7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

C254H294F13N57O17 — CID 160533088

IUPAC7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4c2cnn4C)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4cn[nH]c24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4cnn(C)c24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cc(F)c(F)cc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cc(O)ccc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cnccc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@H]1C
InChIInChI=1S/C33H35F3N6O2.C33H37FN6O3.2C32H39FN8O2.C32H36FN7O2.2C31H37FN8O2.C30H34F4N6O2/c1-20-17-41(12-13-42(20)33(43)21(2)34)31-24-9-11-40(30-8-4-6-22-14-27(35)28(36)15-25(22)30)18-29(24)38-32(26(31)16-37)44-19-23-7-5-10-39(23)3;1-21-18-39(14-15-40(21)33(42)22(2)34)31-27-11-13-38(30-8-4-6-23-16-25(41)9-10-26(23)30)19-29(27)36-32(28(31)17-35)43-20-24-7-5-12-37(24)3;1-20-8-9-23-16-35-38(5)29(23)28(20)39-12-10-25-27(18-39)36-31(43-19-24-7-6-11-37(24)4)26(15-34)30(25)40-13-14-41(21(2)17-40)32(42)22(3)33;1-20-8-9-28-26(16-35-38(28)5)29(20)39-12-10-24-27(18-39)36-31(43-19-23-7-6-11-37(23)4)25(15-34)30(24)40-13-14-41(21(2)17-40)32(42)22(3)33;1-21-18-39(14-15-40(21)32(41)22(2)33)30-26-10-13-38(29-8-4-6-23-17-35-11-9-25(23)29)19-28(26)36-31(27(30)16-34)42-20-24-7-5-12-37(24)3;1-19-7-8-22-15-34-36-27(22)28(19)38-11-9-24-26(17-38)35-30(42-18-23-6-5-10-37(23)4)25(14-33)29(24)39-12-13-40(20(2)16-39)31(41)21(3)32;1-19-7-8-26-25(15-34-36-26)28(19)38-11-9-23-27(17-38)35-30(42-18-22-6-5-10-37(22)4)24(14-33)29(23)39-12-13-40(20(2)16-39)31(41)21(3)32;1-19-16-39(13-14-40(19)29(41)20(2)31)27-22-10-12-38(26-9-5-4-8-24(26)30(32,33)34)17-25(22)36-28(23(27)15-35)42-18-21-7-6-11-37(21)3/h4,6,8,14-15,20,23H,2,5,7,9-13,17-19H2,1,3H3;4,6,8-10,16,21,24,41H,2,5,7,11-15,18-20H2,1,3H3;8-9,16,21,24H,3,6-7,10-14,17-19H2,1-2,4-5H3;8-9,16,21,23H,3,6-7,10-14,17-19H2,1-2,4-5H3;4,6,8-9,11,17,21,24H,2,5,7,10,12-15,18-20H2,1,3H3;7-8,15,20,23H,3,5-6,9-13,16-18H2,1-2,4H3,(H,34,36);7-8,15,20,22H,3,5-6,9-13,16-18H2,1-2,4H3,(H,34,36);4-5,8-9,19,21H,2,6-7,10-14,16-18H2,1,3H3/t20-,23+;2*21-,24+;21-,23+;21-,24+;20-,23+;20-,22+;19-,21+/m11111111/s1
InChIKeyQVUONGXFCWMUPF-FFLRLTSQSA-N
MW4664.50 g/mol
LogP32.69
Rot. Bonds48

About 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (PubChem CID 160533088) has the molecular formula C254H294F13N57O17 and a molecular weight of 4664.50 g/mol. Its IUPAC name is 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.

