5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole

C216H128N32 — CID 159381737

IUPAC5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole
SMILESc1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2cnc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)cnc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2cnc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)ncc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2ncc3cnc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)nc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2ncc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)ncc3n2)cc1
InChIInChI=1S/4C54H32N8/c1-3-15-34(16-4-1)59-46-26-14-10-22-40(46)50-47(59)28-27-39-36-19-7-13-25-45(36)62(51(39)50)54-56-32-33-31-55-53(57-52(33)58-54)61-44-24-12-9-21-38(44)42-29-48-41(30-49(42)61)37-20-8-11-23-43(37)60(48)35-17-5-2-6-18-35;1-3-15-33(16-4-1)59-47-26-14-10-22-39(47)51-48(59)28-27-38-35-19-7-13-25-46(35)62(52(38)51)54-56-32-42-43(58-54)31-55-53(57-42)61-45-24-12-9-21-37(45)41-29-49-40(30-50(41)61)36-20-8-11-23-44(36)60(49)34-17-5-2-6-18-34;1-3-15-33(16-4-1)59-46-26-14-10-22-39(46)51-47(59)28-27-38-35-19-7-13-25-45(35)62(52(38)51)54-56-31-42-53(58-54)55-32-50(57-42)61-44-24-12-9-21-37(44)41-29-48-40(30-49(41)61)36-20-8-11-23-43(36)60(48)34-17-5-2-6-18-34;1-3-15-33(16-4-1)59-45-26-14-10-22-39(45)51-46(59)28-27-38-35-19-7-13-25-44(35)62(52(38)51)50-32-56-53-54(58-50)55-31-49(57-53)61-43-24-12-9-21-37(43)41-29-47-40(30-48(41)61)36-20-8-11-23-42(36)60(47)34-17-5-2-6-18-34/h4*1-32H
InChIKeyLKZNNTOLBBQPKG-UHFFFAOYSA-N
MW3171.62 g/mol
LogP51.23
Rot. Bonds16

About 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole

5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole (PubChem CID 159381737) has the molecular formula C216H128N32 and a molecular weight of 3171.62 g/mol. Its IUPAC name is 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole.

Molecular Properties

Compound Name5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole
PubChem CID159381737
Molecular FormulaC216H128N32
Molecular Weight3171.62 g/mol
Exact Mass3169.10
IUPAC Name5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole
SMILESc1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2cnc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)cnc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2cnc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)ncc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2ncc3cnc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)nc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2ncc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)ncc3n2)cc1
InChIInChI=1S/4C54H32N8/c1-3-15-34(16-4-1)59-46-26-14-10-22-40(46)50-47(59)28-27-39-36-19-7-13-25-45(36)62(51(39)50)54-56-32-33-31-55-53(57-52(33)58-54)61-44-24-12-9-21-38(44)42-29-48-41(30-49(42)61)37-20-8-11-23-43(37)60(48)35-17-5-2-6-18-35;1-3-15-33(16-4-1)59-47-26-14-10-22-39(47)51-48(59)28-27-38-35-19-7-13-25-46(35)62(52(38)51)54-56-32-42-43(58-54)31-55-53(57-42)61-45-24-12-9-21-37(45)41-29-49-40(30-50(41)61)36-20-8-11-23-44(36)60(49)34-17-5-2-6-18-34;1-3-15-33(16-4-1)59-46-26-14-10-22-39(46)51-47(59)28-27-38-35-19-7-13-25-45(35)62(52(38)51)54-56-31-42-53(58-54)55-32-50(57-42)61-44-24-12-9-21-37(44)41-29-48-40(30-49(41)61)36-20-8-11-23-43(36)60(48)34-17-5-2-6-18-34;1-3-15-33(16-4-1)59-45-26-14-10-22-39(45)51-46(59)28-27-38-35-19-7-13-25-44(35)62(52(38)51)50-32-56-53-54(58-50)55-31-49(57-53)61-43-24-12-9-21-37(43)41-29-47-40(30-48(41)61)36-20-8-11-23-42(36)60(47)34-17-5-2-6-18-34/h4*1-32H
InChIKeyLKZNNTOLBBQPKG-UHFFFAOYSA-N
XLogP51.23
TPSA285.12 Ų
H-Bond Donors
H-Bond Acceptors32
Rotatable Bonds16
Heavy Atoms248
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5003171.62
LogP ≤ 551.23
H-Bond Donors ≤ 50
H-Bond Acceptors ≤ 1032

Analyze 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole with MolForge

Explore ADMET properties, 3D molecular structure, drug-likeness score, and discover similar compounds using our AI-powered platform.

