3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one

C212H255F3N44O16 — CID 159030879

IUPAC3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
SMILESCC(=O)n1cc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)c2ccccc21.CN(C(=O)C(C)(C)C)c1ncc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cn1.CN(C(=O)C1CCOCC1)c1ncc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cn1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc3nc(N4CCOCC4)ncc3c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc3ncncc3c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(-c3cccc4c3CC(=O)N4)cc1C#N)C(=O)N2.CN(CC1COC1)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(C(F)(F)F)nc1)C(=O)N2.CN(CCO)c1ncc2cc(N3CC4(CCC(c5ccccc5)(N(C)C)CC4)NC3=O)ccc2n1
InChIInChI=1S/C30H30N6O2.C28H34N6O2.C27H36N6O3.C27H34N6O2.C26H36N6O2.C26H30N4O2.C24H28F3N5O2.C24H27N5O/c1-35(2)30(21-7-4-3-5-8-21)13-11-29(12-14-30)19-36(28(38)34-29)26-18-32-25(15-20(26)17-31)22-9-6-10-24-23(22)16-27(37)33-24;1-32(2)28(22-6-4-3-5-7-22)12-10-27(11-13-28)20-34(26(35)31-27)23-8-9-24-21(18-23)19-29-25(30-24)33-14-16-36-17-15-33;1-31(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-33(25(35)30-26)22-17-28-24(29-18-22)32(3)23(34)20-9-15-36-16-10-20;1-31(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-33(25(35)30-26)22-9-10-23-20(17-22)18-28-24(29-23)32(3)15-16-34;1-24(2,3)21(33)31(6)22-27-16-20(17-28-22)32-18-25(29-23(32)34)12-14-26(15-13-25,30(4)5)19-10-8-7-9-11-19;1-19(31)29-17-23(21-11-7-8-12-22(21)29)30-18-25(27-24(30)32)13-15-26(16-14-25,28(2)3)20-9-5-4-6-10-20;1-31(13-17-14-34-15-17)23(18-5-3-2-4-6-18)9-7-22(8-10-23)16-32(21(33)30-22)19-11-28-20(29-12-19)24(25,26)27;1-28(2)24(19-6-4-3-5-7-19)12-10-23(11-13-24)16-29(22(30)27-23)20-8-9-21-18(14-20)15-25-17-26-21/h3-10,15,18H,11-14,16,19H2,1-2H3,(H,33,37)(H,34,38);3-9,18-19H,10-17,20H2,1-2H3,(H,31,35);4-8,17-18,20H,9-16,19H2,1-3H3,(H,30,35);4-10,17-18,34H,11-16,19H2,1-3H3,(H,30,35);7-11,16-17H,12-15,18H2,1-6H3,(H,29,34);4-12,17H,13-16,18H2,1-3H3,(H,27,32);2-6,11-12,17H,7-10,13-16H2,1H3,(H,30,33);3-9,14-15,17H,10-13,16H2,1-2H3,(H,27,30)
InChIKeyJUWDWJQVXKIQIC-UHFFFAOYSA-N
MW3732.66 g/mol
LogP30.83
Rot. Bonds34

About 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one

3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one (PubChem CID 159030879) has the molecular formula C212H255F3N44O16 and a molecular weight of 3732.66 g/mol. Its IUPAC name is 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one.

Molecular Properties

Compound Name3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
PubChem CID159030879
Molecular FormulaC212H255F3N44O16
Molecular Weight3732.66 g/mol
Exact Mass3730.04
IUPAC Name3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
SMILESCC(=O)n1cc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)c2ccccc21.CN(C(=O)C(C)(C)C)c1ncc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cn1.CN(C(=O)C1CCOCC1)c1ncc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cn1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc3nc(N4CCOCC4)ncc3c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc3ncncc3c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(-c3cccc4c3CC(=O)N4)cc1C#N)C(=O)N2.CN(CC1COC1)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(C(F)(F)F)nc1)C(=O)N2.CN(CCO)c1ncc2cc(N3CC4(CCC(c5ccccc5)(N(C)C)CC4)NC3=O)ccc2n1
InChIInChI=1S/C30H30N6O2.C28H34N6O2.C27H36N6O3.C27H34N6O2.C26H36N6O2.C26H30N4O2.C24H28F3N5O2.C24H27N5O/c1-35(2)30(21-7-4-3-5-8-21)13-11-29(12-14-30)19-36(28(38)34-29)26-18-32-25(15-20(26)17-31)22-9-6-10-24-23(22)16-27(37)33-24;1-32(2)28(22-6-4-3-5-7-22)12-10-27(11-13-28)20-34(26(35)31-27)23-8-9-24-21(18-23)19-29-25(30-24)33-14-16-36-17-15-33;1-31(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-33(25(35)30-26)22-17-28-24(29-18-22)32(3)23(34)20-9-15-36-16-10-20;1-31(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-33(25(35)30-26)22-9-10-23-20(17-22)18-28-24(29-23)32(3)15-16-34;1-24(2,3)21(33)31(6)22-27-16-20(17-28-22)32-18-25(29-23(32)34)12-14-26(15-13-25,30(4)5)19-10-8-7-9-11-19;1-19(31)29-17-23(21-11-7-8-12-22(21)29)30-18-25(27-24(30)32)13-15-26(16-14-25,28(2)3)20-9-5-4-6-10-20;1-31(13-17-14-34-15-17)23(18-5-3-2-4-6-18)9-7-22(8-10-23)16-32(21(33)30-22)19-11-28-20(29-12-19)24(25,26)27;1-28(2)24(19-6-4-3-5-7-19)12-10-23(11-13-24)16-29(22(30)27-23)20-8-9-21-18(14-20)15-25-17-26-21/h3-10,15,18H,11-14,16,19H2,1-2H3,(H,33,37)(H,34,38);3-9,18-19H,10-17,20H2,1-2H3,(H,31,35);4-8,17-18,20H,9-16,19H2,1-3H3,(H,30,35);4-10,17-18,34H,11-16,19H2,1-3H3,(H,30,35);7-11,16-17H,12-15,18H2,1-6H3,(H,29,34);4-12,17H,13-16,18H2,1-3H3,(H,27,32);2-6,11-12,17H,7-10,13-16H2,1H3,(H,30,33);3-9,14-15,17H,10-13,16H2,1-2H3,(H,27,30)
InChIKeyJUWDWJQVXKIQIC-UHFFFAOYSA-N
XLogP30.83
TPSA622.12 Ų
H-Bond Donors10
H-Bond Acceptors41
Rotatable Bonds34
Heavy Atoms275
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003732.66
LogP ≤ 530.83
H-Bond Donors ≤ 510
H-Bond Acceptors ≤ 1041

