4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide

C134H116F8N16O27 — CID 163653980

About 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide

4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide (PubChem CID 163653980) has the molecular formula C134H116F8N16O27 and a molecular weight of 2534.47 g/mol. Its IUPAC name is 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide.

Molecular Properties

• Compound Name: 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide
• PubChem CID: 163653980
• Molecular Formula: C134H116F8N16O27
• Molecular Weight: 2534.47 g/mol
• Exact Mass: 2532.81
• IUPAC Name: 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide
• SMILES: CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)c(F)c1.COc1cc2nccc(Oc3ccc(NC(=O)c4ccn(-c5ccc(F)cc5C)n4)cc3F)c2c2c1OCCO2.COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)c(F)c1.COc1cn(-c2ccc(F)cc2C)nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c4c(c23)OCCO4)c(F)c1
• InChI: InChI=1S/C38H36F2N4O8.C37H34F2N4O8.C30H24F2N4O6.C29H22F2N4O5/c1-2-48-30-11-14-44(26-7-4-24(39)5-8-26)38(46)34(30)37(45)42-25-6-9-29(27(40)22-25)52-31-10-12-41-28-23-32(35-36(33(28)31)51-21-20-50-35)49-17-3-13-43-15-18-47-19-16-43;1-46-29-10-13-43(25-6-3-23(38)4-7-25)37(45)33(29)36(44)41-24-5-8-28(26(39)21-24)51-30-9-11-40-27-22-31(34-35(32(27)30)50-20-19-49-34)48-16-2-12-42-14-17-47-18-15-42;1-16-12-17(31)4-6-21(16)36-15-25(39-3)27(35-36)30(37)34-18-5-7-22(19(32)13-18)42-23-8-9-33-20-14-24(38-2)28-29(26(20)23)41-11-10-40-28;1-16-13-17(30)3-5-22(16)35-10-8-20(34-35)29(36)33-18-4-6-23(19(31)14-18)40-24-7-9-32-21-15-25(37-2)27-28(26(21)24)39-12-11-38-27/h4-12,14,22-23H,2-3,13,15-21H2,1H3,(H,42,45);3-11,13,21-22H,2,12,14-20H2,1H3,(H,41,44);4-9,12-15H,10-11H2,1-3H3,(H,34,37);3-10,13-15H,11-12H2,1-2H3,(H,33,36)
• InChIKey: IOPMKDBXMWLSJU-UHFFFAOYSA-N
• XLogP: 23.24
• TPSA: 447.91 Ų
• H-Bond Donors: 4
• H-Bond Acceptors: 39
• Rotatable Bonds: 36
• Heavy Atoms: 185
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2534.47
LogP ≤ 5	23.24
H-Bond Donors ≤ 5	4
H-Bond Acceptors ≤ 10	39

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'Aliphatic_long_chain', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide?

The IUPAC name of 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide (CID 163653980) is 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide.

What is the SMILES notation for 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide?

The canonical SMILES for 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide is CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)c(F)c1.COc1cc2nccc(Oc3ccc(NC(=O)c4ccn(-c5ccc(F)cc5C)n4)cc3F)c2c2c1OCCO2.COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c4c(c23)OCCO4)c(F)c1.COc1cn(-c2ccc(F)cc2C)nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c4c(c23)OCCO4)c(F)c1.

What is the InChIKey of 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide?

The InChIKey is IOPMKDBXMWLSJU-UHFFFAOYSA-N. The full InChI is InChI=1S/C38H36F2N4O8.C37H34F2N4O8.C30H24F2N4O6.C29H22F2N4O5/c1-2-48-30-11-14-44(26-7-4-24(39)5-8-26)38(46)34(30)37(45)42-25-6-9-29(27(40)22-25)52-31-10-12-41-28-23-32(35-36(33(28)31)51-21-20-50-35)49-17-3-13-43-15-18-47-19-16-43;1-46-29-10-13-43(25-6-3-23(38)4-7-25)37(45)33(29)36(44)41-24-5-8-28(26(39)21-24)51-30-9-11-40-27-22-31(34-35(32(27)30)50-20-19-49-34)48-16-2-12-42-14-17-47-18-15-42;1-16-12-17(31)4-6-21(16)36-15-25(39-3)27(35-36)30(37)34-18-5-7-22(19(32)13-18)42-23-8-9-33-20-14-24(38-2)28-29(26(20)23)41-11-10-40-28;1-16-13-17(30)3-5-22(16)35-10-8-20(34-35)29(36)33-18-4-6-23(19(31)14-18)40-24-7-9-32-21-15-25(37-2)27-28(26(21)24)39-12-11-38-27/h4-12,14,22-23H,2-3,13,15-21H2,1H3,(H,42,45);3-11,13,21-22H,2,12,14-20H2,1H3,(H,41,44);4-9,12-15H,10-11H2,1-3H3,(H,34,37);3-10,13-15H,11-12H2,1-2H3,(H,33,36).

What are the key properties of 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide?

4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide has a molecular weight of 2534.47 g/mol, XLogP of 23.24, 36 rotatable bonds, 4 hydrogen bond donors, and 39 hydrogen bond acceptors.

Where does this data come from?

All data for 4-ethoxy-N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)-4-methoxypyrazole-3-carboxamide;N-[3-fluoro-4-[(5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl)oxy]phenyl]-1-(4-fluoro-2-methylphenyl)pyrazole-3-carboxamide;N-[3-fluoro-4-[[5-(3-morpholin-4-ylpropoxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinolin-10-yl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-2-oxopyridine-3-carboxamide is sourced from PubChem (CID 163653980), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).