2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

C99H106Cl3F7N40O8 — CID 159972957

IUPAC2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
SMILESCN1CCN(c2c(NC(=O)c3c(N)nn4cc(F)cnc34)cncc2C(F)F)CC1.Nc1nn2cc(Cl)cnc2c1C(=O)Nc1cnccc1N1CCC(N2CC(F)(F)C2)CC1.Nc1nn2cc(Cl)cnc2c1C(=O)Nc1cnccc1N1CCC(N2CCC23COC3)CC1.Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(Cl)c1N1CCN(C2COC2)CC1.Nc1nn2cc(F)cnc2c1C(=O)Nc1cnccc1N1CCN(C2COC2)C2CC21
InChIInChI=1S/C22H25ClN8O2.C20H21ClF2N8O.C20H21FN8O2.C19H20ClFN8O2.C18H19F3N8O/c23-14-9-26-20-18(19(24)28-31(20)11-14)21(32)27-16-10-25-5-1-17(16)29-6-2-15(3-7-29)30-8-4-22(30)12-33-13-22;21-12-7-26-18-16(17(24)28-31(18)9-12)19(32)27-14-8-25-4-1-15(14)29-5-2-13(3-6-29)30-10-20(22,23)11-30;21-11-6-24-19-17(18(22)26-29(19)8-11)20(30)25-13-7-23-2-1-14(13)28-4-3-27(12-9-31-10-12)15-5-16(15)28;20-13-6-23-7-14(16(13)28-3-1-27(2-4-28)12-9-31-10-12)25-19(30)15-17(22)26-29-8-11(21)5-24-18(15)29;1-27-2-4-28(5-3-27)14-11(15(20)21)7-23-8-12(14)25-18(30)13-16(22)26-29-9-10(19)6-24-17(13)29/h1,5,9-11,15H,2-4,6-8,12-13H2,(H2,24,28)(H,27,32);1,4,7-9,13H,2-3,5-6,10-11H2,(H2,24,28)(H,27,32);1-2,6-8,12,15-16H,3-5,9-10H2,(H2,22,26)(H,25,30);5-8,12H,1-4,9-10H2,(H2,22,26)(H,25,30);6-9,15H,2-5H2,1H3,(H2,22,26)(H,25,30)
InChIKeyOEUDZXJPXITDCG-UHFFFAOYSA-N
MW2223.55 g/mol
LogP8.41
Rot. Bonds20

About 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (PubChem CID 159972957) has the molecular formula C99H106Cl3F7N40O8 and a molecular weight of 2223.55 g/mol. Its IUPAC name is 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide.

Molecular Properties

Compound Name2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
PubChem CID159972957
Molecular FormulaC99H106Cl3F7N40O8
Molecular Weight2223.55 g/mol
Exact Mass2220.81
IUPAC Name2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
SMILESCN1CCN(c2c(NC(=O)c3c(N)nn4cc(F)cnc34)cncc2C(F)F)CC1.Nc1nn2cc(Cl)cnc2c1C(=O)Nc1cnccc1N1CCC(N2CC(F)(F)C2)CC1.Nc1nn2cc(Cl)cnc2c1C(=O)Nc1cnccc1N1CCC(N2CCC23COC3)CC1.Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(Cl)c1N1CCN(C2COC2)CC1.Nc1nn2cc(F)cnc2c1C(=O)Nc1cnccc1N1CCN(C2COC2)C2CC21
InChIInChI=1S/C22H25ClN8O2.C20H21ClF2N8O.C20H21FN8O2.C19H20ClFN8O2.C18H19F3N8O/c23-14-9-26-20-18(19(24)28-31(20)11-14)21(32)27-16-10-25-5-1-17(16)29-6-2-15(3-7-29)30-8-4-22(30)12-33-13-22;21-12-7-26-18-16(17(24)28-31(18)9-12)19(32)27-14-8-25-4-1-15(14)29-5-2-13(3-6-29)30-10-20(22,23)11-30;21-11-6-24-19-17(18(22)26-29(19)8-11)20(30)25-13-7-23-2-1-14(13)28-4-3-27(12-9-31-10-12)15-5-16(15)28;20-13-6-23-7-14(16(13)28-3-1-27(2-4-28)12-9-31-10-12)25-19(30)15-17(22)26-29-8-11(21)5-24-18(15)29;1-27-2-4-28(5-3-27)14-11(15(20)21)7-23-8-12(14)25-18(30)13-16(22)26-29-9-10(19)6-24-17(13)29/h1,5,9-11,15H,2-4,6-8,12-13H2,(H2,24,28)(H,27,32);1,4,7-9,13H,2-3,5-6,10-11H2,(H2,24,28)(H,27,32);1-2,6-8,12,15-16H,3-5,9-10H2,(H2,22,26)(H,25,30);5-8,12H,1-4,9-10H2,(H2,22,26)(H,25,30);6-9,15H,2-5H2,1H3,(H2,22,26)(H,25,30)
InChIKeyOEUDZXJPXITDCG-UHFFFAOYSA-N
XLogP8.41
TPSA551.09 Ų
H-Bond Donors10
H-Bond Acceptors43
Rotatable Bonds20
Heavy Atoms157
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5002223.55
LogP ≤ 58.41
H-Bond Donors ≤ 510
H-Bond Acceptors ≤ 1043

