1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate

C136H165BrFN35O17 — CID 159902915

About 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate

1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate (PubChem CID 159902915) has the molecular formula C136H165BrFN35O17 and a molecular weight of 2660.95 g/mol. Its IUPAC name is 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate.

Molecular Properties

• Compound Name: 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate
• PubChem CID: 159902915
• Molecular Formula: C136H165BrFN35O17
• Molecular Weight: 2660.95 g/mol
• Exact Mass: 2658.23
• IUPAC Name: 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate
• SMILES: CC(=O)N(C)c1cc2c(cc1F)CCN2Cc1cnc[nH]1.CCN(C(=O)NCc1ccco1)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.CCN(C(C)=O)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.CNC(=O)N(C)c1cc(Br)c2c(c1)N(Cc1cnc[nH]1)CC2.COCCCOC(=O)N(C)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.COCCOC(=O)N(C)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.COCCOC(=O)Nc1ccc2c(c1)N(Cc1cnc[nH]1)CC2.Cc1cc(COC(=O)N(C)c2ccc3c(c2)N(Cc2cnc[nH]2)CC3)no1
• InChI: InChI=1S/C20H23N5O2.C19H21N5O3.C18H24N4O3.C17H22N4O3.C16H20N4O3.C16H20N4O.C15H18BrN5O.C15H17FN4O/c1-2-25(20(26)22-12-18-4-3-9-27-18)17-6-5-15-7-8-24(19(15)10-17)13-16-11-21-14-23-16;1-13-7-15(22-27-13)11-26-19(25)23(2)17-4-3-14-5-6-24(18(14)8-17)10-16-9-20-12-21-16;1-21(18(23)25-9-3-8-24-2)16-5-4-14-6-7-22(17(14)10-16)12-15-11-19-13-20-15;1-20(17(22)24-8-7-23-2)15-4-3-13-5-6-21(16(13)9-15)11-14-10-18-12-19-14;1-22-6-7-23-16(21)19-13-3-2-12-4-5-20(15(12)8-13)10-14-9-17-11-18-14;1-3-20(12(2)21)15-5-4-13-6-7-19(16(13)8-15)10-14-9-17-11-18-14;1-17-15(22)20(2)11-5-13(16)12-3-4-21(14(12)6-11)8-10-7-18-9-19-10;1-10(21)19(2)15-6-14-11(5-13(15)16)3-4-20(14)8-12-7-17-9-18-12/h3-6,9-11,14H,2,7-8,12-13H2,1H3,(H,21,23)(H,22,26);3-4,7-9,12H,5-6,10-11H2,1-2H3,(H,20,21);4-5,10-11,13H,3,6-9,12H2,1-2H3,(H,19,20);3-4,9-10,12H,5-8,11H2,1-2H3,(H,18,19);2-3,8-9,11H,4-7,10H2,1H3,(H,17,18)(H,19,21);4-5,8-9,11H,3,6-7,10H2,1-2H3,(H,17,18);5-7,9H,3-4,8H2,1-2H3,(H,17,22)(H,18,19);5-7,9H,3-4,8H2,1-2H3,(H,17,18)
• InChIKey: NWEQPLZMPYFMEO-UHFFFAOYSA-N
• XLogP: 20.23
• TPSA: 554.47 Ų
• H-Bond Donors: 11
• H-Bond Acceptors: 34
• Rotatable Bonds: 40
• Heavy Atoms: 190
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2660.95
LogP ≤ 5	20.23
H-Bond Donors ≤ 5	11
H-Bond Acceptors ≤ 10	34

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': '>_2_ester_groups', 'substructure': 'N/A'}, {'alert_name': 'Aliphatic_long_chain', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate?

The IUPAC name of 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate (CID 159902915) is 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate.

What is the SMILES notation for 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate?

The canonical SMILES for 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate is CC(=O)N(C)c1cc2c(cc1F)CCN2Cc1cnc[nH]1.CCN(C(=O)NCc1ccco1)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.CCN(C(C)=O)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.CNC(=O)N(C)c1cc(Br)c2c(c1)N(Cc1cnc[nH]1)CC2.COCCCOC(=O)N(C)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.COCCOC(=O)N(C)c1ccc2c(c1)N(Cc1cnc[nH]1)CC2.COCCOC(=O)Nc1ccc2c(c1)N(Cc1cnc[nH]1)CC2.Cc1cc(COC(=O)N(C)c2ccc3c(c2)N(Cc2cnc[nH]2)CC3)no1.

What is the InChIKey of 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate?

The InChIKey is NWEQPLZMPYFMEO-UHFFFAOYSA-N. The full InChI is InChI=1S/C20H23N5O2.C19H21N5O3.C18H24N4O3.C17H22N4O3.C16H20N4O3.C16H20N4O.C15H18BrN5O.C15H17FN4O/c1-2-25(20(26)22-12-18-4-3-9-27-18)17-6-5-15-7-8-24(19(15)10-17)13-16-11-21-14-23-16;1-13-7-15(22-27-13)11-26-19(25)23(2)17-4-3-14-5-6-24(18(14)8-17)10-16-9-20-12-21-16;1-21(18(23)25-9-3-8-24-2)16-5-4-14-6-7-22(17(14)10-16)12-15-11-19-13-20-15;1-20(17(22)24-8-7-23-2)15-4-3-13-5-6-21(16(13)9-15)11-14-10-18-12-19-14;1-22-6-7-23-16(21)19-13-3-2-12-4-5-20(15(12)8-13)10-14-9-17-11-18-14;1-3-20(12(2)21)15-5-4-13-6-7-19(16(13)8-15)10-14-9-17-11-18-14;1-17-15(22)20(2)11-5-13(16)12-3-4-21(14(12)6-11)8-10-7-18-9-19-10;1-10(21)19(2)15-6-14-11(5-13(15)16)3-4-20(14)8-12-7-17-9-18-12/h3-6,9-11,14H,2,7-8,12-13H2,1H3,(H,21,23)(H,22,26);3-4,7-9,12H,5-6,10-11H2,1-2H3,(H,20,21);4-5,10-11,13H,3,6-9,12H2,1-2H3,(H,19,20);3-4,9-10,12H,5-8,11H2,1-2H3,(H,18,19);2-3,8-9,11H,4-7,10H2,1H3,(H,17,18)(H,19,21);4-5,8-9,11H,3,6-7,10H2,1-2H3,(H,17,18);5-7,9H,3-4,8H2,1-2H3,(H,17,22)(H,18,19);5-7,9H,3-4,8H2,1-2H3,(H,17,18).

What are the key properties of 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate?

1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate has a molecular weight of 2660.95 g/mol, XLogP of 20.23, 40 rotatable bonds, 11 hydrogen bond donors, and 34 hydrogen bond acceptors.

Where does this data come from?

All data for 1-[4-bromo-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-1,3-dimethylurea;1-ethyl-3-(furan-2-ylmethyl)-1-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]urea;N-ethyl-N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]acetamide;N-[5-fluoro-1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylacetamide;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]carbamate;2-methoxyethyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;3-methoxypropyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate;(5-methyl-1,2-oxazol-3-yl)methyl N-[1-(1H-imidazol-5-ylmethyl)-2,3-dihydroindol-6-yl]-N-methylcarbamate is sourced from PubChem (CID 159902915), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).