/* ========================================
   ADVANCED MODELING SUITE — SOTA DESIGN
   Ambient BG · Glassmorphism · Micro-interactions
   Fluid Typography · Staggered Animations
   ======================================== */

/* ========================================
   AMBIENT BACKGROUND — Floating gradient orbs
   ======================================== */
body {
  padding-top: 80px;
}
body::before,
body::after {
  content: '';
  position: fixed;
  border-radius: 50%;
  pointer-events: none;
  z-index: -1;
  filter: blur(100px);
  opacity: 0.5;
}
body::before {
  width: 600px; height: 600px;
  top: -15%; left: -10%;
  background: var(--glow-orb-1);
  animation: orbDrift1 30s ease-in-out infinite alternate;
}
body::after {
  width: 500px; height: 500px;
  bottom: -10%; right: -10%;
  background: var(--glow-orb-2);
  animation: orbDrift2 25s ease-in-out infinite alternate;
}
@keyframes orbDrift1 {
  0%   { transform: translate(0, 0) scale(1); }
  50%  { transform: translate(80px, 60px) scale(1.1); }
  100% { transform: translate(-40px, 100px) scale(0.95); }
}
@keyframes orbDrift2 {
  0%   { transform: translate(0, 0) scale(1); }
  50%  { transform: translate(-60px, -80px) scale(1.15); }
  100% { transform: translate(50px, -40px) scale(0.9); }
}

/* ========================================
   HERO — Animated gradient text
   ======================================== */
.advanced-hero {
  text-align: center;
  padding: 3rem 1rem 2rem;
  position: relative;
}
.advanced-hero::before {
  content: '';
  position: absolute;
  top: 50%; left: 50%;
  transform: translate(-50%, -50%);
  width: 600px; height: 300px;
  background: radial-gradient(ellipse, var(--glow-orb-1) 0%, transparent 60%);
  pointer-events: none;
  z-index: 0;
  opacity: 0.6;
}
.advanced-hero h1 {
  font-size: clamp(1.75rem, 4vw, 2.5rem);
  font-weight: 800;
  background: linear-gradient(
    135deg,
    var(--accent-primary) 0%,
    var(--accent-secondary) 40%,
    var(--accent-primary) 80%,
    var(--accent-secondary) 100%
  );
  background-size: 300% 300%;
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  margin-bottom: 0.75rem;
  position: relative;
  z-index: 1;
  animation: heroShimmer 8s ease infinite;
}
@keyframes heroShimmer {
  0%   { background-position: 0% 50%; }
  50%  { background-position: 100% 50%; }
  100% { background-position: 0% 50%; }
}
.advanced-hero p {
  color: var(--text-secondary);
  font-size: clamp(0.9rem, 1.5vw, 1.1rem);
  max-width: 660px;
  margin: 0 auto;
  line-height: 1.7;
  position: relative;
  z-index: 1;
}

/* ========================================
   QUICK NAV PILLS
   ======================================== */
.quick-nav {
  display: flex;
  justify-content: center;
  gap: 0.75rem;
  flex-wrap: wrap;
  margin-bottom: 2rem;
}
.quick-nav a {
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
  padding: 0.5rem 1.25rem;
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 100px;
  color: var(--text-secondary);
  text-decoration: none;
  font-size: 0.85rem;
  font-weight: 500;
  transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
  backdrop-filter: blur(12px);
}
.quick-nav a:hover {
  background: var(--hover-overlay);
  border-color: var(--accent-primary);
  color: var(--accent-primary);
  transform: translateY(-2px);
  box-shadow: var(--cta-glow);
}

/* ========================================
   TAB NAVIGATION — Modern Pill Strip
   ======================================== */
.nav-tabs {
  display: flex;
  gap: 0.375rem;
  padding: 0.375rem;
  background: var(--glass-bg);
  border: 1px solid var(--glass-border) !important;
  border-radius: 16px;
  overflow-x: auto;
  scrollbar-width: none;
  -webkit-overflow-scrolling: touch;
  scroll-snap-type: x proximity;
  backdrop-filter: blur(24px);
  -webkit-backdrop-filter: blur(24px);
  margin-bottom: 2rem;
  box-shadow: var(--shadow-md);
}
.nav-tabs::-webkit-scrollbar { display: none; }

.nav-tabs .nav-item {
  flex: 1 1 auto;
  min-width: 0;
  scroll-snap-align: start;
}
.nav-tabs .nav-link {
  background: transparent;
  border: none !important;
  border-radius: 12px;
  color: var(--text-secondary);
  font-weight: 600;
  font-size: 0.85rem;
  padding: 0.75rem 1rem;
  white-space: nowrap;
  transition: all 0.35s cubic-bezier(0.4, 0, 0.2, 1);
  display: flex;
  align-items: center;
  justify-content: center;
  gap: 0.5rem;
  margin-bottom: 0;
  width: 100%;
  position: relative;
}
.nav-tabs .nav-link:hover {
  background: var(--hover-overlay);
  color: var(--text-primary);
  border-color: transparent !important;
}
.nav-tabs .nav-link.active {
  background: var(--accent-gradient) !important;
  color: #fff !important;
  -webkit-text-fill-color: #fff;
  box-shadow: var(--cta-glow);
  border-color: transparent !important;
  border-radius: 12px;
}
.nav-tabs .nav-link.active i {
  color: inherit;
  -webkit-text-fill-color: inherit;
}

