7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine

C121H141N29O6 — CID 167587500

About 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine

7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine (PubChem CID 167587500) has the molecular formula C121H141N29O6 and a molecular weight of 2097.66 g/mol. Its IUPAC name is 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine.

Molecular Properties

• Compound Name: 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine
• PubChem CID: 167587500
• Molecular Formula: C121H141N29O6
• Molecular Weight: 2097.66 g/mol
• Exact Mass: 2096.16
• IUPAC Name: 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine
• SMILES: CNc1c(-c2cnc(N)c(OCc3ccncc3)n2)ccc2c1CN(C)CC2.Cc1cc(-c2cnc(N)c(OCc3c(C)cnc4[nH]ccc34)n2)cc2c1CCN(C)C2.Cc1cc(-c2cnc(N)c(OCc3ccnc4c3CCN(C)C4)n2)cc2c1CCN(C)C2.Cc1cc(-c2cnc(N)c(OCc3ccnc4c3CN(C)C4)n2)cc2c1CCN(C)C2.Cc1cc(-c2cnc(N)c(OCc3ccncc3OC3CCCCC3)n2)cc2c1CCN(C)C2
• InChI: InChI=1S/C27H33N5O2.C25H30N6O.C24H28N6O.C24H26N6O.C21H24N6O/c1-18-12-20(13-21-16-32(2)11-9-23(18)21)24-14-30-26(28)27(31-24)33-17-19-8-10-29-15-25(19)34-22-6-4-3-5-7-22;1-16-10-18(11-19-13-30(2)8-5-20(16)19)22-12-28-24(26)25(29-22)32-15-17-4-7-27-23-14-31(3)9-6-21(17)23;1-15-8-17(9-18-11-29(2)7-5-19(15)18)21-10-27-23(25)24(28-21)31-14-16-4-6-26-22-13-30(3)12-20(16)22;1-14-8-16(9-17-12-30(3)7-5-18(14)17)21-11-27-22(25)24(29-21)31-13-20-15(2)10-28-23-19(20)4-6-26-23;1-23-19-16(4-3-15-7-10-27(2)12-17(15)19)18-11-25-20(22)21(26-18)28-13-14-5-8-24-9-6-14/h8,10,12-15,22H,3-7,9,11,16-17H2,1-2H3,(H2,28,30);4,7,10-12H,5-6,8-9,13-15H2,1-3H3,(H2,26,28);4,6,8-10H,5,7,11-14H2,1-3H3,(H2,25,27);4,6,8-11H,5,7,12-13H2,1-3H3,(H2,25,27)(H,26,28);3-6,8-9,11,23H,7,10,12-13H2,1-2H3,(H2,22,25)
• InChIKey: HZKHVNYHSQTHLV-UHFFFAOYSA-N
• XLogP: 17.15
• TPSA: 429.33 Ų
• H-Bond Donors: 7
• H-Bond Acceptors: 34
• Rotatable Bonds: 23
• Heavy Atoms: 156
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2097.66
LogP ≤ 5	17.15
H-Bond Donors ≤ 5	7
H-Bond Acceptors ≤ 10	34

Frequently Asked Questions

What is the IUPAC name of 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine?

The IUPAC name of 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine (CID 167587500) is 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine.

What is the SMILES notation for 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine?

The canonical SMILES for 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine is CNc1c(-c2cnc(N)c(OCc3ccncc3)n2)ccc2c1CN(C)CC2.Cc1cc(-c2cnc(N)c(OCc3c(C)cnc4[nH]ccc34)n2)cc2c1CCN(C)C2.Cc1cc(-c2cnc(N)c(OCc3ccnc4c3CCN(C)C4)n2)cc2c1CCN(C)C2.Cc1cc(-c2cnc(N)c(OCc3ccnc4c3CN(C)C4)n2)cc2c1CCN(C)C2.Cc1cc(-c2cnc(N)c(OCc3ccncc3OC3CCCCC3)n2)cc2c1CCN(C)C2.

What is the InChIKey of 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine?

The InChIKey is HZKHVNYHSQTHLV-UHFFFAOYSA-N. The full InChI is InChI=1S/C27H33N5O2.C25H30N6O.C24H28N6O.C24H26N6O.C21H24N6O/c1-18-12-20(13-21-16-32(2)11-9-23(18)21)24-14-30-26(28)27(31-24)33-17-19-8-10-29-15-25(19)34-22-6-4-3-5-7-22;1-16-10-18(11-19-13-30(2)8-5-20(16)19)22-12-28-24(26)25(29-22)32-15-17-4-7-27-23-14-31(3)9-6-21(17)23;1-15-8-17(9-18-11-29(2)7-5-19(15)18)21-10-27-23(25)24(28-21)31-14-16-4-6-26-22-13-30(3)12-20(16)22;1-14-8-16(9-17-12-30(3)7-5-18(14)17)21-11-27-22(25)24(29-21)31-13-20-15(2)10-28-23-19(20)4-6-26-23;1-23-19-16(4-3-15-7-10-27(2)12-17(15)19)18-11-25-20(22)21(26-18)28-13-14-5-8-24-9-6-14/h8,10,12-15,22H,3-7,9,11,16-17H2,1-2H3,(H2,28,30);4,7,10-12H,5-6,8-9,13-15H2,1-3H3,(H2,26,28);4,6,8-10H,5,7,11-14H2,1-3H3,(H2,25,27);4,6,8-11H,5,7,12-13H2,1-3H3,(H2,25,27)(H,26,28);3-6,8-9,11,23H,7,10,12-13H2,1-2H3,(H2,22,25).

What are the key properties of 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine?

7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine has a molecular weight of 2097.66 g/mol, XLogP of 17.15, 23 rotatable bonds, 7 hydrogen bond donors, and 34 hydrogen bond acceptors.

Where does this data come from?

All data for 7-[5-amino-6-(pyridin-4-ylmethoxy)pyrazin-2-yl]-N,2-dimethyl-3,4-dihydro-1H-isoquinolin-8-amine;3-[(3-cyclohexyloxy-4-pyridinyl)methoxy]-5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(7-methyl-6,8-dihydro-5H-1,7-naphthyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(6-methyl-5,7-dihydropyrrolo[3,4-b]pyridin-4-yl)methoxy]pyrazin-2-amine;5-(2,5-dimethyl-3,4-dihydro-1H-isoquinolin-7-yl)-3-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methoxy]pyrazin-2-amine is sourced from PubChem (CID 167587500), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).