5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one

C205H196N46O24 — CID 163526926

IUPAC5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
SMILESCCc1cc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.CCc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.CCn1nc(C)cc1-c1cnc([C@@H]2COc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)[nH]1.Cc1cc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cncc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)c1.Cc1cncc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)c1
InChIInChI=1S/3C26H26N6O3.2C26H23N5O3.3C25H24N6O3/c2*1-3-17-12-21(32(2)31-17)20-13-28-25(29-20)16-10-15-11-18(4-6-22(15)34-14-16)35-23-8-9-27-26-19(23)5-7-24(33)30-26;1-3-32-21(10-15(2)31-32)20-13-28-25(29-20)17-11-16-12-18(4-6-22(16)34-14-17)35-23-8-9-27-26-19(23)5-7-24(33)30-26;2*1-15-8-17(12-27-11-15)21-13-29-25(30-21)18-9-16-10-19(2-4-22(16)33-14-18)34-23-6-7-28-26-20(23)3-5-24(32)31-26;3*1-14-9-20(31(2)30-14)19-12-27-24(28-19)16-10-15-11-17(3-5-21(15)33-13-16)34-22-7-8-26-25-18(22)4-6-23(32)29-25/h2*4,6,8-9,11-13,16H,3,5,7,10,14H2,1-2H3,(H,28,29)(H,27,30,33);4,6,8-10,12-13,17H,3,5,7,11,14H2,1-2H3,(H,28,29)(H,27,30,33);2*2,4,6-8,10-13,18H,3,5,9,14H2,1H3,(H,29,30)(H,28,31,32);3*3,5,7-9,11-12,16H,4,6,10,13H2,1-2H3,(H,27,28)(H,26,29,32)/t2*16-;17-;2*18-;3*16-/m10010110/s1
InChIKeyDPOWZFFMMONJLR-QSRNULCPSA-N
MW3688.12 g/mol
LogP33.59
Rot. Bonds35

About 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one

5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one (PubChem CID 163526926) has the molecular formula C205H196N46O24 and a molecular weight of 3688.12 g/mol. Its IUPAC name is 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one.

Molecular Properties

Compound Name5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
PubChem CID163526926
Molecular FormulaC205H196N46O24
Molecular Weight3688.12 g/mol
Exact Mass3685.55
IUPAC Name5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
SMILESCCc1cc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.CCc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.CCn1nc(C)cc1-c1cnc([C@@H]2COc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)[nH]1.Cc1cc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cncc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)c1.Cc1cncc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)c1
InChIInChI=1S/3C26H26N6O3.2C26H23N5O3.3C25H24N6O3/c2*1-3-17-12-21(32(2)31-17)20-13-28-25(29-20)16-10-15-11-18(4-6-22(15)34-14-16)35-23-8-9-27-26-19(23)5-7-24(33)30-26;1-3-32-21(10-15(2)31-32)20-13-28-25(29-20)17-11-16-12-18(4-6-22(16)34-14-17)35-23-8-9-27-26-19(23)5-7-24(33)30-26;2*1-15-8-17(12-27-11-15)21-13-29-25(30-21)18-9-16-10-19(2-4-22(16)33-14-18)34-23-6-7-28-26-20(23)3-5-24(32)31-26;3*1-14-9-20(31(2)30-14)19-12-27-24(28-19)16-10-15-11-17(3-5-21(15)33-13-16)34-22-7-8-26-25-18(22)4-6-23(32)29-25/h2*4,6,8-9,11-13,16H,3,5,7,10,14H2,1-2H3,(H,28,29)(H,27,30,33);4,6,8-10,12-13,17H,3,5,7,11,14H2,1-2H3,(H,28,29)(H,27,30,33);2*2,4,6-8,10-13,18H,3,5,9,14H2,1H3,(H,29,30)(H,28,31,32);3*3,5,7-9,11-12,16H,4,6,10,13H2,1-2H3,(H,27,28)(H,26,29,32)/t2*16-;17-;2*18-;3*16-/m10010110/s1
InChIKeyDPOWZFFMMONJLR-QSRNULCPSA-N
XLogP33.59
TPSA845.74 Ų
H-Bond Donors16
H-Bond Acceptors54
Rotatable Bonds35
Heavy Atoms275
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003688.12
LogP ≤ 533.59
H-Bond Donors ≤ 516
H-Bond Acceptors ≤ 1054