/* ========================================
   TAB CONTENT — No wrapper chrome
   ======================================== */
.tab-content {
  background: transparent;
  border: none;
  border-radius: 0;
  padding: 0;
  backdrop-filter: none;
}

/* Staggered entrance: each direct child fades in */
.tab-pane {
  animation: paneFadeIn 0.45s ease both;
}
.tab-pane > *:nth-child(1) { animation: childSlideIn 0.4s 0.00s ease both; }
.tab-pane > *:nth-child(2) { animation: childSlideIn 0.4s 0.05s ease both; }
.tab-pane > *:nth-child(3) { animation: childSlideIn 0.4s 0.10s ease both; }
.tab-pane > *:nth-child(4) { animation: childSlideIn 0.4s 0.15s ease both; }
.tab-pane > *:nth-child(5) { animation: childSlideIn 0.4s 0.20s ease both; }
.tab-pane > *:nth-child(6) { animation: childSlideIn 0.4s 0.25s ease both; }
.tab-pane > *:nth-child(7) { animation: childSlideIn 0.4s 0.30s ease both; }
.tab-pane > *:nth-child(8) { animation: childSlideIn 0.4s 0.35s ease both; }

@keyframes paneFadeIn {
  from { opacity: 0; }
  to   { opacity: 1; }
}
@keyframes childSlideIn {
  from { opacity: 0; transform: translateY(16px); }
  to   { opacity: 1; transform: translateY(0); }
}

/* ========================================
   PANE HEADERS
   ======================================== */
.pane-header {
  display: flex;
  align-items: center;
  gap: 1rem;
  margin-bottom: 1.75rem;
  flex-wrap: wrap;
}
.pane-header h2 {
  font-size: clamp(1.3rem, 2.5vw, 1.65rem);
  font-weight: 700;
  color: var(--text-primary);
  margin: 0;
  display: flex;
  align-items: center;
  gap: 0.5rem;
}
.pane-header h2 i {
  background: var(--accent-gradient);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
}

/* ========================================
   GLASS CARDS — Enhanced depth & interaction
   ======================================== */
.glass-card {
  background: var(--glass-bg) !important;
  border: 1px solid var(--glass-border) !important;
  border-radius: 16px !important;
  backdrop-filter: blur(24px);
  -webkit-backdrop-filter: blur(24px);
  transition: all 0.35s cubic-bezier(0.4, 0, 0.2, 1);
  box-shadow: 0 2px 8px rgba(0, 0, 0, 0.08);
}
.glass-card:hover {
  border-color: var(--accent-border) !important;
  box-shadow: var(--shadow-md), 0 0 0 1px var(--accent-border);
  transform: translateY(-2px);
}

/* ========================================
   CARD TITLES — Gradient icon accent
   ======================================== */
.card-title {
  font-size: 1.05rem;
  font-weight: 700;
  color: var(--text-primary);
  display: flex;
  align-items: center;
  gap: 0.5rem;
  margin-bottom: 1.25rem;
  padding-bottom: 0.75rem;
  border-bottom: 1px solid var(--glass-border);
}
.card-title i {
  background: var(--accent-gradient);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  font-size: 1.1rem;
}

/* ========================================
   VIEWERS — Full Width with glow
   ======================================== */
.protein-viewer {
  width: 100%;
  height: 550px;
  background: var(--viewer-bg);
  border-radius: 14px;
  margin: 0.75rem 0;
  position: relative;
  border: 1px solid var(--card-border);
  overflow: hidden;
  box-shadow: inset 0 2px 12px rgba(0, 0, 0, 0.3);
}
.md-trajectory {
  width: 100%;
  height: 450px;
  background: var(--viewer-bg);
  border: 1px solid var(--card-border);
  border-radius: 14px;
  margin: 0.75rem 0;
  overflow: hidden;
  box-shadow: inset 0 2px 12px rgba(0, 0, 0, 0.3);
}
.pharmacophore-canvas {
  height: 550px;
  background: var(--viewer-bg);
  border-radius: 14px;
  border: 1px solid var(--card-border);
  overflow: hidden;
  box-shadow: inset 0 2px 12px rgba(0, 0, 0, 0.3);
}

/* ========================================
   ACTION BARS — Enhanced buttons
   ======================================== */
.action-bar {
  display: flex;
  gap: 0.5rem;
  flex-wrap: wrap;
  margin-top: 1rem;
  padding-top: 1rem;
  border-top: 1px solid var(--glass-border);
}
/* Enhanced button hover for primary/success in tab panes */
.tab-pane .btn-primary,
.tab-pane .btn-success {
  transition: all 0.25s cubic-bezier(0.4, 0, 0.2, 1);
}
.tab-pane .btn-primary:hover,
.tab-pane .btn-success:hover {
  transform: translateY(-1px);
  box-shadow: var(--cta-glow);
}
.tab-pane .btn-primary:active,
.tab-pane .btn-success:active {
  transform: translateY(0);
}

