N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide

C173H151F11N36O10 — CID 163984900

IUPACN-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide
SMILESCC(C)n1cc(C(=O)Nc2cc(F)c(-c3cc(-c4cnn(C)c4)cnc3N)cc2F)c(=O)c(-c2ccc(F)cc2)c1C#N.CC(C)n1cc(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCCCC5)c4)cnc3N)c(F)c2)c(=O)c(-c2ccc(F)cc2)c1C#N.CC(C)n1cc(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCN(C)CC5)c4)cnc3N)c(F)c2)c(=O)c(-c2ccc(F)cc2)c1C#N.CCn1cc(-c2cnc(N)c(-c3ccc(NC(=O)c4cn(C5CCC5)c(C#N)c(-c5ccc(F)cc5)c4=O)cc3F)c2)cn1.N#Cc1c(-c2ccc(F)cc2)c(=O)c(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCCCC5)c4)cnc3N)c(F)c2)cn1C1CCC1
InChIInChI=1S/C37H33F2N7O2.C36H34F2N8O2.C36H33F2N7O2.C33H27F2N7O2.C31H24F3N7O2/c38-25-11-9-22(10-12-25)34-33(17-40)45(27-7-4-8-27)21-31(35(34)47)37(48)44-26-13-14-29(32(39)16-26)30-15-23(18-42-36(30)41)24-19-43-46(20-24)28-5-2-1-3-6-28;1-21(2)45-20-30(34(47)33(32(45)16-39)22-4-6-25(37)7-5-22)36(48)43-26-8-9-28(31(38)15-26)29-14-23(17-41-35(29)40)24-18-42-46(19-24)27-10-12-44(3)13-11-27;1-21(2)44-20-30(34(46)33(32(44)16-39)22-8-10-25(37)11-9-22)36(47)43-26-12-13-28(31(38)15-26)29-14-23(17-41-35(29)40)24-18-42-45(19-24)27-6-4-3-5-7-27;1-2-41-17-21(16-39-41)20-12-26(32(37)38-15-20)25-11-10-23(13-28(25)35)40-33(44)27-18-42(24-4-3-5-24)29(14-36)30(31(27)43)19-6-8-22(34)9-7-19;1-16(2)41-15-23(29(42)28(27(41)11-35)17-4-6-20(32)7-5-17)31(43)39-26-10-24(33)21(9-25(26)34)22-8-18(12-37-30(22)36)19-13-38-40(3)14-19/h9-16,18-21,27-28H,1-8H2,(H2,41,42)(H,44,48);4-9,14-15,17-21,27H,10-13H2,1-3H3,(H2,40,41)(H,43,48);8-15,17-21,27H,3-7H2,1-2H3,(H2,40,41)(H,43,47);6-13,15-18,24H,2-5H2,1H3,(H2,37,38)(H,40,44);4-10,12-16H,1-3H3,(H2,36,37)(H,39,43)
InChIKeyTVKISYWZVWRYGE-UHFFFAOYSA-N
MW3103.33 g/mol
LogP33.29
Rot. Bonds34

About N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide

N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide (PubChem CID 163984900) has the molecular formula C173H151F11N36O10 and a molecular weight of 3103.33 g/mol. Its IUPAC name is N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide.