Molecular Properties

Compound Name7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
PubChem CID160533088
Molecular FormulaC254H294F13N57O17
Molecular Weight4664.50 g/mol
Exact Mass4661.37
IUPAC Name7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4c2cnn4C)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4cn[nH]c24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4cnn(C)c24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cc(F)c(F)cc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cc(O)ccc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cnccc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@H]1C
InChIInChI=1S/C33H35F3N6O2.C33H37FN6O3.2C32H39FN8O2.C32H36FN7O2.2C31H37FN8O2.C30H34F4N6O2/c1-20-17-41(12-13-42(20)33(43)21(2)34)31-24-9-11-40(30-8-4-6-22-14-27(35)28(36)15-25(22)30)18-29(24)38-32(26(31)16-37)44-19-23-7-5-10-39(23)3;1-21-18-39(14-15-40(21)33(42)22(2)34)31-27-11-13-38(30-8-4-6-23-16-25(41)9-10-26(23)30)19-29(27)36-32(28(31)17-35)43-20-24-7-5-12-37(24)3;1-20-8-9-23-16-35-38(5)29(23)28(20)39-12-10-25-27(18-39)36-31(43-19-24-7-6-11-37(24)4)26(15-34)30(25)40-13-14-41(21(2)17-40)32(42)22(3)33;1-20-8-9-28-26(16-35-38(28)5)29(20)39-12-10-24-27(18-39)36-31(43-19-23-7-6-11-37(23)4)25(15-34)30(24)40-13-14-41(21(2)17-40)32(42)22(3)33;1-21-18-39(14-15-40(21)32(41)22(2)33)30-26-10-13-38(29-8-4-6-23-17-35-11-9-25(23)29)19-28(26)36-31(27(30)16-34)42-20-24-7-5-12-37(24)3;1-19-7-8-22-15-34-36-27(22)28(19)38-11-9-24-26(17-38)35-30(42-18-23-6-5-10-37(23)4)25(14-33)29(24)39-12-13-40(20(2)16-39)31(41)21(3)32;1-19-7-8-26-25(15-34-36-26)28(19)38-11-9-23-27(17-38)35-30(42-18-22-6-5-10-37(22)4)24(14-33)29(23)39-12-13-40(20(2)16-39)31(41)21(3)32;1-19-16-39(13-14-40(19)29(41)20(2)31)27-22-10-12-38(26-9-5-4-8-24(26)30(32,33)34)17-25(22)36-28(23(27)15-35)42-18-21-7-6-11-37(21)3/h4,6,8,14-15,20,23H,2,5,7,9-13,17-19H2,1,3H3;4,6,8-10,16,21,24,41H,2,5,7,11-15,18-20H2,1,3H3;8-9,16,21,24H,3,6-7,10-14,17-19H2,1-2,4-5H3;8-9,16,21,23H,3,6-7,10-14,17-19H2,1-2,4-5H3;4,6,8-9,11,17,21,24H,2,5,7,10,12-15,18-20H2,1,3H3;7-8,15,20,23H,3,5-6,9-13,16-18H2,1-2,4H3,(H,34,36);7-8,15,20,22H,3,5-6,9-13,16-18H2,1-2,4H3,(H,34,36);4-5,8-9,19,21H,2,6-7,10-14,16-18H2,1,3H3/t20-,23+;2*21-,24+;21-,23+;21-,24+;20-,23+;20-,22+;19-,21+/m11111111/s1
InChIKeyQVUONGXFCWMUPF-FFLRLTSQSA-N
XLogP32.69
TPSA733.64 Ų
H-Bond Donors3
H-Bond Acceptors64
Rotatable Bonds48
Heavy Atoms341
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5004664.50
LogP ≤ 532.69
H-Bond Donors ≤ 53
H-Bond Acceptors ≤ 1064

Analyze 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile with MolForge

Explore ADMET properties, 3D molecular structure, drug-likeness score, and discover similar compounds using our AI-powered platform.