/* ========================================
   PARAMETER FORMS — Modern controls
   ======================================== */
.param-group {
  margin-bottom: 1rem;
}
.param-group label {
  font-size: 0.78rem;
  font-weight: 600;
  color: var(--text-secondary);
  text-transform: uppercase;
  letter-spacing: 0.6px;
  margin-bottom: 0.4rem;
  display: block;
}
.form-select, .form-control {
  background: var(--input-bg);
  border: 1px solid var(--card-border);
  color: var(--text-primary);
  font-size: 0.9rem;
  border-radius: 10px;
  padding: 0.5rem 0.75rem;
  transition: all 0.25s ease;
}
.form-select:focus, .form-control:focus {
  border-color: var(--accent-primary);
  box-shadow: 0 0 0 3px var(--accent-bg), 0 0 16px var(--accent-bg);
  background: var(--input-focus-bg);
  color: var(--text-primary);
}
.form-range::-webkit-slider-thumb {
  background: var(--accent-primary);
  box-shadow: 0 0 6px var(--accent-bg);
}
.form-range::-webkit-slider-runnable-track {
  background: var(--bar-track-bg);
}

/* Parameter grid — 2 columns for better horizontal use */
.param-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 0 1.5rem;
}
.param-wide {
  grid-column: 1 / -1;
}

/* ========================================
   STATUS PILLS
   ======================================== */
.status-pill {
  display: inline-flex;
  align-items: center;
  gap: 0.375rem;
  padding: 0.3rem 0.85rem;
  border-radius: 100px;
  font-size: 0.75rem;
  font-weight: 600;
  backdrop-filter: blur(10px);
}
.status-pill.demo {
  background: var(--status-demo-bg);
  color: var(--status-demo-color);
  border: 1px solid var(--status-demo-border);
}
.status-pill.online {
  background: var(--status-online-bg);
  color: var(--status-online-color);
  border: 1px solid var(--status-online-border);
}

/* ========================================
   DOCKING — Full-Width Stacked
   ======================================== */
.docking-results {
  margin-top: 0.5rem;
}
.result-card {
  background: var(--glass-bg);
  border-radius: 12px;
  padding: 0.875rem 1rem;
  margin-bottom: 0.625rem;
  display: flex;
  justify-content: space-between;
  align-items: center;
  border: 1px solid var(--glass-border);
  border-left: 3px solid var(--accent-primary);
  transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
  backdrop-filter: blur(10px);
}
.result-card:hover {
  border-color: var(--accent-primary);
  border-left-color: var(--accent-primary);
  transform: translateX(4px);
  box-shadow: var(--cta-glow);
}
.binding-score {
  font-size: 1.25rem;
  font-weight: 700;
  background: var(--accent-gradient);
  -webkit-background-clip: text;
  background-clip: text;
  -webkit-text-fill-color: transparent;
  white-space: nowrap;
}

/* Molecule info panel */
.molecule-info-panel {
  margin-top: 1.25rem;
}
.info-chip {
  display: flex;
  align-items: center;
  gap: 0.75rem;
  padding: 0.875rem 1rem;
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 12px;
  transition: all 0.3s ease;
  backdrop-filter: blur(12px);
}
.info-chip:hover {
  border-color: var(--accent-border);
  box-shadow: var(--shadow-md);
}
.info-chip-icon {
  width: 44px; height: 44px;
  border-radius: 12px;
  background: var(--accent-gradient);
  display: flex; align-items: center; justify-content: center;
  color: white; font-size: 1.1rem; flex-shrink: 0;
  box-shadow: 0 4px 12px rgba(0, 0, 0, 0.15);
}
.info-chip-title { font-weight: 600; font-size: 0.9rem; color: var(--text-primary); }
.info-chip-meta { font-size: 0.75rem; color: var(--text-secondary); }
.ligand-2d-thumb {
  width: 52px; height: 52px;
  border-radius: 8px;
  background: white;
  object-fit: contain;
  margin-left: auto;
  flex-shrink: 0;
  box-shadow: 0 2px 8px rgba(0, 0, 0, 0.1);
}
.binding-site-alert {
  display: flex;
  align-items: center;
  gap: 0.5rem;
  margin-top: 0.75rem;
  padding: 0.75rem 1rem;
  background: rgba(16, 185, 129, 0.08);
  border: 1px solid rgba(16, 185, 129, 0.2);
  border-left: 3px solid var(--success);
  border-radius: 10px;
  color: var(--success);
  font-size: 0.85rem;
  font-weight: 500;
}

/* ========================================
   PHARMACOPHORE — Single Column
   ======================================== */
.pharmacophore-builder {
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
  margin-top: 1rem;
}
.pharmacophore-features {
  background: var(--glass-bg);
  border-radius: 14px;
  padding: 1.25rem;
  border: 1px solid var(--glass-border);
  backdrop-filter: blur(20px);
}
.feature-item {
  padding: 0.75rem 0.875rem;
  background: var(--card-bg);
  border-radius: 10px;
  margin-bottom: 0.5rem;
  cursor: pointer;
  transition: all 0.25s cubic-bezier(0.4, 0, 0.2, 1);
  display: flex;
  align-items: center;
  justify-content: space-between;
  font-size: 0.9rem;
  border: 1px solid transparent;
}
.feature-item:hover {
  background: var(--hover-overlay);
  transform: translateX(4px);
  border-color: var(--accent-border);
  box-shadow: var(--cta-glow);
}
.feature-item .feature-label {
  display: flex;
  align-items: center;
  gap: 0.5rem;
}