Molecular Properties

Compound NameN-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide
PubChem CID163984900
Molecular FormulaC173H151F11N36O10
Molecular Weight3103.33 g/mol
Exact Mass3101.22
IUPAC NameN-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide
SMILESCC(C)n1cc(C(=O)Nc2cc(F)c(-c3cc(-c4cnn(C)c4)cnc3N)cc2F)c(=O)c(-c2ccc(F)cc2)c1C#N.CC(C)n1cc(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCCCC5)c4)cnc3N)c(F)c2)c(=O)c(-c2ccc(F)cc2)c1C#N.CC(C)n1cc(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCN(C)CC5)c4)cnc3N)c(F)c2)c(=O)c(-c2ccc(F)cc2)c1C#N.CCn1cc(-c2cnc(N)c(-c3ccc(NC(=O)c4cn(C5CCC5)c(C#N)c(-c5ccc(F)cc5)c4=O)cc3F)c2)cn1.N#Cc1c(-c2ccc(F)cc2)c(=O)c(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCCCC5)c4)cnc3N)c(F)c2)cn1C1CCC1
InChIInChI=1S/C37H33F2N7O2.C36H34F2N8O2.C36H33F2N7O2.C33H27F2N7O2.C31H24F3N7O2/c38-25-11-9-22(10-12-25)34-33(17-40)45(27-7-4-8-27)21-31(35(34)47)37(48)44-26-13-14-29(32(39)16-26)30-15-23(18-42-36(30)41)24-19-43-46(20-24)28-5-2-1-3-6-28;1-21(2)45-20-30(34(47)33(32(45)16-39)22-4-6-25(37)7-5-22)36(48)43-26-8-9-28(31(38)15-26)29-14-23(17-41-35(29)40)24-18-42-46(19-24)27-10-12-44(3)13-11-27;1-21(2)44-20-30(34(46)33(32(44)16-39)22-8-10-25(37)11-9-22)36(47)43-26-12-13-28(31(38)15-26)29-14-23(17-41-35(29)40)24-18-42-45(19-24)27-6-4-3-5-7-27;1-2-41-17-21(16-39-41)20-12-26(32(37)38-15-20)25-11-10-23(13-28(25)35)40-33(44)27-18-42(24-4-3-5-24)29(14-36)30(31(27)43)19-6-8-22(34)9-7-19;1-16(2)41-15-23(29(42)28(27(41)11-35)17-4-6-20(32)7-5-17)31(43)39-26-10-24(33)21(9-25(26)34)22-8-18(12-37-30(22)36)19-13-38-40(3)14-19/h9-16,18-21,27-28H,1-8H2,(H2,41,42)(H,44,48);4-9,14-15,17-21,27H,10-13H2,1-3H3,(H2,40,41)(H,43,48);8-15,17-21,27H,3-7H2,1-2H3,(H2,40,41)(H,43,47);6-13,15-18,24H,2-5H2,1H3,(H2,37,38)(H,40,44);4-10,12-16H,1-3H3,(H2,36,37)(H,39,43)
InChIKeyTVKISYWZVWRYGE-UHFFFAOYSA-N
XLogP33.29
TPSA661.34 Ų
H-Bond Donors10
H-Bond Acceptors41
Rotatable Bonds34
Heavy Atoms230
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003103.33
LogP ≤ 533.29
H-Bond Donors ≤ 510
H-Bond Acceptors ≤ 1041

