2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one

C161H174ClF5N38O9S4 — CID 159496166

About 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one

2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one (PubChem CID 159496166) has the molecular formula C161H174ClF5N38O9S4 and a molecular weight of 3044.13 g/mol. Its IUPAC name is 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one.

Molecular Properties

• Compound Name: 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one
• PubChem CID: 159496166
• Molecular Formula: C161H174ClF5N38O9S4
• Molecular Weight: 3044.13 g/mol
• Exact Mass: 3041.28
• IUPAC Name: 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one
• SMILES: CC1CN(c2ccc(Nc3ncc4cc(-c5ccc(C6CCCCC6)cn5)c(=O)n(Cc5nccs5)c4n3)cc2F)CCN1.CC1CNCCN1c1ccc(Nc2ncc3cc(-c4cnc(-c5nccs5)nc4)c(=O)n(CC4CCOCC4)c3n2)cc1F.CN1CCC(Oc2ccc(Nc3ncc4cc(-c5ccccc5C5CCCCN5)c(=O)n(CC(F)(F)F)c4n3)cc2)CC1.CN1CCSC(c2ccc(Nc3ncc4cc(-c5ccc(C6CCCCC6)cc5)c(=O)n(-c5nccs5)c4n3)cc2)C1.Cn1cc(C2CCOCC2)nc1-c1cc2cnc(Nc3ccc(N4CCNCC4)c(Cl)c3)nc2n(CC(=O)N2CCCC2)c1=O
• InChI: InChI=1S/C33H35FN8OS.C33H34N6OS2.C32H38ClN9O3.C32H35F3N6O2.C31H32FN9O2S/c1-21-19-41(13-11-35-21)29-10-8-25(16-27(29)34)39-33-38-18-24-15-26(28-9-7-23(17-37-28)22-5-3-2-4-6-22)32(43)42(31(24)40-33)20-30-36-12-14-44-30;1-38-16-18-41-29(21-38)25-11-13-27(14-12-25)36-32-35-20-26-19-28(31(40)39(30(26)37-32)33-34-15-17-42-33)24-9-7-23(8-10-24)22-5-3-2-4-6-22;1-39-19-26(21-6-14-45-15-7-21)37-30(39)24-16-22-18-35-32(36-23-4-5-27(25(33)17-23)40-12-8-34-9-13-40)38-29(22)42(31(24)44)20-28(43)41-10-2-3-11-41;1-40-16-13-24(14-17-40)43-23-11-9-22(10-12-23)38-31-37-19-21-18-27(30(42)41(29(21)39-31)20-32(33,34)35)25-6-2-3-7-26(25)28-8-4-5-15-36-28;1-19-14-33-6-8-40(19)26-3-2-23(13-25(26)32)38-31-37-15-21-12-24(22-16-35-27(36-17-22)29-34-7-11-44-29)30(42)41(28(21)39-31)18-20-4-9-43-10-5-20/h7-10,12,14-18,21-22,35H,2-6,11,13,19-20H2,1H3,(H,38,39,40);7-15,17,19-20,22,29H,2-6,16,18,21H2,1H3,(H,35,36,37);4-5,16-19,21,34H,2-3,6-15,20H2,1H3,(H,35,36,38);2-3,6-7,9-12,18-19,24,28,36H,4-5,8,13-17,20H2,1H3,(H,37,38,39);2-3,7,11-13,15-17,19-20,33H,4-6,8-10,14,18H2,1H3,(H,37,38,39)
• InChIKey: LYURIWSXLMNDCH-UHFFFAOYSA-N
• XLogP: 27.55
• TPSA: 506.53 Ų
• H-Bond Donors: 9
• H-Bond Acceptors: 50
• Rotatable Bonds: 34
• Heavy Atoms: 218
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3044.13
LogP ≤ 5	27.55
H-Bond Donors ≤ 5	9
H-Bond Acceptors ≤ 10	50

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'anil_di_alk_A(478)', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

The IUPAC name of 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one (CID 159496166) is 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one.