/* ========================================
   QSAR — Single Column
   ======================================== */
.qsar-model-builder {
  display: flex;
  flex-direction: column;
  gap: 1.25rem;
  margin-top: 1rem;
}
.descriptor-panel, .model-performance {
  background: var(--glass-bg);
  border-radius: 14px;
  padding: 1.5rem;
  border: 1px solid var(--glass-border);
  backdrop-filter: blur(20px);
}
.performance-metric {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 0.75rem 0;
  border-bottom: 1px solid var(--glass-border);
  font-size: 0.9rem;
  transition: background 0.2s ease;
}
.performance-metric:hover {
  background: var(--hover-overlay-subtle);
  border-radius: 6px;
  padding-left: 0.5rem;
  padding-right: 0.5rem;
}
.performance-metric:last-of-type { border-bottom: none; }
.performance-metric .metric-label-text {
  color: var(--text-secondary);
  font-weight: 500;
}
.performance-metric .metric-value {
  font-weight: 700;
  background: var(--accent-gradient);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  font-family: 'Inter', monospace;
  font-size: 1rem;
}

/* ========================================
   VIRTUAL SCREENING
   ======================================== */
.screening-step {
  padding: 1.5rem;
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 14px;
  backdrop-filter: blur(20px);
  transition: all 0.3s ease;
}
.screening-step:hover {
  border-color: var(--accent-border);
  box-shadow: var(--shadow-md);
}
.step-header {
  display: flex;
  align-items: center;
  gap: 0.75rem;
}
.step-number {
  width: 38px; height: 38px;
  border-radius: 10px;
  background: var(--accent-gradient);
  color: white;
  display: flex; align-items: center; justify-content: center;
  font-weight: 800; font-size: 0.9rem;
  flex-shrink: 0;
  box-shadow: var(--cta-glow);
}
.step-title { font-weight: 700; font-size: 1.05rem; color: var(--text-primary); }
.step-desc { font-size: 0.8rem; color: var(--text-secondary); margin-top: 0.15rem; }

.vs-target-btn.active {
  background: var(--accent-primary) !important;
  color: white !important;
  border-color: var(--accent-primary) !important;
  box-shadow: var(--cta-glow);
}

/* Compound library grid */
.vs-library-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(150px, 1fr));
  gap: 0.625rem;
}
.vs-compound-card {
  padding: 0.75rem;
  background: var(--card-bg);
  border: 2px solid var(--card-border);
  border-radius: 10px;
  cursor: pointer;
  transition: all 0.25s cubic-bezier(0.4, 0, 0.2, 1);
  text-align: center;
  user-select: none;
  position: relative;
}
.vs-compound-card:hover {
  border-color: var(--accent-primary);
  transform: translateY(-3px);
  box-shadow: var(--cta-glow);
}
.vs-compound-card.selected {
  border-color: var(--accent-primary);
  background: var(--hover-overlay);
  box-shadow: var(--shadow-glow);
}
.vs-compound-card.selected::after {
  content: '\f00c';
  font-family: 'Font Awesome 6 Free';
  font-weight: 900;
  position: absolute;
  top: 6px; right: 8px;
  font-size: 0.7rem;
  color: var(--accent-primary);
}
.vs-cc-name { font-weight: 600; font-size: 0.85rem; color: var(--text-primary); }
.vs-cc-class { font-size: 0.72rem; color: var(--accent-primary); margin-top: 0.15rem; }
.vs-cc-mw { font-size: 0.72rem; color: var(--text-secondary); margin-top: 0.15rem; }

/* Results table */
.vs-results-table {
  font-size: 0.85rem;
  color: var(--text-primary);
}
.vs-results-table thead th {
  background: var(--glass-bg);
  color: var(--text-secondary);
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.5px;
  font-weight: 700;
  border-bottom: 2px solid var(--card-border);
  padding: 0.75rem 0.5rem;
  white-space: nowrap;
}
.vs-sortable { cursor: pointer; transition: color 0.2s; }
.vs-sortable:hover { color: var(--accent-primary); }
.vs-results-table tbody td {
  border-bottom: 1px solid var(--glass-border);
  padding: 0.625rem 0.5rem;
  vertical-align: middle;
}
.vs-results-table tbody tr {
  transition: all 0.2s ease;
}
.vs-results-table tbody tr:hover {
  background: var(--hover-overlay-subtle);
}
.rank-badge {
  width: 30px; height: 30px;
  border-radius: 8px;
  display: inline-flex; align-items: center; justify-content: center;
  font-weight: 800; font-size: 0.8rem;
}
.rank-1 { background: linear-gradient(135deg, #fbbf24, #f59e0b); color: #000; box-shadow: 0 2px 8px rgba(251, 191, 36, 0.3); }
.rank-2 { background: linear-gradient(135deg, #94a3b8, #64748b); color: #fff; }
.rank-3 { background: linear-gradient(135deg, #cd7f32, #a0522d); color: #fff; }
.rank-other { background: var(--card-bg); color: var(--text-secondary); border: 1px solid var(--card-border); }
.affinity-bar {
  display: inline-block;
  height: 6px;
  border-radius: 3px;
  background: var(--accent-gradient);
  margin-left: 0.375rem;
  vertical-align: middle;
}
.lipinski-pass { color: var(--success); font-weight: 600; }
.lipinski-fail { color: var(--danger); font-weight: 600; }
.drug-score-bar {
  width: 60px; height: 6px;
  background: var(--bar-track-bg);
  border-radius: 3px;
  display: inline-block;
  vertical-align: middle;
  overflow: hidden;
  margin-left: 0.375rem;
}
.drug-score-fill {
  height: 100%;
  border-radius: 3px;
  transition: width 0.6s cubic-bezier(0.4, 0, 0.2, 1);
}

