3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine

C133H106F33N23O8 — CID 159076035

IUPAC3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
SMILESCC(F)(F)c1cnn2ccc(-c3ccc(C4(C#N)CC4)cc3)cc12.CC(F)(F)c1cnn2ccc(-c3ccc(OC(F)(F)F)cc3)nc12.CC(F)(F)c1cnn2ccc(-c3cnc(OCC(F)(F)F)c(F)c3)nc12.CC(F)c1cnn2ccc(-c3ccc(C(F)(F)F)cc3)nc12.CC(F)c1cnn2ccc(-c3ccc(OC(F)(F)F)cc3)nc12.COC(C)(C)c1ccc(-c2ccn3ncc(C(C)(F)F)c3c2)cc1.COCc1cc(OC(F)(F)F)ccc1-c1ccn2ncc(C(C)(F)F)c2c1.COCc1cc(OC(F)(F)F)ccc1-c1ccn2ncc(C(C)(F)F)c2n1
InChIInChI=1S/C19H15F2N3.C19H20F2N2O.C18H15F5N2O2.C17H14F5N3O2.C15H10F6N4O.C15H10F5N3O.C15H11F4N3O.C15H11F4N3/c1-18(20,21)16-11-23-24-9-6-14(10-17(16)24)13-2-4-15(5-3-13)19(12-22)7-8-19;1-18(2,24-4)15-7-5-13(6-8-15)14-9-10-23-17(11-14)16(12-22-23)19(3,20)21;1-17(19,20)15-9-24-25-6-5-11(8-16(15)25)14-4-3-13(27-18(21,22)23)7-12(14)10-26-2;1-16(18,19)13-8-23-25-6-5-14(24-15(13)25)12-4-3-11(27-17(20,21)22)7-10(12)9-26-2;1-14(17,18)9-6-23-25-3-2-11(24-12(9)25)8-4-10(16)13(22-5-8)26-7-15(19,20)21;1-14(16,17)11-8-21-23-7-6-12(22-13(11)23)9-2-4-10(5-3-9)24-15(18,19)20;1-9(16)12-8-20-22-7-6-13(21-14(12)22)10-2-4-11(5-3-10)23-15(17,18)19;1-9(16)12-8-20-22-7-6-13(21-14(12)22)10-2-4-11(5-3-10)15(17,18)19/h2-6,9-11H,7-8H2,1H3;5-12H,1-4H3;3-9H,10H2,1-2H3;3-8H,9H2,1-2H3;2-6H,7H2,1H3;2-8H,1H3;2-9H,1H3;2-9H,1H3
InChIKeyKAGLUTDSLMQTTE-UHFFFAOYSA-N
MW2781.40 g/mol
LogP36.53
Rot. Bonds29

About 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine

3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine (PubChem CID 159076035) has the molecular formula C133H106F33N23O8 and a molecular weight of 2781.40 g/mol. Its IUPAC name is 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine.

