6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile

C333H316N94O23S3 — CID 159234637

IUPAC6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile
SMILESCC(C)[C@@H](O)C(=O)N1CCN(c2ccc(-c3cc(-c4cn(C)nn4)cn4ncc(C#N)c34)cn2)CC1.CO[C@@H](C(=O)N1CCN(c2ccc(-c3cc(-c4cnc(C)o4)cn4ncc(C#N)c34)cn2)CC1)c1ccccc1.CO[C@H](C(=O)N1CCN(c2ccc(-c3cc(-c4cnc(C)o4)cn4ncc(C#N)c34)cn2)CC1)c1ccccc1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cc(C)n(C[C@@H](C)OC)n5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cnc(C)o5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cnc(C)s5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5sc(C)nc5C)cn5ncc(C#N)c45)cn3)CC2)cn1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@@H](O)c5ccccc5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@H](O)C(C)C)CC4)nc3)c3c(C#N)cnn3c2)s1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@H](O)c5ccccc5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cc1ncc(-c2cc(-c3ccc(N4CCN(Cc5ccccn5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cn1cc(-c2cc(-c3ccc(N4CCNCC4)nc3)c3c(C#N)cnn3c2)nn1
InChIInChI=1S/C32H35N9O2.2C30H27N7O3.C29H28N8OS.2C29H25N7O3.C28H26N8O2.C28H26N8OS.C27H24N8O.C26H27N7O2S.C25H27N9O2.C20H19N9/c1-22-13-29(37-40(22)19-23(2)42-3)26-14-28(32-27(15-33)18-36-41(32)21-26)25-6-7-30(34-17-25)39-11-9-38(10-12-39)20-24-5-8-31(43-4)35-16-24;2*1-20-32-18-26(40-20)23-14-25(28-24(15-31)17-34-37(28)19-23)22-8-9-27(33-16-22)35-10-12-36(13-11-35)30(38)29(39-2)21-6-4-3-5-7-21;1-19-29(39-20(2)34-19)23-12-25(28-24(13-30)16-33-37(28)18-23)22-5-6-26(31-15-22)36-10-8-35(9-11-36)17-21-4-7-27(38-3)32-14-21;2*1-19-31-17-25(39-19)22-13-24(27-23(14-30)16-33-36(27)18-22)21-7-8-26(32-15-21)34-9-11-35(12-10-34)29(38)28(37)20-5-3-2-4-6-20;2*1-19-30-16-25(38-19)22-11-24(28-23(12-29)15-33-36(28)18-22)21-4-5-26(31-14-21)35-9-7-34(8-10-35)17-20-3-6-27(37-2)32-13-20;1-19-30-16-25(36-19)21-12-24(27-22(13-28)15-32-35(27)17-21)20-5-6-26(31-14-20)34-10-8-33(9-11-34)18-23-4-2-3-7-29-23;1-16(2)25(34)26(35)32-8-6-31(7-9-32)23-5-4-18(12-29-23)21-10-19(22-14-28-17(3)36-22)15-33-24(21)20(11-27)13-30-33;1-16(2)24(35)25(36)33-8-6-32(7-9-33)22-5-4-17(12-27-22)20-10-18(21-15-31(3)30-29-21)14-34-23(20)19(11-26)13-28-34;1-27-13-18(25-26-27)15-8-17(20-16(9-21)11-24-29(20)12-15)14-2-3-19(23-10-14)28-6-4-22-5-7-28/h5-8,13-14,16-18,21,23H,9-12,19-20H2,1-4H3;2*3-9,14,16-19,29H,10-13H2,1-2H3;4-7,12,14-16,18H,8-11,17H2,1-3H3;2*2-8,13,15-18,28,37H,9-12H2,1H3;2*3-6,11,13-16,18H,7-10,17H2,1-2H3;2-7,12,14-17H,8-11,18H2,1H3;4-5,10,12-16,25,34H,6-9H2,1-3H3;4-5,10,12-16,24,35H,6-9H2,1-3H3;2-3,8,10-13,22H,4-7H2,1H3/t23-;2*29-;;2*28-;;;;25-;24-;/m110.10...11./s1
InChIKeyKTHYPAUUNXNXMY-CEWVLHMWSA-N
MW6099.03 g/mol
LogP43.60
Rot. Bonds67

About 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile

6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile (PubChem CID 159234637) has the molecular formula C333H316N94O23S3 and a molecular weight of 6099.03 g/mol. Its IUPAC name is 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile.

