4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide

C154H136F21N31O22 — CID 159844261

IUPAC4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
SMILESCOc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2CC[C@@H](O)C2)cn1.COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CCC(O)C2)cn1.Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2CC[C@@H](O)C2)cn1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@H](O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC2)c(-c2cncnc2)c1
InChIInChI=1S/C23H21F3N4O4.C23H21F3N4O3.C22H20F3N5O4.2C22H19F3N4O3.C21H18F3N5O3.C21H18F3N5O2/c1-33-22-27-11-15(12-28-22)19-10-14(2-7-20(19)30-9-8-17(31)13-30)21(32)29-16-3-5-18(6-4-16)34-23(24,25)26;1-14-27-11-16(12-28-14)20-10-15(2-7-21(20)30-9-8-18(31)13-30)22(32)29-17-3-5-19(6-4-17)33-23(24,25)26;1-33-21-27-10-14(11-28-21)18-8-13(9-26-19(18)30-7-6-16(31)12-30)20(32)29-15-2-4-17(5-3-15)34-22(23,24)25;2*23-22(24,25)32-18-4-2-16(3-5-18)28-21(31)14-1-6-20(29-8-7-17(30)12-29)19(9-14)15-10-26-13-27-11-15;22-21(23,24)32-17-3-1-15(2-4-17)28-20(31)13-7-18(14-8-25-12-26-9-14)19(27-10-13)29-6-5-16(30)11-29;22-21(23,24)31-17-5-3-16(4-6-17)28-20(30)14-9-18(15-10-25-13-26-11-15)19(27-12-14)29-7-1-2-8-29/h2-7,10-12,17,31H,8-9,13H2,1H3,(H,29,32);2-7,10-12,18,31H,8-9,13H2,1H3,(H,29,32);2-5,8-11,16,31H,6-7,12H2,1H3,(H,29,32);2*1-6,9-11,13,17,30H,7-8,12H2,(H,28,31);1-4,7-10,12,16,30H,5-6,11H2,(H,28,31);3-6,9-13H,1-2,7-8H2,(H,28,30)/t17-;18-;;2*17-;;/m11.10../s1
InChIKeyNPCAKPKNIRPCIC-NUTTXPJZSA-N
MW3171.93 g/mol
LogP26.60
Rot. Bonds37

About 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide

4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide (PubChem CID 159844261) has the molecular formula C154H136F21N31O22 and a molecular weight of 3171.93 g/mol. Its IUPAC name is 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide.

Molecular Properties

Compound Name4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
PubChem CID159844261
Molecular FormulaC154H136F21N31O22
Molecular Weight3171.93 g/mol
Exact Mass3170.01
IUPAC Name4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
SMILESCOc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2CC[C@@H](O)C2)cn1.COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CCC(O)C2)cn1.Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2CC[C@@H](O)C2)cn1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@H](O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC2)c(-c2cncnc2)c1
InChIInChI=1S/C23H21F3N4O4.C23H21F3N4O3.C22H20F3N5O4.2C22H19F3N4O3.C21H18F3N5O3.C21H18F3N5O2/c1-33-22-27-11-15(12-28-22)19-10-14(2-7-20(19)30-9-8-17(31)13-30)21(32)29-16-3-5-18(6-4-16)34-23(24,25)26;1-14-27-11-16(12-28-14)20-10-15(2-7-21(20)30-9-8-18(31)13-30)22(32)29-17-3-5-19(6-4-17)33-23(24,25)26;1-33-21-27-10-14(11-28-21)18-8-13(9-26-19(18)30-7-6-16(31)12-30)20(32)29-15-2-4-17(5-3-15)34-22(23,24)25;2*23-22(24,25)32-18-4-2-16(3-5-18)28-21(31)14-1-6-20(29-8-7-17(30)12-29)19(9-14)15-10-26-13-27-11-15;22-21(23,24)32-17-3-1-15(2-4-17)28-20(31)13-7-18(14-8-25-12-26-9-14)19(27-10-13)29-6-5-16(30)11-29;22-21(23,24)31-17-5-3-16(4-6-17)28-20(30)14-9-18(15-10-25-13-26-11-15)19(27-12-14)29-7-1-2-8-29/h2-7,10-12,17,31H,8-9,13H2,1H3,(H,29,32);2-7,10-12,18,31H,8-9,13H2,1H3,(H,29,32);2-5,8-11,16,31H,6-7,12H2,1H3,(H,29,32);2*1-6,9-11,13,17,30H,7-8,12H2,(H,28,31);1-4,7-10,12,16,30H,5-6,11H2,(H,28,31);3-6,9-13H,1-2,7-8H2,(H,28,30)/t17-;18-;;2*17-;;/m11.10../s1
InChIKeyNPCAKPKNIRPCIC-NUTTXPJZSA-N
XLogP26.60
TPSA649.96 Ų
H-Bond Donors13
H-Bond Acceptors46
Rotatable Bonds37
Heavy Atoms228
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003171.93
LogP ≤ 526.60
H-Bond Donors ≤ 513
H-Bond Acceptors ≤ 1046

