N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide

C106H101Cl3F12N26O15 — CID 158940017

About N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide

N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide (PubChem CID 158940017) has the molecular formula C106H101Cl3F12N26O15 and a molecular weight of 2313.48 g/mol. Its IUPAC name is N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide.

Molecular Properties

• Compound Name: N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
• PubChem CID: 158940017
• Molecular Formula: C106H101Cl3F12N26O15
• Molecular Weight: 2313.48 g/mol
• Exact Mass: 2310.68
• IUPAC Name: N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
• SMILES: O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC(O)CC2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC[C@@H](O)C2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC[C@H](O)C2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCNC3(CC3)C2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOC(CO)C2)c(-c2ccn[nH]2)c1
• InChI: InChI=1S/C22H21F3N6O2.3C21H20ClF2N5O3.C21H20F3N5O4/c23-22(24,25)33-16-3-1-15(2-4-16)29-20(32)14-11-17(18-5-8-28-30-18)19(26-12-14)31-10-9-27-21(13-31)6-7-21;22-21(23,24)32-16-3-1-14(2-4-16)27-20(31)13-11-17(18-5-8-26-28-18)19(25-12-13)29-9-6-15(30)7-10-29;2*22-21(23,24)32-16-5-3-14(4-6-16)27-20(31)13-10-17(18-7-8-26-28-18)19(25-11-13)29-9-1-2-15(30)12-29;22-21(23,24)33-15-3-1-14(2-4-15)27-20(31)13-9-17(18-5-6-26-28-18)19(25-10-13)29-7-8-32-16(11-29)12-30/h1-5,8,11-12,27H,6-7,9-10,13H2,(H,28,30)(H,29,32);1-5,8,11-12,15,30H,6-7,9-10H2,(H,26,28)(H,27,31);2*3-8,10-11,15,30H,1-2,9,12H2,(H,26,28)(H,27,31);1-6,9-10,16,30H,7-8,11-12H2,(H,26,28)(H,27,31)/t;;2*15-;/m..10./s1
• InChIKey: JKDAMKCLHDXHCE-LQVFFGIHSA-N
• XLogP: 17.94
• TPSA: 517.88 Ų
• H-Bond Donors: 15
• H-Bond Acceptors: 31
• Rotatable Bonds: 29
• Heavy Atoms: 162
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2313.48
LogP ≤ 5	17.94
H-Bond Donors ≤ 5	15
H-Bond Acceptors ≤ 10	31

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'alkyl_halide', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?

The IUPAC name of N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide (CID 158940017) is N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide.

What is the SMILES notation for N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?

The canonical SMILES for N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide is O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC(O)CC2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC[C@@H](O)C2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC[C@H](O)C2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCNC3(CC3)C2)c(-c2ccn[nH]2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOC(CO)C2)c(-c2ccn[nH]2)c1.

What is the InChIKey of N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?

The InChIKey is JKDAMKCLHDXHCE-LQVFFGIHSA-N. The full InChI is InChI=1S/C22H21F3N6O2.3C21H20ClF2N5O3.C21H20F3N5O4/c23-22(24,25)33-16-3-1-15(2-4-16)29-20(32)14-11-17(18-5-8-28-30-18)19(26-12-14)31-10-9-27-21(13-31)6-7-21;22-21(23,24)32-16-3-1-14(2-4-16)27-20(31)13-11-17(18-5-8-26-28-18)19(25-12-13)29-9-6-15(30)7-10-29;2*22-21(23,24)32-16-5-3-14(4-6-16)27-20(31)13-10-17(18-7-8-26-28-18)19(25-11-13)29-9-1-2-15(30)12-29;22-21(23,24)33-15-3-1-14(2-4-15)27-20(31)13-9-17(18-5-6-26-28-18)19(25-10-13)29-7-8-32-16(11-29)12-30/h1-5,8,11-12,27H,6-7,9-10,13H2,(H,28,30)(H,29,32);1-5,8,11-12,15,30H,6-7,9-10H2,(H,26,28)(H,27,31);2*3-8,10-11,15,30H,1-2,9,12H2,(H,26,28)(H,27,31);1-6,9-10,16,30H,7-8,11-12H2,(H,26,28)(H,27,31)/t;;2*15-;/m..10./s1.

What are the key properties of N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?

N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide has a molecular weight of 2313.48 g/mol, XLogP of 17.94, 29 rotatable bonds, 15 hydrogen bond donors, and 31 hydrogen bond acceptors.

Where does this data come from?

All data for N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide is sourced from PubChem (CID 158940017), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).