Molecular Properties

Compound Name6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile
PubChem CID159234637
Molecular FormulaC333H316N94O23S3
Molecular Weight6099.03 g/mol
Exact Mass6094.56
IUPAC Name6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile
SMILESCC(C)[C@@H](O)C(=O)N1CCN(c2ccc(-c3cc(-c4cn(C)nn4)cn4ncc(C#N)c34)cn2)CC1.CO[C@@H](C(=O)N1CCN(c2ccc(-c3cc(-c4cnc(C)o4)cn4ncc(C#N)c34)cn2)CC1)c1ccccc1.CO[C@H](C(=O)N1CCN(c2ccc(-c3cc(-c4cnc(C)o4)cn4ncc(C#N)c34)cn2)CC1)c1ccccc1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cc(C)n(C[C@@H](C)OC)n5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cnc(C)o5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cnc(C)s5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5sc(C)nc5C)cn5ncc(C#N)c45)cn3)CC2)cn1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@@H](O)c5ccccc5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@H](O)C(C)C)CC4)nc3)c3c(C#N)cnn3c2)s1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@H](O)c5ccccc5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cc1ncc(-c2cc(-c3ccc(N4CCN(Cc5ccccn5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cn1cc(-c2cc(-c3ccc(N4CCNCC4)nc3)c3c(C#N)cnn3c2)nn1
InChIInChI=1S/C32H35N9O2.2C30H27N7O3.C29H28N8OS.2C29H25N7O3.C28H26N8O2.C28H26N8OS.C27H24N8O.C26H27N7O2S.C25H27N9O2.C20H19N9/c1-22-13-29(37-40(22)19-23(2)42-3)26-14-28(32-27(15-33)18-36-41(32)21-26)25-6-7-30(34-17-25)39-11-9-38(10-12-39)20-24-5-8-31(43-4)35-16-24;2*1-20-32-18-26(40-20)23-14-25(28-24(15-31)17-34-37(28)19-23)22-8-9-27(33-16-22)35-10-12-36(13-11-35)30(38)29(39-2)21-6-4-3-5-7-21;1-19-29(39-20(2)34-19)23-12-25(28-24(13-30)16-33-37(28)18-23)22-5-6-26(31-15-22)36-10-8-35(9-11-36)17-21-4-7-27(38-3)32-14-21;2*1-19-31-17-25(39-19)22-13-24(27-23(14-30)16-33-36(27)18-22)21-7-8-26(32-15-21)34-9-11-35(12-10-34)29(38)28(37)20-5-3-2-4-6-20;2*1-19-30-16-25(38-19)22-11-24(28-23(12-29)15-33-36(28)18-22)21-4-5-26(31-14-21)35-9-7-34(8-10-35)17-20-3-6-27(37-2)32-13-20;1-19-30-16-25(36-19)21-12-24(27-22(13-28)15-32-35(27)17-21)20-5-6-26(31-14-20)34-10-8-33(9-11-34)18-23-4-2-3-7-29-23;1-16(2)25(34)26(35)32-8-6-31(7-9-32)23-5-4-18(12-29-23)21-10-19(22-14-28-17(3)36-22)15-33-24(21)20(11-27)13-30-33;1-16(2)24(35)25(36)33-8-6-32(7-9-33)22-5-4-17(12-27-22)20-10-18(21-15-31(3)30-29-21)14-34-23(20)19(11-26)13-28-34;1-27-13-18(25-26-27)15-8-17(20-16(9-21)11-24-29(20)12-15)14-2-3-19(23-10-14)28-6-4-22-5-7-28/h5-8,13-14,16-18,21,23H,9-12,19-20H2,1-4H3;2*3-9,14,16-19,29H,10-13H2,1-2H3;4-7,12,14-16,18H,8-11,17H2,1-3H3;2*2-8,13,15-18,28,37H,9-12H2,1H3;2*3-6,11,13-16,18H,7-10,17H2,1-2H3;2-7,12,14-17H,8-11,18H2,1H3;4-5,10,12-16,25,34H,6-9H2,1-3H3;4-5,10,12-16,24,35H,6-9H2,1-3H3;2-3,8,10-13,22H,4-7H2,1H3/t23-;2*29-;;2*28-;;;;25-;24-;/m110.10...11./s1
InChIKeyKTHYPAUUNXNXMY-CEWVLHMWSA-N
XLogP43.60
TPSA1320.80 Ų
H-Bond Donors5
H-Bond Acceptors114
Rotatable Bonds67
Heavy Atoms453
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5006099.03
LogP ≤ 543.60
H-Bond Donors ≤ 55
H-Bond Acceptors ≤ 10114