Analyze 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one with MolForge

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Related Compounds

3-[6-Fluoro-10-(3,3,4,4,5,5-hexafluoropiperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione;3-[6-fluoro-10-(2,2,6,6-tetrafluoromorpholine-4-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione;3-[6-fluoro-10-(3,3,5,5-tetrafluoropiperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione;10-[4-(hydroxymethyl)piperidine-1-carbonyl]-3-(4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-6-carbonitrile
CID 157127357
3-[6-Fluoro-10-(3,3,4,4,5,5-hexafluoropiperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione;3-[6-fluoro-10-(2,2,6,6-tetrafluoromorpholine-4-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione;3-[6-fluoro-10-(3,3,5,5-tetrafluoropiperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione;10-[4-(hydroxymethyl)piperidine-1-carbonyl]-3-(4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-6-carbonitrile;methane
CID 157144191
8-butan-2-yl-2-[4-(piperidin-4-ylamino)anilino]-6-(5-pyrrolidin-3-yl-2-pyridinyl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclopentylphenyl)-2-(3-methyl-4-piperazin-1-ylanilino)-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;2-[4-(4-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[1-(4H-pyrazol-3-yl)-2,3-dihydropyrrol-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-[(1-methylpyrrolidin-3-yl)amino]anilino]-6-[2-(oxolan-3-yl)pyrimidin-5-yl]-8-[[2-(trifluoromethyl)phenyl]methyl]pyrido[2,3-d]pyrimidin-7-one;8-(2-morpholin-4-ylethyl)-2-[4-(piperidin-3-ylamino)anilino]-6-(4-pyrrolidin-2-ylphenyl)pyrido[2,3-d]pyrimidin-7-one;dihydrate
CID 159217137
CID 159349061
CID 159349061
CID 160517310
CID 160517310
3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
CID 161028439
3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-(1-methyl-2-oxo-3H-indol-4-yl)pyrimidin-5-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
CID 161588990
3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;3-[4,6-bis(trifluoromethyl)-3-pyridinyl]-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,5-trimethylpyrazole-3-carboxamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
CID 161614653
6-[4-[(2,3-Difluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-3,3-dimethyl-1-(3-piperidin-1-ylcyclobutyl)indol-2-one;1-[3-(3,3-dimethylpyrrolidin-1-yl)cyclobutyl]-6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-3,3-dimethylindol-2-one;6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-3,3-dimethyl-1-[3-(3-oxa-6-azabicyclo[3.1.1]heptan-6-yl)cyclobutyl]indol-2-one;6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-3,3-dimethyl-1-(3-piperidin-1-ylcyclobutyl)indol-2-one;6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-3,3-dimethyl-1-(3-pyrrolidin-1-ylcyclobutyl)indol-2-one
CID 157574351
1'-acetyl-6-[4-[(7-fluoroisoquinolin-6-yl)-methylamino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1-(3-piperidin-1-ylcyclobutyl)spiro[indole-3,4'-piperidine]-2-one;1-[3-(3,3-dimethylpyrrolidin-1-yl)cyclobutyl]-6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1'-[(3R)-oxolane-3-carbonyl]spiro[indole-3,4'-piperidine]-2-one;6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1'-[(1R,2S)-2-hydroxycyclopentanecarbonyl]-1-(3-piperidin-1-ylcyclobutyl)spiro[indole-3,4'-piperidine]-2-one
CID 158254822
6-[4-[(3-Fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1'-(3-hydroxy-2,2-dimethylpropanoyl)-1-(3-piperidin-1-ylcyclobutyl)spiro[indole-3,4'-piperidine]-2-one;6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1'-(3-methoxycyclobutanecarbonyl)-1-(3-piperidin-1-ylcyclobutyl)spiro[indole-3,4'-piperidine]-2-one;6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1'-(oxetan-3-yl)-1-(3-piperidin-1-ylcyclobutyl)spiro[indole-3,4'-piperidine]-2-one;6-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1-(3-piperidin-1-ylcyclobutyl)-1'-propanoylspiro[indole-3,4'-piperidine]-2-one;6'-[4-[(3-fluoro-4-pyridinyl)amino]-3-propan-2-ylimidazo[4,5-c]pyridin-6-yl]-1'-(3-piperidin-1-ylcyclobutyl)spiro[cyclohexane-1,3'-indole]-2'-one
CID 161989955

