6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide

C138H141F17N26O14S6 — CID 159157417

About 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide

6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide (PubChem CID 159157417) has the molecular formula C138H141F17N26O14S6 and a molecular weight of 2903.18 g/mol. Its IUPAC name is 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide.

Molecular Properties

• Compound Name: 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide
• PubChem CID: 159157417
• Molecular Formula: C138H141F17N26O14S6
• Molecular Weight: 2903.18 g/mol
• Exact Mass: 2900.92
• IUPAC Name: 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide
• SMILES: C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2C2CCC2)nc1)C(F)(F)F.C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2C2CCCCC2)nc1)C(F)(F)F.Cc1ccc2c(C#N)c(-c3ccc(S(=O)(=O)N[C@H](C)C(F)(F)F)cn3)n(CC3CC3)c2c1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ncc(S(=O)(=O)NC(C)C)cn1)n2C1CCCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ncc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCCC1
• InChI: InChI=1S/C24H23F5N4O3S.C24H26F2N4O2S.C23H25F2N5O2S.C23H27N5O2S.C22H19F5N4O3S.C22H21F3N4O2S/c1-14(24(27,28)29)32-37(34,35)17-8-10-20(31-13-17)22-19(12-30)18-9-7-16(36-23(25)26)11-21(18)33(22)15-5-3-2-4-6-15;1-16-7-10-23-20(11-16)21(14-27)24(30(23)18-5-3-2-4-6-18)22-9-8-19(15-28-22)33(31,32)29-17(12-25)13-26;1-15-7-8-21-19(9-15)20(12-26)22(30(21)17-5-3-2-4-6-17)23-27-13-18(14-28-23)33(31,32)29-16(10-24)11-25;1-15(2)27-31(29,30)18-13-25-23(26-14-18)22-20(12-24)19-11-16(3)9-10-21(19)28(22)17-7-5-4-6-8-17;1-12(22(25,26)27)30-35(32,33)15-6-8-18(29-11-15)20-17(10-28)16-7-5-14(34-21(23)24)9-19(16)31(20)13-3-2-4-13;1-13-3-7-17-18(10-26)21(29(20(17)9-13)12-15-4-5-15)19-8-6-16(11-27-19)32(30,31)28-14(2)22(23,24)25/h7-11,13-15,23,32H,2-6H2,1H3;7-11,15,17-18,29H,2-6,12-13H2,1H3;7-9,13-14,16-17,29H,2-6,10-11H2,1H3;9-11,13-15,17,27H,4-8H2,1-3H3;5-9,11-13,21,30H,2-4H2,1H3;3,6-9,11,14-15,28H,4-5,12H2,1-2H3/t14-;;;;12-;14-/m1...11/s1
• InChIKey: KKBJGSRJBMPPAX-VNPMVSQXSA-N
• XLogP: 29.38
• TPSA: 570.92 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 34
• Rotatable Bonds: 39
• Heavy Atoms: 201
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2903.18
LogP ≤ 5	29.38
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	34

Frequently Asked Questions

What is the IUPAC name of 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

The IUPAC name of 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide (CID 159157417) is 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide.

What is the SMILES notation for 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

The canonical SMILES for 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide is C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2C2CCC2)nc1)C(F)(F)F.C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2C2CCCCC2)nc1)C(F)(F)F.Cc1ccc2c(C#N)c(-c3ccc(S(=O)(=O)N[C@H](C)C(F)(F)F)cn3)n(CC3CC3)c2c1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ncc(S(=O)(=O)NC(C)C)cn1)n2C1CCCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ncc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCCC1.

What is the InChIKey of 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

The InChIKey is KKBJGSRJBMPPAX-VNPMVSQXSA-N. The full InChI is InChI=1S/C24H23F5N4O3S.C24H26F2N4O2S.C23H25F2N5O2S.C23H27N5O2S.C22H19F5N4O3S.C22H21F3N4O2S/c1-14(24(27,28)29)32-37(34,35)17-8-10-20(31-13-17)22-19(12-30)18-9-7-16(36-23(25)26)11-21(18)33(22)15-5-3-2-4-6-15;1-16-7-10-23-20(11-16)21(14-27)24(30(23)18-5-3-2-4-6-18)22-9-8-19(15-28-22)33(31,32)29-17(12-25)13-26;1-15-7-8-21-19(9-15)20(12-26)22(30(21)17-5-3-2-4-6-17)23-27-13-18(14-28-23)33(31,32)29-16(10-24)11-25;1-15(2)27-31(29,30)18-13-25-23(26-14-18)22-20(12-24)19-11-16(3)9-10-21(19)28(22)17-7-5-4-6-8-17;1-12(22(25,26)27)30-35(32,33)15-6-8-18(29-11-15)20-17(10-28)16-7-5-14(34-21(23)24)9-19(16)31(20)13-3-2-4-13;1-13-3-7-17-18(10-26)21(29(20(17)9-13)12-15-4-5-15)19-8-6-16(11-27-19)32(30,31)28-14(2)22(23,24)25/h7-11,13-15,23,32H,2-6H2,1H3;7-11,15,17-18,29H,2-6,12-13H2,1H3;7-9,13-14,16-17,29H,2-6,10-11H2,1H3;9-11,13-15,17,27H,4-8H2,1-3H3;5-9,11-13,21,30H,2-4H2,1H3;3,6-9,11,14-15,28H,4-5,12H2,1-2H3/t14-;;;;12-;14-/m1...11/s1.

What are the key properties of 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide?

6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide has a molecular weight of 2903.18 g/mol, XLogP of 29.38, 39 rotatable bonds, 6 hydrogen bond donors, and 34 hydrogen bond acceptors.

Where does this data come from?

All data for 6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclohexyl-6-(difluoromethoxy)indol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-propan-2-ylpyrimidine-5-sulfonamide;6-[3-cyano-1-(cyclopropylmethyl)-6-methylindol-2-yl]-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide is sourced from PubChem (CID 159157417), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).