Analyze 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile with MolForge

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Frequently Asked Questions

What is the IUPAC name of 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile?
The IUPAC name of 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile (CID 159234637) is 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile.
What is the SMILES notation for 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile?
The canonical SMILES for 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile is CC(C)[C@@H](O)C(=O)N1CCN(c2ccc(-c3cc(-c4cn(C)nn4)cn4ncc(C#N)c34)cn2)CC1.CO[C@@H](C(=O)N1CCN(c2ccc(-c3cc(-c4cnc(C)o4)cn4ncc(C#N)c34)cn2)CC1)c1ccccc1.CO[C@H](C(=O)N1CCN(c2ccc(-c3cc(-c4cnc(C)o4)cn4ncc(C#N)c34)cn2)CC1)c1ccccc1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cc(C)n(C[C@@H](C)OC)n5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cnc(C)o5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5cnc(C)s5)cn5ncc(C#N)c45)cn3)CC2)cn1.COc1ccc(CN2CCN(c3ccc(-c4cc(-c5sc(C)nc5C)cn5ncc(C#N)c45)cn3)CC2)cn1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@@H](O)c5ccccc5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@H](O)C(C)C)CC4)nc3)c3c(C#N)cnn3c2)s1.Cc1ncc(-c2cc(-c3ccc(N4CCN(C(=O)[C@H](O)c5ccccc5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cc1ncc(-c2cc(-c3ccc(N4CCN(Cc5ccccn5)CC4)nc3)c3c(C#N)cnn3c2)o1.Cn1cc(-c2cc(-c3ccc(N4CCNCC4)nc3)c3c(C#N)cnn3c2)nn1.
What is the InChIKey of 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile?
The InChIKey is KTHYPAUUNXNXMY-CEWVLHMWSA-N. The full InChI is InChI=1S/C32H35N9O2.2C30H27N7O3.C29H28N8OS.2C29H25N7O3.C28H26N8O2.C28H26N8OS.C27H24N8O.C26H27N7O2S.C25H27N9O2.C20H19N9/c1-22-13-29(37-40(22)19-23(2)42-3)26-14-28(32-27(15-33)18-36-41(32)21-26)25-6-7-30(34-17-25)39-11-9-38(10-12-39)20-24-5-8-31(43-4)35-16-24;2*1-20-32-18-26(40-20)23-14-25(28-24(15-31)17-34-37(28)19-23)22-8-9-27(33-16-22)35-10-12-36(13-11-35)30(38)29(39-2)21-6-4-3-5-7-21;1-19-29(39-20(2)34-19)23-12-25(28-24(13-30)16-33-37(28)18-23)22-5-6-26(31-15-22)36-10-8-35(9-11-36)17-21-4-7-27(38-3)32-14-21;2*1-19-31-17-25(39-19)22-13-24(27-23(14-30)16-33-36(27)18-22)21-7-8-26(32-15-21)34-9-11-35(12-10-34)29(38)28(37)20-5-3-2-4-6-20;2*1-19-30-16-25(38-19)22-11-24(28-23(12-29)15-33-36(28)18-22)21-4-5-26(31-14-21)35-9-7-34(8-10-35)17-20-3-6-27(37-2)32-13-20;1-19-30-16-25(36-19)21-12-24(27-22(13-28)15-32-35(27)17-21)20-5-6-26(31-14-20)34-10-8-33(9-11-34)18-23-4-2-3-7-29-23;1-16(2)25(34)26(35)32-8-6-31(7-9-32)23-5-4-18(12-29-23)21-10-19(22-14-28-17(3)36-22)15-33-24(21)20(11-27)13-30-33;1-16(2)24(35)25(36)33-8-6-32(7-9-33)22-5-4-17(12-27-22)20-10-18(21-15-31(3)30-29-21)14-34-23(20)19(11-26)13-28-34;1-27-13-18(25-26-27)15-8-17(20-16(9-21)11-24-29(20)12-15)14-2-3-19(23-10-14)28-6-4-22-5-7-28/h5-8,13-14,16-18,21,23H,9-12,19-20H2,1-4H3;2*3-9,14,16-19,29H,10-13H2,1-2H3;4-7,12,14-16,18H,8-11,17H2,1-3H3;2*2-8,13,15-18,28,37H,9-12H2,1H3;2*3-6,11,13-16,18H,7-10,17H2,1-2H3;2-7,12,14-17H,8-11,18H2,1H3;4-5,10,12-16,25,34H,6-9H2,1-3H3;4-5,10,12-16,24,35H,6-9H2,1-3H3;2-3,8,10-13,22H,4-7H2,1H3/t23-;2*29-;;2*28-;;;;25-;24-;/m110.10...11./s1.
What are the key properties of 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile?
6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile has a molecular weight of 6099.03 g/mol, XLogP of 43.60, 67 rotatable bonds, 5 hydrogen bond donors, and 114 hydrogen bond acceptors.
Where does this data come from?
All data for 6-(2,4-dimethyl-1,3-thiazol-5-yl)-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-3-methylbutanoyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methyltriazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-hydroxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2R)-2-methoxy-2-phenylacetyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[1-[(2R)-2-methoxypropyl]-5-methylpyrazol-3-yl]-4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]piperazin-1-yl]-3-pyridinyl]-6-(2-methyl-1,3-thiazol-5-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(2-methyl-1,3-oxazol-5-yl)-4-[6-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methyltriazol-4-yl)-4-(6-piperazin-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyridine-3-carbonitrile is sourced from PubChem (CID 159234637), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).