Analyze 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide with MolForge

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Launch Full Analysis

Related Compounds

2-amino-6-chloro-N-(4-imidazol-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-(2-methylimidazol-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-(4-pyrazol-1-yl-3-pyridinyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[4-(trifluoromethyl)imidazol-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 157592250
2-amino-N-[4-[4-[(5S)-1,4-diazabicyclo[3.2.1]octane-4-carbonyl]piperidin-1-yl]-5-fluoro-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[4-[(5R)-1,4-diazabicyclo[3.2.1]octane-4-carbonyl]piperidin-1-yl]-5-fluoro-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[4-(3,3-difluoroazetidine-1-carbonyl)piperidin-1-yl]-5-fluoro-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 158234125
2-amino-N-[4-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(4-ethylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[4-(oxolan-3-yl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 158684303
2-[4-[[8-[8-[(4-Chlorophenyl)methyl]-8-azabicyclo[3.2.1]oct-2-en-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]pyrazol-1-yl]-1-(4-methylpiperazin-1-yl)ethanone;4,4,4-trifluoro-1-[3-[2-[[1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]pyrazol-4-yl]amino]-[1,2,4]triazolo[1,5-a]pyridin-8-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl]butan-1-one;4,4,4-trifluoro-1-[3-[2-[[1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]pyrazol-4-yl]amino]-[1,2,4]triazolo[1,5-a]pyridin-8-yl]-3,6-diazabicyclo[3.1.1]heptan-6-yl]butan-1-one;4,4,4-trifluoro-1-[5-[2-[[1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]pyrazol-4-yl]amino]-[1,2,4]triazolo[1,5-a]pyridin-8-yl]-2,5-diazabicyclo[2.2.2]octan-2-yl]butan-1-one;4,4,4-trifluoro-1-[8-[2-[[1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]pyrazol-4-yl]amino]-[1,2,4]triazolo[1,5-a]pyridin-8-yl]-3,8-diazabicyclo[3.2.1]octan-3-yl]butan-1-one
CID 159616046
2-tert-butyl-6-chloroimidazo[1,2-b]pyridazine;1-[4-[4-tert-butyl-6-(cyclobutylamino)-2-pyridinyl]piperazin-1-yl]ethanone;4-tert-butyl-5-methyl-2-[(1-methylazetidin-3-yl)methyl]pyridine;4-tert-butyl-5-methyl-2-[(1-methylpyrrolidin-3-yl)methyl]pyridine;6-tert-butyl-2-methyl-N-(oxetan-3-yl)pyrimidin-4-amine;4-tert-butyl-5-methyl-2-(pyrrolidin-3-ylmethyl)pyridine;4-tert-butyl-5-methyl-2-[[1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]methyl]pyridine;6-tert-butyl-N-(oxetan-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine;1-[4-[(6-tert-butylpyrimidin-4-yl)amino]piperidin-1-yl]propan-1-one
CID 159657688
2-amino-N-[4-[4-(3-cyanoazetidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[4-(3,3-difluoroazetidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[4-(3-methoxyazetidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[4-(3-methoxy-3-methylazetidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 159948364
2-tert-butyl-6-chloroimidazo[1,2-b]pyridazine;4-tert-butyl-2-[[1-(2,2-difluoropropyl)pyrrolidin-3-yl]methyl]-5-methylpyridine;4-tert-butyl-5-methyl-2-[(1-methylazetidin-3-yl)methyl]pyridine;4-tert-butyl-5-methyl-2-[(1-methylpyrrolidin-3-yl)methyl]pyridine;6-tert-butyl-2-methyl-N-(oxetan-3-yl)pyrimidin-4-amine;4-tert-butyl-5-methyl-2-(pyrrolidin-3-ylmethyl)pyridine;6-tert-butyl-N-(oxetan-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine;1-[4-[(6-tert-butylpyrimidin-4-yl)amino]piperidin-1-yl]butan-1-one;1-[4-[(6-tert-butylpyrimidin-4-yl)amino]piperidin-1-yl]propan-1-one
CID 159982810
2-tert-butyl-6-chloroimidazo[1,2-b]pyridazine;1-[4-[4-tert-butyl-6-(cyclobutylamino)-2-pyridinyl]piperazin-1-yl]ethanone;4-tert-butyl-5-methyl-2-[(1-methylazetidin-3-yl)methyl]pyridine;4-tert-butyl-5-methyl-2-[(1-methylpyrrolidin-3-yl)methyl]pyridine;6-tert-butyl-2-methyl-N-(oxetan-3-yl)pyrimidin-4-amine;4-tert-butyl-5-methyl-2-(pyrrolidin-3-ylmethyl)pyridine;4-tert-butyl-5-methyl-2-[[1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]methyl]pyridine;6-tert-butyl-N-(oxetan-3-yl)-2-(trifluoromethyl)pyrimidin-4-amine;1-[4-[(6-tert-butylpyrimidin-4-yl)amino]piperidin-1-yl]propan-1-one;methane
CID 161019157
2-amino-N-[4-(2-chloro-3-pyridinyl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[1-(1-methylpiperidine-4-carbonyl)-3,6-dihydro-2H-pyridin-4-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-(6-fluoro-2-methyl-3-pyridinyl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-(2-fluoro-3-pyridinyl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-(4-methylpyridazin-3-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-(3-methyl-2-pyridinyl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 157150088
2-amino-N-[4-[4-[4-(azetidin-1-yl)piperidine-1-carbonyl]piperidin-1-yl]-5-fluoro-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(1,4-diazabicyclo[3.2.1]octane-4-carbonyl)piperidin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(3-fluoroazetidine-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 157263355
2-amino-N-[5-chloro-4-[4-(oxolan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-piperazin-1-yl-3-pyridinyl)-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(2-methoxyethyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-[(3S)-oxolan-3-yl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-methyl-4-[4-(oxan-4-yl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CID 157595567
2-amino-6-fluoro-N-[5-fluoro-4-[4-[3-(methoxymethyl)azetidine-1-carbonyl]piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(1-methylazetidin-3-yl)piperazine-1-carbonyl]piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[5-fluoro-4-[4-(4-methylpiperazin-4-ium-1-carbonyl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[4-[(3S)-3-methoxypyrrolidine-1-carbonyl]piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;hydroxide
CID 157606911