Frequently Asked Questions

What is the IUPAC name of 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one?
The IUPAC name of 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one (CID 159030879) is 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one.
What is the SMILES notation for 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one?
The canonical SMILES for 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one is CC(=O)n1cc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)c2ccccc21.CN(C(=O)C(C)(C)C)c1ncc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cn1.CN(C(=O)C1CCOCC1)c1ncc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cn1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc3nc(N4CCOCC4)ncc3c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc3ncncc3c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(-c3cccc4c3CC(=O)N4)cc1C#N)C(=O)N2.CN(CC1COC1)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(C(F)(F)F)nc1)C(=O)N2.CN(CCO)c1ncc2cc(N3CC4(CCC(c5ccccc5)(N(C)C)CC4)NC3=O)ccc2n1.
What is the InChIKey of 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one?
The InChIKey is JUWDWJQVXKIQIC-UHFFFAOYSA-N. The full InChI is InChI=1S/C30H30N6O2.C28H34N6O2.C27H36N6O3.C27H34N6O2.C26H36N6O2.C26H30N4O2.C24H28F3N5O2.C24H27N5O/c1-35(2)30(21-7-4-3-5-8-21)13-11-29(12-14-30)19-36(28(38)34-29)26-18-32-25(15-20(26)17-31)22-9-6-10-24-23(22)16-27(37)33-24;1-32(2)28(22-6-4-3-5-7-22)12-10-27(11-13-28)20-34(26(35)31-27)23-8-9-24-21(18-23)19-29-25(30-24)33-14-16-36-17-15-33;1-31(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-33(25(35)30-26)22-17-28-24(29-18-22)32(3)23(34)20-9-15-36-16-10-20;1-31(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-33(25(35)30-26)22-9-10-23-20(17-22)18-28-24(29-23)32(3)15-16-34;1-24(2,3)21(33)31(6)22-27-16-20(17-28-22)32-18-25(29-23(32)34)12-14-26(15-13-25,30(4)5)19-10-8-7-9-11-19;1-19(31)29-17-23(21-11-7-8-12-22(21)29)30-18-25(27-24(30)32)13-15-26(16-14-25,28(2)3)20-9-5-4-6-10-20;1-31(13-17-14-34-15-17)23(18-5-3-2-4-6-18)9-7-22(8-10-23)16-32(21(33)30-22)19-11-28-20(29-12-19)24(25,26)27;1-28(2)24(19-6-4-3-5-7-19)12-10-23(11-13-24)16-29(22(30)27-23)20-8-9-21-18(14-20)15-25-17-26-21/h3-10,15,18H,11-14,16,19H2,1-2H3,(H,33,37)(H,34,38);3-9,18-19H,10-17,20H2,1-2H3,(H,31,35);4-8,17-18,20H,9-16,19H2,1-3H3,(H,30,35);4-10,17-18,34H,11-16,19H2,1-3H3,(H,30,35);7-11,16-17H,12-15,18H2,1-6H3,(H,29,34);4-12,17H,13-16,18H2,1-3H3,(H,27,32);2-6,11-12,17H,7-10,13-16H2,1H3,(H,30,33);3-9,14-15,17H,10-13,16H2,1-2H3,(H,27,30).
What are the key properties of 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one?
3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one has a molecular weight of 3732.66 g/mol, XLogP of 30.83, 34 rotatable bonds, 10 hydrogen bond donors, and 41 hydrogen bond acceptors.
Where does this data come from?
All data for 3-(1-acetylindol-3-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]quinazolin-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-morpholin-4-ylquinazolin-6-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-2-(2-oxo-1,3-dihydroindol-4-yl)pyridine-4-carbonitrile;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N-methyloxane-4-carboxamide;N-[5-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]pyrimidin-2-yl]-N,2,2-trimethylpropanamide;8-(dimethylamino)-8-phenyl-3-quinazolin-6-yl-1,3-diazaspiro[4.5]decan-2-one;8-[methyl(oxetan-3-ylmethyl)amino]-8-phenyl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one is sourced from PubChem (CID 159030879), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).