2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine

C124H127BCl4F15N27O22Si2 — CID 161485097

About 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine

2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine (PubChem CID 161485097) has the molecular formula C124H127BCl4F15N27O22Si2 and a molecular weight of 2841.31 g/mol. Its IUPAC name is 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine.

Molecular Properties

• Compound Name: 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine
• PubChem CID: 161485097
• Molecular Formula: C124H127BCl4F15N27O22Si2
• Molecular Weight: 2841.31 g/mol
• Exact Mass: 2837.78
• IUPAC Name: 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine
• SMILES: C.C#C[Si](C)(C)C.C=C1c2nc(-c3cnc(OC)c(OC)c3)ccc2C(=O)N1c1cnn(CC(F)(F)F)c1.COc1cc(-c2ccc(C(=O)Nc3cnn(CC(F)(F)F)c3)c(C#C[Si](C)(C)C)n2)cnc1OC.COc1cc(-c2ccc(C(=O)Nc3cnn(CC(F)(F)F)c3)c(Cl)n2)cnc1OC.COc1cc(-c2ccc(C(=O)O)c(Cl)n2)cnc1OC.COc1cc(-c2ccc3c(n2)C(C)N(c2cnn(CC(F)(F)F)c2)C3=O)cnc1OC.COc1cc(B2OC(C)(C)C(C)(C)O2)cnc1OC.Nc1cnn(CC(F)(F)F)c1.O=C(O)c1ccc(Cl)nc1Cl
• InChI: InChI=1S/C23H24F3N5O3Si.C20H18F3N5O3.C20H16F3N5O3.C18H15ClF3N5O3.C13H20BNO4.C13H11ClN2O4.C6H3Cl2NO2.C5H6F3N3.C5H10Si.CH4/c1-33-20-10-15(11-27-22(20)34-2)18-7-6-17(19(30-18)8-9-35(3,4)5)21(32)29-16-12-28-31(13-16)14-23(24,25)26;2*1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12;1-29-14-5-10(6-23-17(14)30-2)13-4-3-12(15(19)26-13)16(28)25-11-7-24-27(8-11)9-18(20,21)22;1-12(2)13(3,4)19-14(18-12)9-7-10(16-5)11(17-6)15-8-9;1-19-10-5-7(6-15-12(10)20-2)9-4-3-8(13(17)18)11(14)16-9;7-4-2-1-3(6(10)11)5(8)9-4;6-5(7,8)3-11-2-4(9)1-10-11;1-5-6(2,3)4;/h6-7,10-13H,14H2,1-5H3,(H,29,32);4-9,11H,10H2,1-3H3;4-9H,1,10H2,2-3H3;3-8H,9H2,1-2H3,(H,25,28);7-8H,1-6H3;3-6H,1-2H3,(H,17,18);1-2H,(H,10,11);1-2H,3,9H2;1H,2-4H3;1H4
• InChIKey: WEWJBRHAOWQWDV-UHFFFAOYSA-N
• XLogP: 24.58
• TPSA: 572.44 Ų
• H-Bond Donors: 5
• H-Bond Acceptors: 43
• Rotatable Bonds: 31
• Heavy Atoms: 195
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2841.31
LogP ≤ 5	24.58
H-Bond Donors ≤ 5	5
H-Bond Acceptors ≤ 10	43

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': '2-halo_pyridine', 'substructure': 'N/A'}, {'alert_name': 'heavy_metal', 'substructure': 'N/A'}, {'alert_name': 'triple_bond', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine?

The IUPAC name of 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine (CID 161485097) is 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine.

What is the SMILES notation for 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine?

The canonical SMILES for 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine is C.C#C[Si](C)(C)C.C=C1c2nc(-c3cnc(OC)c(OC)c3)ccc2C(=O)N1c1cnn(CC(F)(F)F)c1.COc1cc(-c2ccc(C(=O)Nc3cnn(CC(F)(F)F)c3)c(C#C[Si](C)(C)C)n2)cnc1OC.COc1cc(-c2ccc(C(=O)Nc3cnn(CC(F)(F)F)c3)c(Cl)n2)cnc1OC.COc1cc(-c2ccc(C(=O)O)c(Cl)n2)cnc1OC.COc1cc(-c2ccc3c(n2)C(C)N(c2cnn(CC(F)(F)F)c2)C3=O)cnc1OC.COc1cc(B2OC(C)(C)C(C)(C)O2)cnc1OC.Nc1cnn(CC(F)(F)F)c1.O=C(O)c1ccc(Cl)nc1Cl.

What is the InChIKey of 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine?

The InChIKey is WEWJBRHAOWQWDV-UHFFFAOYSA-N. The full InChI is InChI=1S/C23H24F3N5O3Si.C20H18F3N5O3.C20H16F3N5O3.C18H15ClF3N5O3.C13H20BNO4.C13H11ClN2O4.C6H3Cl2NO2.C5H6F3N3.C5H10Si.CH4/c1-33-20-10-15(11-27-22(20)34-2)18-7-6-17(19(30-18)8-9-35(3,4)5)21(32)29-16-12-28-31(13-16)14-23(24,25)26;2*1-11-17-14(19(29)28(11)13-8-25-27(9-13)10-20(21,22)23)4-5-15(26-17)12-6-16(30-2)18(31-3)24-7-12;1-29-14-5-10(6-23-17(14)30-2)13-4-3-12(15(19)26-13)16(28)25-11-7-24-27(8-11)9-18(20,21)22;1-12(2)13(3,4)19-14(18-12)9-7-10(16-5)11(17-6)15-8-9;1-19-10-5-7(6-15-12(10)20-2)9-4-3-8(13(17)18)11(14)16-9;7-4-2-1-3(6(10)11)5(8)9-4;6-5(7,8)3-11-2-4(9)1-10-11;1-5-6(2,3)4;/h6-7,10-13H,14H2,1-5H3,(H,29,32);4-9,11H,10H2,1-3H3;4-9H,1,10H2,2-3H3;3-8H,9H2,1-2H3,(H,25,28);7-8H,1-6H3;3-6H,1-2H3,(H,17,18);1-2H,(H,10,11);1-2H,3,9H2;1H,2-4H3;1H4.

What are the key properties of 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine?

2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine has a molecular weight of 2841.31 g/mol, XLogP of 24.58, 31 rotatable bonds, 5 hydrogen bond donors, and 43 hydrogen bond acceptors.

Where does this data come from?

All data for 2-chloro-6-(5,6-dimethoxy-3-pyridinyl)pyridine-3-carboxylic acid;2-chloro-6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-3-carboxamide;2,6-dichloropyridine-3-carboxylic acid;2-(5,6-dimethoxy-3-pyridinyl)-7-methylidene-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrrolo[3,4-b]pyridin-5-one;2-(5,6-dimethoxy-3-pyridinyl)-7-methyl-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-7H-pyrrolo[3,4-b]pyridin-5-one;6-(5,6-dimethoxy-3-pyridinyl)-N-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-2-(2-trimethylsilylethynyl)pyridine-3-carboxamide;2,3-dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;ethynyl(trimethyl)silane;methane;1-(2,2,2-trifluoroethyl)pyrazol-4-amine is sourced from PubChem (CID 161485097), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).