2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid

C178H163ClF4N12O37 — CID 159747307

About 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid

2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid (PubChem CID 159747307) has the molecular formula C178H163ClF4N12O37 and a molecular weight of 3173.75 g/mol. Its IUPAC name is 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid.

Molecular Properties

• Compound Name: 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid
• PubChem CID: 159747307
• Molecular Formula: C178H163ClF4N12O37
• Molecular Weight: 3173.75 g/mol
• Exact Mass: 3171.09
• IUPAC Name: 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid
• SMILES: COc1ccc(OC(=O)N(CC(=O)O)Cc2ccc(C=C=Cc3nc(-c4ccccc4)oc3C)cc2)cc1.COc1ccc(OC(=O)N(CC(=O)O)Cc2ccc(CCCc3nc(-c4ccccc4)oc3C)cc2)cc1.COc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(C=C=Cc3nc(-c4ccccc4)oc3C)c2)cc1.Cc1oc(-c2ccccc2)nc1CCOc1ccc(CN(CC(=O)O)C(=O)OCc2ccc(OC(F)(F)F)cc2)cc1.Cc1oc(-c2ccccc2)nc1CCOc1cccc(CN(CC(=O)O)C(=O)OCc2ccc(Cl)cc2)c1.Cc1oc(-c2ccccc2)nc1CCOc1cccc(CN(CC(=O)O)C(=O)OCc2ccc(F)cc2)c1
• InChI: InChI=1S/C30H27F3N2O7.C30H26N2O6.C30H30N2O6.C30H26N2O6.C29H27ClN2O6.C29H27FN2O6/c1-20-26(34-28(41-20)23-5-3-2-4-6-23)15-16-39-24-11-7-21(8-12-24)17-35(18-27(36)37)29(38)40-19-22-9-13-25(14-10-22)42-30(31,32)33;1-21-27(31-29(37-21)24-11-4-3-5-12-24)13-7-9-22-8-6-10-23(18-22)19-32(20-28(33)34)30(35)38-26-16-14-25(36-2)15-17-26;2*1-21-27(31-29(37-21)24-8-4-3-5-9-24)10-6-7-22-11-13-23(14-12-22)19-32(20-28(33)34)30(35)38-26-17-15-25(36-2)16-18-26;2*1-20-26(31-28(38-20)23-7-3-2-4-8-23)14-15-36-25-9-5-6-22(16-25)17-32(18-27(33)34)29(35)37-19-21-10-12-24(30)13-11-21/h2-14H,15-19H2,1H3,(H,36,37);3-6,8-18H,19-20H2,1-2H3,(H,33,34);3-5,8-9,11-18H,6-7,10,19-20H2,1-2H3,(H,33,34);3-5,7-18H,19-20H2,1-2H3,(H,33,34);2*2-13,16H,14-15,17-19H2,1H3,(H,33,34)
• InChIKey: NDEXMZPGDYCVGG-UHFFFAOYSA-N
• XLogP: 36.23
• TPSA: 621.83 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 37
• Rotatable Bonds: 63
• Heavy Atoms: 232
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3173.75
LogP ≤ 5	36.23
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	37

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': '>_2_ester_groups', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid?

The IUPAC name of 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid (CID 159747307) is 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid.

What is the SMILES notation for 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid?

The canonical SMILES for 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid is COc1ccc(OC(=O)N(CC(=O)O)Cc2ccc(C=C=Cc3nc(-c4ccccc4)oc3C)cc2)cc1.COc1ccc(OC(=O)N(CC(=O)O)Cc2ccc(CCCc3nc(-c4ccccc4)oc3C)cc2)cc1.COc1ccc(OC(=O)N(CC(=O)O)Cc2cccc(C=C=Cc3nc(-c4ccccc4)oc3C)c2)cc1.Cc1oc(-c2ccccc2)nc1CCOc1ccc(CN(CC(=O)O)C(=O)OCc2ccc(OC(F)(F)F)cc2)cc1.Cc1oc(-c2ccccc2)nc1CCOc1cccc(CN(CC(=O)O)C(=O)OCc2ccc(Cl)cc2)c1.Cc1oc(-c2ccccc2)nc1CCOc1cccc(CN(CC(=O)O)C(=O)OCc2ccc(F)cc2)c1.

What is the InChIKey of 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid?

The InChIKey is NDEXMZPGDYCVGG-UHFFFAOYSA-N. The full InChI is InChI=1S/C30H27F3N2O7.C30H26N2O6.C30H30N2O6.C30H26N2O6.C29H27ClN2O6.C29H27FN2O6/c1-20-26(34-28(41-20)23-5-3-2-4-6-23)15-16-39-24-11-7-21(8-12-24)17-35(18-27(36)37)29(38)40-19-22-9-13-25(14-10-22)42-30(31,32)33;1-21-27(31-29(37-21)24-11-4-3-5-12-24)13-7-9-22-8-6-10-23(18-22)19-32(20-28(33)34)30(35)38-26-16-14-25(36-2)15-17-26;2*1-21-27(31-29(37-21)24-8-4-3-5-9-24)10-6-7-22-11-13-23(14-12-22)19-32(20-28(33)34)30(35)38-26-17-15-25(36-2)16-18-26;2*1-20-26(31-28(38-20)23-7-3-2-4-8-23)14-15-36-25-9-5-6-22(16-25)17-32(18-27(33)34)29(35)37-19-21-10-12-24(30)13-11-21/h2-14H,15-19H2,1H3,(H,36,37);3-6,8-18H,19-20H2,1-2H3,(H,33,34);3-5,8-9,11-18H,6-7,10,19-20H2,1-2H3,(H,33,34);3-5,7-18H,19-20H2,1-2H3,(H,33,34);2*2-13,16H,14-15,17-19H2,1H3,(H,33,34).

What are the key properties of 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid?

2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid has a molecular weight of 3173.75 g/mol, XLogP of 36.23, 63 rotatable bonds, 6 hydrogen bond donors, and 37 hydrogen bond acceptors.

Where does this data come from?

All data for 2-[(4-chlorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-fluorophenyl)methoxycarbonyl-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[3-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propa-1,2-dienyl]phenyl]methyl]amino]acetic acid;2-[(4-methoxyphenoxy)carbonyl-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]phenyl]methyl]amino]acetic acid;2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl-[[4-(trifluoromethoxy)phenyl]methoxycarbonyl]amino]acetic acid is sourced from PubChem (CID 159747307), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).