N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide

C84H105F7N24O4 — CID 160602073

IUPACN-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide
SMILESCc1ncc(-c2cc(F)c3n[nH]c(C(=O)NC4CCN(CC(C)F)CC4)c3c2)n1C.Cc1ncc(-c2cc(F)c3n[nH]c(C(=O)N[C@H]4CCN(CC(C)C)C[C@@H]4F)c3c2)n1C.Cn1cc(-c2cc(F)c3n[nH]c(C(=O)NC4CCN(CC(C)(C)C)CC4)c3c2)cn1.Cn1cc(-c2ccc3[nH]nc(C(=O)NCC(F)(F)CN4CCCC4)c3c2)cn1
InChIInChI=1S/C22H28F2N6O.C22H29FN6O.C21H26F2N6O.C19H22F2N6O/c1-12(2)10-30-6-5-18(17(24)11-30)26-22(31)21-15-7-14(8-16(23)20(15)27-28-21)19-9-25-13(3)29(19)4;1-22(2,3)13-29-7-5-16(6-8-29)25-21(30)20-17-9-14(15-11-24-28(4)12-15)10-18(23)19(17)26-27-20;1-12(22)11-29-6-4-15(5-7-29)25-21(30)20-16-8-14(9-17(23)19(16)26-27-20)18-10-24-13(2)28(18)3;1-26-10-14(9-23-26)13-4-5-16-15(8-13)17(25-24-16)18(28)22-11-19(20,21)12-27-6-2-3-7-27/h7-9,12,17-18H,5-6,10-11H2,1-4H3,(H,26,31)(H,27,28);9-12,16H,5-8,13H2,1-4H3,(H,25,30)(H,26,27);8-10,12,15H,4-7,11H2,1-3H3,(H,25,30)(H,26,27);4-5,8-10H,2-3,6-7,11-12H2,1H3,(H,22,28)(H,24,25)/t17-,18-;;;/m0.../s1
InChIKeyREKFISHUMOJUFT-NCXIRTITSA-N
MW1647.91 g/mol
LogP11.94
Rot. Bonds20

About N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide

N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide (PubChem CID 160602073) has the molecular formula C84H105F7N24O4 and a molecular weight of 1647.91 g/mol. Its IUPAC name is N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide.

Molecular Properties

Compound NameN-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide
PubChem CID160602073
Molecular FormulaC84H105F7N24O4
Molecular Weight1647.91 g/mol
Exact Mass1646.86
IUPAC NameN-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide
SMILESCc1ncc(-c2cc(F)c3n[nH]c(C(=O)NC4CCN(CC(C)F)CC4)c3c2)n1C.Cc1ncc(-c2cc(F)c3n[nH]c(C(=O)N[C@H]4CCN(CC(C)C)C[C@@H]4F)c3c2)n1C.Cn1cc(-c2cc(F)c3n[nH]c(C(=O)NC4CCN(CC(C)(C)C)CC4)c3c2)cn1.Cn1cc(-c2ccc3[nH]nc(C(=O)NCC(F)(F)CN4CCCC4)c3c2)cn1
InChIInChI=1S/C22H28F2N6O.C22H29FN6O.C21H26F2N6O.C19H22F2N6O/c1-12(2)10-30-6-5-18(17(24)11-30)26-22(31)21-15-7-14(8-16(23)20(15)27-28-21)19-9-25-13(3)29(19)4;1-22(2,3)13-29-7-5-16(6-8-29)25-21(30)20-17-9-14(15-11-24-28(4)12-15)10-18(23)19(17)26-27-20;1-12(22)11-29-6-4-15(5-7-29)25-21(30)20-16-8-14(9-17(23)19(16)26-27-20)18-10-24-13(2)28(18)3;1-26-10-14(9-23-26)13-4-5-16-15(8-13)17(25-24-16)18(28)22-11-19(20,21)12-27-6-2-3-7-27/h7-9,12,17-18H,5-6,10-11H2,1-4H3,(H,26,31)(H,27,28);9-12,16H,5-8,13H2,1-4H3,(H,25,30)(H,26,27);8-10,12,15H,4-7,11H2,1-3H3,(H,25,30)(H,26,27);4-5,8-10H,2-3,6-7,11-12H2,1H3,(H,22,28)(H,24,25)/t17-,18-;;;/m0.../s1
InChIKeyREKFISHUMOJUFT-NCXIRTITSA-N
XLogP11.94
TPSA315.36 Ų
H-Bond Donors8
H-Bond Acceptors20
Rotatable Bonds20
Heavy Atoms119
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5001647.91
LogP ≤ 511.94
H-Bond Donors ≤ 58
H-Bond Acceptors ≤ 1020