/* ========================================
   AI COPILOT
   ======================================== */
.copilot-container {
  display: flex;
  flex-direction: column;
  height: 700px;
  max-height: 80vh;
  background: var(--glass-bg);
  border-radius: 18px;
  border: 1px solid var(--glass-border);
  overflow: hidden;
  backdrop-filter: blur(24px);
  box-shadow: var(--shadow-md);
}
.copilot-context-banner {
  display: flex;
  align-items: center;
  padding: 0.6rem 1rem;
  background: var(--hover-overlay-subtle);
  border-bottom: 1px solid var(--glass-border);
  font-size: 0.8rem;
  color: var(--text-secondary);
  flex-wrap: wrap;
  gap: 0.5rem;
}
.copilot-mode-badge {
  margin-left: auto;
  font-size: 0.7rem;
  padding: 0.2rem 0.6rem;
  border-radius: 20px;
  background: var(--copilot-btn-bg);
  white-space: nowrap;
}
.copilot-mode-badge.online { color: var(--success); }
.copilot-mode-badge.offline { color: var(--warning-color, #f0ad4e); }

.copilot-quick-actions {
  display: flex;
  gap: 0.5rem;
  padding: 0.75rem 1rem;
  flex-wrap: wrap;
  border-bottom: 1px solid var(--glass-border);
}
.copilot-quick-btn {
  background: var(--copilot-btn-bg);
  border: 1px solid var(--copilot-btn-border);
  color: var(--text-secondary);
  padding: 0.4rem 0.85rem;
  border-radius: 100px;
  font-size: 0.78rem;
  cursor: pointer;
  transition: all 0.25s cubic-bezier(0.4, 0, 0.2, 1);
  white-space: nowrap;
}
.copilot-quick-btn:hover {
  background: var(--accent-bg);
  border-color: var(--accent-primary);
  color: var(--accent-primary);
  box-shadow: var(--shadow-glow);
  transform: translateY(-1px);
}
.copilot-quick-btn:disabled {
  opacity: 0.4;
  cursor: not-allowed;
  transform: none;
}

.copilot-chat {
  flex: 1;
  overflow-y: auto;
  padding: 1.25rem;
  display: flex;
  flex-direction: column;
  gap: 0.75rem;
  scroll-behavior: smooth;
}
.copilot-chat::-webkit-scrollbar { width: 5px; }
.copilot-chat::-webkit-scrollbar-track { background: transparent; }
.copilot-chat::-webkit-scrollbar-thumb { background: var(--scrollbar-thumb); border-radius: 3px; }

.copilot-msg {
  max-width: 85%;
  padding: 0.875rem 1.125rem;
  border-radius: 18px;
  font-size: 0.88rem;
  line-height: 1.6;
  animation: msgFadeIn 0.35s cubic-bezier(0.4, 0, 0.2, 1);
}
@keyframes msgFadeIn {
  from { opacity: 0; transform: translateY(10px) scale(0.97); }
  to { opacity: 1; transform: translateY(0) scale(1); }
}
.copilot-msg.user {
  align-self: flex-end;
  background: var(--accent-gradient);
  color: #fff;
  border-bottom-right-radius: 4px;
  box-shadow: 0 2px 12px rgba(0, 0, 0, 0.1);
}
.copilot-msg.ai {
  align-self: flex-start;
  background: var(--msg-ai-bg);
  border: 1px solid var(--msg-ai-border);
  color: var(--text-primary);
  border-bottom-left-radius: 4px;
}
.copilot-msg .msg-header {
  display: flex;
  align-items: center;
  gap: 0.5rem;
  margin-bottom: 0.4rem;
  font-size: 0.72rem;
  opacity: 0.6;
}
.copilot-msg .msg-header .msg-avatar {
  width: 20px; height: 20px;
  border-radius: 50%;
  display: flex; align-items: center; justify-content: center;
  font-size: 0.6rem;
}
.copilot-msg.ai .msg-avatar { background: var(--accent-bg-strong); color: var(--accent-primary); }
.copilot-msg.user .msg-avatar { background: rgba(255,255,255,0.2); color: #fff; }

/* AI message markdown */
.copilot-msg.ai .msg-body h6 { color: var(--accent-primary); font-size: 0.85rem; margin: 0.6rem 0 0.3rem; }
.copilot-msg.ai .msg-body strong { color: var(--text-primary); }
.copilot-msg.ai .msg-body ul, .copilot-msg.ai .msg-body ol { margin: 0.3rem 0; padding-left: 1.2rem; }
.copilot-msg.ai .msg-body li { margin-bottom: 0.2rem; }
.copilot-msg.ai .msg-body code { background: var(--copilot-code-bg); padding: 0.15rem 0.4rem; border-radius: 4px; font-size: 0.82rem; }
.copilot-msg.ai .msg-body .offline-badge {
  display: inline-block;
  background: rgba(240,173,78,0.15);
  color: var(--warning-color, #f0ad4e);
  padding: 0.15rem 0.5rem;
  border-radius: 10px;
  font-size: 0.72rem;
  margin-bottom: 0.5rem;
}
.copilot-msg.ai .msg-body .disclaimer {
  font-size: 0.75rem;
  opacity: 0.5;
  margin-top: 0.5rem;
  font-style: italic;
}