Molecular Properties

Compound Name3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
PubChem CID159076035
Molecular FormulaC133H106F33N23O8
Molecular Weight2781.40 g/mol
Exact Mass2779.81
IUPAC Name3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
SMILESCC(F)(F)c1cnn2ccc(-c3ccc(C4(C#N)CC4)cc3)cc12.CC(F)(F)c1cnn2ccc(-c3ccc(OC(F)(F)F)cc3)nc12.CC(F)(F)c1cnn2ccc(-c3cnc(OCC(F)(F)F)c(F)c3)nc12.CC(F)c1cnn2ccc(-c3ccc(C(F)(F)F)cc3)nc12.CC(F)c1cnn2ccc(-c3ccc(OC(F)(F)F)cc3)nc12.COC(C)(C)c1ccc(-c2ccn3ncc(C(C)(F)F)c3c2)cc1.COCc1cc(OC(F)(F)F)ccc1-c1ccn2ncc(C(C)(F)F)c2c1.COCc1cc(OC(F)(F)F)ccc1-c1ccn2ncc(C(C)(F)F)c2n1
InChIInChI=1S/C19H15F2N3.C19H20F2N2O.C18H15F5N2O2.C17H14F5N3O2.C15H10F6N4O.C15H10F5N3O.C15H11F4N3O.C15H11F4N3/c1-18(20,21)16-11-23-24-9-6-14(10-17(16)24)13-2-4-15(5-3-13)19(12-22)7-8-19;1-18(2,24-4)15-7-5-13(6-8-15)14-9-10-23-17(11-14)16(12-22-23)19(3,20)21;1-17(19,20)15-9-24-25-6-5-11(8-16(15)25)14-4-3-13(27-18(21,22)23)7-12(14)10-26-2;1-16(18,19)13-8-23-25-6-5-14(24-15(13)25)12-4-3-11(27-17(20,21)22)7-10(12)9-26-2;1-14(17,18)9-6-23-25-3-2-11(24-12(9)25)8-4-10(16)13(22-5-8)26-7-15(19,20)21;1-14(16,17)11-8-21-23-7-6-12(22-13(11)23)9-2-4-10(5-3-9)24-15(18,19)20;1-9(16)12-8-20-22-7-6-13(21-14(12)22)10-2-4-11(5-3-10)23-15(17,18)19;1-9(16)12-8-20-22-7-6-13(21-14(12)22)10-2-4-11(5-3-10)15(17,18)19/h2-6,9-11H,7-8H2,1H3;5-12H,1-4H3;3-9H,10H2,1-2H3;3-8H,9H2,1-2H3;2-6H,7H2,1H3;2-8H,1H3;2-9H,1H3;2-9H,1H3
InChIKeyKAGLUTDSLMQTTE-UHFFFAOYSA-N
XLogP36.53
TPSA313.37 Ų
H-Bond Donors
H-Bond Acceptors31
Rotatable Bonds29
Heavy Atoms197
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5002781.40
LogP ≤ 536.53
H-Bond Donors ≤ 50
H-Bond Acceptors ≤ 1031

