33-30(24(29)16-32)39-19-22-9-7-12-34(22)4;1-4-26(38)37-14-13-36(16-19(37)2)28-21-10-12-35(25-9-5-8-23(30)27(25)31)17-24(21)33-29(22(28)15-32)39-18-20-7-6-11-34(20)3;1-4-26(38)36-14-13-35(16-19(36)2)27-21-10-12-34(28-23(30)8-5-9-25(28)37)17-24(21)32-29(22(27)15-31)39-18-20-7-6-11-33(20)3;1-4-25(36)35-14-19(15-35)31-26-21-10-12-34(27-18(2)7-5-9-23(27)29)16-24(21)32-28(22(26)13-30)37-17-20-8-6-11-33(20)3/h4,9-10,17,21-23H,1,5-8,11-15,18-20H2,2-3H3,(H,35,37);4-6,8,10,16-17,22,24,40H,1,7,9,11-15,19-21H2,2-3H3;5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;5,8-9,16,21-22H,1,6-7,10-14,17-19H2,2-4H3,(H,33,35);4,12,14,18-19H,1,5-11,15-17H2,2-3H3,(H,34,36);5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;2*4-6,9-10,20-21H,1,7-8,11-15,17-19H2,2-3H3;5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;4-5,8-9,19-20H,1,6-7,10-14,16-18H2,2-3H3;4-5,8-9,19-20,37H,1,6-7,10-14,16-18H2,2-3H3;4-5,7,9,19-20H,1,6,8,10-12,14-17H2,2-3H3,(H,31,32)/t21-,23+;22-,24+;2*21-,22+;18-,19+;21-,22+;20-,21+;20-,21-;21-,22+;2*19-,20+;20-/m111111101110/s1
InChIKeyIIVPVJIPANOILO-HZVQSFCJSA-N
MW6722.23 g/mol
LogP47.48
Rot. Bonds74

About 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (PubChem CID 158712024) has the molecular formula C364H433Cl5F12N78O26 and a molecular weight of 6722.23 g/mol. Its IUPAC name is 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.

