(2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide

C281H284F6N68O16 — CID 161181391

IUPAC(2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide
SMILESCC(C)c1[nH]ccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C#N)ncc2c(N)n1.CC(C)c1[nH]ccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C#N)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3C4COCC43)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC34CNC4)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@@H](C)CO)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@H](C)CO)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@H]3CCC[C@@H]3O)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C(F)(F)F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3ccn[nH]3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(N[C@@H]3CCNC3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(N[C@H]3CCNC3)ncc2c(N)n1.Cc1ccccc1C1Cc2cc(NC(=O)C3C[C@@H]3C(F)(F)F)ncc2C(N)=N1
InChIInChI=1S/C22H20N6O.C21H23N5O2.C21H21N5O.C21H20N4O2.C20H19F3N4O.C20H17F3N4O.2C20H20N6O.2C20H20N4O.2C19H21N5O2.2C19H21N5/c1-12-4-2-3-5-14(12)19-8-13-9-20(24-11-17(13)21(23)26-19)27-22(29)16-10-15(16)18-6-7-25-28-18;1-12-5-2-3-6-14(12)17-9-13-10-19(23-11-15(13)20(22)24-17)26-21(28)25-16-7-4-8-18(16)27;1-12-4-2-3-5-14(12)17-6-13-7-18(24-9-15(13)19(22)25-17)26-20(27)16-8-21(16)10-23-11-21;1-11-4-2-3-5-13(11)17-6-12-7-18(23-8-14(12)20(22)24-17)25-21(26)19-15-9-27-10-16(15)19;2*1-10-4-2-3-5-12(10)16-6-11-7-17(25-9-14(11)18(24)26-16)27-19(28)13-8-15(13)20(21,22)23;2*1-10(2)18-13(3-4-23-18)16-6-11-7-17(24-9-15(11)19(22)25-16)26-20(27)14-5-12(14)8-21;2*1-11-5-3-4-6-14(11)17-8-13-9-18(22-10-16(13)19(21)23-17)24-20(25)15-7-12(15)2;2*1-11-5-3-4-6-14(11)16-7-13-8-17(21-9-15(13)18(20)23-16)24-19(26)22-12(2)10-25;2*1-12-4-2-3-5-15(12)17-8-13-9-18(23-14-6-7-21-10-14)22-11-16(13)19(20)24-17/h2-9,11,15-16H,10H2,1H3,(H2,23,26)(H,25,28)(H,24,27,29);2-3,5-6,9-11,16,18,27H,4,7-8H2,1H3,(H2,22,24)(H2,23,25,26,28);2-7,9,16,23H,8,10-11H2,1H3,(H2,22,25)(H,24,26,27);2-8,15-16,19H,9-10H2,1H3,(H2,22,24)(H,23,25,26);2-5,7,9,13,15-16H,6,8H2,1H3,(H2,24,26)(H,25,27,28);2-7,9,13,15H,8H2,1H3,(H2,24,26)(H,25,27,28);2*3-4,6-7,9-10,12,14,23H,5H2,1-2H3,(H2,22,25)(H,24,26,27);2*3-6,8-10,12,15H,7H2,1-2H3,(H2,21,23)(H,22,24,25);2*3-9,12,25H,10H2,1-2H3,(H2,20,23)(H2,21,22,24,26);2*2-5,8-9,11,14,21H,6-7,10H2,1H3,(H2,20,24)(H,22,23)/t15-,16-;16-,18-;;;13?,15-,16?;13-,15-;2*12-,14+;2*12-,15-;2*12-;2*14-/m10..0110101010/s1
InChIKeyUSMVBIOOFDQSAT-RKDCLANISA-N
MW4983.81 g/mol
LogP46.21
Rot. Bonds47

About (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide

(2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide (PubChem CID 161181391) has the molecular formula C281H284F6N68O16 and a molecular weight of 4983.81 g/mol. Its IUPAC name is (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide.

