3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole

C162H106N18 — CID 159940548

IUPAC3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole
SMILESC1=CC(c2ccc(-c3cn4cccnc4n3)cc2)c2ccc3c(ccc4c(-c5ccccc5)c(-c5ccccc5)n(-c5ccc(-c6cn7ccccc7n6)cc5)c43)c2C1.c1ccc(-c2c(-c3ccccc3)n(-c3ccc(-c4nc5ccccc5n4-c4ccccc4)cc3)c3c2ccc2c4cccc(-c5ccc(-c6cn7cccnc7n6)cc5)c4ccc23)cc1.c1ccc(-c2c(-c3ccccc3)n(-c3cccc(-c4ccncc4)n3)c3c2ccc2c4cccc(-c5ccc(-c6cn7cccnc7n6)cc5)c4ccc23)cc1
InChIInChI=1S/C59H38N6.C53H36N6.C50H32N6/c1-4-14-41(15-5-1)55-51-35-33-49-47-21-12-20-46(39-24-26-40(27-25-39)53-38-63-37-13-36-60-59(63)62-53)48(47)32-34-50(49)57(51)65(56(55)42-16-6-2-7-17-42)45-30-28-43(29-31-45)58-61-52-22-10-11-23-54(52)64(58)44-18-8-3-9-19-44;1-3-11-38(12-4-1)50-46-29-27-44-42-16-9-15-41(35-18-20-36(21-19-35)48-34-58-32-10-30-54-53(58)56-48)43(42)26-28-45(44)52(46)59(51(50)39-13-5-2-6-14-39)40-24-22-37(23-25-40)47-33-57-31-8-7-17-49(57)55-47;1-3-10-36(11-4-1)47-43-25-23-41-39-15-7-14-38(33-18-20-34(21-19-33)45-32-55-31-9-28-52-50(55)54-45)40(39)22-24-42(41)49(43)56(48(47)37-12-5-2-6-13-37)46-17-8-16-44(53-46)35-26-29-51-30-27-35/h1-38H;1-15,17-34,41H,16H2;1-32H
InChIKeyOAUZARWAAZMRIC-UHFFFAOYSA-N
MW2304.76 g/mol
LogP39.14
Rot. Bonds19

About 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole

3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole (PubChem CID 159940548) has the molecular formula C162H106N18 and a molecular weight of 2304.76 g/mol. Its IUPAC name is 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole.

Molecular Properties

Compound Name3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole
PubChem CID159940548
Molecular FormulaC162H106N18
Molecular Weight2304.76 g/mol
Exact Mass2302.88
IUPAC Name3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole
SMILESC1=CC(c2ccc(-c3cn4cccnc4n3)cc2)c2ccc3c(ccc4c(-c5ccccc5)c(-c5ccccc5)n(-c5ccc(-c6cn7ccccc7n6)cc5)c43)c2C1.c1ccc(-c2c(-c3ccccc3)n(-c3ccc(-c4nc5ccccc5n4-c4ccccc4)cc3)c3c2ccc2c4cccc(-c5ccc(-c6cn7cccnc7n6)cc5)c4ccc23)cc1.c1ccc(-c2c(-c3ccccc3)n(-c3cccc(-c4ccncc4)n3)c3c2ccc2c4cccc(-c5ccc(-c6cn7cccnc7n6)cc5)c4ccc23)cc1
InChIInChI=1S/C59H38N6.C53H36N6.C50H32N6/c1-4-14-41(15-5-1)55-51-35-33-49-47-21-12-20-46(39-24-26-40(27-25-39)53-38-63-37-13-36-60-59(63)62-53)48(47)32-34-50(49)57(51)65(56(55)42-16-6-2-7-17-42)45-30-28-43(29-31-45)58-61-52-22-10-11-23-54(52)64(58)44-18-8-3-9-19-44;1-3-11-38(12-4-1)50-46-29-27-44-42-16-9-15-41(35-18-20-36(21-19-35)48-34-58-32-10-30-54-53(58)56-48)43(42)26-28-45(44)52(46)59(51(50)39-13-5-2-6-14-39)40-24-22-37(23-25-40)47-33-57-31-8-7-17-49(57)55-47;1-3-10-36(11-4-1)47-43-25-23-41-39-15-7-14-38(33-18-20-34(21-19-33)45-32-55-31-9-28-52-50(55)54-45)40(39)22-24-42(41)49(43)56(48(47)37-12-5-2-6-13-37)46-17-8-16-44(53-46)35-26-29-51-30-27-35/h1-38H;1-15,17-34,41H,16H2;1-32H
InChIKeyOAUZARWAAZMRIC-UHFFFAOYSA-N
XLogP39.14
TPSA166.26 Ų
H-Bond Donors
H-Bond Acceptors18
Rotatable Bonds19
Heavy Atoms180
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5002304.76
LogP ≤ 539.14
H-Bond Donors ≤ 50
H-Bond Acceptors ≤ 1018

