(2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride

C155H215Br4ClFN21O19S2 — CID 167609921

About (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride

(2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride (PubChem CID 167609921) has the molecular formula C155H215Br4ClFN21O19S2 and a molecular weight of 3115.76 g/mol. Its IUPAC name is (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride.

Molecular Properties

• Compound Name: (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride
• PubChem CID: 167609921
• Molecular Formula: C155H215Br4ClFN21O19S2
• Molecular Weight: 3115.76 g/mol
• Exact Mass: 3109.24
• IUPAC Name: (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride
• SMILES: CC(=O)CN1CCC(CCCN(c2ccc(-n3ccnc3)c(Br)c2)c2cc(-c3c(C)noc3C)ccc2C)CC1.CC(C)(C)OC(=O)CBr.CC(C)(C)OC(=O)N1CCC(CCCO)CC1.CCCCC1CCN(C(=O)OC(C)(C)C)CC1.CS(=O)(=O)Cl.Cc1ccc(-c2c(C)noc2C)cc1N(CCCC1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(-n2ccnc2)c(Br)c1.Cc1ccc(-c2c(C)noc2C)cc1N(CCCC1CCN(CC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1)c1ccc(-n2ccnc2)c(Br)c1.[2H]CF
• InChI: InChI=1S/C54H66BrN9O5S.C34H42BrN5O3.C32H38BrN5O2.C14H27NO2.C13H25NO3.C6H11BrO2.CH3ClO2S.CH3F/c1-33-11-12-41(49-35(3)60-69-37(49)5)26-46(33)63(42-17-18-45(44(55)27-42)62-25-21-56-31-62)22-9-10-38-19-23-61(24-20-38)30-48(66)59-51(54(6,7)8)53(68)64-29-43(65)28-47(64)52(67)58-34(2)39-13-15-40(16-14-39)50-36(4)57-32-70-50;1-23-9-10-27(32-24(2)37-43-25(32)3)20-31(23)40(28-11-12-30(29(35)21-28)39-19-15-36-22-39)16-7-8-26-13-17-38(18-14-26)33(41)42-34(4,5)6;1-22-7-8-27(32-24(3)35-40-25(32)4)18-31(22)38(14-5-6-26-11-15-36(16-12-26)20-23(2)39)28-9-10-30(29(33)19-28)37-17-13-34-21-37;1-5-6-7-12-8-10-15(11-9-12)13(16)17-14(2,3)4;1-13(2,3)17-12(16)14-8-6-11(7-9-14)5-4-10-15;1-6(2,3)9-5(8)4-7;1-5(2,3)4;1-2/h11-18,21,25-27,31-32,34,38,43,47,51,65H,9-10,19-20,22-24,28-30H2,1-8H3,(H,58,67)(H,59,66);9-12,15,19-22,26H,7-8,13-14,16-18H2,1-6H3;7-10,13,17-19,21,26H,5-6,11-12,14-16,20H2,1-4H3;12H,5-11H2,1-4H3;11,15H,4-10H2,1-3H3;4H2,1-3H3;1H3;1H3/t34-,43+,47-,51+;;;;;;;/m0......./s1/i;;;;;;;1D
• InChIKey: KXADAVXIYARYDK-JUVQURHMSA-N
• XLogP: 34.59
• TPSA: 445.74 Ų
• H-Bond Donors: 4
• H-Bond Acceptors: 35
• Rotatable Bonds: 41
• Heavy Atoms: 203
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	3115.76
LogP ≤ 5	34.59
H-Bond Donors ≤ 5	4
H-Bond Acceptors ≤ 10	35

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'dyes5A(27)', 'substructure': 'N/A'}, {'alert_name': '>_2_ester_groups', 'substructure': 'N/A'}, {'alert_name': 'alkyl_halide', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride?

The IUPAC name of (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride (CID 167609921) is (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride.

What is the SMILES notation for (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride?

The canonical SMILES for (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride is CC(=O)CN1CCC(CCCN(c2ccc(-n3ccnc3)c(Br)c2)c2cc(-c3c(C)noc3C)ccc2C)CC1.CC(C)(C)OC(=O)CBr.CC(C)(C)OC(=O)N1CCC(CCCO)CC1.CCCCC1CCN(C(=O)OC(C)(C)C)CC1.CS(=O)(=O)Cl.Cc1ccc(-c2c(C)noc2C)cc1N(CCCC1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(-n2ccnc2)c(Br)c1.Cc1ccc(-c2c(C)noc2C)cc1N(CCCC1CCN(CC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1)c1ccc(-n2ccnc2)c(Br)c1.[2H]CF.

What is the InChIKey of (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride?

The InChIKey is KXADAVXIYARYDK-JUVQURHMSA-N. The full InChI is InChI=1S/C54H66BrN9O5S.C34H42BrN5O3.C32H38BrN5O2.C14H27NO2.C13H25NO3.C6H11BrO2.CH3ClO2S.CH3F/c1-33-11-12-41(49-35(3)60-69-37(49)5)26-46(33)63(42-17-18-45(44(55)27-42)62-25-21-56-31-62)22-9-10-38-19-23-61(24-20-38)30-48(66)59-51(54(6,7)8)53(68)64-29-43(65)28-47(64)52(67)58-34(2)39-13-15-40(16-14-39)50-36(4)57-32-70-50;1-23-9-10-27(32-24(2)37-43-25(32)3)20-31(23)40(28-11-12-30(29(35)21-28)39-19-15-36-22-39)16-7-8-26-13-17-38(18-14-26)33(41)42-34(4,5)6;1-22-7-8-27(32-24(3)35-40-25(32)4)18-31(22)38(14-5-6-26-11-15-36(16-12-26)20-23(2)39)28-9-10-30(29(33)19-28)37-17-13-34-21-37;1-5-6-7-12-8-10-15(11-9-12)13(16)17-14(2,3)4;1-13(2,3)17-12(16)14-8-6-11(7-9-14)5-4-10-15;1-6(2,3)9-5(8)4-7;1-5(2,3)4;1-2/h11-18,21,25-27,31-32,34,38,43,47,51,65H,9-10,19-20,22-24,28-30H2,1-8H3,(H,58,67)(H,59,66);9-12,15,19-22,26H,7-8,13-14,16-18H2,1-6H3;7-10,13,17-19,21,26H,5-6,11-12,14-16,20H2,1-4H3;12H,5-11H2,1-4H3;11,15H,4-10H2,1-3H3;4H2,1-3H3;1H3;1H3/t34-,43+,47-,51+;;;;;;;/m0......./s1/i;;;;;;;1D.

What are the key properties of (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride?

(2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride has a molecular weight of 3115.76 g/mol, XLogP of 34.59, 41 rotatable bonds, 4 hydrogen bond donors, and 35 hydrogen bond acceptors.

Where does this data come from?

All data for (2S,4R)-1-[(2S)-2-[[2-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;1-[4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidin-1-yl]propan-2-one;tert-butyl 2-bromoacetate;tert-butyl 4-[3-(3-bromo-N-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methylphenyl]-4-imidazol-1-ylanilino)propyl]piperidine-1-carboxylate;tert-butyl 4-butylpiperidine-1-carboxylate;tert-butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate;deuterio(fluoro)methane;methanesulfonyl chloride is sourced from PubChem (CID 167609921), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).