2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide

C162H190ClF6N43O9S3 — CID 159541126

About 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide

2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide (PubChem CID 159541126) has the molecular formula C162H190ClF6N43O9S3 and a molecular weight of 3129.24 g/mol. Its IUPAC name is 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide.

Molecular Properties

• Compound Name: 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide
• PubChem CID: 159541126
• Molecular Formula: C162H190ClF6N43O9S3
• Molecular Weight: 3129.24 g/mol
• Exact Mass: 3126.45
• IUPAC Name: 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide
• SMILES: CCn1c(=O)c(-c2nc(C3CCCNC3)ncc2C)cc2cnc(Nc3ccc(N4CCN5CCCC5C4)cc3)nc21.Cc1cc(C2CCCN2C)cnc1-c1cc2cnc(Nc3ccc(N4CCNC(C)C4)c(F)c3)nc2n(CCN(C)S(C)(=O)=O)c1=O.Cc1nc(C2CCCCC2)ncc1-c1cc2cnc(Nc3ccc(N4C[C@@H](C)N[C@@H](C)C4)c(F)c3)nc2n(C(C)C)c1=O.Cc1nc(C2CCCCN2)ccc1-c1cc2cnc(Nc3ccc(N4CCNCC4)c(Cl)c3)nc2n(C2CCN(S(C)(=O)=O)CC2)c1=O.O=c1c(-c2ccc(-c3nncs3)cc2F)cc2cnc(Nc3ccc(N4CCNCC4)c(C(F)(F)F)c3)nc2n1CC1CC1
• InChI: InChI=1S/C34H42ClN9O3S.C33H42FN9O3S.C33H41FN8O.C32H39N9O.C30H26F4N8OS/c1-22-26(7-8-30(39-22)29-5-3-4-12-37-29)27-19-23-21-38-34(40-24-6-9-31(28(35)20-24)42-17-13-36-14-18-42)41-32(23)44(33(27)45)25-10-15-43(16-11-25)48(2,46)47;1-21-15-23(28-7-6-11-40(28)3)18-36-30(21)26-16-24-19-37-33(39-31(24)43(32(26)44)14-13-41(4)47(5,45)46)38-25-8-9-29(27(34)17-25)42-12-10-35-22(2)20-42;1-19(2)42-31-24(13-26(32(42)43)27-16-35-30(38-22(27)5)23-9-7-6-8-10-23)15-36-33(40-31)39-25-11-12-29(28(34)14-25)41-17-20(3)37-21(4)18-41;1-3-41-30-23(16-27(31(41)42)28-21(2)17-34-29(37-28)22-6-4-12-33-18-22)19-35-32(38-30)36-24-8-10-25(11-9-24)40-15-14-39-13-5-7-26(39)20-40;31-24-12-18(27-40-37-16-44-27)3-5-21(24)22-11-19-14-36-29(39-26(19)42(28(22)43)15-17-1-2-17)38-20-4-6-25(23(13-20)30(32,33)34)41-9-7-35-8-10-41/h6-9,19-21,25,29,36-37H,3-5,10-18H2,1-2H3,(H,38,40,41);8-9,15-19,22,28,35H,6-7,10-14,20H2,1-5H3,(H,37,38,39);11-16,19-21,23,37H,6-10,17-18H2,1-5H3,(H,36,39,40);8-11,16-17,19,22,26,33H,3-7,12-15,18,20H2,1-2H3,(H,35,36,38);3-6,11-14,16-17,35H,1-2,7-10,15H2,(H,36,38,39)/t;;20-,21+
• InChIKey: MEFMHBRZAVXZQE-HXEVNAASSA-N
• XLogP: 23.91
• TPSA: 571.79 Ų
• H-Bond Donors: 11
• H-Bond Acceptors: 51
• Rotatable Bonds: 35
• Heavy Atoms: 224
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3129.24
LogP ≤ 5	23.91
H-Bond Donors ≤ 5	11
H-Bond Acceptors ≤ 10	51

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'anil_di_alk_A(478)', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide?

The IUPAC name of 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide (CID 159541126) is 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide.

