5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile

C87H93FN22O8 — CID 167618740

About 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile

5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile (PubChem CID 167618740) has the molecular formula C87H93FN22O8 and a molecular weight of 1593.84 g/mol. Its IUPAC name is 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile.

Molecular Properties

• Compound Name: 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
• PubChem CID: 167618740
• Molecular Formula: C87H93FN22O8
• Molecular Weight: 1593.84 g/mol
• Exact Mass: 1592.75
• IUPAC Name: 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
• SMILES: CC(C)(O)COc1cn2ncc(C#N)c2c(-c2ccc(N3CCC(Oc4ccccn4)CC3)nc2)c1F.COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(N5CC(C(C)(C)O)C5)cn5ncc(C#N)c45)cn2)C3)cn1.COc1ccc(OC2CCN(c3ccc(-c4cc(N5CC(C(C)(C)O)C5)cn5ncc(C#N)c45)cn3)CC2)nn1
• InChI: InChI=1S/C31H34N8O2.C29H32N8O3.C27H27FN6O3/c1-31(2,40)23-15-36(16-23)24-9-27(30-22(10-32)13-35-39(30)19-24)21-5-6-28(33-12-21)37-17-25-8-26(18-37)38(25)14-20-4-7-29(41-3)34-11-20;1-29(2,38)21-16-36(17-21)22-12-24(28-20(13-30)15-32-37(28)18-22)19-4-5-25(31-14-19)35-10-8-23(9-11-35)40-27-7-6-26(39-3)33-34-27;1-27(2,35)17-36-21-16-34-26(19(13-29)15-32-34)24(25(21)28)18-6-7-22(31-14-18)33-11-8-20(9-12-33)37-23-5-3-4-10-30-23/h4-7,9,11-13,19,23,25-26,40H,8,14-18H2,1-3H3;4-7,12,14-15,18,21,23,38H,8-11,16-17H2,1-3H3;3-7,10,14-16,20,35H,8-9,11-12,17H2,1-2H3
• InChIKey: MDACVXQSRYRKIL-UHFFFAOYSA-N
• XLogP: 10.66
• TPSA: 339.78 Ų
• H-Bond Donors: 3
• H-Bond Acceptors: 30
• Rotatable Bonds: 21
• Heavy Atoms: 118
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	1593.84
LogP ≤ 5	10.66
H-Bond Donors ≤ 5	3
H-Bond Acceptors ≤ 10	30

Frequently Asked Questions

What is the IUPAC name of 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?

The IUPAC name of 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile (CID 167618740) is 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile.

What is the SMILES notation for 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?

The canonical SMILES for 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile is CC(C)(O)COc1cn2ncc(C#N)c2c(-c2ccc(N3CCC(Oc4ccccn4)CC3)nc2)c1F.COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(N5CC(C(C)(C)O)C5)cn5ncc(C#N)c45)cn2)C3)cn1.COc1ccc(OC2CCN(c3ccc(-c4cc(N5CC(C(C)(C)O)C5)cn5ncc(C#N)c45)cn3)CC2)nn1.

What is the InChIKey of 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?

The InChIKey is MDACVXQSRYRKIL-UHFFFAOYSA-N. The full InChI is InChI=1S/C31H34N8O2.C29H32N8O3.C27H27FN6O3/c1-31(2,40)23-15-36(16-23)24-9-27(30-22(10-32)13-35-39(30)19-24)21-5-6-28(33-12-21)37-17-25-8-26(18-37)38(25)14-20-4-7-29(41-3)34-11-20;1-29(2,38)21-16-36(17-21)22-12-24(28-20(13-30)15-32-37(28)18-22)19-4-5-25(31-14-19)35-10-8-23(9-11-35)40-27-7-6-26(39-3)33-34-27;1-27(2,35)17-36-21-16-34-26(19(13-29)15-32-34)24(25(21)28)18-6-7-22(31-14-18)33-11-8-20(9-12-33)37-23-5-3-4-10-30-23/h4-7,9,11-13,19,23,25-26,40H,8,14-18H2,1-3H3;4-7,12,14-15,18,21,23,38H,8-11,16-17H2,1-3H3;3-7,10,14-16,20,35H,8-9,11-12,17H2,1-2H3.

What are the key properties of 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?

5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile has a molecular weight of 1593.84 g/mol, XLogP of 10.66, 21 rotatable bonds, 3 hydrogen bond donors, and 30 hydrogen bond acceptors.

Where does this data come from?

All data for 5-fluoro-6-(2-hydroxy-2-methylpropoxy)-4-[6-(4-pyridin-2-yloxypiperidin-1-yl)-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[4-(6-methoxypyridazin-3-yl)oxypiperidin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-[3-(2-hydroxypropan-2-yl)azetidin-1-yl]-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile is sourced from PubChem (CID 167618740), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).