Analyze N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide with MolForge

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Related Compounds

N-[4-[2-amino-5-(1-piperidin-4-ylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide
CID 146424675
N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide
CID 146424693
N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide
CID 146424744
N-[4-[2-amino-5-(1-piperidin-4-ylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide
CID 151992044
N-benzyl-6-[3-pyridin-3-yl-5-(trifluoromethyl)pyrazol-1-yl]pyridine-3-carboxamide;N-cyclohexyl-6-[3-pyridin-3-yl-5-(trifluoromethyl)pyrazol-1-yl]pyridine-3-carboxamide;N-(3,3-diphenylpropyl)-6-[3-pyridin-3-yl-5-(trifluoromethyl)pyrazol-1-yl]pyridine-3-carboxamide;N-hexyl-6-[3-pyridin-3-yl-5-(trifluoromethyl)pyrazol-1-yl]pyridine-3-carboxamide;N-(2-phenylethyl)-4-[5-pyridin-3-yl-3-(trifluoromethyl)pyrazol-1-yl]benzamide;N-(3-phenylpropyl)-4-[5-pyridin-3-yl-3-(trifluoromethyl)pyrazol-1-yl]benzamide
CID 157141744
(2S)-N-[5-(3,3-difluoropyrrolidin-1-yl)-2-pyridinyl]-2-[2-(4-methylphenyl)ethylamino]-2-phenylacetamide;(2R)-N-[5-(3,3-difluoropyrrolidin-1-yl)-2-pyridinyl]-2-[2-(4-methylphenyl)ethylamino]-2-phenylacetamide;(2R)-N-[5-(3-ethyl-2-oxoimidazolidin-1-yl)-2-pyridinyl]-2-[2-(4-methylphenyl)ethylamino]-2-phenylacetamide;(2S)-N-[5-(3-ethyl-2-oxoimidazolidin-1-yl)-2-pyridinyl]-2-[2-(4-methylphenyl)ethylamino]-2-phenylacetamide;(2R)-N-[3-fluoro-5-(1-methylpyrazol-4-yl)-2-pyridinyl]-2-[2-(4-methylphenyl)ethylamino]-2-phenylacetamide;(2S)-N-[3-fluoro-5-(1-methylpyrazol-4-yl)-2-pyridinyl]-2-[2-(4-methylphenyl)ethylamino]-2-phenylacetamide
CID 157287413
2,6-difluoro-N-[5-[1-methyl-3-(2-methylphenyl)pyrazol-5-yl]-2-pyridinyl]benzamide;2,6-difluoro-N-[5-[1-methyl-4-(trifluoromethyl)pyrrol-2-yl]-2-pyridinyl]benzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2,6-difluorobenzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2-fluorobenzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2-methylbenzamide;2-fluoro-N-[5-[1-methyl-3-(2-methylphenyl)pyrazol-5-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-[1-methyl-3-(2-methylphenyl)pyrazol-5-yl]-2-pyridinyl]benzamide
CID 157943421
bis(3-(3-fluoro-4-methylpyrazol-1-yl)-1-[4-isocyano-3-(trifluoromethyl)phenyl]-3-methylbutan-2-one);bis(1-[4-isocyano-3-(trifluoromethyl)phenyl]-3-methyl-3-(3-methylpyrrol-1-yl)butan-2-one);1-[4-[4-isocyano-3-(trifluoromethyl)phenyl]-2-methyl-3-oxobutan-2-yl]-N-methylpyrrole-3-carboxamide;2-[4-isocyano-3-(trifluoromethyl)phenyl]-1-[1-(4-methylpyrazol-1-yl)cyclobutyl]ethanone;1-[6-isocyano-5-(trifluoromethyl)-3-pyridinyl]-3-methyl-3-(4-methylpyrazol-1-yl)butan-2-one;2-[6-isocyano-5-(trifluoromethyl)-3-pyridinyl]-1-[1-(4-methylpyrazol-1-yl)cyclobutyl]ethanone
CID 158654461
4-fluoro-2-[1-[6-isocyano-1-oxido-5-(trifluoromethyl)pyridin-1-ium-3-yl]-3-methyl-2-oxopentan-3-yl]-1H-pyrazol-5-one;4-fluoro-2-[1-[2-[6-isocyano-5-(trifluoromethyl)-3-pyridinyl]acetyl]cyclobutyl]-1H-pyrazol-5-one;1-[1-(4-fluoro-2-oxidopyrazol-2-ium-1-yl)cyclohexyl]-2-[6-isocyano-5-(trifluoromethyl)-3-pyridinyl]ethanone;1-[1-(4-fluoropyrazol-1-yl)cyclobutyl]-2-[6-isocyano-5-(trifluoromethyl)-3-pyridinyl]ethanone;1-[1-(4-fluoropyrazol-1-yl)cyclohexyl]-2-[6-isocyano-5-(trifluoromethyl)-3-pyridinyl]ethanone;1-[1-(4-fluoropyrazol-1-yl)cyclopentyl]-2-[4-isocyano-3-(trifluoromethyl)phenyl]ethanone;1-[1-(4-fluoropyrazol-1-yl)cyclopentyl]-2-[4-methyl-3-(trifluoromethyl)phenyl]ethanone;3-(4-fluoropyrazol-1-yl)-1-[6-isocyano-5-(trifluoromethyl)-3-pyridinyl]-3-methylpentan-2-one
CID 159329079
2,6-difluoro-N-[5-[1-methyl-4-(trifluoromethyl)pyrrol-2-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[1-methyl-4-(trifluoromethyl)pyrrol-2-yl]-2-pyridinyl]benzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2,6-difluorobenzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2-fluorobenzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2-methylbenzamide
CID 159408728
N-[5-[3-(2,6-difluorocyclohexa-1,3-dien-1-yl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2-methylbenzamide;2,6-difluoro-N-[5-[1-methyl-4-(trifluoromethyl)pyrrol-2-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[1-methyl-4-(trifluoromethyl)pyrrol-2-yl]-2-pyridinyl]benzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2,6-difluorobenzamide;N-[5-[3-(2,6-difluorophenyl)-1-methylpyrazol-5-yl]-2-pyridinyl]-2-fluorobenzamide;2-fluoro-N-[5-[1-methyl-3-(2-methylphenyl)pyrazol-5-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-[1-methyl-3-(2-methylphenyl)pyrazol-5-yl]-2-pyridinyl]benzamide
CID 161645545
(2S)-2-[2-(4-cyanophenyl)ethylamino]-2-(3-hexylphenyl)-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]acetamide;(2R)-2-[2-(4-cyanophenyl)ethylamino]-2-(3-hexylphenyl)-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]acetamide;(2S)-2-(4-cyanophenyl)-2-[2-(4-methylphenyl)ethylamino]-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]acetamide;(2R)-2-(4-cyanophenyl)-2-[2-(4-methylphenyl)ethylamino]-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]acetamide;(2R)-2-(4-hexylphenyl)-2-[2-(4-methylphenyl)ethylamino]-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]acetamide;(2S)-2-[2-(4-methylphenyl)ethylamino]-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]-2-[3-(trifluoromethyl)phenyl]acetamide;(2R)-2-[2-(4-methylphenyl)ethylamino]-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]-2-[4-(trifluoromethyl)phenyl]acetamide;(2S)-2-[2-(4-methylphenyl)ethylamino]-N-[5-(1-methylpyrazol-4-yl)-2-pyridinyl]-2-[4-(trifluoromethyl)phenyl]acetamide
CID 161861634