Launch Full Analysis

Frequently Asked Questions

What is the IUPAC name of 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The IUPAC name of 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (CID 160533088) is 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.
What is the SMILES notation for 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The canonical SMILES for 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4[nH]ncc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4c2cnn4C)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4cn[nH]c24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2c(C)ccc4cnn(C)c24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cc(F)c(F)cc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cc(O)ccc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cnccc24)C3)C[C@H]1C.C=C(F)C(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2ccccc2C(F)(F)F)C3)C[C@H]1C.
What is the InChIKey of 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The InChIKey is QVUONGXFCWMUPF-FFLRLTSQSA-N. The full InChI is InChI=1S/C33H35F3N6O2.C33H37FN6O3.2C32H39FN8O2.C32H36FN7O2.2C31H37FN8O2.C30H34F4N6O2/c1-20-17-41(12-13-42(20)33(43)21(2)34)31-24-9-11-40(30-8-4-6-22-14-27(35)28(36)15-25(22)30)18-29(24)38-32(26(31)16-37)44-19-23-7-5-10-39(23)3;1-21-18-39(14-15-40(21)33(42)22(2)34)31-27-11-13-38(30-8-4-6-23-16-25(41)9-10-26(23)30)19-29(27)36-32(28(31)17-35)43-20-24-7-5-12-37(24)3;1-20-8-9-23-16-35-38(5)29(23)28(20)39-12-10-25-27(18-39)36-31(43-19-24-7-6-11-37(24)4)26(15-34)30(25)40-13-14-41(21(2)17-40)32(42)22(3)33;1-20-8-9-28-26(16-35-38(28)5)29(20)39-12-10-24-27(18-39)36-31(43-19-23-7-6-11-37(23)4)25(15-34)30(24)40-13-14-41(21(2)17-40)32(42)22(3)33;1-21-18-39(14-15-40(21)32(41)22(2)33)30-26-10-13-38(29-8-4-6-23-17-35-11-9-25(23)29)19-28(26)36-31(27(30)16-34)42-20-24-7-5-12-37(24)3;1-19-7-8-22-15-34-36-27(22)28(19)38-11-9-24-26(17-38)35-30(42-18-23-6-5-10-37(23)4)25(14-33)29(24)39-12-13-40(20(2)16-39)31(41)21(3)32;1-19-7-8-26-25(15-34-36-26)28(19)38-11-9-23-27(17-38)35-30(42-18-22-6-5-10-37(22)4)24(14-33)29(23)39-12-13-40(20(2)16-39)31(41)21(3)32;1-19-16-39(13-14-40(19)29(41)20(2)31)27-22-10-12-38(26-9-5-4-8-24(26)30(32,33)34)17-25(22)36-28(23(27)15-35)42-18-21-7-6-11-37(21)3/h4,6,8,14-15,20,23H,2,5,7,9-13,17-19H2,1,3H3;4,6,8-10,16,21,24,41H,2,5,7,11-15,18-20H2,1,3H3;8-9,16,21,24H,3,6-7,10-14,17-19H2,1-2,4-5H3;8-9,16,21,23H,3,6-7,10-14,17-19H2,1-2,4-5H3;4,6,8-9,11,17,21,24H,2,5,7,10,12-15,18-20H2,1,3H3;7-8,15,20,23H,3,5-6,9-13,16-18H2,1-2,4H3,(H,34,36);7-8,15,20,22H,3,5-6,9-13,16-18H2,1-2,4H3,(H,34,36);4-5,8-9,19,21H,2,6-7,10-14,16-18H2,1,3H3/t20-,23+;2*21-,24+;21-,23+;21-,24+;20-,23+;20-,22+;19-,21+/m11111111/s1.
What are the key properties of 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile has a molecular weight of 4664.50 g/mol, XLogP of 32.69, 48 rotatable bonds, 3 hydrogen bond donors, and 64 hydrogen bond acceptors.
Where does this data come from?
All data for 7-(6,7-difluoronaphthalen-1-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,5-dimethylindazol-4-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(1,6-dimethylindazol-7-yl)-4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-isoquinolin-5-yl-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-7-(6-methyl-1H-indazol-7-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-[(3R)-4-(2-fluoroprop-2-enoyl)-3-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7-[2-(trifluoromethyl)phenyl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is sourced from PubChem (CID 160533088), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).