2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine

C226H142N6O6P4S2Si4 — CID 159784663

About 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine

2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine (PubChem CID 159784663) has the molecular formula C226H142N6O6P4S2Si4 and a molecular weight of 3338.03 g/mol. Its IUPAC name is 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine.

Molecular Properties

• Compound Name: 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine
• PubChem CID: 159784663
• Molecular Formula: C226H142N6O6P4S2Si4
• Molecular Weight: 3338.03 g/mol
• Exact Mass: 3334.85
• IUPAC Name: 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine
• SMILES: O=P(c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3)(c1ccc2ccc3cccnc3c2n1)c1ccc2ccc3cccnc3c2n1.O=P(c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3)(c1ccccn1)c1ccccn1.O=P(c1ccc2oc3ccccc3c2c1)(c1ccc2oc3ccccc3c2c1)c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3.O=P(c1ccc2sc3ccccc3c2c1)(c1ccc2sc3ccccc3c2c1)c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3
• InChI: InChI=1S/C60H37N4OPSi.C60H37O3PSi.C60H37OPS2Si.C46H31N2OPSi/c65-66(55-31-27-40-25-23-38-13-11-33-61-57(38)59(40)63-55,56-32-28-41-26-24-39-14-12-34-62-58(39)60(41)64-56)42-29-30-47-49(35-42)45-19-7-8-20-46(45)50-36-52-48-21-9-10-22-53(48)67(54(52)37-51(47)50,43-15-3-1-4-16-43)44-17-5-2-6-18-44;61-64(39-28-31-57-52(34-39)46-21-9-12-24-55(46)62-57,40-29-32-58-53(35-40)47-22-10-13-25-56(47)63-58)38-27-30-45-49(33-38)43-19-7-8-20-44(43)50-36-54-48-23-11-14-26-59(48)65(60(54)37-51(45)50,41-15-3-1-4-16-41)42-17-5-2-6-18-42;61-62(39-28-31-57-52(34-39)46-21-9-12-24-55(46)63-57,40-29-32-58-53(35-40)47-22-10-13-25-56(47)64-58)38-27-30-45-49(33-38)43-19-7-8-20-44(43)50-36-54-48-23-11-14-26-59(48)65(60(54)37-51(45)50,41-15-3-1-4-16-41)42-17-5-2-6-18-42;49-50(45-23-11-13-27-47-45,46-24-12-14-28-48-46)32-25-26-37-39(29-32)35-19-7-8-20-36(35)40-30-42-38-21-9-10-22-43(38)51(44(42)31-41(37)40,33-15-3-1-4-16-33)34-17-5-2-6-18-34/h1-37H;2*1-37H;1-31H
• InChIKey: NHULMTTYURZZBY-UHFFFAOYSA-N
• XLogP: 42.09
• TPSA: 171.90 Ų
• H-Bond Acceptors: 14
• Rotatable Bonds: 20
• Heavy Atoms: 248
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	3338.03
LogP ≤ 5	42.09
H-Bond Donors ≤ 5	0
H-Bond Acceptors ≤ 10	14

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'heavy_metal', 'substructure': 'N/A'}, {'alert_name': 'phosphor', 'substructure': 'N/A'}, {'alert_name': 'Polycyclic_aromatic_hydrocarbon_3', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine?

The IUPAC name of 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine (CID 159784663) is 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine.

What is the SMILES notation for 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine?

The canonical SMILES for 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine is O=P(c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3)(c1ccc2ccc3cccnc3c2n1)c1ccc2ccc3cccnc3c2n1.O=P(c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3)(c1ccccn1)c1ccccn1.O=P(c1ccc2oc3ccccc3c2c1)(c1ccc2oc3ccccc3c2c1)c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3.O=P(c1ccc2sc3ccccc3c2c1)(c1ccc2sc3ccccc3c2c1)c1ccc2c(c1)c1ccccc1c1cc3c(cc21)[Si](c1ccccc1)(c1ccccc1)c1ccccc1-3.

What is the InChIKey of 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine?

The InChIKey is NHULMTTYURZZBY-UHFFFAOYSA-N. The full InChI is InChI=1S/C60H37N4OPSi.C60H37O3PSi.C60H37OPS2Si.C46H31N2OPSi/c65-66(55-31-27-40-25-23-38-13-11-33-61-57(38)59(40)63-55,56-32-28-41-26-24-39-14-12-34-62-58(39)60(41)64-56)42-29-30-47-49(35-42)45-19-7-8-20-46(45)50-36-52-48-21-9-10-22-53(48)67(54(52)37-51(47)50,43-15-3-1-4-16-43)44-17-5-2-6-18-44;61-64(39-28-31-57-52(34-39)46-21-9-12-24-55(46)62-57,40-29-32-58-53(35-40)47-22-10-13-25-56(47)63-58)38-27-30-45-49(33-38)43-19-7-8-20-44(43)50-36-54-48-23-11-14-26-59(48)65(60(54)37-51(45)50,41-15-3-1-4-16-41)42-17-5-2-6-18-42;61-62(39-28-31-57-52(34-39)46-21-9-12-24-55(46)63-57,40-29-32-58-53(35-40)47-22-10-13-25-56(47)64-58)38-27-30-45-49(33-38)43-19-7-8-20-44(43)50-36-54-48-23-11-14-26-59(48)65(60(54)37-51(45)50,41-15-3-1-4-16-41)42-17-5-2-6-18-42;49-50(45-23-11-13-27-47-45,46-24-12-14-28-48-46)32-25-26-37-39(29-32)35-19-7-8-20-36(35)40-30-42-38-21-9-10-22-43(38)51(44(42)31-41(37)40,33-15-3-1-4-16-33)34-17-5-2-6-18-34/h1-37H;2*1-37H;1-31H.

What are the key properties of 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine?

2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine has a molecular weight of 3338.03 g/mol, XLogP of 42.09, 20 rotatable bonds, 0 hydrogen bond donors, and 14 hydrogen bond acceptors.

Where does this data come from?

All data for 2-[dibenzofuran-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzofuran;2-[dibenzothiophen-2-yl-(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)phosphoryl]dibenzothiophene;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-(1,10-phenanthrolin-2-yl)phosphoryl]-1,10-phenanthroline;2-[(23,23-diphenyl-23-silahexacyclo[12.11.0.02,7.08,13.016,24.017,22]pentacosa-1(25),2(7),3,5,8,10,12,14,16(24),17,19,21-dodecaen-5-yl)-pyridin-2-ylphosphoryl]pyridine is sourced from PubChem (CID 159784663), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).