Computed Properties (RDKit)

Structural Alerts{'alert_name': 'isolated_alkene', 'substructure': 'N/A'}, {'alert_name': 'Polycyclic_aromatic_hydrocarbon_3', 'substructure': 'N/A'}

Analyze 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole with MolForge

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Related Compounds

3-[4-(3H-imidazo[1,2-a]pyridin-4-ium-2-yl)phenyl]-6-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-1,2-diphenylnaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole
CID 159098605
1,2-diphenyl-3,7-bis(6-pyridin-4-yl-2-pyridinyl)benzo[e]indole;1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]-7-(6-pyridin-4-yl-2-pyridinyl)benzo[e]indole;3-[3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-1,2-diphenylbenzo[e]indol-7-yl]-1,10-phenanthroline;3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-1,2-diphenyl-7-(6-pyridin-4-yl-2-pyridinyl)benzo[e]indole;3-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-7-(6-pyridin-4-yl-2-pyridinyl)benzo[e]indole
CID 160605946
2,3-diphenyl-1-[4-(1-phenylbenzimidazol-2-yl)phenyl]-6-(6-pyridin-4-yl-2-pyridinyl)benzo[g]indole
CID 58556594
15-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-3,4-diphenyl-5-(6-pyridin-4-yl-2-pyridinyl)-5-azapentacyclo[11.8.0.02,6.07,12.016,21]henicosa-1(13),2(6),3,7,9,11,14,16,18,20-decaene
CID 58454060
1-[4-(3aH-benzimidazol-2-yl)phenyl]-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-2,3-diphenylbenzo[f]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-2,3-diphenyl-1-[4-(1-phenylbenzimidazol-2-yl)phenyl]benzo[f]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-2,3-diphenyl-1-(6-pyridin-4-yl-2-pyridinyl)benzo[f]indole
CID 162061987
3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-9,10-diphenyl-8-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-f]indole;3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-9,10-diphenyl-8-[4-(3-phenylimidazo[1,2-a]pyridin-2-yl)phenyl]naphtho[1,2-f]indole;3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-9,10-diphenyl-8-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-f]indole
CID 158195374
2,3-dimethyl-1,6-bis(6-pyridin-4-yl-2-pyridinyl)benzo[g]indole;2-[4-[1-(9,9-dimethylfluoren-2-yl)-2,3-dimethylbenzo[g]indol-6-yl]phenyl]-1,3-benzoxazole;2-[4-(2,3-dimethyl-1-naphthalen-2-ylbenzo[g]indol-6-yl)phenyl]-1,3-benzoxazole;2,3-dimethyl-1-[4-(1-phenylbenzimidazol-2-yl)phenyl]-6-(6-pyridin-4-yl-2-pyridinyl)benzo[g]indole;1-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-2,3-dimethyl-6-(6-pyridin-4-yl-2-pyridinyl)benzo[g]indole
CID 161045816
2,3-diphenyl-1-[4-(1-phenylbenzimidazol-2-yl)phenyl]-7-(6-pyridin-4-yl-2-pyridinyl)naphtho[2,1-e]indole
CID 58175268
5-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-7-phenylindolo[2,3-b]carbazole;5-[4-(1,10-phenanthrolin-2-yl)phenyl]-7-phenylindolo[2,3-b]carbazole;7-phenyl-5-[4-(1-phenylbenzimidazol-2-yl)phenyl]indolo[2,3-b]carbazole;7-phenyl-5-[4-(2-phenylbenzimidazol-1-yl)phenyl]indolo[2,3-b]carbazole
CID 161320232
9-phenyl-16-[4-(1-phenylbenzimidazol-2-yl)phenyl]-4,9-diazahexacyclo[13.6.2.02,10.03,8.012,22.019,23]tricosa-1(22),2(10),3(8),4,6,11,13,15,17,19(23),20-undecaene;9-phenyl-16-(6-pyridin-4-yl-2-pyridinyl)-4,9-diazahexacyclo[13.6.2.02,10.03,8.012,22.019,23]tricosa-1(22),2(10),3(8),4,6,11,13,15,17,19(23),20-undecaene;9-(6-pyridin-4-yl-2-pyridinyl)-4,9-diazahexacyclo[13.6.2.02,10.03,8.012,22.019,23]tricosa-1(22),2(10),3(8),4,6,11,13,15(23),16,18,20-undecaene
CID 160774939
3,4-dimethyl-5-[4-(1-phenylbenzimidazol-2-yl)phenyl]-15-(6-pyridin-4-yl-2-pyridinyl)-5-azapentacyclo[11.8.0.02,6.07,12.016,21]henicosa-1(13),2(6),3,7,9,11,14,16,18,20-decaene
CID 58454119
5,22-diphenyl-18-[4-(1-phenylbenzimidazol-2-yl)phenyl]-9-thia-18-azahexacyclo[15.7.0.02,10.03,8.011,16.019,24]tetracosa-1(17),2(10),3(8),4,6,11,13,15,19(24),20,22-undecaene;18-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-5,22-diphenyl-9-thia-18-azahexacyclo[15.7.0.02,10.03,8.011,16.019,24]tetracosa-1(17),2(10),3(8),4,6,11,13,15,19(24),20,22-undecaene
CID 158353313