Molecular Properties

Compound Name(2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide
PubChem CID161181391
Molecular FormulaC281H284F6N68O16
Molecular Weight4983.81 g/mol
Exact Mass4980.34
IUPAC Name(2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide
SMILESCC(C)c1[nH]ccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C#N)ncc2c(N)n1.CC(C)c1[nH]ccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C#N)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3C4COCC43)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC34CNC4)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@@H](C)CO)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@H](C)CO)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@H]3CCC[C@@H]3O)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C(F)(F)F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3ccn[nH]3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(N[C@@H]3CCNC3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(N[C@H]3CCNC3)ncc2c(N)n1.Cc1ccccc1C1Cc2cc(NC(=O)C3C[C@@H]3C(F)(F)F)ncc2C(N)=N1
InChIInChI=1S/C22H20N6O.C21H23N5O2.C21H21N5O.C21H20N4O2.C20H19F3N4O.C20H17F3N4O.2C20H20N6O.2C20H20N4O.2C19H21N5O2.2C19H21N5/c1-12-4-2-3-5-14(12)19-8-13-9-20(24-11-17(13)21(23)26-19)27-22(29)16-10-15(16)18-6-7-25-28-18;1-12-5-2-3-6-14(12)17-9-13-10-19(23-11-15(13)20(22)24-17)26-21(28)25-16-7-4-8-18(16)27;1-12-4-2-3-5-14(12)17-6-13-7-18(24-9-15(13)19(22)25-17)26-20(27)16-8-21(16)10-23-11-21;1-11-4-2-3-5-13(11)17-6-12-7-18(23-8-14(12)20(22)24-17)25-21(26)19-15-9-27-10-16(15)19;2*1-10-4-2-3-5-12(10)16-6-11-7-17(25-9-14(11)18(24)26-16)27-19(28)13-8-15(13)20(21,22)23;2*1-10(2)18-13(3-4-23-18)16-6-11-7-17(24-9-15(11)19(22)25-16)26-20(27)14-5-12(14)8-21;2*1-11-5-3-4-6-14(11)17-8-13-9-18(22-10-16(13)19(21)23-17)24-20(25)15-7-12(15)2;2*1-11-5-3-4-6-14(11)16-7-13-8-17(21-9-15(13)18(20)23-16)24-19(26)22-12(2)10-25;2*1-12-4-2-3-5-15(12)17-8-13-9-18(23-14-6-7-21-10-14)22-11-16(13)19(20)24-17/h2-9,11,15-16H,10H2,1H3,(H2,23,26)(H,25,28)(H,24,27,29);2-3,5-6,9-11,16,18,27H,4,7-8H2,1H3,(H2,22,24)(H2,23,25,26,28);2-7,9,16,23H,8,10-11H2,1H3,(H2,22,25)(H,24,26,27);2-8,15-16,19H,9-10H2,1H3,(H2,22,24)(H,23,25,26);2-5,7,9,13,15-16H,6,8H2,1H3,(H2,24,26)(H,25,27,28);2-7,9,13,15H,8H2,1H3,(H2,24,26)(H,25,27,28);2*3-4,6-7,9-10,12,14,23H,5H2,1-2H3,(H2,22,25)(H,24,26,27);2*3-6,8-10,12,15H,7H2,1-2H3,(H2,21,23)(H,22,24,25);2*3-9,12,25H,10H2,1-2H3,(H2,20,23)(H2,21,22,24,26);2*2-5,8-9,11,14,21H,6-7,10H2,1H3,(H2,20,24)(H,22,23)/t15-,16-;16-,18-;;;13?,15-,16?;13-,15-;2*12-,14+;2*12-,15-;2*12-;2*14-/m10..0110101010/s1
InChIKeyUSMVBIOOFDQSAT-RKDCLANISA-N
XLogP46.21
TPSA1347.87 Ų
H-Bond Donors40
H-Bond Acceptors66
Rotatable Bonds47
Heavy Atoms371
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5004983.81
LogP ≤ 546.21
H-Bond Donors ≤ 540
H-Bond Acceptors ≤ 1066