Analyze 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide with MolForge

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Related Compounds

5-(4-cyano-3-pyridinyl)-6-[(3R)-3-methylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(6-ethyl-3-pyridinyl)-6-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(5-fluoro-3-pyridinyl)-6-[(3R)-3-methylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(2-methyl-3-pyridinyl)-6-[(3R)-3-methylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(5-methyl-3-pyridinyl)-6-[(3R)-3-methylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(6-methyl-3-pyridinyl)-6-[(3R)-3-methylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157086001
6-(3-acetamidopyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3R)-3-(aminomethyl)pyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypyrrolidin-1-yl]-5-pyrimidin-5-ylpyridine-3-carboxamide;6-[3-(dimethylamino)pyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S)-3-(methylamino)pyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157098816
5-(6-ethyl-3-pyridinyl)-6-[(3S)-3-ethylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(6-ethyl-3-pyridinyl)-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3R)-3-ethylpyrrolidin-1-yl]-5-(6-methyl-3-pyridinyl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S)-3-ethylpyrrolidin-1-yl]-5-(6-methyl-3-pyridinyl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3R)-3-ethylpyrrolidin-1-yl]-5-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S)-3-ethylpyrrolidin-1-yl]-5-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157135157
5-(5-cyano-3-pyridinyl)-6-[2-hydroxyethyl(methyl)amino]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[ethyl(2-hydroxyethyl)amino]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(5-fluoro-3-pyridinyl)-6-[2-hydroxyethyl(methyl)amino]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-hydroxyethyl(methyl)amino]-5-(6-methyl-3-pyridinyl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-hydroxyethyl(methyl)amino]-5-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-hydroxyethyl(methyl)amino]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157176480
N-[4-[chloro(difluoro)methoxy]phenyl]-5-(5-cyano-3-pyridinyl)-6-[2-hydroxyethyl(methyl)amino]pyridine-3-carboxamide;5-(5-cyano-3-pyridinyl)-6-[ethyl(2-hydroxyethyl)amino]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(5-cyano-3-pyridinyl)-6-[2-hydroxyethyl(methyl)amino]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[ethyl(2-hydroxyethyl)amino]-5-(5-fluoro-3-pyridinyl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[ethyl(2-hydroxyethyl)amino]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(2-hydroxyethylamino)-5-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157187034
N-(1-hydroxy-2-methylpropan-2-yl)-6-(5-methoxy-1-methylindol-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carboxamide;N-(1-hydroxy-2-methylpropan-2-yl)-3-(4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-1-methylindole-5-carboxamide;6-(5-methoxy-1-methylindol-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxamide;6-(5-methoxy-1-methylindol-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-4-carbonitrile;6-(5-methoxy-1-methylindol-3-yl)-4-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine
CID 157204082
6-(azepan-1-yl)-5-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(1,3-dihydroisoindol-2-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(4-methyl-1,4-diazepan-1-yl)-5-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(4-methylpiperazin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(9-oxo-2-azaspiro[4.4]nonan-2-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-(2-oxo-1,3-oxazolidin-3-yl)-3-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]benzamide
CID 157205967
5-(3-tert-butyl-5-fluorophenyl)-6-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(2-ethylmorpholin-4-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(3-ethylphenyl)-6-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(3-fluorophenyl)-6-[(3R)-3-methylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;methyl 3-fluoro-5-[2-[(3R)-3-hydroxypyrrolidin-1-yl]-5-[[4-(trifluoromethoxy)phenyl]carbamoyl]-3-pyridinyl]benzoate;6-[(3R)-3-methylpyrrolidin-1-yl]-5-phenyl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157241165
5-(5-fluoro-6-methyl-3-pyridinyl)-6-(3-hydroxy-3-methylazetidin-1-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(5-fluoro-3-pyridinyl)-6-(3-hydroxy-3-methylazetidin-1-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(3-hydroxyazetidin-1-yl)-5-(6-methyl-3-pyridinyl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(3-hydroxy-3-methylazetidin-1-yl)-5-(6-methyl-3-pyridinyl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(3-hydroxy-3-methylazetidin-1-yl)-5-pyridin-3-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-5-(6-methyl-3-pyridinyl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157241206
N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-ethylpyrrolidin-1-yl]-5-pyrimidin-5-ylpyridine-3-carboxamide;6-[(3S)-3-ethylpyrrolidin-1-yl]-5-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-(3-ethylpyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3R)-3-ethylpyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S)-3-ethylpyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(2-ethynylpyrimidin-5-yl)-6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157243511
1-[[2-(difluoromethoxy)-5-methylphenyl]methyl]-2-methyl-6-(2-propan-2-ylpyrimidin-5-yl)indazol-3-one;1-[[2-(difluoromethoxy)-5-morpholin-4-ylphenyl]methyl]-6-[2-(2-hydroxypropan-2-yl)pyrimidin-5-yl]-2-methylindazol-3-one;1-[[2-(difluoromethoxy)phenyl]methyl]-5-fluoro-6-[2-[(2R)-4-(2-hydroxyacetyl)-2-methylpiperazin-1-yl]pyrimidin-5-yl]-2-methylindazol-3-one;1-[[1-[(4-ethyl-3-pyridinyl)methyl]-4-(trifluoromethyl)pyrrol-3-yl]methyl]-6-[2-(2-hydroxypropan-2-yl)pyrimidin-5-yl]-2-methylindazol-3-one;6-[2-(2-hydroxypropan-2-yl)pyrimidin-5-yl]-2-methyl-1-[[1-(pyridin-3-ylmethyl)-4-(trifluoromethyl)pyrrol-3-yl]methyl]indazol-3-one
CID 157304080
5-(5-cyano-3-pyridinyl)-N-[3-fluoro-4-(trifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]pyridine-3-carboxamide;5-(5-cyano-3-pyridinyl)-6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-(trifluoromethylsulfanyl)phenyl]pyridine-3-carboxamide;5-(5-cyano-3-pyridinyl)-6-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-(trifluoromethylsulfanyl)phenyl]pyridine-3-carboxamide;5-(5-fluoro-3-pyridinyl)-N-[3-fluoro-4-(trifluoromethoxy)phenyl]-6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]pyridine-3-carboxamide;5-(5-fluoro-3-pyridinyl)-N-[3-fluoro-4-(trifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]pyridine-3-carboxamide;5-(5-fluoro-3-pyridinyl)-6-[(3S)-3-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-(trifluoromethylsulfanyl)phenyl]pyridine-3-carboxamide
CID 157308010

