1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one

C161H138ClF2N29O7S7 — CID 161393032

IUPAC1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one
SMILESCc1cc(-c2ncc(CCC(=O)c3cnc(-c4cccc(C)n4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cccc(Cl)c4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ccccn4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cncc(F)c4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cnccn4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ncccc4F)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ncccn4)s3)cc2C)ccn1
InChIInChI=1S/C24H20ClN3OS.C24H22N4OS.2C23H19FN4OS.C23H20N4OS.2C22H19N5OS/c1-15-10-17(13-27-23(15)18-8-9-26-16(2)11-18)6-7-21(29)22-14-28-24(30-22)19-4-3-5-20(25)12-19;1-15-11-18(13-26-23(15)19-9-10-25-17(3)12-19)7-8-21(29)22-14-27-24(30-22)20-6-4-5-16(2)28-20;1-14-7-16(10-27-22(14)17-5-6-26-15(2)8-17)3-4-20(29)21-13-28-23(30-21)18-9-19(24)12-25-11-18;1-14-10-16(12-27-21(14)17-7-9-25-15(2)11-17)5-6-19(29)20-13-28-23(30-20)22-18(24)4-3-8-26-22;1-15-11-17(13-26-22(15)18-8-10-24-16(2)12-18)6-7-20(28)21-14-27-23(29-21)19-5-3-4-9-25-19;1-14-10-16(12-26-20(14)17-6-9-23-15(2)11-17)4-5-18(28)19-13-27-22(29-19)21-24-7-3-8-25-21;1-14-9-16(11-26-21(14)17-5-6-24-15(2)10-17)3-4-19(28)20-13-27-22(29-20)18-12-23-7-8-25-18/h3-5,8-14H,6-7H2,1-2H3;4-6,9-14H,7-8H2,1-3H3;5-13H,3-4H2,1-2H3;3-4,7-13H,5-6H2,1-2H3;3-5,8-14H,6-7H2,1-2H3;3,6-13H,4-5H2,1-2H3;5-13H,3-4H2,1-2H3
InChIKeyVTFXEQJQHMTRLP-UHFFFAOYSA-N
MW2888.99 g/mol
LogP36.30
Rot. Bonds42

About 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one

1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one (PubChem CID 161393032) has the molecular formula C161H138ClF2N29O7S7 and a molecular weight of 2888.99 g/mol. Its IUPAC name is 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one.

Molecular Properties

Compound Name1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one
PubChem CID161393032
Molecular FormulaC161H138ClF2N29O7S7
Molecular Weight2888.99 g/mol
Exact Mass2885.90
IUPAC Name1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one
SMILESCc1cc(-c2ncc(CCC(=O)c3cnc(-c4cccc(C)n4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cccc(Cl)c4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ccccn4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cncc(F)c4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cnccn4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ncccc4F)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ncccn4)s3)cc2C)ccn1
InChIInChI=1S/C24H20ClN3OS.C24H22N4OS.2C23H19FN4OS.C23H20N4OS.2C22H19N5OS/c1-15-10-17(13-27-23(15)18-8-9-26-16(2)11-18)6-7-21(29)22-14-28-24(30-22)19-4-3-5-20(25)12-19;1-15-11-18(13-26-23(15)19-9-10-25-17(3)12-19)7-8-21(29)22-14-27-24(30-22)20-6-4-5-16(2)28-20;1-14-7-16(10-27-22(14)17-5-6-26-15(2)8-17)3-4-20(29)21-13-28-23(30-21)18-9-19(24)12-25-11-18;1-14-10-16(12-27-21(14)17-7-9-25-15(2)11-17)5-6-19(29)20-13-28-23(30-20)22-18(24)4-3-8-26-22;1-15-11-17(13-26-22(15)18-8-10-24-16(2)12-18)6-7-20(28)21-14-27-23(29-21)19-5-3-4-9-25-19;1-14-10-16(12-26-20(14)17-6-9-23-15(2)11-17)4-5-18(28)19-13-27-22(29-19)21-24-7-3-8-25-21;1-14-9-16(11-26-21(14)17-5-6-24-15(2)10-17)3-4-19(28)20-13-27-22(29-20)18-12-23-7-8-25-18/h3-5,8-14H,6-7H2,1-2H3;4-6,9-14H,7-8H2,1-3H3;5-13H,3-4H2,1-2H3;3-4,7-13H,5-6H2,1-2H3;3-5,8-14H,6-7H2,1-2H3;3,6-13H,4-5H2,1-2H3;5-13H,3-4H2,1-2H3
InChIKeyVTFXEQJQHMTRLP-UHFFFAOYSA-N
XLogP36.30
TPSA493.30 Ų
H-Bond Donors
H-Bond Acceptors43
Rotatable Bonds42
Heavy Atoms207
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5002888.99
LogP ≤ 536.30
H-Bond Donors ≤ 50
H-Bond Acceptors ≤ 1043