Analyze 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine with MolForge

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Related Compounds

3-(1,1-Difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;ethane;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine;5-[4-(2-methoxypropan-2-yl)phenyl]-3-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CID 142362599
8-[5-[[5-Fluoro-7-[[[8-[5-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methylamino]-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]-[1,2,4]triazolo[4,3-a]pyridin-5-yl]-methylamino]methyl]-2,3-dihydro-1-benzofuran-4-yl]methylamino]-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]-[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile
CID 156107791
N-(3,5-difluorophenyl)-8-(3-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;N-(3,5-difluorophenyl)-8-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine;N-(3-fluorophenyl)-8-(3-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;8-(3-methoxyphenyl)-N-(2-methyl-4-pyridinyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;8-(3-methoxyphenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;8-(3-methoxyphenyl)-N-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-2-amine
CID 157068880
1-[4-[6-(1,1-Difluoroethyl)imidazo[1,5-a]pyrimidin-3-yl]-3-methoxyphenyl]cyclopropane-1-carbonitrile;1-[4-[6-(1,1-difluoroethyl)imidazo[1,5-a]pyrimidin-3-yl]phenyl]cyclopropane-1-carbonitrile;bis(3-(1,1-difluoroethyl)-6-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]imidazo[1,5-a]pyrazine);3-(1,1-difluoroethyl)-6-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]imidazo[1,5-a]pyridine-1-carbonitrile;6-(1,1-difluoroethyl)-8-methyl-3-[4-(trifluoromethoxy)phenyl]imidazo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-6-[6-(2,2,2-trifluoroethoxy)-3-pyridinyl]imidazo[1,5-a]pyridine-1-carbonitrile;6-(1,1-difluoroethyl)-3-[4-(trifluoromethyl)phenyl]imidazo[1,5-a]pyrimidine
CID 157071658
3-[difluoro(methoxy)methyl]-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1-fluoroethyl)-6-[2-fluoro-4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyrazine;3-(1-fluoroethyl)-6-[4-(2-methoxypropan-2-yl)phenyl]-[1,2,4]triazolo[4,3-a]pyrazine;3-(1-fluoroethyl)-6-[2-methoxy-4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyrazine;3-(1-fluoroethyl)-6-[2-methyl-4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyrazine;3-(1-fluoroethyl)-6-[6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-[1,2,4]triazolo[4,3-a]pyrazine;3-(2-fluoro-2-methylcyclopropyl)-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-[[(2S)-oxan-2-yl]methyl]-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-[[(2R)-oxan-2-yl]methyl]-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine
CID 157150882
6-[4-(1,1-Difluoroethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine;6-[4-(1,1-difluoroethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[3,4-f][1,2,4]triazine;3-(difluoromethyl)-6-(4-phenoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine;6-(3,5-difluoro-4-phenoxyphenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine;6-(4-phenoxyphenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine;6-(4-phenoxyphenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
CID 157166926
6-(4-Cyclopropyl-2-methoxyphenyl)-3-(1,1-difluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazine;3-(1,1-difluoroethyl)-6-[2-fluoro-4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1,1-difluoroethyl)-6-[4-(2-methoxypropan-2-yl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1,1-difluoroethyl)-6-[2-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1,1-difluoroethyl)-6-[4-methyl-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-[1,2,4]triazolo[4,3-b]pyridazine;1-[4-[3-(1,1-difluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-3-methoxyphenyl]cyclopropane-1-carbonitrile;3-ethyl-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine
CID 157179546
6-[4-(1-Cyanocyclopropyl)phenyl]-3-(1,1-difluoroethyl)imidazo[1,5-a]pyridine-1-carbonitrile;3-(1,1-difluoroethyl)-6-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]imidazo[1,5-a]pyrazine;1-[4-[3-(1,1-difluoroethyl)imidazo[1,5-a]pyrazin-6-yl]phenyl]cyclopropane-1-carbonitrile;7-(1,1-difluoroethyl)-2-[4-(trifluoromethoxy)phenyl]imidazo[1,5-b]pyridazine-5-carbonitrile;3-(1-fluoroethyl)-6-[4-(trifluoromethoxy)phenyl]imidazo[1,5-a]pyridine-1-carbonitrile;6-(3-fluoro-3-methylcyclobutyl)-3-[4-(trifluoromethoxy)phenyl]imidazo[1,5-a]pyrimidine
CID 157183479
3-(1,1-Difluoroethyl)-6-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1,1-difluoroethyl)-6-[2-methoxy-4-(2-methoxypropan-2-yl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1,1-difluoroethyl)-6-[2-(methoxymethyl)-4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]pyrazine;3-[difluoro(methoxy)methyl]-6-[2-methyl-4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1-fluorocyclopropyl)-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyrazine;1-pyrrolidin-1-yl-2-[6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]ethanone
CID 157255937
N-(3,5-difluorophenyl)-8-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine;N-(3-fluorophenyl)-8-(3-methylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;8-(2-fluorophenyl)-N-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine;N-(3-fluorophenyl)-8-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine;N-(4-fluorophenyl)-8-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine;N-(2-methyl-4-pyridinyl)-8-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine;N-phenyl-8-[3-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
CID 157307599
3-(1,1-Difluoroethyl)-6-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]imidazo[1,2-a]pyrazine;1-[4-[3-(1,1-difluoroethyl)imidazo[1,2-a]pyrazin-6-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-6-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrazine;3-(1,1-difluoroethyl)-6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine;2-methyl-6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)imidazo[1,2-a]pyrimidine
CID 157455809
3-Cyclopropyl-6-[6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-[1,2,4]triazolo[4,3-b]pyridazine;1-[4-[3-(1,1-difluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]phenyl]cyclopropane-1-carbonitrile;3-(3-fluoro-3-methylcyclobutyl)-6-[2-methoxy-4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(oxolan-2-ylmethyl)-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(oxolan-3-ylmethyl)-6-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[4,3-b]pyridazine;3-(1,1,2,2-tetrafluoropropyl)-6-[6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-[1,2,4]triazolo[4,3-b]pyridazine
CID 157478349