/* Typing indicator */
.copilot-typing {
  display: flex;
  align-items: center;
  gap: 0.5rem;
  padding: 0.75rem 1rem;
  align-self: flex-start;
  font-size: 0.8rem;
  color: var(--text-secondary);
}
.typing-dots { display: flex; gap: 4px; }
.typing-dots span {
  width: 7px; height: 7px;
  border-radius: 50%;
  background: var(--accent-primary);
  animation: typingBounce 1.4s infinite ease-in-out;
}
.typing-dots span:nth-child(2) { animation-delay: 0.2s; }
.typing-dots span:nth-child(3) { animation-delay: 0.4s; }
@keyframes typingBounce {
  0%, 80%, 100% { transform: scale(0.5); opacity: 0.25; }
  40% { transform: scale(1); opacity: 1; }
}

.copilot-input-row {
  display: flex;
  gap: 0.5rem;
  padding: 0.75rem 1rem;
  border-top: 1px solid var(--glass-border);
  background: var(--input-row-bg);
}
.copilot-input {
  flex: 1;
  background: var(--copilot-btn-bg);
  border: 1px solid var(--glass-border);
  border-radius: 100px;
  padding: 0.55rem 1.125rem;
  color: var(--text-primary);
  font-size: 0.88rem;
  outline: none;
  transition: all 0.25s ease;
}
.copilot-input:focus {
  border-color: var(--accent-primary);
  box-shadow: 0 0 0 3px var(--accent-bg), 0 0 16px var(--accent-bg);
}
.copilot-input::placeholder { color: var(--text-secondary); opacity: 0.5; }
.copilot-send-btn {
  width: 42px; height: 42px;
  border-radius: 50%;
  padding: 0;
  display: flex; align-items: center; justify-content: center;
  transition: all 0.25s;
}
.copilot-send-btn:hover {
  transform: scale(1.08);
  box-shadow: var(--cta-glow);
}
.copilot-export-btn {
  width: 42px; height: 42px;
  border-radius: 50%;
  padding: 0;
  display: flex; align-items: center; justify-content: center;
  font-size: 0.8rem;
}

/* ========================================
   AI DRUG DISCOVERY LAB
   ======================================== */
.dl-algo-row {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 1rem;
  margin-bottom: 1.5rem;
}
.dl-algo-card {
  padding: 1.25rem;
  background: var(--glass-bg);
  border: 2px solid var(--glass-border);
  border-radius: 14px;
  cursor: pointer;
  transition: all 0.35s cubic-bezier(0.4, 0, 0.2, 1);
  display: flex;
  align-items: center;
  gap: 1rem;
  position: relative;
  backdrop-filter: blur(20px);
}
.dl-algo-card:hover {
  border-color: var(--accent-primary);
  transform: translateY(-3px);
  box-shadow: var(--cta-glow);
}
.dl-algo-card.selected {
  border-color: var(--accent-primary);
  background: var(--hover-overlay);
  box-shadow: var(--shadow-glow);
}
.dl-algo-icon {
  width: 52px; height: 52px;
  border-radius: 14px;
  background: var(--hover-overlay);
  display: flex; align-items: center; justify-content: center;
  font-size: 1.3rem;
  color: var(--accent-primary);
  flex-shrink: 0;
  transition: all 0.3s;
}
.dl-algo-card.selected .dl-algo-icon {
  background: var(--accent-gradient);
  color: #fff;
  box-shadow: var(--cta-glow);
}
.dl-algo-name { font-weight: 700; font-size: 1rem; color: var(--text-primary); }
.dl-algo-desc { font-size: 0.75rem; color: var(--text-secondary); margin-top: 0.15rem; line-height: 1.3; }
.dl-algo-check { margin-left: auto; font-size: 1.2rem; color: var(--accent-primary); opacity: 0; transition: opacity 0.25s; }
.dl-algo-card.selected .dl-algo-check { opacity: 1; }

/* Drug Lab — Single Column Layout */
.dl-main-layout {
  display: flex;
  flex-direction: column;
  gap: 1.5rem;
  margin-top: 0.5rem;
}
.dl-params-col {
  display: flex;
  flex-direction: column;
  gap: 0.6rem;
}

.dl-controls-bar {
  display: flex;
  gap: 0.5rem;
  flex-wrap: wrap;
  align-items: center;
  padding: 0.85rem 1rem;
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 12px;
  backdrop-filter: blur(20px);
}
.dl-controls-bar .btn { font-size: 0.82rem; }
.dl-controls-bar .form-select {
  font-size: 0.8rem;
  background-color: var(--card-bg);
  color: var(--text-primary);
  border-color: var(--card-border);
}

.dl-epoch-progress {
  padding: 0.85rem 1rem;
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 12px;
  backdrop-filter: blur(20px);
}
.dl-progress-track {
  height: 8px;
  background: var(--bar-track-bg);
  border-radius: 4px;
  overflow: hidden;
}
.dl-progress-fill {
  height: 100%;
  background: var(--accent-gradient);
  border-radius: 4px;
  transition: width 0.3s ease;
  position: relative;
}
/* Animated pulse on active progress */
.dl-progress-fill::after {
  content: '';
  position: absolute;
  inset: 0;
  background: linear-gradient(90deg, transparent 0%, rgba(255,255,255,0.3) 50%, transparent 100%);
  background-size: 200% 100%;
  animation: progressPulse 2s linear infinite;
}
@keyframes progressPulse {
  0%   { background-position: -200% 0; }
  100% { background-position: 200% 0; }
}