Analyze 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one with MolForge

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Launch Full Analysis

Related Compounds

1-[3-Chloro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(1,3-thiazol-2-yl)ethanone;2-(5-chloro-3-pyridinyl)-1-[3-fluoro-5-[methyl(pyrimidin-5-yl)amino]phenyl]ethanone;1-[4-fluoro-3-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(5-fluoro-2-pyridinyl)ethanone;1-[4-fluoro-3-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(4-methyl-1,3-thiazol-2-yl)ethanone;1-[3-fluoro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-[5-(trifluoromethyl)-2-pyridinyl]ethanone
CID 157502588
2-[1-[[6-(2-acetamidoethylamino)pyrimidine-4-carbonyl]amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-4-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-[6-(2-methylimidazol-1-yl)pyrimidin-4-yl]-4-oxobutan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-[6-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-4-oxobutan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[1-[[6-(3-piperidin-4-ylpropyl)pyrimidine-4-carbonyl]amino]ethyl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[1-[(6-pyrrol-1-ylpyrimidine-4-carbonyl)amino]ethyl]-1,3-thiazole-5-carboxamide
CID 157678747
2-[4-[6-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]pyrimidin-4-yl]-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;2-[4-[6-(3-aminopropylamino)pyrimidin-4-yl]-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-oxo-4-[6-(2-piperidin-4-ylethyl)pyrimidin-4-yl]butan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-oxo-4-[6-(piperidin-4-ylmethyl)pyrimidin-4-yl]butan-2-yl]-1,3-thiazole-5-carboxamide
CID 158182407
2-[(2S)-4-[6-[2-(azetidin-3-yl)acetyl]pyrimidin-4-yl]-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;2-[(2S)-4-(6-butanoylpyrimidin-4-yl)-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;2-[(2S)-4-(6-carbamoylpyrimidin-4-yl)-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[(2S)-4-oxo-4-[6-(2-piperidin-4-ylacetyl)pyrimidin-4-yl]butan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[(2S)-4-oxo-4-(6-propanoylpyrimidin-4-yl)butan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-oxo-4-[6-(3-pyridin-3-ylpropanoyl)pyrimidin-4-yl]butan-2-yl]-1,3-thiazole-5-carboxamide
CID 158516167
N-(6-chloro-[1,3]thiazolo[4,5-c]pyridin-2-yl)benzamide;N-(6-methyl-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide;N-(6-methyl-[1,3]thiazolo[4,5-c]pyridin-2-yl)pyridine-2-carboxamide;N-(6-methyl-[1,3]thiazolo[4,5-c]pyridin-2-yl)pyridine-3-carboxamide;N-(6-methyl-[1,3]thiazolo[4,5-c]pyridin-2-yl)pyrimidine-5-carboxamide;N-(6-methyl-[1,3]thiazolo[4,5-c]pyridin-2-yl)-1,2-thiazole-3-carboxamide;N-(6-methyl-[1,3]thiazolo[4,5-c]pyridin-2-yl)-1,3-thiazole-4-carboxamide;N-[6-(trifluoromethyl)-[1,3]thiazolo[4,5-c]pyridin-2-yl]pyrimidine-2-carboxamide
CID 161163173
1-[3-Chloro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(5-chloro-2-pyridinyl)ethanone;1-[3-chloro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(4-methyl-1,3-thiazol-2-yl)ethanone;1-[3-chloro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-[5-(trifluoromethyl)-2-pyridinyl]ethanone;1-[4-fluoro-3-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(6-methyl-2-pyridinyl)ethanone;1-[3-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(1,3-thiazol-2-yl)ethanone
CID 161235518
2-[4-[6-(4-aminobutyl)pyrimidin-4-yl]-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;2-[4-[6-(3-aminopropyl)pyrimidin-4-yl]-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;2-[4-[5-chloro-6-[(1-methylpiperidin-4-yl)methylamino]pyrimidin-4-yl]-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-[6-[3-(diethylamino)propylamino]pyrimidin-4-yl]-4-oxobutan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-[6-[3-(4-methylpiperazin-1-yl)propyl]pyrimidin-4-yl]-4-oxobutan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-oxo-4-[6-(3-pyrrolidin-1-ylpropylamino)pyrimidin-4-yl]butan-2-yl]-1,3-thiazole-5-carboxamide
CID 161260886
2-[(2S)-4-[6-[2-(azetidin-3-yl)acetyl]pyrimidin-4-yl]-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;2-[(2S)-4-(6-carbamoylpyrimidin-4-yl)-4-oxobutan-2-yl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[(2S)-4-oxo-4-[6-(2-piperidin-4-ylacetyl)pyrimidin-4-yl]butan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[(2S)-4-oxo-4-(6-propanoylpyrimidin-4-yl)butan-2-yl]-1,3-thiazole-5-carboxamide;N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-2-[4-oxo-4-[6-(3-pyridin-3-ylpropanoyl)pyrimidin-4-yl]butan-2-yl]-1,3-thiazole-5-carboxamide
CID 161561812
1-[2-[[6-[(3R)-3-aminopyrrolidin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazol-5-yl]-2-(2-chloro-4-deuterio-6-methylphenyl)ethanone;1-(2-amino-1,3-thiazol-5-yl)-2-(2-chloro-4-deuterio-6-methylphenyl)ethanone;2-(2-chloro-4-deuterio-6-methylphenyl)-1-[2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazol-5-yl]ethanone;2-(2-chloro-4-deuterio-6-methylphenyl)-1-[2-[[2-methyl-6-[(3R)-3-methylpyrrolidin-1-yl]pyrimidin-4-yl]amino]-1,3-thiazol-5-yl]ethanone;4-chloro-2,6-dimethylpyrimidine;methane;(3R)-3-methylpyrrolidine
CID 157207961
2-(5-Chloro-3-pyridinyl)-1-[3-fluoro-5-[methyl(pyrimidin-5-yl)amino]phenyl]ethanone;1-[3-[methyl(pyridin-3-yl)amino]phenyl]-2-(4-methyl-1,3-thiazol-2-yl)ethanone;1-[3-[methyl(pyridin-3-yl)amino]phenyl]-2-(1,3-thiazol-2-yl)ethanone;1-[3-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(4-methyl-1,3-thiazol-2-yl)ethanone;1-[3-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(1,3-thiazol-2-yl)ethanone
CID 157342539
1-[3-Chloro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(5-chloro-3-pyridinyl)ethanone;2-(4-chloro-2-pyridinyl)-1-[3-fluoro-5-[methyl(pyrimidin-5-yl)amino]phenyl]ethanone;1-[3-fluoro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(4-methyl-2-pyridinyl)ethanone;1-[3-[methyl(pyridin-3-yl)amino]phenyl]-2-(4-methyl-1,3-thiazol-2-yl)ethanone;1-[3-[methyl(pyridin-3-yl)amino]phenyl]-2-(1,3-thiazol-2-yl)ethanone
CID 157585373
1-[3-Chloro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(5-methyl-3-pyridinyl)ethanone;1-[3-chloro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(1,3-thiazol-2-yl)ethanone;1-[3-fluoro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(5-fluoro-4-methyl-1,3-thiazol-2-yl)ethanone;1-[3-fluoro-5-[methyl(pyrimidin-5-yl)amino]phenyl]-2-(5-methyl-2-pyridinyl)ethanone
CID 158119578