Analyze (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide with MolForge

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Frequently Asked Questions

What is the IUPAC name of (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide?
The IUPAC name of (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide (CID 161181391) is (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide.
What is the SMILES notation for (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide?
The canonical SMILES for (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide is CC(C)c1[nH]ccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C#N)ncc2c(N)n1.CC(C)c1[nH]ccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C#N)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3C4COCC43)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC34CNC4)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@@H](C)CO)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@H](C)CO)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)N[C@H]3CCC[C@@H]3O)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C(F)(F)F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3C)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3ccn[nH]3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3C)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(N[C@@H]3CCNC3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(N[C@H]3CCNC3)ncc2c(N)n1.Cc1ccccc1C1Cc2cc(NC(=O)C3C[C@@H]3C(F)(F)F)ncc2C(N)=N1.
What is the InChIKey of (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide?
The InChIKey is USMVBIOOFDQSAT-RKDCLANISA-N. The full InChI is InChI=1S/C22H20N6O.C21H23N5O2.C21H21N5O.C21H20N4O2.C20H19F3N4O.C20H17F3N4O.2C20H20N6O.2C20H20N4O.2C19H21N5O2.2C19H21N5/c1-12-4-2-3-5-14(12)19-8-13-9-20(24-11-17(13)21(23)26-19)27-22(29)16-10-15(16)18-6-7-25-28-18;1-12-5-2-3-6-14(12)17-9-13-10-19(23-11-15(13)20(22)24-17)26-21(28)25-16-7-4-8-18(16)27;1-12-4-2-3-5-14(12)17-6-13-7-18(24-9-15(13)19(22)25-17)26-20(27)16-8-21(16)10-23-11-21;1-11-4-2-3-5-13(11)17-6-12-7-18(23-8-14(12)20(22)24-17)25-21(26)19-15-9-27-10-16(15)19;2*1-10-4-2-3-5-12(10)16-6-11-7-17(25-9-14(11)18(24)26-16)27-19(28)13-8-15(13)20(21,22)23;2*1-10(2)18-13(3-4-23-18)16-6-11-7-17(24-9-15(11)19(22)25-16)26-20(27)14-5-12(14)8-21;2*1-11-5-3-4-6-14(11)17-8-13-9-18(22-10-16(13)19(21)23-17)24-20(25)15-7-12(15)2;2*1-11-5-3-4-6-14(11)16-7-13-8-17(21-9-15(13)18(20)23-16)24-19(26)22-12(2)10-25;2*1-12-4-2-3-5-15(12)17-8-13-9-18(23-14-6-7-21-10-14)22-11-16(13)19(20)24-17/h2-9,11,15-16H,10H2,1H3,(H2,23,26)(H,25,28)(H,24,27,29);2-3,5-6,9-11,16,18,27H,4,7-8H2,1H3,(H2,22,24)(H2,23,25,26,28);2-7,9,16,23H,8,10-11H2,1H3,(H2,22,25)(H,24,26,27);2-8,15-16,19H,9-10H2,1H3,(H2,22,24)(H,23,25,26);2-5,7,9,13,15-16H,6,8H2,1H3,(H2,24,26)(H,25,27,28);2-7,9,13,15H,8H2,1H3,(H2,24,26)(H,25,27,28);2*3-4,6-7,9-10,12,14,23H,5H2,1-2H3,(H2,22,25)(H,24,26,27);2*3-6,8-10,12,15H,7H2,1-2H3,(H2,21,23)(H,22,24,25);2*3-9,12,25H,10H2,1-2H3,(H2,20,23)(H2,21,22,24,26);2*2-5,8-9,11,14,21H,6-7,10H2,1H3,(H2,20,24)(H,22,23)/t15-,16-;16-,18-;;;13?,15-,16?;13-,15-;2*12-,14+;2*12-,15-;2*12-;2*14-/m10..0110101010/s1.
What are the key properties of (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide?
(2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide has a molecular weight of 4983.81 g/mol, XLogP of 46.21, 47 rotatable bonds, 40 hydrogen bond donors, and 66 hydrogen bond acceptors.
Where does this data come from?
All data for (2S)-N-[8-amino-6-(2-methylphenyl)-5,6-dihydro-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-5-azaspiro[2.3]hexane-2-carboxamide;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(1S,2S)-2-hydroxycyclopentyl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2R)-1-hydroxypropan-2-yl]urea;1-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-[(2S)-1-hydroxypropan-2-yl]urea;N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(2-propan-2-yl-1H-pyrrol-3-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;3-(2-methylphenyl)-6-N-[(3R)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;3-(2-methylphenyl)-6-N-[(3S)-pyrrolidin-3-yl]-2,7-naphthyridine-1,6-diamine;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-methylcyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1H-pyrazol-5-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(trifluoromethyl)cyclopropane-1-carboxamide is sourced from PubChem (CID 161181391), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).