N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide

C145H170F6N26O15 — CID 159911180

About N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide

N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide (PubChem CID 159911180) has the molecular formula C145H170F6N26O15 and a molecular weight of 2631.11 g/mol. Its IUPAC name is N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide.

Molecular Properties

• Compound Name: N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide
• PubChem CID: 159911180
• Molecular Formula: C145H170F6N26O15
• Molecular Weight: 2631.11 g/mol
• Exact Mass: 2629.32
• IUPAC Name: N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide
• SMILES: C.C=CC(=O)N1CCCC[C@@H](n2c(NC(=O)c3cccc(C)c3)nc3ccc4c(c32)C(F)(F)CN(C)CCO4)C1.C=CC(=O)N1CCCC[C@@H](n2c(NC(=O)c3cccc(C)c3)nc3ccc4c(c32)CN(C)CCO4)C1.C=CC(=O)N1CCCC[C@@H](n2c(NC(=O)c3ccccc3)nc3ccc4c(c32)OCC(F)(F)CN4C)C1.C=CC(=O)N1CCC[C@@H](n2c(NC(=O)c3cccc(C)c3)nc3ccc4c(c32)CN(C)CCO4)C1.CN1CC(F)(F)COc2ccc3nc(NC(=O)c4ccccc4)n([C@@H]4CCCCN(C(=O)/C=C/CN5CCCCC5)C4)c3c21
• InChI: InChI=1S/C33H40F2N6O3.C29H33F2N5O3.C28H33N5O3.C27H29F2N5O3.C27H31N5O3.CH4/c1-38-22-33(34,35)23-44-27-16-15-26-29(30(27)38)41(32(36-26)37-31(43)24-11-4-2-5-12-24)25-13-6-9-20-40(21-25)28(42)14-10-19-39-17-7-3-8-18-39;1-4-24(37)35-13-6-5-10-21(17-35)36-26-22(32-28(36)33-27(38)20-9-7-8-19(2)16-20)11-12-23-25(26)29(30,31)18-34(3)14-15-39-23;1-4-25(34)32-13-6-5-10-21(17-32)33-26-22-18-31(3)14-15-36-24(22)12-11-23(26)29-28(33)30-27(35)20-9-7-8-19(2)16-20;1-3-22(35)33-14-8-7-11-19(15-33)34-23-20(30-26(34)31-25(36)18-9-5-4-6-10-18)12-13-21-24(23)37-17-27(28,29)16-32(21)2;1-4-24(33)31-12-6-9-20(16-31)32-25-21-17-30(3)13-14-35-23(21)11-10-22(25)28-27(32)29-26(34)19-8-5-7-18(2)15-19;/h2,4-5,10-12,14-16,25H,3,6-9,13,17-23H2,1H3,(H,36,37,43);4,7-9,11-12,16,21H,1,5-6,10,13-15,17-18H2,2-3H3,(H,32,33,38);4,7-9,11-12,16,21H,1,5-6,10,13-15,17-18H2,2-3H3,(H,29,30,35);3-6,9-10,12-13,19H,1,7-8,11,14-17H2,2H3,(H,30,31,36);4-5,7-8,10-11,15,20H,1,6,9,12-14,16-17H2,2-3H3,(H,28,29,34);1H4/b14-10+;;;;;/t25-;2*21-;19-;20-;/m11111./s1
• InChIKey: NXEWRDQTSPBZRF-GTAHTUMOSA-N
• XLogP: 23.16
• TPSA: 401.74 Ų
• H-Bond Donors: 5
• H-Bond Acceptors: 31
• Rotatable Bonds: 22
• Heavy Atoms: 192
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2631.11
LogP ≤ 5	23.16
H-Bond Donors ≤ 5	5
H-Bond Acceptors ≤ 10	31

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'Michael_acceptor_1', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide?

The IUPAC name of N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide (CID 159911180) is N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide.

What is the SMILES notation for N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide?

