potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide

C142H174B2Br2IKN14O24S2 — CID 163580745

About potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide

potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide (PubChem CID 163580745) has the molecular formula C142H174B2Br2IKN14O24S2 and a molecular weight of 2872.60 g/mol. Its IUPAC name is potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide.

Molecular Properties

• Compound Name: potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide
• PubChem CID: 163580745
• Molecular Formula: C142H174B2Br2IKN14O24S2
• Molecular Weight: 2872.60 g/mol
• Exact Mass: 2868.95
• IUPAC Name: potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide
• SMILES: CC(=O)N1C[C@@H](C)N(CCOc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[C@@H](C)C1.COc1cc(-c2ccc(OCCN3[C@H](C)CN(C(C)=O)C[C@@H]3C)cc2)ccc1-c1cn(C)c(=O)c2[nH]ccc12.COc1cc(-c2ccc(OCCN3[C@H](C)CN(C(C)=O)C[C@@H]3C)cc2)ccc1-c1cn(C)c(=O)c2c1ccn2S(=O)(=O)c1ccc(C)cc1.COc1cc(-c2ccc(OCCN3[C@H](C)CN(C(C)=O)C[C@@H]3C)cc2)ccc1Br.COc1cc(I)ccc1Br.Cc1ccc(S(=O)(=O)n2ccc3c(B4OC(C)(C)C(C)(C)O4)cn(C)c(=O)c32)cc1.[K+].[OH-]
• InChI: InChI=1S/C38H42N4O6S.C31H36N4O4.C23H29BrN2O3.C22H35BN2O4.C21H25BN2O5S.C7H6BrIO.K.H2O/c1-25-7-14-32(15-8-25)49(45,46)42-18-17-34-35(24-39(5)38(44)37(34)42)33-16-11-30(21-36(33)47-6)29-9-12-31(13-10-29)48-20-19-41-26(2)22-40(28(4)43)23-27(41)3;1-20-17-34(22(3)36)18-21(2)35(20)14-15-39-25-9-6-23(7-10-25)24-8-11-26(29(16-24)38-5)28-19-33(4)31(37)30-27(28)12-13-32-30;1-16-14-25(18(3)27)15-17(2)26(16)11-12-29-21-8-5-19(6-9-21)20-7-10-22(24)23(13-20)28-4;1-16-14-24(18(3)26)15-17(2)25(16)12-13-27-20-10-8-19(9-11-20)23-28-21(4,5)22(6,7)29-23;1-14-7-9-15(10-8-14)30(26,27)24-12-11-16-17(13-23(6)19(25)18(16)24)22-28-20(2,3)21(4,5)29-22;1-10-7-4-5(9)2-3-6(7)8;;/h7-18,21,24,26-27H,19-20,22-23H2,1-6H3;6-13,16,19-21,32H,14-15,17-18H2,1-5H3;5-10,13,16-17H,11-12,14-15H2,1-4H3;8-11,16-17H,12-15H2,1-7H3;7-13H,1-6H3;2-4H,1H3;;1H2/q;;;;;;+1;/p-1/t26-,27+;20-,21+;2*16-,17+
• InChIKey: GHIMSYSJTBFCJO-ZGCCGMQDSA-M
• XLogP: 18.90
• TPSA: 394.89 Ų
• H-Bond Donors: 1
• H-Bond Acceptors: 33
• Rotatable Bonds: 31
• Heavy Atoms: 188
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2872.60
LogP ≤ 5	18.90
H-Bond Donors ≤ 5	1
H-Bond Acceptors ≤ 10	33

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'heavy_metal', 'substructure': 'N/A'}, {'alert_name': 'iodine', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide?

The IUPAC name of potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide (CID 163580745) is potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide.

What is the SMILES notation for potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide?

The canonical SMILES for potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide is CC(=O)N1C[C@@H](C)N(CCOc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[C@@H](C)C1.COc1cc(-c2ccc(OCCN3[C@H](C)CN(C(C)=O)C[C@@H]3C)cc2)ccc1-c1cn(C)c(=O)c2[nH]ccc12.COc1cc(-c2ccc(OCCN3[C@H](C)CN(C(C)=O)C[C@@H]3C)cc2)ccc1-c1cn(C)c(=O)c2c1ccn2S(=O)(=O)c1ccc(C)cc1.COc1cc(-c2ccc(OCCN3[C@H](C)CN(C(C)=O)C[C@@H]3C)cc2)ccc1Br.COc1cc(I)ccc1Br.Cc1ccc(S(=O)(=O)n2ccc3c(B4OC(C)(C)C(C)(C)O4)cn(C)c(=O)c32)cc1.[K+].[OH-].

What is the InChIKey of potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide?

The InChIKey is GHIMSYSJTBFCJO-ZGCCGMQDSA-M. The full InChI is InChI=1S/C38H42N4O6S.C31H36N4O4.C23H29BrN2O3.C22H35BN2O4.C21H25BN2O5S.C7H6BrIO.K.H2O/c1-25-7-14-32(15-8-25)49(45,46)42-18-17-34-35(24-39(5)38(44)37(34)42)33-16-11-30(21-36(33)47-6)29-9-12-31(13-10-29)48-20-19-41-26(2)22-40(28(4)43)23-27(41)3;1-20-17-34(22(3)36)18-21(2)35(20)14-15-39-25-9-6-23(7-10-25)24-8-11-26(29(16-24)38-5)28-19-33(4)31(37)30-27(28)12-13-32-30;1-16-14-25(18(3)27)15-17(2)26(16)11-12-29-21-8-5-19(6-9-21)20-7-10-22(24)23(13-20)28-4;1-16-14-24(18(3)26)15-17(2)25(16)12-13-27-20-10-8-19(9-11-20)23-28-21(4,5)22(6,7)29-23;1-14-7-9-15(10-8-14)30(26,27)24-12-11-16-17(13-23(6)19(25)18(16)24)22-28-20(2,3)21(4,5)29-22;1-10-7-4-5(9)2-3-6(7)8;;/h7-18,21,24,26-27H,19-20,22-23H2,1-6H3;6-13,16,19-21,32H,14-15,17-18H2,1-5H3;5-10,13,16-17H,11-12,14-15H2,1-4H3;8-11,16-17H,12-15H2,1-7H3;7-13H,1-6H3;2-4H,1H3;;1H2/q;;;;;;+1;/p-1/t26-,27+;20-,21+;2*16-,17+;;;;.

What are the key properties of potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide?

potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide has a molecular weight of 2872.60 g/mol, XLogP of 18.90, 31 rotatable bonds, 1 hydrogen bond donors, and 33 hydrogen bond acceptors.

Where does this data come from?

All data for potassium;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-c]pyridin-7-one;4-[4-[4-[2-[(2S,6R)-4-acetyl-2,6-dimethylpiperazin-1-yl]ethoxy]phenyl]-2-methoxyphenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one;1-bromo-4-iodo-2-methoxybenzene;1-[(3R,5S)-4-[2-[4-(4-bromo-3-methoxyphenyl)phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone;1-[(3S,5R)-3,5-dimethyl-4-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperazin-1-yl]ethanone;6-methyl-1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridin-7-one;hydroxide is sourced from PubChem (CID 163580745), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).