Molecular Properties

Compound Name7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
PubChem CID158712024
Molecular FormulaC364H433Cl5F12N78O26
Molecular Weight6722.23 g/mol
Exact Mass6715.32
IUPAC Name7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2Cl)C3)C1.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2C(F)(F)F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2Cl)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C4CC4)ccc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(Cl)c(F)cc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(O)cccc2F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cc(O)cc4ccccc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc(Cl)c2Cl)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@H]1C
InChIInChI=1S/C33H40N8O2.C33H38N6O3.C31H37F3N6O2.C31H38N8O2.C30H34ClFN8O2.C30H37ClN6O2.2C30H35F3N6O2.C30H37FN6O2.C29H34Cl2N6O2.C29H35FN6O3.C28H33ClN6O2/c1-4-30(42)41-15-14-40(18-21(41)2)32-25-11-13-39(31-24(22-7-8-22)9-10-28-27(31)17-35-37-28)19-29(25)36-33(26(32)16-34)43-20-23-6-5-12-38(23)3;1-4-31(41)39-15-14-38(19-22(39)2)32-27-11-13-37(30-17-25(40)16-23-8-5-6-10-26(23)30)20-29(27)35-33(28(32)18-34)42-21-24-9-7-12-36(24)3;1-5-27(41)40-15-14-39(17-21(40)3)29-23-11-13-38(28-20(2)8-6-10-25(28)31(32,33)34)18-26(23)36-30(24(29)16-35)42-19-22-9-7-12-37(22)4;1-5-28(40)39-14-13-38(17-21(39)3)30-23-10-12-37(29-20(2)8-9-26-25(29)16-33-35-26)18-27(23)34-31(24(30)15-32)41-19-22-7-6-11-36(22)4;1-4-26(41)40-11-10-39(15-18(40)2)28-20-7-9-38(29-22-14-34-36-24(22)12-23(32)27(29)31)16-25(20)35-30(21(28)13-33)42-17-19-6-5-8-37(19)3;1-5-27(38)37-15-14-36(17-21(37)3)29-23-11-13-35(28-20(2)8-6-10-25(28)31)18-26(23)33-30(24(29)16-32)39-19-22-9-7-12-34(22)4;2*1-4-27(40)39-15-14-38(17-20(39)2)28-22-11-13-37(26-10-6-5-9-24(26)30(31,32)33)18-25(22)35-29(23(28)16-34)41-19-21-8-7-12-36(21)3;1-5-27(38)37-15-14-36(17-21(37)3)29-23-11-13-35(28-20(2)8-6-10-25(28)31)18-26(23)33-30(24(29)16-32)39-19-22-9-7-12-34(22)4;1-4-26(38)37-14-13-36(16-19(37)2)28-21-10-12-35(25-9-5-8-23(30)27(25)31)17-24(21)33-29(22(28)15-32)39-18-20-7-6-11-34(20)3;1-4-26(38)36-14-13-35(16-19(36)2)27-21-10-12-34(28-23(30)8-5-9-25(28)37)17-24(21)32-29(22(27)15-31)39-18-20-7-6-11-33(20)3;1-4-25(36)35-14-19(15-35)31-26-21-10-12-34(27-18(2)7-5-9-23(27)29)16-24(21)32-28(22(26)13-30)37-17-20-8-6-11-33(20)3/h4,9-10,17,21-23H,1,5-8,11-15,18-20H2,2-3H3,(H,35,37);4-6,8,10,16-17,22,24,40H,1,7,9,11-15,19-21H2,2-3H3;5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;5,8-9,16,21-22H,1,6-7,10-14,17-19H2,2-4H3,(H,33,35);4,12,14,18-19H,1,5-11,15-17H2,2-3H3,(H,34,36);5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;2*4-6,9-10,20-21H,1,7-8,11-15,17-19H2,2-3H3;5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;4-5,8-9,19-20H,1,6-7,10-14,16-18H2,2-3H3;4-5,8-9,19-20,37H,1,6-7,10-14,16-18H2,2-3H3;4-5,7,9,19-20H,1,6,8,10-12,14-17H2,2-3H3,(H,31,32)/t21-,23+;22-,24+;2*21-,22+;18-,19+;21-,22+;20-,21+;20-,21-;21-,22+;2*19-,20+;20-/m111111101110/s1
InChIKeyIIVPVJIPANOILO-HZVQSFCJSA-N
XLogP47.48
TPSA1046.57 Ų
H-Bond Donors6
H-Bond Acceptors89
Rotatable Bonds74
Heavy Atoms485
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5006722.23
LogP ≤ 547.48
H-Bond Donors ≤ 56
H-Bond Acceptors ≤ 1089