What is the SMILES notation for 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

The canonical SMILES for 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one is CC1CN(c2ccc(Nc3ncc4cc(-c5ccc(C6CCCCC6)cn5)c(=O)n(Cc5nccs5)c4n3)cc2F)CCN1.CC1CNCCN1c1ccc(Nc2ncc3cc(-c4cnc(-c5nccs5)nc4)c(=O)n(CC4CCOCC4)c3n2)cc1F.CN1CCC(Oc2ccc(Nc3ncc4cc(-c5ccccc5C5CCCCN5)c(=O)n(CC(F)(F)F)c4n3)cc2)CC1.CN1CCSC(c2ccc(Nc3ncc4cc(-c5ccc(C6CCCCC6)cc5)c(=O)n(-c5nccs5)c4n3)cc2)C1.Cn1cc(C2CCOCC2)nc1-c1cc2cnc(Nc3ccc(N4CCNCC4)c(Cl)c3)nc2n(CC(=O)N2CCCC2)c1=O.

What is the InChIKey of 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

The InChIKey is LYURIWSXLMNDCH-UHFFFAOYSA-N. The full InChI is InChI=1S/C33H35FN8OS.C33H34N6OS2.C32H38ClN9O3.C32H35F3N6O2.C31H32FN9O2S/c1-21-19-41(13-11-35-21)29-10-8-25(16-27(29)34)39-33-38-18-24-15-26(28-9-7-23(17-37-28)22-5-3-2-4-6-22)32(43)42(31(24)40-33)20-30-36-12-14-44-30;1-38-16-18-41-29(21-38)25-11-13-27(14-12-25)36-32-35-20-26-19-28(31(40)39(30(26)37-32)33-34-15-17-42-33)24-9-7-23(8-10-24)22-5-3-2-4-6-22;1-39-19-26(21-6-14-45-15-7-21)37-30(39)24-16-22-18-35-32(36-23-4-5-27(25(33)17-23)40-12-8-34-9-13-40)38-29(22)42(31(24)44)20-28(43)41-10-2-3-11-41;1-40-16-13-24(14-17-40)43-23-11-9-22(10-12-23)38-31-37-19-21-18-27(30(42)41(29(21)39-31)20-32(33,34)35)25-6-2-3-7-26(25)28-8-4-5-15-36-28;1-19-14-33-6-8-40(19)26-3-2-23(13-25(26)32)38-31-37-15-21-12-24(22-16-35-27(36-17-22)29-34-7-11-44-29)30(42)41(28(21)39-31)18-20-4-9-43-10-5-20/h7-10,12,14-18,21-22,35H,2-6,11,13,19-20H2,1H3,(H,38,39,40);7-15,17,19-20,22,29H,2-6,16,18,21H2,1H3,(H,35,36,37);4-5,16-19,21,34H,2-3,6-15,20H2,1H3,(H,35,36,38);2-3,6-7,9-12,18-19,24,28,36H,4-5,8,13-17,20H2,1H3,(H,37,38,39);2-3,7,11-13,15-17,19-20,33H,4-6,8-10,14,18H2,1H3,(H,37,38,39).

What are the key properties of 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one?

2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one has a molecular weight of 3044.13 g/mol, XLogP of 27.55, 34 rotatable bonds, 9 hydrogen bond donors, and 50 hydrogen bond acceptors.

Where does this data come from?

All data for 2-(3-chloro-4-piperazin-1-ylanilino)-6-[1-methyl-4-(oxan-4-yl)imidazol-2-yl]-8-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-d]pyrimidin-7-one;6-(4-cyclohexylphenyl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-cyclohexyl-2-pyridinyl)-2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-8-(oxan-4-ylmethyl)-6-[2-(1,3-thiazol-2-yl)pyrimidin-5-yl]pyrido[2,3-d]pyrimidin-7-one;2-[4-(1-methylpiperidin-4-yl)oxyanilino]-6-(2-piperidin-2-ylphenyl)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one is sourced from PubChem (CID 159496166), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).