Analyze N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide with MolForge

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Related Compounds

CRAF inhibitor
CID 127039888
5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]pyridin-3-yl]-N-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1H-indazole-3-carboxamide
CID 89450403
5-[5-[(2,6-difluorobenzoyl)amino]-3-pyridinyl]-N-[6-(4-methylpiperazin-1-yl)-3-pyridinyl]-1H-indazole-3-carboxamide
CID 118381143
6-fluoro-N-[6-[(1-methylpiperidin-4-yl)amino]-3-pyridinyl]-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide
CID 154654845
1-(2-((2S,4R)-2-(6-(1H-pyrazol-4-yl)pyridin-2-ylcarbamoyl)-4-fluoropyrrolidin-1-yl)-2-oxoethyl)-5-(pyrimidin-2-ylethynyl)-1H-indazole-3-carboxamide
CID 118322929
N-[1-(2-fluoro-2-methylpropyl)piperidin-4-yl]-5-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide
CID 118381438
US10822352, Comp No. 640
CID 126642807
(2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(((3S,5S,7S)-adamantan-1-yl)methyl)-4-fluoropyrrolidine-2-carboxamide
CID 126642827
(1R,3S,5R)-2-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(1-(2,2,2-trifluoroethyl) pyrrolidin-3-yl)-2-azabicyclo[3.1.0] hexane-3-carboxamide
CID 126643098
(2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrazolo[1,5-a]pyrimidin-6-yl)-1H-indazol-1-yl)acetyl)-4-fluoro-N-(6-(trifluoromethyl) pyrazin-2-yl)pyrrolidine-2-carboxamide
CID 126643128
(2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-4-fluoro-N-(6-(trifluoromethyl) pyrazin-2-yl)pyrrolidine-2-carboxamide
CID 126643379
(2S,4R)-N-(1-(1H-pyrazole-4-carbonyl)piperidin-4-yl)-1-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-4-fluoropyrrolidine-2-carboxamide
CID 126643502

Frequently Asked Questions

What is the IUPAC name of N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide?
The IUPAC name of N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide (CID 160602073) is N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide.
What is the SMILES notation for N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide?
The canonical SMILES for N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide is Cc1ncc(-c2cc(F)c3n[nH]c(C(=O)NC4CCN(CC(C)F)CC4)c3c2)n1C.Cc1ncc(-c2cc(F)c3n[nH]c(C(=O)N[C@H]4CCN(CC(C)C)C[C@@H]4F)c3c2)n1C.Cn1cc(-c2cc(F)c3n[nH]c(C(=O)NC4CCN(CC(C)(C)C)CC4)c3c2)cn1.Cn1cc(-c2ccc3[nH]nc(C(=O)NCC(F)(F)CN4CCCC4)c3c2)cn1.
What is the InChIKey of N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide?
The InChIKey is REKFISHUMOJUFT-NCXIRTITSA-N. The full InChI is InChI=1S/C22H28F2N6O.C22H29FN6O.C21H26F2N6O.C19H22F2N6O/c1-12(2)10-30-6-5-18(17(24)11-30)26-22(31)21-15-7-14(8-16(23)20(15)27-28-21)19-9-25-13(3)29(19)4;1-22(2,3)13-29-7-5-16(6-8-29)25-21(30)20-17-9-14(15-11-24-28(4)12-15)10-18(23)19(17)26-27-20;1-12(22)11-29-6-4-15(5-7-29)25-21(30)20-16-8-14(9-17(23)19(16)26-27-20)18-10-24-13(2)28(18)3;1-26-10-14(9-23-26)13-4-5-16-15(8-13)17(25-24-16)18(28)22-11-19(20,21)12-27-6-2-3-7-27/h7-9,12,17-18H,5-6,10-11H2,1-4H3,(H,26,31)(H,27,28);9-12,16H,5-8,13H2,1-4H3,(H,25,30)(H,26,27);8-10,12,15H,4-7,11H2,1-3H3,(H,25,30)(H,26,27);4-5,8-10H,2-3,6-7,11-12H2,1H3,(H,22,28)(H,24,25)/t17-,18-;;;/m0.../s1.
What are the key properties of N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide?
N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide has a molecular weight of 1647.91 g/mol, XLogP of 11.94, 20 rotatable bonds, 8 hydrogen bond donors, and 20 hydrogen bond acceptors.
Where does this data come from?
All data for N-(2,2-difluoro-3-pyrrolidin-1-ylpropyl)-5-(1-methylpyrazol-4-yl)-1H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[(3S,4S)-3-fluoro-1-(2-methylpropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;5-(2,3-dimethylimidazol-4-yl)-7-fluoro-N-[1-(2-fluoropropyl)piperidin-4-yl]-2H-indazole-3-carboxamide;N-[1-(2,2-dimethylpropyl)piperidin-4-yl]-7-fluoro-5-(1-methylpyrazol-4-yl)-2H-indazole-3-carboxamide is sourced from PubChem (CID 160602073), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).