Analyze 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one with MolForge

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Related Compounds

US10183939, Example 11
CID 118948407
US10183939, Example 4
CID 118948412
CID 159096803
CID 159096803
2-[4-(1,1-difluoroethoxy)phenyl]-1-[4-[6-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazin-1-yl]ethanone;2-[4-(1-fluoroethoxy)phenyl]-1-[4-[6-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazin-1-yl]ethanone;3-(5-fluoro-6-methoxy-3-pyridinyl)-1-[4-[6-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one;3-(4-fluorophenyl)-1-[4-[6-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one;(3R)-3-(3-methoxyphenyl)-1-[4-[6-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazin-1-yl]butan-1-one
CID 160459919
5-[[3-[5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
CID 162712920
5-[[3-[5-[5-methyl-2-(2,2,2-trifluoroethyl)pyrazol-3-yl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
CID 162712935
5-[[(3S)-3-[5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
CID 162772349
5-[[(3R)-3-[5-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
CID 162772351
2,2-difluoro-N-[4-[[3-(5-phenyl-1H-imidazol-2-yl)-3,4-dihydro-2H-chromen-6-yl]oxy]-2-pyridinyl]cyclopropane-1-carboxamide;1-fluoro-N-[4-[[3-(5-phenyl-1H-imidazol-2-yl)-3,4-dihydro-2H-chromen-6-yl]oxy]-2-pyridinyl]cyclopropane-1-carboxamide;2-morpholin-4-yl-N-[4-[[3-(5-phenyl-1H-imidazol-2-yl)-3,4-dihydro-2H-chromen-6-yl]oxy]-2-pyridinyl]acetamide;bis(N-[4-[[3-(5-phenyl-1H-imidazol-2-yl)-3,4-dihydro-2H-chromen-6-yl]oxy]-2-pyridinyl]cyclopropanecarboxamide);N-[4-[[3-(5-phenyl-1H-imidazol-2-yl)-3,4-dihydro-2H-chromen-6-yl]oxy]pyrimidin-2-yl]cyclopropanecarboxamide
CID 163469682
5-[[3-[5-(2,4-dimethoxypyrimidin-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-[3-[(dimethylamino)methyl]-5-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(3-methoxyphenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[3-[5-(4-methylphenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[3-[5-[3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
CID 163523451
5-[[3-[5-(3-cyclopropyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(1,3-dimethylpyrazol-4-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(6-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(5-methylthiophen-2-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-[5-methyl-2-(2,2,2-trifluoroethyl)pyrazol-3-yl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
CID 163618667
5-[[3-[5-(2-fluoro-5-methylphenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(3-fluorophenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(5-methoxy-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-[3-(3-methylbutyl)-5-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(2-methylphenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[3-[5-(3-methylphenyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
CID 163652781

Frequently Asked Questions

What is the IUPAC name of 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one?
The IUPAC name of 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one (CID 163526926) is 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one.
What is the SMILES notation for 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one?
The canonical SMILES for 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one is CCc1cc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.CCc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.CCn1nc(C)cc1-c1cnc([C@@H]2COc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)[nH]1.Cc1cc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)n(C)n1.Cc1cncc(-c2cnc([C@@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)c1.Cc1cncc(-c2cnc([C@H]3COc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)[nH]2)c1.
What is the InChIKey of 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one?
The InChIKey is DPOWZFFMMONJLR-QSRNULCPSA-N. The full InChI is InChI=1S/3C26H26N6O3.2C26H23N5O3.3C25H24N6O3/c2*1-3-17-12-21(32(2)31-17)20-13-28-25(29-20)16-10-15-11-18(4-6-22(15)34-14-16)35-23-8-9-27-26-19(23)5-7-24(33)30-26;1-3-32-21(10-15(2)31-32)20-13-28-25(29-20)17-11-16-12-18(4-6-22(16)34-14-17)35-23-8-9-27-26-19(23)5-7-24(33)30-26;2*1-15-8-17(12-27-11-15)21-13-29-25(30-21)18-9-16-10-19(2-4-22(16)33-14-18)34-23-6-7-28-26-20(23)3-5-24(32)31-26;3*1-14-9-20(31(2)30-14)19-12-27-24(28-19)16-10-15-11-17(3-5-21(15)33-13-16)34-22-7-8-26-25-18(22)4-6-23(32)29-25/h2*4,6,8-9,11-13,16H,3,5,7,10,14H2,1-2H3,(H,28,29)(H,27,30,33);4,6,8-10,12-13,17H,3,5,7,11,14H2,1-2H3,(H,28,29)(H,27,30,33);2*2,4,6-8,10-13,18H,3,5,9,14H2,1H3,(H,29,30)(H,28,31,32);3*3,5,7-9,11-12,16H,4,6,10,13H2,1-2H3,(H,27,28)(H,26,29,32)/t2*16-;17-;2*18-;3*16-/m10010110/s1.
What are the key properties of 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one?
5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one has a molecular weight of 3688.12 g/mol, XLogP of 33.59, 35 rotatable bonds, 16 hydrogen bond donors, and 54 hydrogen bond acceptors.
Where does this data come from?
All data for 5-[[(3R)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;bis(5-[[(3S)-3-[5-(2,5-dimethylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one);5-[[(3R)-3-[5-(2-ethyl-5-methylpyrazol-3-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(3-ethyl-1-methylpyrazol-5-yl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3R)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one;5-[[(3S)-3-[5-(5-methyl-3-pyridinyl)-1H-imidazol-2-yl]-3,4-dihydro-2H-chromen-6-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one is sourced from PubChem (CID 163526926), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).