What is the SMILES notation for 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide?

The canonical SMILES for 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide is CCn1c(=O)c(-c2nc(C3CCCNC3)ncc2C)cc2cnc(Nc3ccc(N4CCN5CCCC5C4)cc3)nc21.Cc1cc(C2CCCN2C)cnc1-c1cc2cnc(Nc3ccc(N4CCNC(C)C4)c(F)c3)nc2n(CCN(C)S(C)(=O)=O)c1=O.Cc1nc(C2CCCCC2)ncc1-c1cc2cnc(Nc3ccc(N4C[C@@H](C)N[C@@H](C)C4)c(F)c3)nc2n(C(C)C)c1=O.Cc1nc(C2CCCCN2)ccc1-c1cc2cnc(Nc3ccc(N4CCNCC4)c(Cl)c3)nc2n(C2CCN(S(C)(=O)=O)CC2)c1=O.O=c1c(-c2ccc(-c3nncs3)cc2F)cc2cnc(Nc3ccc(N4CCNCC4)c(C(F)(F)F)c3)nc2n1CC1CC1.

What is the InChIKey of 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide?

The InChIKey is MEFMHBRZAVXZQE-HXEVNAASSA-N. The full InChI is InChI=1S/C34H42ClN9O3S.C33H42FN9O3S.C33H41FN8O.C32H39N9O.C30H26F4N8OS/c1-22-26(7-8-30(39-22)29-5-3-4-12-37-29)27-19-23-21-38-34(40-24-6-9-31(28(35)20-24)42-17-13-36-14-18-42)41-32(23)44(33(27)45)25-10-15-43(16-11-25)48(2,46)47;1-21-15-23(28-7-6-11-40(28)3)18-36-30(21)26-16-24-19-37-33(39-31(24)43(32(26)44)14-13-41(4)47(5,45)46)38-25-8-9-29(27(34)17-25)42-12-10-35-22(2)20-42;1-19(2)42-31-24(13-26(32(42)43)27-16-35-30(38-22(27)5)23-9-7-6-8-10-23)15-36-33(40-31)39-25-11-12-29(28(34)14-25)41-17-20(3)37-21(4)18-41;1-3-41-30-23(16-27(31(41)42)28-21(2)17-34-29(37-28)22-6-4-12-33-18-22)19-35-32(38-30)36-24-8-10-25(11-9-24)40-15-14-39-13-5-7-26(39)20-40;31-24-12-18(27-40-37-16-44-27)3-5-21(24)22-11-19-14-36-29(39-26(19)42(28(22)43)15-17-1-2-17)38-20-4-6-25(23(13-20)30(32,33)34)41-9-7-35-8-10-41/h6-9,19-21,25,29,36-37H,3-5,10-18H2,1-2H3,(H,38,40,41);8-9,15-19,22,28,35H,6-7,10-14,20H2,1-5H3,(H,37,38,39);11-16,19-21,23,37H,6-10,17-18H2,1-5H3,(H,36,39,40);8-11,16-17,19,22,26,33H,3-7,12-15,18,20H2,1-2H3,(H,35,36,38);3-6,11-14,16-17,35H,1-2,7-10,15H2,(H,36,38,39)/t;;20-,21+;;.

What are the key properties of 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide?

2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide has a molecular weight of 3129.24 g/mol, XLogP of 23.91, 35 rotatable bonds, 11 hydrogen bond donors, and 51 hydrogen bond acceptors.

Where does this data come from?

All data for 2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-ethyl-6-(5-methyl-2-piperidin-3-ylpyrimidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;2-(3-chloro-4-piperazin-1-ylanilino)-6-(2-methyl-6-piperidin-2-yl-3-pyridinyl)-8-(1-methylsulfonylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(2-cyclohexyl-4-methylpyrimidin-5-yl)-2-[4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-propan-2-ylpyrido[2,3-d]pyrimidin-7-one;8-(cyclopropylmethyl)-6-[2-fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-[3-methyl-5-(1-methylpyrrolidin-2-yl)-2-pyridinyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide is sourced from PubChem (CID 159541126), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).