.dl-param-section {
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 12px;
  overflow: hidden;
  backdrop-filter: blur(20px);
  transition: border-color 0.3s;
}
.dl-param-section:hover {
  border-color: var(--accent-border);
}
.dl-param-section-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 0.75rem 1rem;
  cursor: pointer;
  font-weight: 600;
  font-size: 0.85rem;
  color: var(--text-primary);
  transition: background 0.2s;
  user-select: none;
}
.dl-param-section-header:hover { background: var(--hover-overlay-subtle); }
.dl-collapse-icon { transition: transform 0.3s cubic-bezier(0.4, 0, 0.2, 1); font-size: 0.65rem; color: var(--text-secondary); }
.dl-param-section-header.collapsed .dl-collapse-icon { transform: rotate(-90deg); }
.dl-param-section-body { padding: 0.25rem 1rem 1rem; }

.dl-weight-sum {
  font-size: 0.78rem;
  color: var(--text-secondary);
  text-align: right;
  padding-top: 0.4rem;
  border-top: 1px solid var(--glass-border);
  margin-top: 0.4rem;
}

/* Dashboard charts — 2-col grid */
.dl-dashboard-col {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1rem;
}
.dl-chart-panel {
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 14px;
  padding: 1rem;
  min-height: 240px;
  backdrop-filter: blur(20px);
  transition: all 0.3s ease;
}
.dl-chart-panel:hover {
  border-color: var(--accent-border);
  box-shadow: var(--shadow-md);
}
.dl-chart-title {
  font-size: 0.72rem;
  font-weight: 700;
  color: var(--text-secondary);
  text-transform: uppercase;
  letter-spacing: 0.5px;
  margin-bottom: 0.6rem;
}
.dl-chart-title i {
  background: var(--accent-gradient);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
}
.dl-chart-container { height: 200px; position: relative; }
.dl-chart-radar-container { height: 220px; }

/* Molecules Showcase */
.dl-molecules-showcase {
  margin-top: 1.5rem;
  padding: 1.25rem;
  background: var(--glass-bg);
  border: 1px solid var(--glass-border);
  border-radius: 14px;
  backdrop-filter: blur(20px);
}
.dl-showcase-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: 1rem;
  flex-wrap: wrap;
  gap: 0.5rem;
}
.dl-mol-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(200px, 1fr));
  gap: 1rem;
}
.dl-mol-placeholder {
  grid-column: 1 / -1;
  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;
  padding: 3rem;
  gap: 0.75rem;
  border: 2px dashed var(--glass-border);
  border-radius: 12px;
}
.dl-mol-card {
  background: var(--copilot-btn-bg);
  border: 1px solid var(--glass-border);
  border-radius: 14px;
  padding: 1rem;
  transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
  position: relative;
}
.dl-mol-card:hover {
  border-color: var(--accent-primary);
  transform: translateY(-4px);
  box-shadow: var(--cta-glow);
}
.dl-mol-rank {
  position: absolute; top: 8px; left: 8px;
  width: 26px; height: 26px;
  border-radius: 8px;
  display: flex; align-items: center; justify-content: center;
  font-weight: 800; font-size: 0.7rem;
}
.dl-mol-rank.gold { background: linear-gradient(135deg,#fbbf24,#f59e0b); color: #000; box-shadow: 0 2px 8px rgba(251, 191, 36, 0.4); }
.dl-mol-rank.silver { background: linear-gradient(135deg,#94a3b8,#64748b); color: #fff; }
.dl-mol-rank.bronze { background: linear-gradient(135deg,#cd7f32,#a0522d); color: #fff; }
.dl-mol-rank.default { background: var(--hover-overlay); color: var(--text-secondary); }
.dl-mol-img {
  width: 100%; height: 100px;
  background: #fff;
  border-radius: 8px;
  object-fit: contain;
  margin-bottom: 0.6rem;
}
.dl-mol-name { font-weight: 700; font-size: 0.82rem; color: var(--text-primary); white-space: nowrap; overflow: hidden; text-overflow: ellipsis; }
.dl-mol-smiles { font-family: monospace; font-size: 0.65rem; color: var(--text-secondary); white-space: nowrap; overflow: hidden; text-overflow: ellipsis; margin-top: 0.15rem; }
.dl-mol-props { display: grid; grid-template-columns: 1fr 1fr; gap: 0.15rem 0.5rem; margin-top: 0.55rem; font-size: 0.72rem; }
.dl-mol-prop-label { color: var(--text-secondary); }
.dl-mol-prop-value { color: var(--accent-primary); font-weight: 600; text-align: right; }
.dl-mol-score-bar { margin-top: 0.5rem; height: 5px; background: var(--bar-track-bg); border-radius: 3px; overflow: hidden; }
.dl-mol-score-fill { height: 100%; border-radius: 3px; }