Frequently Asked Questions

What is the IUPAC name of 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?
The IUPAC name of 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide (CID 159844261) is 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide.
What is the SMILES notation for 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?
The canonical SMILES for 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide is COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2CC[C@@H](O)C2)cn1.COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CCC(O)C2)cn1.Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2CC[C@@H](O)C2)cn1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@H](O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(O)C2)c(-c2cncnc2)c1.O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC2)c(-c2cncnc2)c1.
What is the InChIKey of 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?
The InChIKey is NPCAKPKNIRPCIC-NUTTXPJZSA-N. The full InChI is InChI=1S/C23H21F3N4O4.C23H21F3N4O3.C22H20F3N5O4.2C22H19F3N4O3.C21H18F3N5O3.C21H18F3N5O2/c1-33-22-27-11-15(12-28-22)19-10-14(2-7-20(19)30-9-8-17(31)13-30)21(32)29-16-3-5-18(6-4-16)34-23(24,25)26;1-14-27-11-16(12-28-14)20-10-15(2-7-21(20)30-9-8-18(31)13-30)22(32)29-17-3-5-19(6-4-17)33-23(24,25)26;1-33-21-27-10-14(11-28-21)18-8-13(9-26-19(18)30-7-6-16(31)12-30)20(32)29-15-2-4-17(5-3-15)34-22(23,24)25;2*23-22(24,25)32-18-4-2-16(3-5-18)28-21(31)14-1-6-20(29-8-7-17(30)12-29)19(9-14)15-10-26-13-27-11-15;22-21(23,24)32-17-3-1-15(2-4-17)28-20(31)13-7-18(14-8-25-12-26-9-14)19(27-10-13)29-6-5-16(30)11-29;22-21(23,24)31-17-5-3-16(4-6-17)28-20(30)14-9-18(15-10-25-13-26-11-15)19(27-12-14)29-7-1-2-8-29/h2-7,10-12,17,31H,8-9,13H2,1H3,(H,29,32);2-7,10-12,18,31H,8-9,13H2,1H3,(H,29,32);2-5,8-11,16,31H,6-7,12H2,1H3,(H,29,32);2*1-6,9-11,13,17,30H,7-8,12H2,(H,28,31);1-4,7-10,12,16,30H,5-6,11H2,(H,28,31);3-6,9-13H,1-2,7-8H2,(H,28,30)/t17-;18-;;2*17-;;/m11.10../s1.
What are the key properties of 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide?
4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide has a molecular weight of 3171.93 g/mol, XLogP of 26.60, 37 rotatable bonds, 13 hydrogen bond donors, and 46 hydrogen bond acceptors.
Where does this data come from?
All data for 4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-(2-methoxypyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-(2-methylpyrimidin-5-yl)-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3R)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;4-[(3S)-3-hydroxypyrrolidin-1-yl]-3-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]benzamide;6-(3-hydroxypyrrolidin-1-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-pyrimidin-5-yl-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide is sourced from PubChem (CID 159844261), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).