Analyze 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile with MolForge

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What is the IUPAC name of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The IUPAC name of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (CID 158712024) is 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.
What is the SMILES notation for 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The canonical SMILES for 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2Cl)C3)C1.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2C(F)(F)F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2Cl)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)cccc2F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C4CC4)ccc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(Cl)c(F)cc4[nH]ncc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(O)cccc2F)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cc(O)cc4ccccc24)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc(Cl)c2Cl)C3)C[C@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@@H]1C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@H]1C.
What is the InChIKey of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The InChIKey is IIVPVJIPANOILO-HZVQSFCJSA-N. The full InChI is InChI=1S/C33H40N8O2.C33H38N6O3.C31H37F3N6O2.C31H38N8O2.C30H34ClFN8O2.C30H37ClN6O2.2C30H35F3N6O2.C30H37FN6O2.C29H34Cl2N6O2.C29H35FN6O3.C28H33ClN6O2/c1-4-30(42)41-15-14-40(18-21(41)2)32-25-11-13-39(31-24(22-7-8-22)9-10-28-27(31)17-35-37-28)19-29(25)36-33(26(32)16-34)43-20-23-6-5-12-38(23)3;1-4-31(41)39-15-14-38(19-22(39)2)32-27-11-13-37(30-17-25(40)16-23-8-5-6-10-26(23)30)20-29(27)35-33(28(32)18-34)42-21-24-9-7-12-36(24)3;1-5-27(41)40-15-14-39(17-21(40)3)29-23-11-13-38(28-20(2)8-6-10-25(28)31(32,33)34)18-26(23)36-30(24(29)16-35)42-19-22-9-7-12-37(22)4;1-5-28(40)39-14-13-38(17-21(39)3)30-23-10-12-37(29-20(2)8-9-26-25(29)16-33-35-26)18-27(23)34-31(24(30)15-32)41-19-22-7-6-11-36(22)4;1-4-26(41)40-11-10-39(15-18(40)2)28-20-7-9-38(29-22-14-34-36-24(22)12-23(32)27(29)31)16-25(20)35-30(21(28)13-33)42-17-19-6-5-8-37(19)3;1-5-27(38)37-15-14-36(17-21(37)3)29-23-11-13-35(28-20(2)8-6-10-25(28)31)18-26(23)33-30(24(29)16-32)39-19-22-9-7-12-34(22)4;2*1-4-27(40)39-15-14-38(17-20(39)2)28-22-11-13-37(26-10-6-5-9-24(26)30(31,32)33)18-25(22)35-29(23(28)16-34)41-19-21-8-7-12-36(21)3;1-5-27(38)37-15-14-36(17-21(37)3)29-23-11-13-35(28-20(2)8-6-10-25(28)31)18-26(23)33-30(24(29)16-32)39-19-22-9-7-12-34(22)4;1-4-26(38)37-14-13-36(16-19(37)2)28-21-10-12-35(25-9-5-8-23(30)27(25)31)17-24(21)33-29(22(28)15-32)39-18-20-7-6-11-34(20)3;1-4-26(38)36-14-13-35(16-19(36)2)27-21-10-12-34(28-23(30)8-5-9-25(28)37)17-24(21)32-29(22(27)15-31)39-18-20-7-6-11-33(20)3;1-4-25(36)35-14-19(15-35)31-26-21-10-12-34(27-18(2)7-5-9-23(27)29)16-24(21)32-28(22(26)13-30)37-17-20-8-6-11-33(20)3/h4,9-10,17,21-23H,1,5-8,11-15,18-20H2,2-3H3,(H,35,37);4-6,8,10,16-17,22,24,40H,1,7,9,11-15,19-21H2,2-3H3;5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;5,8-9,16,21-22H,1,6-7,10-14,17-19H2,2-4H3,(H,33,35);4,12,14,18-19H,1,5-11,15-17H2,2-3H3,(H,34,36);5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;2*4-6,9-10,20-21H,1,7-8,11-15,17-19H2,2-3H3;5-6,8,10,21-22H,1,7,9,11-15,17-19H2,2-4H3;4-5,8-9,19-20H,1,6-7,10-14,16-18H2,2-3H3;4-5,8-9,19-20,37H,1,6-7,10-14,16-18H2,2-3H3;4-5,7,9,19-20H,1,6,8,10-12,14-17H2,2-3H3,(H,31,32)/t21-,23+;22-,24+;2*21-,22+;18-,19+;21-,22+;20-,21+;20-,21-;21-,22+;2*19-,20+;20-/m111111101110/s1.
What are the key properties of 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile has a molecular weight of 6722.23 g/mol, XLogP of 47.48, 74 rotatable bonds, 6 hydrogen bond donors, and 89 hydrogen bond acceptors.
Where does this data come from?
All data for 7-(5-chloro-6-fluoro-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-chloro-6-methylphenyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-cyclopropyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2,3-dichlorophenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-hydroxyphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(2-fluoro-6-methylphenyl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(3-hydroxynaphthalen-1-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-methyl-6-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3S)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-3-methyl-4-prop-2-enoylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is sourced from PubChem (CID 158712024), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).