Frequently Asked Questions

What is the IUPAC name of 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one?
The IUPAC name of 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one (CID 161393032) is 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one.
What is the SMILES notation for 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one?
The canonical SMILES for 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one is Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cccc(C)n4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cccc(Cl)c4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ccccn4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cncc(F)c4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4cnccn4)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ncccc4F)s3)cc2C)ccn1.Cc1cc(-c2ncc(CCC(=O)c3cnc(-c4ncccn4)s3)cc2C)ccn1.
What is the InChIKey of 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one?
The InChIKey is VTFXEQJQHMTRLP-UHFFFAOYSA-N. The full InChI is InChI=1S/C24H20ClN3OS.C24H22N4OS.2C23H19FN4OS.C23H20N4OS.2C22H19N5OS/c1-15-10-17(13-27-23(15)18-8-9-26-16(2)11-18)6-7-21(29)22-14-28-24(30-22)19-4-3-5-20(25)12-19;1-15-11-18(13-26-23(15)19-9-10-25-17(3)12-19)7-8-21(29)22-14-27-24(30-22)20-6-4-5-16(2)28-20;1-14-7-16(10-27-22(14)17-5-6-26-15(2)8-17)3-4-20(29)21-13-28-23(30-21)18-9-19(24)12-25-11-18;1-14-10-16(12-27-21(14)17-7-9-25-15(2)11-17)5-6-19(29)20-13-28-23(30-20)22-18(24)4-3-8-26-22;1-15-11-17(13-26-22(15)18-8-10-24-16(2)12-18)6-7-20(28)21-14-27-23(29-21)19-5-3-4-9-25-19;1-14-10-16(12-26-20(14)17-6-9-23-15(2)11-17)4-5-18(28)19-13-27-22(29-19)21-24-7-3-8-25-21;1-14-9-16(11-26-21(14)17-5-6-24-15(2)10-17)3-4-19(28)20-13-27-22(29-20)18-12-23-7-8-25-18/h3-5,8-14H,6-7H2,1-2H3;4-6,9-14H,7-8H2,1-3H3;5-13H,3-4H2,1-2H3;3-4,7-13H,5-6H2,1-2H3;3-5,8-14H,6-7H2,1-2H3;3,6-13H,4-5H2,1-2H3;5-13H,3-4H2,1-2H3.
What are the key properties of 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one?
1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one has a molecular weight of 2888.99 g/mol, XLogP of 36.30, 42 rotatable bonds, 0 hydrogen bond donors, and 43 hydrogen bond acceptors.
Where does this data come from?
All data for 1-[2-(3-chlorophenyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(3-fluoro-2-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;1-[2-(5-fluoro-3-pyridinyl)-1,3-thiazol-5-yl]-3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-[2-(6-methyl-2-pyridinyl)-1,3-thiazol-5-yl]propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrazin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyridin-2-yl-1,3-thiazol-5-yl)propan-1-one;3-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-1-(2-pyrimidin-2-yl-1,3-thiazol-5-yl)propan-1-one is sourced from PubChem (CID 161393032), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).