4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene

C224H304F10N6O20 — CID 159154039

About 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene

4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene (PubChem CID 159154039) has the molecular formula C224H304F10N6O20 and a molecular weight of 3590.90 g/mol. Its IUPAC name is 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene.

Molecular Properties

• Compound Name: 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene
• PubChem CID: 159154039
• Molecular Formula: C224H304F10N6O20
• Molecular Weight: 3590.90 g/mol
• Exact Mass: 3588.28
• IUPAC Name: 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene
• SMILES: CC(C)(C)c1ccc(C(F)(F)F)cc1.CC(C)(C)c1ccc(COC#N)cc1.CC(C)(C)c1ccc(F)cc1.CC(C)(C)c1ccc(N)cc1.CC(C)(C)c1ccc(O)cc1.CC(C)(C)c1ccc(OC(F)(F)F)cc1.CC(C)(C)c1ccc(OC(F)F)cc1.CC(C)(C)c1ccc(OCCF)cc1.CC(C)(C)c1ccc(OCc2ccccc2)cc1.CC(C)(C)c1ccc2c(c1)NCCO2.CC(C)(C)c1ccc2c(c1)OCC(=O)N2.CC(C)(C)c1ccc2c(c1)OCCN2.CC(C)(C)c1ccc2c(c1)OCCO2.CC(C)(C)c1ccc2c(c1)OCO2.CC(C)Oc1ccc(C(C)(C)C)cc1.CCOc1ccc(C(C)(C)C)cc1.CN1CCOc2cc(C(C)(C)C)ccc21.COc1ccc(C(C)(C)C)cc1.COc1ccc(OC)c(C(C)(C)C)c1
• InChI: InChI=1S/C17H20O.C13H19NO.C13H20O.C12H17FO.C12H15NO2.2C12H17NO.C12H15NO.C12H16O2.C12H18O2.C12H18O.C11H13F3O.C11H13F3.C11H14F2O.C11H14O2.C11H16O.C10H13F.C10H15N.C10H14O/c1-17(2,3)15-9-11-16(12-10-15)18-13-14-7-5-4-6-8-14;1-13(2,3)10-5-6-11-12(9-10)15-8-7-14(11)4;1-10(2)14-12-8-6-11(7-9-12)13(3,4)5;1-12(2,3)10-4-6-11(7-5-10)14-9-8-13;1-12(2,3)8-4-5-9-10(6-8)15-7-11(14)13-9;1-12(2,3)9-4-5-11-10(8-9)13-6-7-14-11;1-12(2,3)9-4-5-10-11(8-9)14-7-6-13-10;1-12(2,3)11-6-4-10(5-7-11)8-14-9-13;1-12(2,3)9-4-5-10-11(8-9)14-7-6-13-10;1-12(2,3)10-8-9(13-4)6-7-11(10)14-5;1-5-13-11-8-6-10(7-9-11)12(2,3)4;1-10(2,3)8-4-6-9(7-5-8)15-11(12,13)14;1-10(2,3)8-4-6-9(7-5-8)11(12,13)14;1-11(2,3)8-4-6-9(7-5-8)14-10(12)13;1-11(2,3)8-4-5-9-10(6-8)13-7-12-9;1-11(2,3)9-5-7-10(12-4)8-6-9;3*1-10(2,3)8-4-6-9(11)7-5-8/h4-12H,13H2,1-3H3;5-6,9H,7-8H2,1-4H3;6-10H,1-5H3;4-7H,8-9H2,1-3H3;4-6H,7H2,1-3H3,(H,13,14);2*4-5,8,13H,6-7H2,1-3H3;4-7H,8H2,1-3H3;4-5,8H,6-7H2,1-3H3;6-8H,1-5H3;6-9H,5H2,1-4H3;4-7H,1-3H3;4-7H,1-3H3;4-7,10H,1-3H3;4-6H,7H2,1-3H3;5-8H,1-4H3;4-7H,1-3H3;4-7H,11H2,1-3H3;4-7,11H,1-3H3
• InChIKey: KJQWWOTVWAPSEY-UHFFFAOYSA-N
• XLogP: 60.05
• TPSA: 292.58 Ų
• H-Bond Donors: 5
• H-Bond Acceptors: 25
• Rotatable Bonds: 18
• Heavy Atoms: 260
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	3590.90
LogP ≤ 5	60.05
H-Bond Donors ≤ 5	5
H-Bond Acceptors ≤ 10	25

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'aniline', 'substructure': 'N/A'}, {'alert_name': 'cyanate_/aminonitrile_/thiocyanate', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene?

The IUPAC name of 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene (CID 159154039) is 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene.

What is the SMILES notation for 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene?