/* ========================================
   MODALS — Enhanced depth
   ======================================== */
.modal-content {
  background: var(--bg-secondary);
  border: 1px solid var(--card-border);
  color: var(--text-primary);
  border-radius: 20px;
  overflow: hidden;
  box-shadow: var(--shadow-lg);
}
.modal-header {
  border-bottom: 1px solid var(--glass-border);
  padding: 1.25rem 1.5rem;
}
.modal-body { padding: 1.5rem; }
.modal-footer { border-top: 1px solid var(--glass-border); }
.modal-title {
  font-weight: 700;
  display: flex;
  align-items: center;
  gap: 0.5rem;
}
.modal-title i {
  background: var(--accent-gradient);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
}
.btn-close { filter: var(--btn-close-filter); }
.selector-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(220px, 1fr));
  gap: 0.75rem;
  margin-top: 1rem;
}
.selector-card {
  padding: 1rem;
  background: var(--glass-bg);
  border: 2px solid var(--card-border);
  border-radius: 12px;
  cursor: pointer;
  transition: all 0.25s cubic-bezier(0.4, 0, 0.2, 1);
  backdrop-filter: blur(10px);
}
.selector-card:hover {
  border-color: var(--accent-primary);
  background: var(--hover-overlay);
  transform: translateY(-3px);
  box-shadow: var(--cta-glow);
}
.selector-card .sc-title { font-weight: 600; font-size: 0.95rem; color: var(--text-primary); }
.selector-card .sc-subtitle { font-size: 0.8rem; color: var(--text-secondary); margin-top: 0.2rem; }
.selector-card .sc-badge {
  display: inline-block;
  font-size: 0.7rem;
  padding: 0.2rem 0.6rem;
  border-radius: 6px;
  background: var(--accent-bg);
  color: var(--accent-primary);
  font-weight: 600;
  margin-top: 0.5rem;
}
.custom-id-row {
  display: flex;
  gap: 0.5rem;
  margin-top: 1.25rem;
  padding-top: 1.25rem;
  border-top: 1px solid var(--glass-border);
}
.custom-id-row .form-control { flex: 1; }
.selector-section-label {
  font-size: 0.72rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.6px;
  color: var(--text-secondary);
  margin-bottom: 0.5rem;
}

/* ========================================
   RESPONSIVE
   ======================================== */

/* Tablets */
@media (max-width: 991.98px) {
  .nav-tabs {
    flex-wrap: nowrap;
    overflow-x: auto;
  }
  .nav-tabs .nav-item {
    flex: 0 0 auto;
  }
  .param-grid {
    grid-template-columns: 1fr;
  }
  .dl-algo-row { grid-template-columns: 1fr; }
  .dl-dashboard-col { grid-template-columns: 1fr; }
}

@media (max-width: 767.98px) {
  body { padding-top: 65px; }
  body::before { width: 350px; height: 350px; }
  body::after { width: 300px; height: 300px; }

  .advanced-hero { padding: 1.5rem 0.5rem 1rem; }
  .advanced-hero::before { width: 300px; height: 150px; }

  .quick-nav { gap: 0.5rem; margin-bottom: 1.25rem; }
  .quick-nav a { font-size: 0.8rem; padding: 0.375rem 0.75rem; }

  .nav-tabs {
    gap: 0.25rem;
    padding: 0.25rem;
    border-radius: 12px;
    margin-bottom: 1.25rem;
  }
  .nav-tabs .nav-link {
    padding: 0.5rem 0.75rem;
    font-size: 0.75rem;
    border-radius: 10px;
    flex-direction: column;
    gap: 0.2rem;
  }
  .nav-tabs .nav-link i.me-2 {
    margin-right: 0 !important;
  }

  .pane-header h2 { font-size: 1.25rem; }
  .card-title { border-bottom: none; padding-bottom: 0; }

  .protein-viewer { height: 300px; }
  .pharmacophore-canvas { height: 300px; }
  .md-trajectory { height: 250px; }

  .action-bar .btn { font-size: 0.8rem; padding: 0.375rem 0.625rem; }

  .copilot-container { height: 600px; }
  .copilot-quick-btn { font-size: 0.7rem; padding: 0.25rem 0.5rem; }
  .copilot-msg { max-width: 92%; font-size: 0.82rem; }
  .copilot-context-banner { font-size: 0.72rem; }

  .vs-library-grid { grid-template-columns: repeat(auto-fill, minmax(110px, 1fr)); gap: 0.375rem; }
  .vs-cc-name { font-size: 0.8rem; }
  .screening-step { padding: 1rem; }
  .step-title { font-size: 0.9rem; }
  .vs-results-table { font-size: 0.75rem; }

  .info-chip { padding: 0.5rem 0.75rem; gap: 0.5rem; }
  .info-chip-icon { width: 36px; height: 36px; font-size: 0.9rem; }

  .dl-mol-grid { grid-template-columns: repeat(auto-fill, minmax(150px, 1fr)); }
  .dl-chart-container { height: 160px; }
  .dl-algo-card { padding: 0.85rem; }
  .dl-algo-icon { width: 40px; height: 40px; font-size: 1rem; }

  /* Disable stagger on mobile for snappier feel */
  .tab-pane > * { animation: none !important; }
  .tab-pane { animation: paneFadeIn 0.3s ease both; }
}

@media (max-width: 575.98px) {
  body { padding-top: 60px; }
  .protein-viewer { height: 250px; }
  .pharmacophore-canvas { height: 250px; }
  .md-trajectory { height: 200px; }
  .nav-tabs .nav-link { padding: 0.4rem 0.5rem; font-size: 0.7rem; }
  .vs-library-grid { grid-template-columns: repeat(3, 1fr); }
}

/* ========================================
   ACCESSIBILITY
   ======================================== */
:focus-visible {
  outline: 2px solid var(--accent-primary);
  outline-offset: 2px;
}
.skip-link:focus {
  top: 0 !important;
}

/* Firefox scrollbar */
* {
  scrollbar-width: thin;
  scrollbar-color: var(--scrollbar-thumb) transparent;
}

/* Reduced motion — disable ALL animations */
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after {
    animation-duration: 0.01ms !important;
    animation-iteration-count: 1 !important;
    transition-duration: 0.01ms !important;
  }
  body::before, body::after {
    animation: none !important;
  }
}