The canonical SMILES for N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide is C.C=CC(=O)N1CCCC[C@@H](n2c(NC(=O)c3cccc(C)c3)nc3ccc4c(c32)C(F)(F)CN(C)CCO4)C1.C=CC(=O)N1CCCC[C@@H](n2c(NC(=O)c3cccc(C)c3)nc3ccc4c(c32)CN(C)CCO4)C1.C=CC(=O)N1CCCC[C@@H](n2c(NC(=O)c3ccccc3)nc3ccc4c(c32)OCC(F)(F)CN4C)C1.C=CC(=O)N1CCC[C@@H](n2c(NC(=O)c3cccc(C)c3)nc3ccc4c(c32)CN(C)CCO4)C1.CN1CC(F)(F)COc2ccc3nc(NC(=O)c4ccccc4)n([C@@H]4CCCCN(C(=O)/C=C/CN5CCCCC5)C4)c3c21.

What is the InChIKey of N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide?

The InChIKey is NXEWRDQTSPBZRF-GTAHTUMOSA-N. The full InChI is InChI=1S/C33H40F2N6O3.C29H33F2N5O3.C28H33N5O3.C27H29F2N5O3.C27H31N5O3.CH4/c1-38-22-33(34,35)23-44-27-16-15-26-29(30(27)38)41(32(36-26)37-31(43)24-11-4-2-5-12-24)25-13-6-9-20-40(21-25)28(42)14-10-19-39-17-7-3-8-18-39;1-4-24(37)35-13-6-5-10-21(17-35)36-26-22(32-28(36)33-27(38)20-9-7-8-19(2)16-20)11-12-23-25(26)29(30,31)18-34(3)14-15-39-23;1-4-25(34)32-13-6-5-10-21(17-32)33-26-22-18-31(3)14-15-36-24(22)12-11-23(26)29-28(33)30-27(35)20-9-7-8-19(2)16-20;1-3-22(35)33-14-8-7-11-19(15-33)34-23-20(30-26(34)31-25(36)18-9-5-4-6-10-18)12-13-21-24(23)37-17-27(28,29)16-32(21)2;1-4-24(33)31-12-6-9-20(16-31)32-25-21-17-30(3)13-14-35-23(21)11-10-22(25)28-27(32)29-26(34)19-8-5-7-18(2)15-19;/h2,4-5,10-12,14-16,25H,3,6-9,13,17-23H2,1H3,(H,36,37,43);4,7-9,11-12,16,21H,1,5-6,10,13-15,17-18H2,2-3H3,(H,32,33,38);4,7-9,11-12,16,21H,1,5-6,10,13-15,17-18H2,2-3H3,(H,29,30,35);3-6,9-10,12-13,19H,1,7-8,11,14-17H2,2H3,(H,30,31,36);4-5,7-8,10-11,15,20H,1,6,9,12-14,16-17H2,2-3H3,(H,28,29,34);1H4/b14-10+;;;;;/t25-;2*21-;19-;20-;/m11111./s1.

What are the key properties of N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide?

N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide has a molecular weight of 2631.11 g/mol, XLogP of 23.16, 22 rotatable bonds, 5 hydrogen bond donors, and 31 hydrogen bond acceptors.

Where does this data come from?

All data for N-[8,8-difluoro-10-methyl-1-[(3R)-1-[(E)-4-piperidin-1-ylbut-2-enoyl]azepan-3-yl]-7,9-dihydroimidazo[4,5-g][1,5]benzoxazepin-2-yl]benzamide;N-[8,8-difluoro-6-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-7,9-dihydroimidazo[4,5-i][1,5]benzoxazepin-2-yl]benzamide;N-[15,15-difluoro-13-methyl-3-[(3R)-1-prop-2-enoylazepan-3-yl]-10-oxa-3,5,13-triazatricyclo[7.6.0.02,6]pentadeca-1(9),2(6),4,7-tetraen-4-yl]-3-methylbenzamide;methane;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylazepan-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide;3-methyl-N-[9-methyl-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]-8,10-dihydro-7H-imidazo[4,5-g][1,4]benzoxazepin-2-yl]benzamide is sourced from PubChem (CID 159911180), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).