Frequently Asked Questions

What is the IUPAC name of 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole?
The IUPAC name of 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole (CID 159940548) is 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole.
What is the SMILES notation for 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole?
The canonical SMILES for 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole is C1=CC(c2ccc(-c3cn4cccnc4n3)cc2)c2ccc3c(ccc4c(-c5ccccc5)c(-c5ccccc5)n(-c5ccc(-c6cn7ccccc7n6)cc5)c43)c2C1.c1ccc(-c2c(-c3ccccc3)n(-c3ccc(-c4nc5ccccc5n4-c4ccccc4)cc3)c3c2ccc2c4cccc(-c5ccc(-c6cn7cccnc7n6)cc5)c4ccc23)cc1.c1ccc(-c2c(-c3ccccc3)n(-c3cccc(-c4ccncc4)n3)c3c2ccc2c4cccc(-c5ccc(-c6cn7cccnc7n6)cc5)c4ccc23)cc1.
What is the InChIKey of 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole?
The InChIKey is OAUZARWAAZMRIC-UHFFFAOYSA-N. The full InChI is InChI=1S/C59H38N6.C53H36N6.C50H32N6/c1-4-14-41(15-5-1)55-51-35-33-49-47-21-12-20-46(39-24-26-40(27-25-39)53-38-63-37-13-36-60-59(63)62-53)48(47)32-34-50(49)57(51)65(56(55)42-16-6-2-7-17-42)45-30-28-43(29-31-45)58-61-52-22-10-11-23-54(52)64(58)44-18-8-3-9-19-44;1-3-11-38(12-4-1)50-46-29-27-44-42-16-9-15-41(35-18-20-36(21-19-35)48-34-58-32-10-30-54-53(58)56-48)43(42)26-28-45(44)52(46)59(51(50)39-13-5-2-6-14-39)40-24-22-37(23-25-40)47-33-57-31-8-7-17-49(57)55-47;1-3-10-36(11-4-1)47-43-25-23-41-39-15-7-14-38(33-18-20-34(21-19-33)45-32-55-31-9-28-52-50(55)54-45)40(39)22-24-42(41)49(43)56(48(47)37-12-5-2-6-13-37)46-17-8-16-44(53-46)35-26-29-51-30-27-35/h1-38H;1-15,17-34,41H,16H2;1-32H.
What are the key properties of 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole?
3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole has a molecular weight of 2304.76 g/mol, XLogP of 39.14, 19 rotatable bonds, 0 hydrogen bond donors, and 18 hydrogen bond acceptors.
Where does this data come from?
All data for 3-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-6,9-dihydronaphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-[4-(1-phenylbenzimidazol-2-yl)phenyl]naphtho[1,2-g]indole;6-(4-imidazo[1,2-a]pyrimidin-2-ylphenyl)-1,2-diphenyl-3-(6-pyridin-4-yl-2-pyridinyl)naphtho[1,2-g]indole is sourced from PubChem (CID 159940548), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).