Frequently Asked Questions

What is the IUPAC name of 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
The IUPAC name of 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (CID 159972957) is 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide.
What is the SMILES notation for 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
The canonical SMILES for 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide is CN1CCN(c2c(NC(=O)c3c(N)nn4cc(F)cnc34)cncc2C(F)F)CC1.Nc1nn2cc(Cl)cnc2c1C(=O)Nc1cnccc1N1CCC(N2CC(F)(F)C2)CC1.Nc1nn2cc(Cl)cnc2c1C(=O)Nc1cnccc1N1CCC(N2CCC23COC3)CC1.Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(Cl)c1N1CCN(C2COC2)CC1.Nc1nn2cc(F)cnc2c1C(=O)Nc1cnccc1N1CCN(C2COC2)C2CC21.
What is the InChIKey of 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
The InChIKey is OEUDZXJPXITDCG-UHFFFAOYSA-N. The full InChI is InChI=1S/C22H25ClN8O2.C20H21ClF2N8O.C20H21FN8O2.C19H20ClFN8O2.C18H19F3N8O/c23-14-9-26-20-18(19(24)28-31(20)11-14)21(32)27-16-10-25-5-1-17(16)29-6-2-15(3-7-29)30-8-4-22(30)12-33-13-22;21-12-7-26-18-16(17(24)28-31(18)9-12)19(32)27-14-8-25-4-1-15(14)29-5-2-13(3-6-29)30-10-20(22,23)11-30;21-11-6-24-19-17(18(22)26-29(19)8-11)20(30)25-13-7-23-2-1-14(13)28-4-3-27(12-9-31-10-12)15-5-16(15)28;20-13-6-23-7-14(16(13)28-3-1-27(2-4-28)12-9-31-10-12)25-19(30)15-17(22)26-29-8-11(21)5-24-18(15)29;1-27-2-4-28(5-3-27)14-11(15(20)21)7-23-8-12(14)25-18(30)13-16(22)26-29-9-10(19)6-24-17(13)29/h1,5,9-11,15H,2-4,6-8,12-13H2,(H2,24,28)(H,27,32);1,4,7-9,13H,2-3,5-6,10-11H2,(H2,24,28)(H,27,32);1-2,6-8,12,15-16H,3-5,9-10H2,(H2,22,26)(H,25,30);5-8,12H,1-4,9-10H2,(H2,22,26)(H,25,30);6-9,15H,2-5H2,1H3,(H2,22,26)(H,25,30).
What are the key properties of 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide?
2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide has a molecular weight of 2223.55 g/mol, XLogP of 8.41, 20 rotatable bonds, 10 hydrogen bond donors, and 43 hydrogen bond acceptors.
Where does this data come from?
All data for 2-amino-6-chloro-N-[4-[4-(3,3-difluoroazetidin-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-chloro-N-[4-[4-(6-oxa-1-azaspiro[3.3]heptan-1-yl)piperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-[4-(oxetan-3-yl)piperazin-1-yl]-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-(difluoromethyl)-4-(4-methylpiperazin-1-yl)-3-pyridinyl]-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-6-fluoro-N-[4-[5-(oxetan-3-yl)-2,5-diazabicyclo[4.1.0]heptan-2-yl]-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide is sourced from PubChem (CID 159972957), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).