Frequently Asked Questions

What is the IUPAC name of N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide?
The IUPAC name of N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide (CID 163984900) is N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide.
What is the SMILES notation for N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide?
The canonical SMILES for N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide is CC(C)n1cc(C(=O)Nc2cc(F)c(-c3cc(-c4cnn(C)c4)cnc3N)cc2F)c(=O)c(-c2ccc(F)cc2)c1C#N.CC(C)n1cc(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCCCC5)c4)cnc3N)c(F)c2)c(=O)c(-c2ccc(F)cc2)c1C#N.CC(C)n1cc(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCN(C)CC5)c4)cnc3N)c(F)c2)c(=O)c(-c2ccc(F)cc2)c1C#N.CCn1cc(-c2cnc(N)c(-c3ccc(NC(=O)c4cn(C5CCC5)c(C#N)c(-c5ccc(F)cc5)c4=O)cc3F)c2)cn1.N#Cc1c(-c2ccc(F)cc2)c(=O)c(C(=O)Nc2ccc(-c3cc(-c4cnn(C5CCCCC5)c4)cnc3N)c(F)c2)cn1C1CCC1.
What is the InChIKey of N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide?
The InChIKey is TVKISYWZVWRYGE-UHFFFAOYSA-N. The full InChI is InChI=1S/C37H33F2N7O2.C36H34F2N8O2.C36H33F2N7O2.C33H27F2N7O2.C31H24F3N7O2/c38-25-11-9-22(10-12-25)34-33(17-40)45(27-7-4-8-27)21-31(35(34)47)37(48)44-26-13-14-29(32(39)16-26)30-15-23(18-42-36(30)41)24-19-43-46(20-24)28-5-2-1-3-6-28;1-21(2)45-20-30(34(47)33(32(45)16-39)22-4-6-25(37)7-5-22)36(48)43-26-8-9-28(31(38)15-26)29-14-23(17-41-35(29)40)24-18-42-46(19-24)27-10-12-44(3)13-11-27;1-21(2)44-20-30(34(46)33(32(44)16-39)22-8-10-25(37)11-9-22)36(47)43-26-12-13-28(31(38)15-26)29-14-23(17-41-35(29)40)24-18-42-45(19-24)27-6-4-3-5-7-27;1-2-41-17-21(16-39-41)20-12-26(32(37)38-15-20)25-11-10-23(13-28(25)35)40-33(44)27-18-42(24-4-3-5-24)29(14-36)30(31(27)43)19-6-8-22(34)9-7-19;1-16(2)41-15-23(29(42)28(27(41)11-35)17-4-6-20(32)7-5-17)31(43)39-26-10-24(33)21(9-25(26)34)22-8-18(12-37-30(22)36)19-13-38-40(3)14-19/h9-16,18-21,27-28H,1-8H2,(H2,41,42)(H,44,48);4-9,14-15,17-21,27H,10-13H2,1-3H3,(H2,40,41)(H,43,48);8-15,17-21,27H,3-7H2,1-2H3,(H2,40,41)(H,43,47);6-13,15-18,24H,2-5H2,1H3,(H2,37,38)(H,40,44);4-10,12-16H,1-3H3,(H2,36,37)(H,39,43).
What are the key properties of N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide?
N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide has a molecular weight of 3103.33 g/mol, XLogP of 33.29, 34 rotatable bonds, 10 hydrogen bond donors, and 41 hydrogen bond acceptors.
Where does this data come from?
All data for N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-(1-cyclohexylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-ethylpyrazol-4-yl)-3-pyridinyl]-3-fluorophenyl]-6-cyano-1-cyclobutyl-5-(4-fluorophenyl)-4-oxopyridine-3-carboxamide;N-[4-[2-amino-5-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-3-pyridinyl]-3-fluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide;N-[4-[2-amino-5-(1-methylpyrazol-4-yl)-3-pyridinyl]-2,5-difluorophenyl]-6-cyano-5-(4-fluorophenyl)-4-oxo-1-propan-2-ylpyridine-3-carboxamide is sourced from PubChem (CID 163984900), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).