The canonical SMILES for 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene is CC(C)(C)c1ccc(C(F)(F)F)cc1.CC(C)(C)c1ccc(COC#N)cc1.CC(C)(C)c1ccc(F)cc1.CC(C)(C)c1ccc(N)cc1.CC(C)(C)c1ccc(O)cc1.CC(C)(C)c1ccc(OC(F)(F)F)cc1.CC(C)(C)c1ccc(OC(F)F)cc1.CC(C)(C)c1ccc(OCCF)cc1.CC(C)(C)c1ccc(OCc2ccccc2)cc1.CC(C)(C)c1ccc2c(c1)NCCO2.CC(C)(C)c1ccc2c(c1)OCC(=O)N2.CC(C)(C)c1ccc2c(c1)OCCN2.CC(C)(C)c1ccc2c(c1)OCCO2.CC(C)(C)c1ccc2c(c1)OCO2.CC(C)Oc1ccc(C(C)(C)C)cc1.CCOc1ccc(C(C)(C)C)cc1.CN1CCOc2cc(C(C)(C)C)ccc21.COc1ccc(C(C)(C)C)cc1.COc1ccc(OC)c(C(C)(C)C)c1.

What is the InChIKey of 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene?

The InChIKey is KJQWWOTVWAPSEY-UHFFFAOYSA-N. The full InChI is InChI=1S/C17H20O.C13H19NO.C13H20O.C12H17FO.C12H15NO2.2C12H17NO.C12H15NO.C12H16O2.C12H18O2.C12H18O.C11H13F3O.C11H13F3.C11H14F2O.C11H14O2.C11H16O.C10H13F.C10H15N.C10H14O/c1-17(2,3)15-9-11-16(12-10-15)18-13-14-7-5-4-6-8-14;1-13(2,3)10-5-6-11-12(9-10)15-8-7-14(11)4;1-10(2)14-12-8-6-11(7-9-12)13(3,4)5;1-12(2,3)10-4-6-11(7-5-10)14-9-8-13;1-12(2,3)8-4-5-9-10(6-8)15-7-11(14)13-9;1-12(2,3)9-4-5-11-10(8-9)13-6-7-14-11;1-12(2,3)9-4-5-10-11(8-9)14-7-6-13-10;1-12(2,3)11-6-4-10(5-7-11)8-14-9-13;1-12(2,3)9-4-5-10-11(8-9)14-7-6-13-10;1-12(2,3)10-8-9(13-4)6-7-11(10)14-5;1-5-13-11-8-6-10(7-9-11)12(2,3)4;1-10(2,3)8-4-6-9(7-5-8)15-11(12,13)14;1-10(2,3)8-4-6-9(7-5-8)11(12,13)14;1-11(2,3)8-4-6-9(7-5-8)14-10(12)13;1-11(2,3)8-4-5-9-10(6-8)13-7-12-9;1-11(2,3)9-5-7-10(12-4)8-6-9;3*1-10(2,3)8-4-6-9(11)7-5-8/h4-12H,13H2,1-3H3;5-6,9H,7-8H2,1-4H3;6-10H,1-5H3;4-7H,8-9H2,1-3H3;4-6H,7H2,1-3H3,(H,13,14);2*4-5,8,13H,6-7H2,1-3H3;4-7H,8H2,1-3H3;4-5,8H,6-7H2,1-3H3;6-8H,1-5H3;6-9H,5H2,1-4H3;4-7H,1-3H3;4-7H,1-3H3;4-7,10H,1-3H3;4-6H,7H2,1-3H3;5-8H,1-4H3;4-7H,1-3H3;4-7H,11H2,1-3H3;4-7,11H,1-3H3.

What are the key properties of 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene?

4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene has a molecular weight of 3590.90 g/mol, XLogP of 60.05, 18 rotatable bonds, 5 hydrogen bond donors, and 25 hydrogen bond acceptors.

Where does this data come from?

All data for 4-tert-butylaniline;5-tert-butyl-1,3-benzodioxole;7-tert-butyl-4H-1,4-benzoxazin-3-one;1-tert-butyl-4-(difluoromethoxy)benzene;6-tert-butyl-2,3-dihydro-1,4-benzodioxine;6-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;7-tert-butyl-3,4-dihydro-2H-1,4-benzoxazine;2-tert-butyl-1,4-dimethoxybenzene;1-tert-butyl-4-ethoxybenzene;1-tert-butyl-4-fluorobenzene;1-tert-butyl-4-(2-fluoroethoxy)benzene;1-tert-butyl-4-methoxybenzene;7-tert-butyl-4-methyl-2,3-dihydro-1,4-benzoxazine;4-tert-butylphenol;1-tert-butyl-4-phenylmethoxybenzene;(4-tert-butylphenyl)methyl cyanate;1-tert-butyl-4-propan-2-yloxybenzene;1-tert-butyl-4-(trifluoromethoxy)benzene;1-tert-butyl-4-(trifluoromethyl)benzene is sourced from PubChem (CID 159154039), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).