(2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide

C82H67F21N12O12 — CID 161223025

About (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide

(2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide (PubChem CID 161223025) has the molecular formula C82H67F21N12O12 and a molecular weight of 1811.47 g/mol. Its IUPAC name is (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide.

Molecular Properties

• Compound Name: (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide
• PubChem CID: 161223025
• Molecular Formula: C82H67F21N12O12
• Molecular Weight: 1811.47 g/mol
• Exact Mass: 1810.47
• IUPAC Name: (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide
• SMILES: C[C@@H]1Cc2c(-c3ccc(F)cc3F)cc(C(N)=O)nc2O[C@H]1COC(F)F.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@@H](C(F)F)CC2.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@H](C(F)F)CC2.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@H](CC(F)(F)F)CC2.NC(=O)c1cc(-c2cnn(C(F)F)c2)c2c(n1)O[C@@H](COC(F)F)CC2
• InChI: InChI=1S/C18H16F4N2O3.C17H13F5N2O2.2C16H12F4N2O2.C15H14F4N4O3/c1-8-4-12-11(10-3-2-9(19)5-13(10)20)6-14(16(23)25)24-17(12)27-15(8)7-26-18(21)22;18-8-1-3-10(13(19)5-8)12-6-14(15(23)25)24-16-11(12)4-2-9(26-16)7-17(20,21)22;2*17-7-1-2-8(11(18)5-7)10-6-12(15(21)23)22-16-9(10)3-4-13(24-16)14(19)20;16-14(17)23-5-7(4-21-23)10-3-11(12(20)24)22-13-9(10)2-1-8(26-13)6-25-15(18)19/h2-3,5-6,8,15,18H,4,7H2,1H3,(H2,23,25);1,3,5-6,9H,2,4,7H2,(H2,23,25);2*1-2,5-6,13-14H,3-4H2,(H2,21,23);3-5,8,14-15H,1-2,6H2,(H2,20,24)/t8-,15+;9-;2*13-;8-/m10101/s1
• InChIKey: UXTNVDKRNUYZSW-FHQZCFTESA-N
• XLogP: 15.62
• TPSA: 362.33 Ų
• H-Bond Donors: 5
• H-Bond Acceptors: 19
• Rotatable Bonds: 20
• Heavy Atoms: 127
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	1811.47
LogP ≤ 5	15.62
H-Bond Donors ≤ 5	5
H-Bond Acceptors ≤ 10	19

Frequently Asked Questions

What is the IUPAC name of (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

The IUPAC name of (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide (CID 161223025) is (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide.

What is the SMILES notation for (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

The canonical SMILES for (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide is C[C@@H]1Cc2c(-c3ccc(F)cc3F)cc(C(N)=O)nc2O[C@H]1COC(F)F.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@@H](C(F)F)CC2.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@H](C(F)F)CC2.NC(=O)c1cc(-c2ccc(F)cc2F)c2c(n1)O[C@H](CC(F)(F)F)CC2.NC(=O)c1cc(-c2cnn(C(F)F)c2)c2c(n1)O[C@@H](COC(F)F)CC2.

What is the InChIKey of (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

The InChIKey is UXTNVDKRNUYZSW-FHQZCFTESA-N. The full InChI is InChI=1S/C18H16F4N2O3.C17H13F5N2O2.2C16H12F4N2O2.C15H14F4N4O3/c1-8-4-12-11(10-3-2-9(19)5-13(10)20)6-14(16(23)25)24-17(12)27-15(8)7-26-18(21)22;18-8-1-3-10(13(19)5-8)12-6-14(15(23)25)24-16-11(12)4-2-9(26-16)7-17(20,21)22;2*17-7-1-2-8(11(18)5-7)10-6-12(15(21)23)22-16-9(10)3-4-13(24-16)14(19)20;16-14(17)23-5-7(4-21-23)10-3-11(12(20)24)22-13-9(10)2-1-8(26-13)6-25-15(18)19/h2-3,5-6,8,15,18H,4,7H2,1H3,(H2,23,25);1,3,5-6,9H,2,4,7H2,(H2,23,25);2*1-2,5-6,13-14H,3-4H2,(H2,21,23);3-5,8,14-15H,1-2,6H2,(H2,20,24)/t8-,15+;9-;2*13-;8-/m10101/s1.

What are the key properties of (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide?

(2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide has a molecular weight of 1811.47 g/mol, XLogP of 15.62, 20 rotatable bonds, 5 hydrogen bond donors, and 19 hydrogen bond acceptors.

Where does this data come from?

All data for (2R)-2-(difluoromethoxymethyl)-5-[1-(difluoromethyl)pyrazol-4-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R,3R)-2-(difluoromethoxymethyl)-5-(2,4-difluorophenyl)-3-methyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2R)-2-(difluoromethyl)-5-(2,4-difluorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide;(2S)-5-(2,4-difluorophenyl)-2-(2,2,2-trifluoroethyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide is sourced from PubChem (CID 161223025), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).