N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)

C187H263N35O36 — CID 167612070

About N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)

N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione) (PubChem CID 167612070) has the molecular formula C187H263N35O36 and a molecular weight of 3577.37 g/mol. Its IUPAC name is N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione).

Molecular Properties

• Compound Name: N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)
• PubChem CID: 167612070
• Molecular Formula: C187H263N35O36
• Molecular Weight: 3577.37 g/mol
• Exact Mass: 3574.98
• IUPAC Name: N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)
• SMILES: CC(=O)NCCOCCC(=O)CCCn1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc21.CC(=O)NCCOCCC(=O)N1CCc2cc(Cn3nc(-c4ccc5oc(N)nc5c4)c4c(N)ncnc43)ccc2C1.CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)C[C@@H](O)[C@H](C)/C=C(/C)[C@@H](O)[C@@H](OC)C(=NOCC(=O)CCc2cnc(N3CCN(c4ncc(C)c(N)n4)CC3)nc2)[C@H](C)C[C@H](C)/C=C\C=C\C=C\1C.CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)C[C@@H](O)[C@H](C)/C=C(/C)[C@@H](O)[C@@H](OC)C(=NOCC(=O)CCc2cnc(N3CCN(c4ncc(C)c(N)n4)CC3)nc2)[C@H](C)C[C@H](C)/C=C\C=C\C=C\1C
• InChI: InChI=1S/2C68H103N9O14.C29H31N9O4.C22H26N8O4/c2*1-41-17-13-12-14-18-42(2)56(86-9)35-52-24-20-48(8)68(85,91-52)62(82)64(83)77-26-16-15-19-53(77)65(84)90-57(44(4)33-49-22-25-54(79)58(34-49)87-10)36-55(80)43(3)32-46(6)60(81)61(88-11)59(45(5)31-41)74-89-40-51(78)23-21-50-38-71-66(72-39-50)75-27-29-76(30-28-75)67-70-37-47(7)63(69)73-67;1-17(39)32-8-11-41-10-7-24(40)37-9-6-19-12-18(2-3-21(19)15-37)14-38-28-25(27(30)33-16-34-28)26(36-38)20-4-5-23-22(13-20)35-29(31)42-23;1-13(31)25-7-10-33-9-6-15(32)3-2-8-30-21-18(20(23)26-12-27-21)19(29-30)14-4-5-17-16(11-14)28-22(24)34-17/h2*12-14,17-18,32,37-39,41,43-45,48-49,52-58,60-61,79-81,85H,15-16,19-31,33-36,40H2,1-11H3,(H2,69,70,73);2-5,12-13,16H,6-11,14-15H2,1H3,(H2,31,35)(H,32,39)(H2,30,33,34);4-5,11-12H,2-3,6-10H2,1H3,(H2,24,28)(H,25,31)(H2,23,26,27)/b2*14-12+,17-13-,42-18+,46-32-,74-59?;;/t2*41-,43-,44-,45-,48-,49+,52+,53+,54-,55-,56+,57+,58-,60-,61+,68-;;/m11../s1
• InChIKey: LEUMDFBASMYTBE-VFHNHJATSA-N
• XLogP: 17.52
• TPSA: 965.86 Ų
• H-Bond Donors: 16
• H-Bond Acceptors: 66
• Rotatable Bonds: 48
• Heavy Atoms: 258
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3577.37
LogP ≤ 5	17.52
H-Bond Donors ≤ 5	16
H-Bond Acceptors ≤ 10	66

Frequently Asked Questions

What is the IUPAC name of N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)?

The IUPAC name of N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione) (CID 167612070) is N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione).

What is the SMILES notation for N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)?

The canonical SMILES for N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione) is CC(=O)NCCOCCC(=O)CCCn1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc21.CC(=O)NCCOCCC(=O)N1CCc2cc(Cn3nc(-c4ccc5oc(N)nc5c4)c4c(N)ncnc43)ccc2C1.CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)C[C@@H](O)[C@H](C)/C=C(/C)[C@@H](O)[C@@H](OC)C(=NOCC(=O)CCc2cnc(N3CCN(c4ncc(C)c(N)n4)CC3)nc2)[C@H](C)C[C@H](C)/C=C\C=C\C=C\1C.CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)C[C@@H](O)[C@H](C)/C=C(/C)[C@@H](O)[C@@H](OC)C(=NOCC(=O)CCc2cnc(N3CCN(c4ncc(C)c(N)n4)CC3)nc2)[C@H](C)C[C@H](C)/C=C\C=C\C=C\1C.

What is the InChIKey of N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)?

The InChIKey is LEUMDFBASMYTBE-VFHNHJATSA-N. The full InChI is InChI=1S/2C68H103N9O14.C29H31N9O4.C22H26N8O4/c2*1-41-17-13-12-14-18-42(2)56(86-9)35-52-24-20-48(8)68(85,91-52)62(82)64(83)77-26-16-15-19-53(77)65(84)90-57(44(4)33-49-22-25-54(79)58(34-49)87-10)36-55(80)43(3)32-46(6)60(81)61(88-11)59(45(5)31-41)74-89-40-51(78)23-21-50-38-71-66(72-39-50)75-27-29-76(30-28-75)67-70-37-47(7)63(69)73-67;1-17(39)32-8-11-41-10-7-24(40)37-9-6-19-12-18(2-3-21(19)15-37)14-38-28-25(27(30)33-16-34-28)26(36-38)20-4-5-23-22(13-20)35-29(31)42-23;1-13(31)25-7-10-33-9-6-15(32)3-2-8-30-21-18(20(23)26-12-27-21)19(29-30)14-4-5-17-16(11-14)28-22(24)34-17/h2*12-14,17-18,32,37-39,41,43-45,48-49,52-58,60-61,79-81,85H,15-16,19-31,33-36,40H2,1-11H3,(H2,69,70,73);2-5,12-13,16H,6-11,14-15H2,1H3,(H2,31,35)(H,32,39)(H2,30,33,34);4-5,11-12H,2-3,6-10H2,1H3,(H2,24,28)(H,25,31)(H2,23,26,27)/b2*14-12+,17-13-,42-18+,46-32-,74-59?;;/t2*41-,43-,44-,45-,48-,49+,52+,53+,54-,55-,56+,57+,58-,60-,61+,68-;;/m11../s1.

What are the key properties of N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione)?

N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione) has a molecular weight of 3577.37 g/mol, XLogP of 17.52, 48 rotatable bonds, 16 hydrogen bond donors, and 66 hydrogen bond acceptors.

Where does this data come from?

All data for N-[2-[3-[6-[[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropoxy]ethyl]acetamide;N-[2-[6-[4-amino-3-(2-amino-1,3-benzoxazol-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-3-oxohexoxy]ethyl]acetamide;bis((1R,9S,12S,14R,15R,16E,18R,19S,21R,23S,24E,26E,28E,30S,32S,35R)-20-[4-[2-[4-(4-amino-5-methylpyrimidin-2-yl)piperazin-1-yl]pyrimidin-5-yl]-2-oxobutoxy]imino-1,14,18-trihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10-trione) is sourced from PubChem (CID 167612070), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).