2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

C112H101N25O11 — CID 165009193

About 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile (PubChem CID 165009193) has the molecular formula C112H101N25O11 and a molecular weight of 1973.20 g/mol. Its IUPAC name is 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile.

Molecular Properties

• Compound Name: 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile
• PubChem CID: 165009193
• Molecular Formula: C112H101N25O11
• Molecular Weight: 1973.20 g/mol
• Exact Mass: 1971.81
• IUPAC Name: 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile
• SMILES: C#Cc1ccc(OC2CCN(c3ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn3)CC2)cc1.C#Cc1ccc(OC2CN(c3ccc(-c4cc(OCC(N)=O)cn5ncc(C#N)c45)cn3)C2)cn1.C#Cc1ccc(OC2CN(c3ccc(-c4cc(OCCN5CCCC5)cn5ncc(C#N)c45)cn3)C2)cn1.C#Cc1ccc(O[C@@H]2CCN(c3ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn3)C2)cn1
• InChI: InChI=1S/C30H29N5O3.C29H27N7O2.C28H26N6O3.C25H19N7O3/c1-4-21-5-8-24(9-6-21)38-25-11-13-34(14-12-25)28-10-7-22(17-32-28)27-15-26(37-20-30(2,3)36)19-35-29(27)23(16-31)18-33-35;1-2-23-6-7-24(17-31-23)38-26-18-35(19-26)28-8-5-21(15-32-28)27-13-25(37-12-11-34-9-3-4-10-34)20-36-29(27)22(14-30)16-33-36;1-4-21-6-7-22(15-30-21)37-23-9-10-33(16-23)26-8-5-19(13-31-26)25-11-24(36-18-28(2,3)35)17-34-27(25)20(12-29)14-32-34;1-2-18-4-5-19(11-28-18)35-21-12-31(13-21)24-6-3-16(9-29-24)22-7-20(34-15-23(27)33)14-32-25(22)17(8-26)10-30-32/h1,5-10,15,17-19,25,36H,11-14,20H2,2-3H3;1,5-8,13,15-17,20,26H,3-4,9-12,18-19H2;1,5-8,11,13-15,17,23,35H,9-10,16,18H2,2-3H3;1,3-7,9-11,14,21H,12-13,15H2,(H2,27,33)/t;;23-;/m..1./s1
• InChIKey: JKWXCVTZZZZKIZ-JRRUULGYSA-N
• XLogP: 13.06
• TPSA: 428.18 Ų
• H-Bond Donors: 3
• H-Bond Acceptors: 35
• Rotatable Bonds: 29
• Heavy Atoms: 148
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	1973.20
LogP ≤ 5	13.06
H-Bond Donors ≤ 5	3
H-Bond Acceptors ≤ 10	35

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'triple_bond', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile?

The IUPAC name of 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile (CID 165009193) is 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile.

What is the SMILES notation for 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile?

The canonical SMILES for 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile is C#Cc1ccc(OC2CCN(c3ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn3)CC2)cc1.C#Cc1ccc(OC2CN(c3ccc(-c4cc(OCC(N)=O)cn5ncc(C#N)c45)cn3)C2)cn1.C#Cc1ccc(OC2CN(c3ccc(-c4cc(OCCN5CCCC5)cn5ncc(C#N)c45)cn3)C2)cn1.C#Cc1ccc(O[C@@H]2CCN(c3ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn3)C2)cn1.

What is the InChIKey of 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile?

The InChIKey is JKWXCVTZZZZKIZ-JRRUULGYSA-N. The full InChI is InChI=1S/C30H29N5O3.C29H27N7O2.C28H26N6O3.C25H19N7O3/c1-4-21-5-8-24(9-6-21)38-25-11-13-34(14-12-25)28-10-7-22(17-32-28)27-15-26(37-20-30(2,3)36)19-35-29(27)23(16-31)18-33-35;1-2-23-6-7-24(17-31-23)38-26-18-35(19-26)28-8-5-21(15-32-28)27-13-25(37-12-11-34-9-3-4-10-34)20-36-29(27)22(14-30)16-33-36;1-4-21-6-7-22(15-30-21)37-23-9-10-33(16-23)26-8-5-19(13-31-26)25-11-24(36-18-28(2,3)35)17-34-27(25)20(12-29)14-32-34;1-2-18-4-5-19(11-28-18)35-21-12-31(13-21)24-6-3-16(9-29-24)22-7-20(34-15-23(27)33)14-32-25(22)17(8-26)10-30-32/h1,5-10,15,17-19,25,36H,11-14,20H2,2-3H3;1,5-8,13,15-17,20,26H,3-4,9-12,18-19H2;1,5-8,11,13-15,17,23,35H,9-10,16,18H2,2-3H3;1,3-7,9-11,14,21H,12-13,15H2,(H2,27,33)/t;;23-;/m..1./s1.

What are the key properties of 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile?

2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile has a molecular weight of 1973.20 g/mol, XLogP of 13.06, 29 rotatable bonds, 3 hydrogen bond donors, and 35 hydrogen bond acceptors.

Where does this data come from?

All data for 2-[3-cyano-4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridin-6-yl]oxyacetamide;4-[6-[4-(4-ethynylphenoxy)piperidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[3-[(6-ethynyl-3-pyridinyl)oxy]azetidin-1-yl]-3-pyridinyl]-6-(2-pyrrolidin-1-ylethoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[(3R)-3-[(6-ethynyl-3-pyridinyl)oxy]pyrrolidin-1-yl]-3-pyridinyl]-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile is sourced from PubChem (CID 165009193), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).