Launch Full Analysis

Related Compounds

11-[6-(12-cyclohexa-1,5-dien-1-ylindolo[3,2-c]carbazol-5-yl)pyrimido[5,4-d]pyrimidin-2-yl]-5-phenylindolo[3,2-b]carbazole
CID 70912495
5-phenyl-12-(6-phenylpyrimido[5,4-d]pyrimidin-2-yl)indolo[3,2-c]carbazole
CID 170407048
9-phenyl-23-quinazolin-2-yl-9,23-diazahexacyclo[11.11.0.02,10.03,8.016,24.017,22]tetracosa-1(13),2(10),3,5,7,11,14,16(24),17,19,21-undecaene
CID 122465142
5-[2-(11-cyclohexa-2,4-dien-1-ylindolo[3,2-b]carbazol-5-yl)pyrimido[4,5-d]pyrimidin-7-yl]-12-phenylindolo[3,2-c]carbazole
CID 70912496
5-[4,6-di(carbazol-9-yl)pyrimidin-2-yl]-12-phenylindolo[3,2-c]carbazole;5-[4,6-di(carbazol-9-yl)-1,3,5-triazin-2-yl]-12-phenylindolo[3,2-c]carbazole
CID 159211280
5-phenyl-12-[4-(9-phenylcarbazol-3-yl)quinolin-2-yl]indolo[3,2-c]carbazole
CID 71291270
4-[14-(4-phenylphenyl)-9,14-diazapentacyclo[11.7.0.02,10.03,8.015,20]icosa-1(13),2(10),3,5,7,11,15,17,19-nonaen-9-yl]-3,5-diazapentacyclo[18.4.0.02,7.08,13.014,19]tetracosa-1(24),2,4,6,8,10,12,14,16,18,20,22-dodecaene;4-[5-(4-phenylphenyl)indolo[3,2-b]carbazol-11-yl]-3,5-diazapentacyclo[18.4.0.02,7.08,13.014,19]tetracosa-1(24),2,4,6,8,10,12,14,16,18,20,22-dodecaene;4-[7-(4-phenylphenyl)indolo[2,3-b]carbazol-5-yl]-3,5-diazapentacyclo[18.4.0.02,7.08,13.014,19]tetracosa-1(24),2,4,6,8,10,12,14,16,18,20,22-dodecaene;4-[5-(4-phenylphenyl)indolo[3,2-c]carbazol-12-yl]-3,5-diazapentacyclo[18.4.0.02,7.08,13.014,19]tetracosa-1(24),2,4,6,8,10,12,14,16,18,20,22-dodecaene
CID 158466135
5-(3-carbazol-9-ylphenyl)-11-[3-(5-phenylindolo[3,2-c]carbazol-12-yl)phenyl]indolo[3,2-b]carbazole
CID 88917500
5-phenyl-11-[3-(12-phenylindolo[3,2-c]carbazol-5-yl)phenyl]indolo[3,2-b]carbazole
CID 58038298
5-(4,6-diphenyl-1,3,5-triazin-2-yl)-15-phenyl-24-pyridin-2-yl-5,15,24-triazaheptacyclo[14.11.0.02,14.04,12.06,11.017,25.018,23]heptacosa-1(16),2(14),3,6,8,10,12,17(25),18,20,22,26-dodecaene
CID 118301337
11-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-phenyl-3-(12-phenylindolo[3,2-c]carbazol-5-yl)indolo[3,2-b]carbazole
CID 90195034
10-phenyl-22-quinazolin-2-yl-10,22-diazahexacyclo[11.11.0.03,11.04,9.015,23.016,21]tetracosa-1(24),2,4,6,8,11,13,15(23),16,18,20-undecaene
CID 122465132

Frequently Asked Questions

What is the IUPAC name of 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole?
The IUPAC name of 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole (CID 159381737) is 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole.
What is the SMILES notation for 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole?
The canonical SMILES for 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole is c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2cnc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)cnc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2cnc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)ncc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2ncc3cnc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)nc3n2)cc1.c1ccc(-n2c3ccccc3c3cc4c(cc32)c2ccccc2n4-c2ncc3nc(-n4c5ccccc5c5ccc6c(c7ccccc7n6-c6ccccc6)c54)ncc3n2)cc1.
What is the InChIKey of 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole?
The InChIKey is LKZNNTOLBBQPKG-UHFFFAOYSA-N. The full InChI is InChI=1S/4C54H32N8/c1-3-15-34(16-4-1)59-46-26-14-10-22-40(46)50-47(59)28-27-39-36-19-7-13-25-45(36)62(51(39)50)54-56-32-33-31-55-53(57-52(33)58-54)61-44-24-12-9-21-38(44)42-29-48-41(30-49(42)61)37-20-8-11-23-43(37)60(48)35-17-5-2-6-18-35;1-3-15-33(16-4-1)59-47-26-14-10-22-39(47)51-48(59)28-27-38-35-19-7-13-25-46(35)62(52(38)51)54-56-32-42-43(58-54)31-55-53(57-42)61-45-24-12-9-21-37(45)41-29-49-40(30-50(41)61)36-20-8-11-23-44(36)60(49)34-17-5-2-6-18-34;1-3-15-33(16-4-1)59-46-26-14-10-22-39(46)51-47(59)28-27-38-35-19-7-13-25-45(35)62(52(38)51)54-56-31-42-53(58-54)55-32-50(57-42)61-44-24-12-9-21-37(44)41-29-48-40(30-49(41)61)36-20-8-11-23-43(36)60(48)34-17-5-2-6-18-34;1-3-15-33(16-4-1)59-45-26-14-10-22-39(45)51-46(59)28-27-38-35-19-7-13-25-44(35)62(52(38)51)50-32-56-53-54(58-50)55-31-49(57-53)61-43-24-12-9-21-37(43)41-29-47-40(30-48(41)61)36-20-8-11-23-42(36)60(47)34-17-5-2-6-18-34/h4*1-32H.
What are the key properties of 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole?
5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole has a molecular weight of 3171.62 g/mol, XLogP of 51.23, 16 rotatable bonds, 0 hydrogen bond donors, and 32 hydrogen bond acceptors.
Where does this data come from?
All data for 5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pteridin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrazino[2,3-b]pyrazin-6-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[4,5-d]pyrimidin-7-yl]indolo[3,2-b]carbazole;5-phenyl-11-[2-(5-phenylindolo[3,2-c]carbazol-12-yl)pyrimido[5,4-d]pyrimidin-6-yl]indolo[3,2-b]carbazole is sourced from PubChem (CID 159381737), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).