Frequently Asked Questions

What is the IUPAC name of 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine?
The IUPAC name of 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine (CID 159076035) is 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine.
What is the SMILES notation for 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine?
The canonical SMILES for 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine is CC(F)(F)c1cnn2ccc(-c3ccc(C4(C#N)CC4)cc3)cc12.CC(F)(F)c1cnn2ccc(-c3ccc(OC(F)(F)F)cc3)nc12.CC(F)(F)c1cnn2ccc(-c3cnc(OCC(F)(F)F)c(F)c3)nc12.CC(F)c1cnn2ccc(-c3ccc(C(F)(F)F)cc3)nc12.CC(F)c1cnn2ccc(-c3ccc(OC(F)(F)F)cc3)nc12.COC(C)(C)c1ccc(-c2ccn3ncc(C(C)(F)F)c3c2)cc1.COCc1cc(OC(F)(F)F)ccc1-c1ccn2ncc(C(C)(F)F)c2c1.COCc1cc(OC(F)(F)F)ccc1-c1ccn2ncc(C(C)(F)F)c2n1.
What is the InChIKey of 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine?
The InChIKey is KAGLUTDSLMQTTE-UHFFFAOYSA-N. The full InChI is InChI=1S/C19H15F2N3.C19H20F2N2O.C18H15F5N2O2.C17H14F5N3O2.C15H10F6N4O.C15H10F5N3O.C15H11F4N3O.C15H11F4N3/c1-18(20,21)16-11-23-24-9-6-14(10-17(16)24)13-2-4-15(5-3-13)19(12-22)7-8-19;1-18(2,24-4)15-7-5-13(6-8-15)14-9-10-23-17(11-14)16(12-22-23)19(3,20)21;1-17(19,20)15-9-24-25-6-5-11(8-16(15)25)14-4-3-13(27-18(21,22)23)7-12(14)10-26-2;1-16(18,19)13-8-23-25-6-5-14(24-15(13)25)12-4-3-11(27-17(20,21)22)7-10(12)9-26-2;1-14(17,18)9-6-23-25-3-2-11(24-12(9)25)8-4-10(16)13(22-5-8)26-7-15(19,20)21;1-14(16,17)11-8-21-23-7-6-12(22-13(11)23)9-2-4-10(5-3-9)24-15(18,19)20;1-9(16)12-8-20-22-7-6-13(21-14(12)22)10-2-4-11(5-3-10)23-15(17,18)19;1-9(16)12-8-20-22-7-6-13(21-14(12)22)10-2-4-11(5-3-10)15(17,18)19/h2-6,9-11H,7-8H2,1H3;5-12H,1-4H3;3-9H,10H2,1-2H3;3-8H,9H2,1-2H3;2-6H,7H2,1H3;2-8H,1H3;2-9H,1H3;2-9H,1H3.
What are the key properties of 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine?
3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine has a molecular weight of 2781.40 g/mol, XLogP of 36.53, 29 rotatable bonds, 0 hydrogen bond donors, and 31 hydrogen bond acceptors.
Where does this data come from?
All data for 3-(1,1-difluoroethyl)-5-[5-fluoro-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyridine;3-(1,1-difluoroethyl)-5-[2-(methoxymethyl)-4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1,1-difluoroethyl)-5-[4-(2-methoxypropan-2-yl)phenyl]pyrazolo[1,5-a]pyridine;1-[4-[3-(1,1-difluoroethyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl]cyclopropane-1-carbonitrile;3-(1,1-difluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethoxy)phenyl]pyrazolo[1,5-a]pyrimidine;3-(1-fluoroethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine is sourced from PubChem (CID 159076035), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).